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2014, Graduate studies in mathematics, ISBN 0821883194, Volume 158, xv, 284
Book
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 04/2013, Volume 2, Issue 4, pp. 1 - 14
Population pharmacokinetic models are used to describe the time course of drug exposure in patients and to investigate sources of variability in patient... 
Tutorial
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 08/2013, Volume 2, Issue 8, pp. 1 - 12
The aim of this tutorial is to introduce the concept of physiologically based pharmacokinetic (PBPK) modeling to individuals in the pharmaceutical industry who... 
Tutorial
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 09/2012, Volume 1, Issue 9, pp. 1 - 14
Modeling is an important tool in drug development; population modeling is a complex process requiring robust underlying procedures for ensuring clean data,... 
Tutorial
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 11/2014, Volume 3, Issue 11, pp. 1 - 13
Increased regulatory demands for pediatric drug development research have fostered interest in the use of modeling and simulation among industry and academia.... 
Tutorial
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 01/2014, Volume 3, Issue 1, pp. 1 - 16
Population pharmacodynamic (PD) models describe the time course of drug effects, relating exposure to response, and providing a more robust understanding of... 
Tutorial
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 02/2015, Volume 4, Issue 2, pp. 1 - 14
BioModels is a reference repository hosting mathematical models that describe the dynamic interactions of biological components at various scales. The resource... 
Tutorial
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 06/2015, Volume 4, Issue 6, pp. 324 - 337
Target‐mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to... 
Tutorial
Journal Article
2015, 3rd edition., Graduate studies in mathematics, ISBN 9781470423117, Volume 165, 180, 2 v.
Book
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 07/2013, Volume 2, Issue 7, pp. 1 - 8
This tutorial describes the development of a population pharmacokinetic (Pop PK) analysis guidance within Pfizer, which strives for improved consistency and... 
Tutorial
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 10/2015, Volume 4, Issue 10, pp. 565 - 575
This tutorial aims at promoting good practices for exposure–response (E‐R) analyses of clinical endpoints in drug development. The focus is on practical... 
Tutorial
Journal Article
CPT: Pharmacometrics and Systems Pharmacology, ISSN 2163-8306, 01/2015, Volume 4, Issue 1, pp. 12 - 27
Anticancer agents often have a narrow therapeutic index (TI), requiring precise dosing to ensure sufficient exposure for clinical activity while minimizing... 
Tutorial
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 01/2019, Volume 8, Issue 1, pp. 12 - 25
BioGears is an open‐source, lumped parameter, full‐body human physiology engine. Its purpose is to provide realistic and comprehensive simulations for medical... 
Tutorial
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 05/2013, Volume 2, Issue 5, pp. 1 - 8
Models for time to event provide the link between standard pharmacokinetic–dynamic models disease progression, and clinical outcome events. The biological... 
Tutorial
Journal Article