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American journal of human genetics, ISSN 0002-9297, 2016, Volume 99, Issue 5, pp. 1190 - 1198
.... To gain insights into its genetics, we performed whole-genome sequencing at very deep coverage of tumor-control pairs in 33 samples... 
OCULAR MELANOMA | CELLS | COLORECTAL-CANCER | PROTEINS DLK1 | METASTASES | GENETICS & HEREDITY | RISK | EXPRESSION | RADIATION | SF3B1 | SOMATIC MUTATIONS | Melanoma - diagnosis | Exons | Humans | Middle Aged | Male | Phosphoproteins - metabolism | Case-Control Studies | RNA Splicing Factors - metabolism | DNA Copy Number Variations | Melanoma - genetics | Melanocytes - pathology | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Ubiquitin Thiolesterase - metabolism | Adult | Female | Membrane Proteins - metabolism | Eukaryotic Initiation Factor-1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Uveal Neoplasms - genetics | Genome-Wide Association Study | Tumor Suppressor Proteins - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Tumor Suppressor p53-Binding Protein 1 - genetics | Membrane Proteins - genetics | Eukaryotic Initiation Factor-1 - genetics | Ubiquitin-Protein Ligases - metabolism | GTP-Binding Protein alpha Subunits - genetics | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Ubiquitin Thiolesterase - genetics | Skin Neoplasms | Uveal Neoplasms - diagnosis | Aged | Mutation | Ubiquitin-Protein Ligases - genetics | Genetic aspects | Nucleotide sequencing | Methods | Melanoma | DNA sequencing | Report
Journal Article
Neuron, ISSN 0896-6273, 02/2013, Volume 77, Issue 3, pp. 472 - 484
Major outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and... 
MUTANT MICE | CORTICAL AXONS | THALAMOCORTICAL AXONS | GROWTH | SEMAPHORIN 3E | CENTRAL-NERVOUS-SYSTEM | GUIDANCE | CHICK HINDLIMB | CAJAL-RETZIUS CELLS | NEUROSCIENCES | CEREBRAL-CORTEX | Thyroid Nuclear Factor 1 | Age Factors | Embryo, Mammalian | Leukocyte L1 Antigen Complex - metabolism | Gene Expression Regulation, Developmental - genetics | Axons - physiology | Cerebral Cortex - cytology | Neural Pathways - physiology | DNA-Binding Proteins - metabolism | POU Domain Factors - genetics | tau Proteins - genetics | Thalamus - physiology | Contactin 2 - metabolism | Repressor Proteins - metabolism | Glycoproteins - genetics | Tumor Suppressor Proteins - metabolism | Wnt3A Protein - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Mice, Transgenic | Nuclear Proteins - metabolism | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | S100 Calcium Binding Protein G - metabolism | Transcription Factors - metabolism | Animals | Calbindin 2 | Thalamus - cytology | Cerebral Cortex - physiology | Luminescent Proteins - genetics | Mice | Body Patterning - genetics | Luminescent Proteins - metabolism | Developmental biology | Neurons | Studies | Laboratories | Experiments | Repressor Proteins | Cerebral Cortex | Cellular Biology | Neural Pathways | tau Proteins | Life Sciences | Contactin 2 | Gene Expression Regulation, Developmental | Body Patterning | Thalamus | Membrane Glycoproteins | Luminescent Proteins | DNA-Binding Proteins | POU Domain Factors | Calcium-Binding Protein, Vitamin D-Dependent | Glycoproteins | Nerve Tissue Proteins | Nuclear Proteins | Membrane Proteins | Axons | Homeodomain Proteins | Leukocyte L1 Antigen Complex | Transcription Factors | Wnt3A Protein | Tumor Suppressor Proteins | reciprocal connections | handshake | waiting period | PlexinD1 | axon guidance | Sema3E | thalamocortical | corticothalamic
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 471, Issue 7336, pp. 119 - 123
Misrepair of DNA double-strand breaks produced by the V(D)J recombinase (the RAG1/RAG2 proteins) at immunoglobulin (Ig... 
THYMIC LYMPHOMA | REPAIR | LYMPHOCYTE DEVELOPMENT | B-CELL | ROLES | TRANSLOCATIONS | MULTIDISCIPLINARY SCIENCES | V(D)J RECOMBINATION | DOUBLE-STRAND BREAKS | GENE AMPLIFICATION | ATM-DEFICIENT MICE | Genomic Instability | Protein-Serine-Threonine Kinases - deficiency | Gene Rearrangement, T-Lymphocyte - genetics | Chromosomes, Mammalian - genetics | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Recombination, Genetic - genetics | Lymphoma - pathology | Chromosome Deletion | Tumor Suppressor Proteins - metabolism | Kaplan-Meier Estimate | Protein-Serine-Threonine Kinases - genetics | Thymus Gland - cytology | Lymphoma - genetics | In Situ Hybridization, Fluorescence | Ataxia Telangiectasia Mutated Proteins | Genes, p53 - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Disease Progression | Animals | Genes, Immunoglobulin Heavy Chain - genetics | Mice | Receptors, Antigen, T-Cell - genetics | Translocation, Genetic - genetics | Causes of | Tumor suppressor genes | Lymphomas | Genetic aspects | Abnormalities | Software | Chromosomes | Deoxyribonucleic acid--DNA | Cell cycle | Apoptosis | Tumors | Thymus Gland | Translocation, Genetic | Protein-Serine-Threonine Kinases | Gene Rearrangement, T-Lymphocyte | Receptors, Antigen, T-Cell | Lymphoma | Chromosomes, Mammalian | Genes, Immunoglobulin Heavy Chain | Life Sciences | Genes, p53 | Immunology | Recombination, Genetic | Cell Cycle Proteins | Tumor Suppressor Proteins | DNA-Binding Proteins
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2008, Volume 283, Issue 9, pp. 5496 - 5509
... (protein kinase A /PK G /PK C ) kinases. It is a tumor suppressor gene originally isolated from Drosophila and recently isolated from mice and humans... 
YES-ASSOCIATED PROTEIN | APOPTOSIS | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | KINASE | HIPPO PATHWAY | CELL-PROLIFERATION | DROSOPHILA LATS | PROMOTES | HUMAN HOMOLOG | Oncogene Proteins - genetics | Phosphorylation | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Humans | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Cell Nucleus - metabolism | Cell Transformation, Neoplastic - genetics | Tumor Suppressor Proteins - genetics | Nuclear Proteins - genetics | Active Transport, Cell Nucleus - genetics | Intracellular Signaling Peptides and Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | Drosophila | Oncogene Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Phosphoproteins - genetics | Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Transcription Factors - metabolism | Animals | Cell Nucleus - genetics | Adaptor Proteins, Signal Transducing - genetics | Mice | Drosophila Proteins - genetics | HeLa Cells | Transcription, Genetic - genetics | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Motifs - genetics
Journal Article
Nature cell biology, ISSN 1476-4679, 2018, Volume 20, Issue 8, pp. 954 - 965
.... We identified two previously uncharacterized proteins, C2Oorf196 and FAM35A, whose inactivation confers strong PARP-inhibitor resistance... 
PATHWAY CHOICE | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | 53BP1 | CLASS-SWITCH RECOMBINATION | FANCONI-ANEMIA | DIFFERENTIAL EXPRESSION ANALYSIS | POLYMERASE-ZETA | TELOMERES | CELL BIOLOGY | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Polymerase | Inhibitors | Prostate | Viability | Tumors | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
Nature, ISSN 0028-0836, 08/2009, Volume 460, Issue 7257, pp. 904 - 908
.... aUPD is associated not only with loss-of-function mutations of tumour suppressor genes... 
TRANSFORMATION | PROTEIN | RETROVIRAL VECTOR GCDNSAP | NEGATIVE REGULATION | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | V-CBL | MUTATIONS | UBIQUITIN LIGASES | MYELODYSPLASTIC SYNDROMES | P53 | NIH 3T3 Cells | Neoplasm Transplantation | ras Proteins - genetics | Phosphorylation | Proto-Oncogene Proteins c-cbl - metabolism | Humans | Leukemia, Myeloid - genetics | Molecular Sequence Data | ras Proteins - metabolism | Male | Leukemia, Myeloid - pathology | Allelic Imbalance | Ubiquitination | Base Sequence | Female | Proto-Oncogene Proteins c-cbl - deficiency | Genes, Tumor Suppressor | Proto-Oncogene Proteins c-cbl - genetics | Amino Acid Sequence | Oncogenes - genetics | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Chromosomes, Human, Pair 11 - genetics | Proto-Oncogene Proteins c-cbl - chemistry | Mice, Knockout | Animals | Uniparental Disomy - genetics | Leukemia, Myeloid - metabolism | Mice, Nude | Mutant Proteins - chemistry | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Protein Conformation | Mice | Mutation | Gene mutations | Myelocytic leukemia | Physiological aspects | Tumor suppressor genes | Development and progression | Genetic aspects | Nonlymphoid leukemia | Research | Protein kinases | Proteins | Genes | Amino acids | Kinases | Cells | Clinical outcomes | Crystal structure | cytokine sensitivity | tumor suppressor | myelodysplasia | 490 | LOH | ubiquitination
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 5110 - 13
.... The Tumor Suppressor Candidate 3 (TUSC3) at chromosome 8p22 known to be frequently deleted in cancer is often found to be deleted in advanced stage of solid tumors... 
CELL LUNG-CANCER | GLUCOSE-REGULATED PROTEINS | FREQUENT ALLELIC LOSS | HOMOZYGOUS DELETION | OXIDOREDUCTASE ACTIVITY | TUMOR PROGRESSION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ENDOPLASMIC-RETICULUM STRESS | OVARIAN-CANCER | MESENCHYMAL TRANSITION | Endoribonucleases - genetics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | MicroRNAs - metabolism | Activating Transcription Factor 6 - genetics | Tumor Suppressor Protein p53 - genetics | In Situ Hybridization | Tumor Suppressor Proteins - genetics | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - physiology | Gene Expression Regulation, Neoplastic - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Cell Proliferation - genetics | Tumor Suppressor Proteins - metabolism | Endoribonucleases - metabolism | Unfolded Protein Response - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Membrane Proteins - genetics | Endoplasmic Reticulum-Associated Degradation - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Cell Proliferation - physiology | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Xenograft Model Antitumor Assays | Activating Transcription Factor 6 - metabolism | Animals | Endoplasmic Reticulum-Associated Degradation - physiology | Cell Line, Tumor | Signal Transduction - physiology | Mice | Ubiquitin-Protein Ligases - genetics | Unfolded Protein Response - physiology | Small cell lung carcinoma | p53 Protein | Lung cancer | Non-small cell lung carcinoma | Lung carcinoma | Metastasis | Substrates | Metastases | Proteins | Protein folding | Chromosome 8 | Tumor suppressor genes | miRNA | Solid tumors | Tumors | Cancer
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2017, Volume 114, Issue 5, pp. 1027 - 1032
Journal Article