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Nature Chemical Biology, ISSN 1552-4450, 2011, Volume 7, Issue 5, pp. 285 - 295
Journal Article
Journal Article
EMBO reports, ISSN 1469-221X, 01/2010, Volume 11, Issue 1, pp. 45 - 51
Autophagy is the cellular homeostatic pathway that delivers large cytosolic materials for degradation in the lysosome. Recent evidence indicates that autophagy... 
mitophagy | Nix | LC3 | GABARAP | selective autophagy | Selective autophagy | Mitophagy | APOPTOSIS | PROTEIN | RETICULOCYTE MATURATION | UBIQUITIN | BNIP3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-DEATH | CELL BIOLOGY | STRUCTURAL BASIS | DEGRADATION | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Cercopithecus aethiops | Molecular Sequence Data | Substrate Specificity | Autophagy - physiology | Mitochondrial Proteins - genetics | Proto-Oncogene Proteins - chemistry | Mitochondrial Proteins - metabolism | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Membrane Proteins - metabolism | Binding Sites | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Blotting, Western | Amino Acid Motifs | Autophagy-Related Protein 8 Family | Animals | Membrane Proteins - chemistry | Reticulocytes - cytology | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Mice | Receptors, GABA-A - metabolism | COS Cells | Proteins | Mitochondria | Cellular biology | Cytoplasm | Index Medicus | Scientific Report
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2010, Volume 107, Issue 23, pp. 10532 - 10537
The Hippo signaling pathway regulates organ size and tissue homeostasis from Drosophila to mammals. At the core of the Hippo pathway is a kinase cascade... 
Proteins | Epithelial cells | Noise reduction | Drosophila | Transmembrane proteins | Gene expression regulation | Cell membranes | Embryos | Regulator genes | Tumors | Development | Signal transduction | Apical-basal polarity | Organ size | APOPTOSIS | development | organ size | signal transduction | MULTIDISCIPLINARY SCIENCES | apical-basal polarity | EPITHELIAL POLARITY | CELL-PROLIFERATION | HOMOLOG | DOMAIN PROTEIN | DROSOPHILA STARDUST | PATHWAY | GROWTH | FAT | Cell Polarity | Drosophila melanogaster - embryology | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - metabolism | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Conserved Sequence | Membrane Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Signal Transduction | Animals, Genetically Modified | Membrane Proteins - genetics | Drosophila melanogaster - cytology | Drosophila Proteins - chemistry | Animals | Membrane Proteins - chemistry | Protein Binding | Drosophila melanogaster - growth & development | Drosophila Proteins - genetics | Mutation | Growth | Analysis | Physiological aspects | Cellular signal transduction | Research | Health aspects | Membrane proteins | Protein binding | Tissue | Membranes | Insects | Developmental biology | Kinases | Binding sites | Index Medicus | Biological Sciences
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 10/2010, Volume 17, Issue 10, pp. 1247 - 1254
Inherited mutations in human PALB2 are associated with a predisposition to breast and pancreatic cancers. PALB2's tumor-suppressing effect is thought to be... 
POLY(ADP-RIBOSE) POLYMERASE | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | HISTONE H2AX | FANCONI-ANEMIA | CELL BIOLOGY | RAD51 | BIOPHYSICS | IN-VIVO | SUSCEPTIBILITY GENE | D-LOOP FORMATION | DNA-REPAIR | Recombination, Genetic - physiology | DNA, Neoplasm - metabolism | Humans | Neoplasm Proteins - physiology | DNA Repair - physiology | Molecular Sequence Data | Structure-Activity Relationship | DNA Breaks, Double-Stranded | BRCA2 Protein - physiology | Breast Neoplasms - metabolism | Base Sequence | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Female | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Nucleic Acid Conformation | Fanconi Anemia Complementation Group N Protein | Peptide Fragments - metabolism | Neoplasm Proteins - chemistry | Nuclear Proteins - chemistry | Poly(ADP-ribose) Polymerase Inhibitors | Protein Interaction Mapping | Tumor Suppressor Proteins - physiology | Peptide Fragments - chemistry | Apoptosis Regulatory Proteins | Models, Biological | Rad51 Recombinase - chemistry | Rad51 Recombinase - physiology | BRCA2 Protein - chemistry | Nuclear Proteins - physiology | Poly (ADP-Ribose) Polymerase-1 | Breast cancer | Genetic aspects | Research | BRCA mutations | Ovarian cancer | Proteins | Mutation | Molecular biology | Prostate cancer | Index Medicus | homologous recombination | BRCA2 | PALB2
Journal Article
Science, ISSN 0036-8075, 9/2012, Volume 337, Issue 6101, pp. 1541 - 1546
De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur... 
Spleen | Myeloid cells | Genes | DNA | REPORTS | Stem cells | Neutrophils | Bone marrow | Bone marrow cells | Genetic mutation | Tumors | ASXL1 | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | LEUKEMIA | UBIQUITIN HYDROLASE | PREDISPOSE | MYELODYSPLASTIC SYNDROMES | Myeloid Cells - cytology | Humans | Leukemia, Myelomonocytic, Chronic - genetics | Myeloid Cells - physiology | Host Cell Factor C1 - metabolism | Leukemia, Myelomonocytic, Chronic - metabolism | Chromatin Immunoprecipitation | Hematopoiesis | Gene Deletion | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Bone Marrow Transplantation | Myeloid Progenitor Cells - cytology | Ubiquitin Thiolesterase - metabolism | Leukemia, Myelomonocytic, Chronic - pathology | Genes, Tumor Suppressor | Repressor Proteins - metabolism | Promoter Regions, Genetic | Myelodysplastic Syndromes - metabolism | Tumor Suppressor Proteins - metabolism | Gene Expression Regulation | Embryonic Development | Ubiquitin Thiolesterase - genetics | N-Acetylglucosaminyltransferases - metabolism | Gene Knock-In Techniques | Mice, Knockout | Animals | Myeloid Progenitor Cells - physiology | Cell Transformation, Neoplastic | Mice | Myelodysplastic Syndromes - genetics | Myelodysplastic Syndromes - pathology | Ubiquitin Thiolesterase - chemistry | Gene silencing | Tumor suppressor genes | Genetic engineering | Research | Properties | Observations | Enzymes | Mutation | Gene expression | Molecular biology | Leukemia | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2006, Volume 126, Issue 2, pp. 269 - 283
The PML tumor suppressor controls key pathways for growth suppression, induction of apoptosis, and cellular senescence. PML loss occurs frequently in human... 
APOPTOSIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-KINASE CK2 | DNA-DAMAGE | GROWTH | SENESCENCE | NUCLEAR-BODY FORMATION | EXPRESSION | CARCINOMA | P53 | CELL BIOLOGY | NIH 3T3 Cells | Protein Subunits | Transcription Factors - chemistry | Humans | Transcriptional Activation | Ubiquitin - metabolism | Neoplasm Proteins - antagonists & inhibitors | Casein Kinase II - genetics | Tumor Suppressor Proteins - chemistry | p38 Mitogen-Activated Protein Kinases - metabolism | Neoplasm Proteins - genetics | Genes, Tumor Suppressor | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Lung Neoplasms - enzymology | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Neoplasm Proteins - chemistry | Nuclear Proteins - chemistry | Serine - metabolism | Leupeptins - pharmacology | Tumor Suppressor Proteins - physiology | Cell Line, Tumor | Mice | Carcinoma, Non-Small-Cell Lung - enzymology | Enzyme Activation | Proteasome Endopeptidase Complex - metabolism | Sequence Deletion | Phosphorylation | Tumor Suppressor Proteins - antagonists & inhibitors | Neoplasm Proteins - physiology | Molecular Sequence Data | Lung Neoplasms - pathology | Neoplasm Proteins - metabolism | Tumor Suppressor Proteins - genetics | Nuclear Proteins - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Protein Structure, Tertiary | Cell Line | Green Fluorescent Proteins - metabolism | Transcription Factors - physiology | Carcinoma, Non-Small-Cell Lung - genetics | RNA, Small Interfering - pharmacology | Casein Kinase II - antagonists & inhibitors | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Serine - chemistry | Transcription Factors - metabolism | Triazoles - pharmacology | Animals | Hemagglutinins - chemistry | Nuclear Proteins - antagonists & inhibitors | Nuclear Proteins - physiology | Casein Kinase II - metabolism | Cell Line, Transformed | Promyelocytic Leukemia Protein | Sorbitol - pharmacology | Amino Acid Substitution | Apoptosis | Genetic research | Tumor suppressor genes | Research | Protein kinases | Oncogenes | Prevention | Casein | Health aspects | Analysis | Lung cancer | Cancer | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/2011, Volume 30, Issue 12, pp. 2325 - 2335
The Hippo tumour suppressor pathway is a conserved signalling pathway that controls organ size. The core of the Hpo pathway is a kinase cascade, which in... 
hippo signalling | F‐actin | growth regulation | F-actin | TISSUE-GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | YORKIE PHOSPHORYLATION | TEAD/TEF FAMILY | CELL BIOLOGY | REGULATE CELL-PROLIFERATION | SIGNALING PATHWAY | GENE-EXPRESSION | CONTACT INHIBITION | SIZE-CONTROL | TUMOR-SUPPRESSOR PATHWAY | PROMOTES APOPTOSIS | Wings, Animal - cytology | Cell Proliferation | Humans | Drosophila melanogaster - genetics | Actins - genetics | Drosophila Proteins - biosynthesis | Organ Specificity - genetics | Wings, Animal - growth & development | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Actins - chemistry | RNA Caps - antagonists & inhibitors | RNA Caps - chemistry | Intracellular Signaling Peptides and Proteins - genetics | Cytoskeleton - chemistry | RNA Caps - genetics | Actins - biosynthesis | Carrier Proteins - biosynthesis | Cells, Cultured | Cytoskeleton - genetics | Drosophila melanogaster - cytology | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Drosophila Proteins - chemistry | Carrier Proteins - genetics | Phenotype | Animals | Drosophila melanogaster - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Wings, Animal - chemistry | Protein-Serine-Threonine Kinases - chemistry | Drosophila Proteins - genetics | HeLa Cells | Proteins | Signal transduction | Tumors | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 09/2012, Volume 120, Issue 11, pp. 2280 - 2289
Peripheral T-cell lymphomas (PTCLs) are aggressive malignancies of mature T lymphocytes with 5-year overall survival rates of only similar to 35%. Improvement... 
LUNG-CANCER | OVEREXPRESSION | CANCER DEVELOPMENT | P53 PROTEIN | TRANSLOCATIONS | MUTATIONS | P63 | IDENTIFICATION | HEMATOLOGY | EXPRESSION | CARCINOMA | Oncogene Proteins, Fusion - metabolism | Transcription Factors - chemistry | Oligonucleotide Array Sequence Analysis | United States | Humans | Male | Lymphoma, Large B-Cell, Diffuse - metabolism | Oxidoreductases - chemistry | Tumor Suppressor Protein p53 - genetics | Oncogene Proteins, Fusion - chemistry | WW Domain-Containing Oxidoreductase | DNA Mutational Analysis | Lymphoma, T-Cell, Peripheral - metabolism | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Female | Repressor Proteins - metabolism | Genome-Wide Association Study | Repressor Proteins - chemistry | Tumor Suppressor Proteins - metabolism | Lymphoma, Large B-Cell, Diffuse - pathology | Oxidoreductases - metabolism | Oxidoreductases - genetics | Lymphoma, T-Cell, Peripheral - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Repressor Proteins - genetics | Mutant Proteins - metabolism | Transcription Factors - genetics | Sequence Homology, Nucleic Acid | Lymphoma, Large B-Cell, Diffuse - mortality | Transcription Factors - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - chemistry | Oncogene Proteins, Fusion - genetics | Gene Rearrangement | Lymphoma, T-Cell, Peripheral - pathology | Mutant Proteins - chemistry | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Tumor Suppressor Protein p53 - chemistry | Mutation | Lymphoma, Large B-Cell, Diffuse - genetics | Lymphoma, T-Cell, Peripheral - mortality | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 10/2010, Volume 17, Issue 10, pp. 1255 - 1259
Journal Article