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The Journal of clinical investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3742 - 3754
.... Surprisingly, we found that loss of the tumor suppressor gene neurofibromatosis type 1 (Nf1) increased HSF1 levels and triggered its activation in mouse embryonic fibroblasts... 
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | NIH 3T3 Cells | Phosphorylation | Macrolides - toxicity | Humans | Neoplasm Proteins - physiology | Transcription Factors - deficiency | Withanolides - toxicity | Gene Expression Regulation, Neoplastic | Neurofibromin 1 - deficiency | Genes, Neurofibromatosis 1 | DNA-Binding Proteins - deficiency | Gene Knockdown Techniques | Heat Shock Transcription Factors | MAP Kinase Signaling System | RNA, Messenger - biosynthesis | Cell Transformation, Neoplastic - genetics | Nerve Sheath Neoplasms - pathology | Active Transport, Cell Nucleus | Neoplasm Proteins - genetics | Cell Line, Tumor - metabolism | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Neoplasm Proteins - biosynthesis | Mice, Inbred C57BL | Neurofibromin 1 - physiology | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Transcription Factors - biosynthesis | Hot Temperature | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Animals | RNA, Neoplasm - biosynthesis | RNA, Neoplasm - genetics | Mice | Mice, Inbred BALB C | Neoplasm Proteins - deficiency | Protein Processing, Post-Translational | DNA-Binding Proteins - biosynthesis | Leupeptins - toxicity | Heat shock proteins | Physiological aspects | Tumor suppressor genes | Genetic aspects | Research | Carcinogenesis | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
Oncogene, ISSN 1476-5594, 01/2013, Volume 33, Issue 5, pp. 556 - 566
Retinoblastoma (Rb) protein is a tumor suppressor that is dysregulated in a majority of human cancers... 
Metabolism | Cancer | Glutamine | Retinoblastoma Protein | Tumor Suppressor | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Proliferation | Reactive Oxygen Species - metabolism | Glutamate-Cysteine Ligase - biosynthesis | Minor Histocompatibility Antigens | Glutamine - metabolism | Retinoblastoma-Like Protein p107 - genetics | Adenosine Triphosphate - biosynthesis | Oxygen - metabolism | Glutathione - biosynthesis | RNA Interference | Retinoblastoma-Like Protein p130 - metabolism | Fibroblasts | Biological Transport - genetics | Amino Acid Transport System ASC - genetics | Ketoglutaric Acids - metabolism | Glutaminase - biosynthesis | Promoter Regions, Genetic | Retinoblastoma-Like Protein p107 - metabolism | Retinoblastoma Protein - metabolism | Cells, Cultured | Amino Acid Transport System ASC - metabolism | Glutaminase - metabolism | Mice, Knockout | Animals | E2F3 Transcription Factor - biosynthesis | Cell Cycle | Retinoblastoma Protein - genetics | E2F3 Transcription Factor - metabolism | Mice | RNA, Small Interfering | Retinoblastoma-Like Protein p130 - genetics | Amino Acid Transport System ASC - biosynthesis | Glutaminase - genetics | Oncology, Experimental | Physiological aspects | Genetic research | Tumor suppressor genes | Genetic aspects | Research | Studies | Tumors | Index Medicus
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 03/2006, Volume 66, Issue 5, pp. 2725 - 2731
.... Renal clear cell carcinoma (RCC) is characterized by loss of function of the von Hippel-Lindau tumor suppressor (VHL... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | RNA, Small Interfering - genetics | Kidney Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Kidney Neoplasms - metabolism | Zinc Finger E-box Binding Homeobox 2 | Cadherins - biosynthesis | Hypoxia-Inducible Factor 1 - genetics | Repressor Proteins - physiology | RNA, Messenger - biosynthesis | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Transcription, Genetic | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Cadherins - genetics | Hypoxia-Inducible Factor 1 - biosynthesis | Basic Helix-Loop-Helix Transcription Factors - physiology | Transcription Factors - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Homeodomain Proteins - biosynthesis | Carcinoma, Renal Cell - pathology | Down-Regulation | Hypoxia-Inducible Factor 1 - physiology | RNA, Messenger - genetics | Von Hippel-Lindau Tumor Suppressor Protein - biosynthesis | Repressor Proteins - genetics | Von Hippel-Lindau Tumor Suppressor Protein - physiology | Epithelial Cells - pathology | Transcription Factors - biosynthesis | Transcription Factors - genetics | Homeodomain Proteins - genetics | Carcinoma, Renal Cell - metabolism | Repressor Proteins - biosynthesis | Biopsy | Cell Adhesion - physiology | Kidney Neoplasms - pathology | Homeodomain Proteins - physiology | Mesoderm - pathology | Zinc Finger E-box-Binding Homeobox 1 | Index Medicus
Journal Article
Journal Article
Oncology reports, ISSN 1021-335X, 04/2015, Volume 33, Issue 4, pp. 1976 - 1984
Journal Article
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 01/2004, Volume 172, Issue 1, pp. 567 - 576
.... Overexpression of STAT3 DN completely inhibited IL-10-induced suppressor of cytokine signaling 3, tissue inhibitor of MMP-1, TNF receptor expression, and the recently identified IL-10-inducible genes... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | SOCS-3 protein | Index Medicus | Abridged Index Medicus
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 03/2016, Volume 133, Issue 11, pp. 1081 - 1092
BACKGROUND—Adult mammalian cardiomyocytes (CMs) have the potential to proliferate, but this is not sufficient to generate adequate CMs after myocardial... 
Myocardial infarction | Regeneration | Myocytes, cardiac | Molecular biology | Cell cycle | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Single-Blind Method | T-Box Domain Proteins - physiology | RNA, Small Interfering - genetics | T-Box Domain Proteins - biosynthesis | Muscle Proteins - biosynthesis | RNA, Messenger - biosynthesis | RNA Interference | Cell Division | Myocardial Infarction - pathology | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Electrocardiography | Female | Myocardial Infarction - physiopathology | Genes, Reporter | Heart - physiopathology | Immediate-Early Proteins - physiology | Cell Size - drug effects | Immediate-Early Proteins - biosynthesis | RNA, Messenger - genetics | Genes, cdc - drug effects | Mice, Transgenic | Myocardium - pathology | Cell Cycle Proteins - biosynthesis | Myocardial Infarction - metabolism | Random Allocation | Fetal Proteins - biosynthesis | T-Box Domain Proteins - genetics | Gene Expression Regulation - drug effects | Muscle Proteins - genetics | Myocytes, Cardiac - pathology | Tumor Suppressor Proteins - physiology | Organ Size - drug effects | Animals | Immediate-Early Proteins - genetics | Signal Transduction - drug effects | Tamoxifen - pharmacology | Myocytes, Cardiac - metabolism | Fetal Proteins - genetics | Mice | Tumor Suppressor Proteins - biosynthesis | Cell proliferation | Care and treatment | Transcription factors | Research | Heart attack | Heart cells | Index Medicus | Abridged Index Medicus | molecular biology | remodeling | myocytes | myocardial infarction
Journal Article