1970, Perspectives in immunology, 536
Book
Cancer, ISSN 0008-543X, 02/2012, Volume 118, Issue 4, pp. 997 - 1006
The authors systematically reviewed the literature and conducted a pooled analysis of studies on small renal masses who underwent active surveillance to...
progression | neoplasms | metastasis | natural history | observation | active surveillance | Cell Proliferation | Humans | Middle Aged | Male | Neoplasm Metastasis - diagnostic imaging | Tumor Burden | Disease Progression | Radiography | Kidney Neoplasms - diagnostic imaging | Neoplasm Metastasis - pathology | Aged, 80 and over | Adult | Female | Kidney Neoplasms - pathology | Aged | Care and treatment | Oncology, Experimental | Development and progression | Research | Risk factors | Tumors | Cancer
progression | neoplasms | metastasis | natural history | observation | active surveillance | Cell Proliferation | Humans | Middle Aged | Male | Neoplasm Metastasis - diagnostic imaging | Tumor Burden | Disease Progression | Radiography | Kidney Neoplasms - diagnostic imaging | Neoplasm Metastasis - pathology | Aged, 80 and over | Adult | Female | Kidney Neoplasms - pathology | Aged | Care and treatment | Oncology, Experimental | Development and progression | Research | Risk factors | Tumors | Cancer
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 02/2017, Volume 14, Issue 3, pp. 155 - 167
Metastatic spread of tumour cells is the main cause of cancer-related deaths. Understanding the mechanisms of tumour-cell dissemination has, therefore, become...
LUNG METASTASIS | FAS LIGAND INTERACTIONS | NATURAL-KILLER-CELLS | STEM-CELLS | HLA-G EXPRESSION | ONCOLOGY | COLORECTAL-CANCER | PD-L1 EXPRESSION | BREAST-CANCER PATIENTS | REGULATORY T-CELLS | METASTATIC BREAST | Cell Hypoxia - immunology | Humans | HLA Antigens - immunology | Neoplastic Cells, Circulating - immunology | Immunologic Surveillance - immunology | CD47 Antigen - immunology | Fas Ligand Protein - immunology | Tumor Microenvironment - immunology | Neoplasm Metastasis | Apoptosis - immunology | Killer Cells, Natural - immunology | T-Lymphocytes - immunology | Macrophages - immunology | Tumor Escape - immunology | Immune response | Research | Oncology, Experimental | Cancer cells | Cancer
LUNG METASTASIS | FAS LIGAND INTERACTIONS | NATURAL-KILLER-CELLS | STEM-CELLS | HLA-G EXPRESSION | ONCOLOGY | COLORECTAL-CANCER | PD-L1 EXPRESSION | BREAST-CANCER PATIENTS | REGULATORY T-CELLS | METASTATIC BREAST | Cell Hypoxia - immunology | Humans | HLA Antigens - immunology | Neoplastic Cells, Circulating - immunology | Immunologic Surveillance - immunology | CD47 Antigen - immunology | Fas Ligand Protein - immunology | Tumor Microenvironment - immunology | Neoplasm Metastasis | Apoptosis - immunology | Killer Cells, Natural - immunology | T-Lymphocytes - immunology | Macrophages - immunology | Tumor Escape - immunology | Immune response | Research | Oncology, Experimental | Cancer cells | Cancer
Journal Article
European Urology, ISSN 0302-2838, 05/2018, Volume 73, Issue 5, pp. 706 - 712
Many patients who are on active surveillance (AS) for prostate cancer will have surveillance prostate needle biopsies (PNBs) without any cancer evident. To...
Prostate biopsy | Prostate cancer | Active surveillance | MANAGEMENT | MEN | UROLOGY & NEPHROLOGY | GRADE | COHORT | OUTCOMES | PROGRAM | Immunohistochemistry | Multivariate Analysis | Prostatic Neoplasms - pathology | Prognosis | Neoplasm Grading - methods | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Male | Asymptomatic Diseases | Prostate-Specific Antigen - blood | Prostatic Neoplasms - therapy | Biomarkers, Tumor - blood | Role | Watchful Waiting - methods | Time Factors | Neoplasm Invasiveness - pathology | Prostatic Neoplasms - classification | Aged | Retrospective Studies | Biopsy, Needle | Cohort Studies | Research | Oncology, Experimental | Analysis | Cancer
Prostate biopsy | Prostate cancer | Active surveillance | MANAGEMENT | MEN | UROLOGY & NEPHROLOGY | GRADE | COHORT | OUTCOMES | PROGRAM | Immunohistochemistry | Multivariate Analysis | Prostatic Neoplasms - pathology | Prognosis | Neoplasm Grading - methods | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Male | Asymptomatic Diseases | Prostate-Specific Antigen - blood | Prostatic Neoplasms - therapy | Biomarkers, Tumor - blood | Role | Watchful Waiting - methods | Time Factors | Neoplasm Invasiveness - pathology | Prostatic Neoplasms - classification | Aged | Retrospective Studies | Biopsy, Needle | Cohort Studies | Research | Oncology, Experimental | Analysis | Cancer
Journal Article
BJU International, ISSN 1464-4096, 12/2016, Volume 118, Issue 6, pp. 935 - 939
Objective To report the oncological safety and the risk of progression for patients with non‐muscle‐invasive bladder cancer (NMIBC) included in an active...
recurrence | NMIBC | TURBT | active surveillance | CYSTOSCOPY | MANAGEMENT | RECURRENT | UROLOGY & NEPHROLOGY | OUTCOMES | CARCINOMA | TUMORS | PROGRESSION | Prospective Studies | Risk Assessment | Neoplasm Invasiveness | Humans | Male | Treatment Outcome | Muscle, Smooth | Time Factors | Urinary Bladder Neoplasms - therapy | Urinary Bladder Neoplasms - pathology | Female | Italy | Watchful Waiting | Aged | Urinary Bladder Neoplasms - epidemiology | Surveillance | Cellular biology | Patients | Bladder cancer
recurrence | NMIBC | TURBT | active surveillance | CYSTOSCOPY | MANAGEMENT | RECURRENT | UROLOGY & NEPHROLOGY | OUTCOMES | CARCINOMA | TUMORS | PROGRESSION | Prospective Studies | Risk Assessment | Neoplasm Invasiveness | Humans | Male | Treatment Outcome | Muscle, Smooth | Time Factors | Urinary Bladder Neoplasms - therapy | Urinary Bladder Neoplasms - pathology | Female | Italy | Watchful Waiting | Aged | Urinary Bladder Neoplasms - epidemiology | Surveillance | Cellular biology | Patients | Bladder cancer
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 11/2018, Volume 96, Issue 10, pp. 1035 - 1048
CD8+ T‐regulatory (Treg) cells are emerging as crucial components of immune system. Previous studies have reported the presence of FOXP3+CD8+ Treg cells,...
IFNγ | Treg cells | immunosurvillance | FOXP3 | tumor | RHEUMATOID-ARTHRITIS | CD8(+) | DENDRITIC CELLS | IFN gamma | IMMUNOLOGY | VERSUS-HOST-DISEASE | CANCER | CELL BIOLOGY | SUPPRESS | MICE | AUTOIMMUNE-DISEASE | SELF-TOLERANCE | Cell proliferation | CD8 antigen | Effector cells | Immunosurveillance | Lymphocytes T | Cells | Adoptive transfer | CD4 antigen | Immunology | Clonal deletion | Developmental stages | Immunotherapy | γ-Interferon | Interleukin 1 | Interleukin 10 | CD25 antigen | Foxp3 protein | Histocompatibility antigen HLA | Tumors | Immune system | Cancer
IFNγ | Treg cells | immunosurvillance | FOXP3 | tumor | RHEUMATOID-ARTHRITIS | CD8(+) | DENDRITIC CELLS | IFN gamma | IMMUNOLOGY | VERSUS-HOST-DISEASE | CANCER | CELL BIOLOGY | SUPPRESS | MICE | AUTOIMMUNE-DISEASE | SELF-TOLERANCE | Cell proliferation | CD8 antigen | Effector cells | Immunosurveillance | Lymphocytes T | Cells | Adoptive transfer | CD4 antigen | Immunology | Clonal deletion | Developmental stages | Immunotherapy | γ-Interferon | Interleukin 1 | Interleukin 10 | CD25 antigen | Foxp3 protein | Histocompatibility antigen HLA | Tumors | Immune system | Cancer
Journal Article
Academic Radiology, ISSN 1076-6332, 11/2018, Volume 25, Issue 11, pp. 1381 - 1387
Rationale and Objectives: Prediction of growth, in particular knowing the possibility of aggressive cancer in small renal masses on active surveillance,...
complications | nephrometry score | partial nephrectomy | Kidney | TUMORS | CELL CARCINOMA | VARIABILITY | PREDICTORS | BENIGN HISTOLOGY | OUTCOMES | INDEX | DELAYED INTERVENTION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ROBOTIC PARTIAL NEPHRECTOMY | MALIGNANT-DISEASE | Predictive Value of Tests | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Kidney Neoplasms - surgery | Kidney Neoplasms - diagnostic imaging | Neoplasm Grading | Nephrectomy | Adult | Female | Kidney Neoplasms - pathology | Aged | Retrospective Studies | Cohort Studies | Medicine, Experimental | Medical research | CT imaging | Analysis
complications | nephrometry score | partial nephrectomy | Kidney | TUMORS | CELL CARCINOMA | VARIABILITY | PREDICTORS | BENIGN HISTOLOGY | OUTCOMES | INDEX | DELAYED INTERVENTION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ROBOTIC PARTIAL NEPHRECTOMY | MALIGNANT-DISEASE | Predictive Value of Tests | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Kidney Neoplasms - surgery | Kidney Neoplasms - diagnostic imaging | Neoplasm Grading | Nephrectomy | Adult | Female | Kidney Neoplasms - pathology | Aged | Retrospective Studies | Cohort Studies | Medicine, Experimental | Medical research | CT imaging | Analysis
Journal Article
JAMA, ISSN 0098-7484, 03/2014, Volume 311, Issue 12, pp. 1209 - 1217
IMPORTANCE Barrett esophagus containing low-grade dysplasia is associated with an increased risk of developing esophageal adenocarcinoma, a cancer with a...
SYSTEM | MEDICINE, GENERAL & INTERNAL | GENERAL-POPULATION | MANAGEMENT | RESECTION | ADENOCARCINOMA | FOCAL ABLATION | RISK | PREVALENCE | INTRAEPITHELIAL NEOPLASIA | PROGRESSION | Esophageal Neoplasms - etiology | Barrett Esophagus - complications | Adenocarcinoma - etiology | Humans | Middle Aged | Esophageal Neoplasms - prevention & control | Male | Treatment Outcome | Disease Progression | Barrett Esophagus - surgery | Esophagoscopy | Catheter Ablation - methods | Esophagus - pathology | Adenocarcinoma - prevention & control | Female | Watchful Waiting | Aged | Catheter Ablation - adverse effects | Barrett Esophagus - classification | Clinical trials | Patient safety | Medical treatment | Esophageal cancer | Tumors
SYSTEM | MEDICINE, GENERAL & INTERNAL | GENERAL-POPULATION | MANAGEMENT | RESECTION | ADENOCARCINOMA | FOCAL ABLATION | RISK | PREVALENCE | INTRAEPITHELIAL NEOPLASIA | PROGRESSION | Esophageal Neoplasms - etiology | Barrett Esophagus - complications | Adenocarcinoma - etiology | Humans | Middle Aged | Esophageal Neoplasms - prevention & control | Male | Treatment Outcome | Disease Progression | Barrett Esophagus - surgery | Esophagoscopy | Catheter Ablation - methods | Esophagus - pathology | Adenocarcinoma - prevention & control | Female | Watchful Waiting | Aged | Catheter Ablation - adverse effects | Barrett Esophagus - classification | Clinical trials | Patient safety | Medical treatment | Esophageal cancer | Tumors
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 20, Issue 6, pp. 781 - 796
Tumor immune surveillance and cancer immunotherapies are thought to depend on the intratumoral infiltration of activated CD8 T cells. Intratumoral CD8 T cells...
EFFECTOR T-CELLS | MELANOMA | ONCOLOGY | HOST | INTERLEUKIN-10 | INDUCTION | CANCER | PROMOTES | BREAST | CELL BIOLOGY | Neoplasm Transplantation | Tumor Escape | Granzymes - metabolism | Humans | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Interferon-gamma - metabolism | Breast Neoplasms - metabolism | Neoplasms, Experimental - pathology | Neoplasms, Experimental - immunology | Interleukin-10 Receptor alpha Subunit - metabolism | Mammary Neoplasms, Experimental - pathology | CD8-Positive T-Lymphocytes - metabolism | Interleukin-10 - metabolism | Female | Mammary Neoplasms, Experimental - blood supply | Antineoplastic Agents - pharmacology | Interferon-gamma - genetics | Mammary Neoplasms, Experimental - drug therapy | Skin Neoplasms - pathology | Skin Neoplasms - immunology | Mice, Inbred C57BL | Mice, Transgenic | Skin Neoplasms - chemically induced | Tumor Burden | CD8-Positive T-Lymphocytes - enzymology | Animals | Spleen - metabolism | Interleukin-10 Receptor alpha Subunit - genetics | Interleukin-10 - genetics | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Perforin - metabolism | Interleukin-10 - immunology | Neoplasms, Experimental - drug therapy | Cytotoxicity, Immunologic
EFFECTOR T-CELLS | MELANOMA | ONCOLOGY | HOST | INTERLEUKIN-10 | INDUCTION | CANCER | PROMOTES | BREAST | CELL BIOLOGY | Neoplasm Transplantation | Tumor Escape | Granzymes - metabolism | Humans | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Interferon-gamma - metabolism | Breast Neoplasms - metabolism | Neoplasms, Experimental - pathology | Neoplasms, Experimental - immunology | Interleukin-10 Receptor alpha Subunit - metabolism | Mammary Neoplasms, Experimental - pathology | CD8-Positive T-Lymphocytes - metabolism | Interleukin-10 - metabolism | Female | Mammary Neoplasms, Experimental - blood supply | Antineoplastic Agents - pharmacology | Interferon-gamma - genetics | Mammary Neoplasms, Experimental - drug therapy | Skin Neoplasms - pathology | Skin Neoplasms - immunology | Mice, Inbred C57BL | Mice, Transgenic | Skin Neoplasms - chemically induced | Tumor Burden | CD8-Positive T-Lymphocytes - enzymology | Animals | Spleen - metabolism | Interleukin-10 Receptor alpha Subunit - genetics | Interleukin-10 - genetics | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Perforin - metabolism | Interleukin-10 - immunology | Neoplasms, Experimental - drug therapy | Cytotoxicity, Immunologic
Journal Article
European Urology, ISSN 0302-2838, 2016, Volume 71, Issue 4, pp. 648 - 655
Abstract Background Published data on prostate magnetic resonance imaging (MRI) during follow-up of men on active surveillance are lacking. Current guidelines...
Urology | Prostate cancer | Active surveillance | Prostate MRI | UROLOGY & NEPHROLOGY | FOLLOW-UP | MRI | Prostatic Neoplasms - pathology | Europe | Humans | Documentation | Male | Tumor Burden | Consensus | Advisory Committees | Watchful Waiting - methods | Magnetic Resonance Imaging - standards | Oncology Nursing | Prostatic Neoplasms - diagnostic imaging | Radiology | Practice Guidelines as Topic | Task forces | Hospitals | Magnetic resonance imaging
Urology | Prostate cancer | Active surveillance | Prostate MRI | UROLOGY & NEPHROLOGY | FOLLOW-UP | MRI | Prostatic Neoplasms - pathology | Europe | Humans | Documentation | Male | Tumor Burden | Consensus | Advisory Committees | Watchful Waiting - methods | Magnetic Resonance Imaging - standards | Oncology Nursing | Prostatic Neoplasms - diagnostic imaging | Radiology | Practice Guidelines as Topic | Task forces | Hospitals | Magnetic resonance imaging
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 06/2015, Volume 427, Issue 11, pp. 2013 - 2022
A tumor is a heterogeneous population of cells that provides an environment in which every cell resides in a microenvironmental niche. Microscopic evaluation...
pathology | proximity ligation assay | padlock probe | image analysis | molecular profiling | PADLOCK PROBES | STEM-CELLS | INTERACTIONS IN-SITU | HUMAN BREAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRATUMOR HETEROGENEITY | COMPLEXES | POSTTRANSLATIONAL MODIFICATIONS | CANCER | MEMBRANE 2-HYBRID ASSAY | PROTEIN INTERACTIONS | Neoplasms - metabolism | Neoplasms - genetics | Signal Transduction | Humans | Pathology, Molecular - methods | Tumor Microenvironment | Image Processing, Computer-Assisted - methods | Proteomics - methods | Neoplasms - pathology | In Situ Hybridization - methods | Immunohistochemistry | Development and progression | Analysis | Tumors | Biological Sciences | Naturvetenskap | Biologiska vetenskaper | Natural Sciences
pathology | proximity ligation assay | padlock probe | image analysis | molecular profiling | PADLOCK PROBES | STEM-CELLS | INTERACTIONS IN-SITU | HUMAN BREAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRATUMOR HETEROGENEITY | COMPLEXES | POSTTRANSLATIONAL MODIFICATIONS | CANCER | MEMBRANE 2-HYBRID ASSAY | PROTEIN INTERACTIONS | Neoplasms - metabolism | Neoplasms - genetics | Signal Transduction | Humans | Pathology, Molecular - methods | Tumor Microenvironment | Image Processing, Computer-Assisted - methods | Proteomics - methods | Neoplasms - pathology | In Situ Hybridization - methods | Immunohistochemistry | Development and progression | Analysis | Tumors | Biological Sciences | Naturvetenskap | Biologiska vetenskaper | Natural Sciences
Journal Article