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Nature (London), ISSN 0028-0836, 08/2009, Volume 460, Issue 7257, pp. 904 - 908
.... aUPD is associated not only with loss-of-function mutations of tumour suppressor genes... 
TRANSFORMATION | PROTEIN | RETROVIRAL VECTOR GCDNSAP | NEGATIVE REGULATION | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | V-CBL | MUTATIONS | UBIQUITIN LIGASES | MYELODYSPLASTIC SYNDROMES | P53 | NIH 3T3 Cells | Neoplasm Transplantation | ras Proteins - genetics | Phosphorylation | Proto-Oncogene Proteins c-cbl - metabolism | Humans | Leukemia, Myeloid - genetics | Molecular Sequence Data | ras Proteins - metabolism | Male | Leukemia, Myeloid - pathology | Allelic Imbalance | Ubiquitination | Base Sequence | Female | Proto-Oncogene Proteins c-cbl - deficiency | Genes, Tumor Suppressor | Proto-Oncogene Proteins c-cbl - genetics | Amino Acid Sequence | Oncogenes - genetics | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Chromosomes, Human, Pair 11 - genetics | Proto-Oncogene Proteins c-cbl - chemistry | Mice, Knockout | Animals | Uniparental Disomy - genetics | Leukemia, Myeloid - metabolism | Mice, Nude | Mutant Proteins - chemistry | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Protein Conformation | Mice | Mutation | Gene mutations | Myelocytic leukemia | Physiological aspects | Tumor suppressor genes | Development and progression | Genetic aspects | Nonlymphoid leukemia | Research | Protein kinases | Proteins | Genes | Amino acids | Kinases | Cells | Clinical outcomes | Crystal structure | cytokine sensitivity | tumor suppressor | myelodysplasia | 490 | LOH | ubiquitination
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 02/2013, Volume 77, Issue 3, pp. 472 - 484
Major outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and... 
MUTANT MICE | CORTICAL AXONS | THALAMOCORTICAL AXONS | GROWTH | SEMAPHORIN 3E | CENTRAL-NERVOUS-SYSTEM | GUIDANCE | CHICK HINDLIMB | CAJAL-RETZIUS CELLS | NEUROSCIENCES | CEREBRAL-CORTEX | Thyroid Nuclear Factor 1 | Age Factors | Embryo, Mammalian | Leukocyte L1 Antigen Complex - metabolism | Gene Expression Regulation, Developmental - genetics | Axons - physiology | Cerebral Cortex - cytology | Neural Pathways - physiology | DNA-Binding Proteins - metabolism | POU Domain Factors - genetics | tau Proteins - genetics | Thalamus - physiology | Contactin 2 - metabolism | Repressor Proteins - metabolism | Glycoproteins - genetics | Tumor Suppressor Proteins - metabolism | Wnt3A Protein - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Mice, Transgenic | Nuclear Proteins - metabolism | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | S100 Calcium Binding Protein G - metabolism | Transcription Factors - metabolism | Animals | Calbindin 2 | Thalamus - cytology | Cerebral Cortex - physiology | Luminescent Proteins - genetics | Mice | Body Patterning - genetics | Luminescent Proteins - metabolism | Developmental biology | Neurons | Studies | Laboratories | Experiments | Repressor Proteins | Cerebral Cortex | Cellular Biology | Neural Pathways | tau Proteins | Life Sciences | Contactin 2 | Gene Expression Regulation, Developmental | Body Patterning | Thalamus | Membrane Glycoproteins | Luminescent Proteins | DNA-Binding Proteins | POU Domain Factors | Calcium-Binding Protein, Vitamin D-Dependent | Glycoproteins | Nerve Tissue Proteins | Nuclear Proteins | Membrane Proteins | Axons | Homeodomain Proteins | Leukocyte L1 Antigen Complex | Transcription Factors | Wnt3A Protein | Tumor Suppressor Proteins | reciprocal connections | handshake | waiting period | PlexinD1 | axon guidance | Sema3E | thalamocortical | corticothalamic
Journal Article
Nature cell biology, ISSN 1465-7392, 2017, Volume 19, Issue 10, pp. 1226 - 1236
.... Anti-apoptotic BCL-2 proteins engage a BCL-2 homology (BH) domain sequence found in SUFU (suppressor of fused... 
SIGNAL | APOPTOSIS | ACTIVATION | SONIC HEDGEHOG | PATHWAY | MCL-1 | GENOMIC ANALYSIS | RESISTANCE | PROLIFERATION | MEDULLOBLASTOMA | CELL BIOLOGY | Neoplasms - metabolism | NIH 3T3 Cells | Transcription, Genetic - drug effects | Cell Proliferation | Zinc Finger Protein GLI1 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-X Protein - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Molecular Mimicry | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - deficiency | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Peptide Fragments - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Survival | Zinc Finger Protein GLI1 - genetics | Repressor Proteins - genetics | Genotype | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Mice, Knockout | Neoplasms - drug therapy | Phenotype | Animals | Mice, Nude | CRISPR-Cas Systems | Mice | Neoplasms - pathology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Genes | Genetic aspects | Genetic transcription | Drug resistance | Binding proteins | Tumors | Protein binding | Regulators | Cell survival | Bcl-2 protein | Transcription | Decision making | Homology | Gene expression | Mcl-1 protein | Proteins | Signaling | Mitochondria | DNA-binding protein | Bcl-x protein | Cell death | Feedforward | Deoxyribonucleic acid--DNA | Cancer
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2008, Volume 283, Issue 9, pp. 5496 - 5509
... (protein kinase A /PK G /PK C ) kinases. It is a tumor suppressor gene originally isolated from Drosophila and recently isolated from mice and humans... 
YES-ASSOCIATED PROTEIN | APOPTOSIS | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | KINASE | HIPPO PATHWAY | CELL-PROLIFERATION | DROSOPHILA LATS | PROMOTES | HUMAN HOMOLOG | Oncogene Proteins - genetics | Phosphorylation | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Humans | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Cell Nucleus - metabolism | Cell Transformation, Neoplastic - genetics | Tumor Suppressor Proteins - genetics | Nuclear Proteins - genetics | Active Transport, Cell Nucleus - genetics | Intracellular Signaling Peptides and Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | Drosophila | Oncogene Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Phosphoproteins - genetics | Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Transcription Factors - metabolism | Animals | Cell Nucleus - genetics | Adaptor Proteins, Signal Transducing - genetics | Mice | Drosophila Proteins - genetics | HeLa Cells | Transcription, Genetic - genetics | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Motifs - genetics
Journal Article
Oncogene, ISSN 0950-9232, 09/2008, Volume 27, Issue 38, pp. 5115 - 5123
Cancer development results from deregulated control of stem cell populations and alterations in their surrounding environment. Notch signaling is an important... 
Epigenetics | Keratinocytes | Cancer stem cells | p63 | Rho signaling | p53 | SIGNALING PATHWAYS | RBP-J-KAPPA | HAIR FOLLICLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | keratinocytes | BETA-CATENIN | P53 HOMOLOG | epigenetics | CELL BIOLOGY | ONCOLOGY | GROWTH ARREST | CERVICAL-CANCER CELLS | GENETICS & HEREDITY | NEGATIVE TRANSCRIPTIONAL REGULATOR | KERATINOCYTE STEM-CELLS | cancer stem cells | NF-KAPPA-B | Species Specificity | Keratinocytes - radiation effects | Humans | Receptors, Notch - genetics | Tumor Suppressor Protein p53 - physiology | Neoplasms - virology | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Tumor Virus Infections - physiopathology | Tumor Suppressor Proteins - genetics | Female | Neoplasms - physiopathology | Cell Differentiation - physiology | Genes, Tumor Suppressor | Oncogene Proteins, Viral - physiology | Receptors, Notch - physiology | Uterine Cervical Neoplasms - physiopathology | Uterine Cervical Neoplasms - genetics | Ultraviolet Rays - adverse effects | Tumor Suppressor Proteins - physiology | Keratinocytes - pathology | Animals | Uterine Cervical Neoplasms - virology | Signal Transduction - physiology | Mice | Apoptosis - physiology | DNA Damage | Receptor, Notch1 - genetics | Receptor, Notch1 - physiology | Care and treatment | Tumor suppressor genes | Cellular signal transduction | Genetic aspects | Research | Health aspects | Risk factors | Cancer | Signal transduction | Gene expression | Stem cells | Cell cycle | cancer therapy | carcinogenesis
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2017, Volume 292, Issue 37, pp. 15205 - 15215
... reactivation in cancer are not well-understood. Surprisingly, here we found occupancy of the metastasis suppressor non-metastatic 2 (NME2... 
CELLS | ACTIVATION | NM23-H2 | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | TRANSCRIPTION | GENE-EXPRESSION | HUMAN CANCERS | PROMOTER | GENOME | Epigenetic Repression | Humans | Protein Multimerization | Neoplasm Proteins - antagonists & inhibitors | Fibrosarcoma - metabolism | Neoplasm Proteins - metabolism | NM23 Nucleoside Diphosphate Kinases - genetics | NM23 Nucleoside Diphosphate Kinases - metabolism | Repressor Proteins - antagonists & inhibitors | Fibrosarcoma - pathology | Telomerase - genetics | Chromatin Immunoprecipitation | RNA Interference | Carcinoma - enzymology | G-Quadruplexes | Telomerase - metabolism | Carcinoma - pathology | Neoplasm Proteins - genetics | Genes, Reporter | Repressor Proteins - metabolism | Recombinant Proteins - metabolism | NM23 Nucleoside Diphosphate Kinases - chemistry | Promoter Regions, Genetic | Repressor Proteins - chemistry | Mutagenesis, Site-Directed | Histone Demethylases - chemistry | NM23 Nucleoside Diphosphate Kinases - antagonists & inhibitors | Cells, Cultured | Recombinant Proteins - chemistry | Repressor Proteins - genetics | Neoplasm Proteins - chemistry | Histone Demethylases - metabolism | Point Mutation | Cell Line, Tumor | Carcinoma - metabolism | Telomerase - antagonists & inhibitors | Fibrosarcoma - enzymology | Amino Acid Substitution | Gene Regulation | transcription regulation | chromatin modification | G-quadruplex | telomerase reverse transcriptase (TERT) | NME2 | REST repressor complex | epigenetics
Journal Article