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cancer (270) 270
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twist-related protein 1 (235) 235
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epithelial-mesenchymal transition - genetics (151) 151
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gene-expression (143) 143
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analysis (141) 141
immunohistochemistry (139) 139
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gene (135) 135
cell movement (134) 134
breast cancer (133) 133
gene expression regulation, developmental (133) 133
cadherins - genetics (131) 131
emt (128) 128
molecular sequence data (128) 128
cell proliferation (126) 126
breast neoplasms - pathology (125) 125
reverse transcriptase polymerase chain reaction (125) 125
breast neoplasms - genetics (123) 123
protein (123) 123
saethre-chotzen-syndrome (123) 123
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twist-related protein 1 - biosynthesis (115) 115
apoptosis (114) 114
base sequence (113) 113
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rna, messenger - genetics (110) 110
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growth (106) 106
multidisciplinary sciences (106) 106
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nuclear proteins - physiology (105) 105
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snail (104) 104
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drosophila (99) 99
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blotting, western (97) 97
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Nature Cell Biology, ISSN 1465-7392, 05/2017, Volume 19, Issue 5, pp. 518 - 529
Journal Article
Nature Cell Biology, ISSN 1465-7392, 10/2010, Volume 12, Issue 10, pp. 982 - 992
Journal Article
Nature, ISSN 0028-0836, 02/2010, Volume 463, Issue 7283, pp. 958 - 962
Heterozygous mutations in the gene encoding the CHD (chromodomain helicase DNA-binding domain) member CHD7, an ATP-dependent chromatin remodeller homologous to... 
NETWORK | COMPLEX | PROTEIN | CHROMATIN | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | TRANSCRIPTION | POLYMERASE-II | MUTATIONS | EXPRESSION | CHARGE-SYNDROME | Embryonic Stem Cells - metabolism | Embryo, Nonmammalian - cytology | Embryonic Stem Cells - cytology | Xenopus Proteins - genetics | Humans | Multipotent Stem Cells - metabolism | Embryo, Nonmammalian - metabolism | Embryo, Nonmammalian - embryology | DNA-Binding Proteins - deficiency | Neural Crest - metabolism | Xenopus Proteins - chemistry | DNA-Binding Proteins - metabolism | Gene Expression Regulation, Developmental | Transcription, Genetic | Cell Differentiation | Xenopus laevis - genetics | DNA Helicases - genetics | Snail Family Transcription Factors | SOX9 Transcription Factor - metabolism | Cell Line | DNA Helicases - chemistry | Neural Crest - cytology | Xenopus laevis - embryology | Chromosomal Proteins, Non-Histone - metabolism | DNA Helicases - deficiency | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Syndrome | Chromosomal Proteins, Non-Histone - genetics | Transcription Factors - metabolism | Cell Lineage | DNA Helicases - metabolism | Animals | Xenopus Proteins - deficiency | Multipotent Stem Cells - cytology | Neural Crest - embryology | Xenopus laevis - metabolism | Twist-Related Protein 1 - genetics | Protein Binding | Xenopus Proteins - metabolism | Enhancer Elements, Genetic - genetics | Twist-Related Protein 1 - metabolism | SOX9 Transcription Factor - genetics | Cell Movement | Chromatin | Drosophila | Polybrominated biphenyls | Physiological aspects | Genetic aspects | Research | Structure | Embryonic stem cells | Helicases | Proteins | Labeling | Evacuations & rescues | Cell adhesion & migration | Human | Peripheral nervous system | Genes | Charge | Bones | Activation | Numerical control | Gene expression | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 51, pp. 42695 - 42707
Development of metastatic disease accounts for the vast majority of cancer-related deaths. Nevertheless, few treatments exist that are designed to specifically... 
ACTIVATION | ZEB1 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | ATM | REGULATORS | HYPOXIA | MIR-200 FAMILY | CANCER | EXPRESSION | Carcinoma, Ductal, Breast - genetics | Cell Proliferation | Epithelial Cells - metabolism | Cadherins - metabolism | Polycomb Repressive Complex 1 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Genetic Loci - genetics | Molecular Sequence Data | MicroRNAs - metabolism | Cell Shape - genetics | Epithelial-Mesenchymal Transition - genetics | Breast - metabolism | DNA-Binding Proteins - metabolism | Base Sequence | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Carcinoma, Ductal, Breast - pathology | Female | Cadherins - genetics | Nuclear Proteins - genetics | Breast - pathology | Protein-Serine-Threonine Kinases - metabolism | Multigene Family - genetics | Tumor Suppressor Proteins - metabolism | Neoplasm Invasiveness | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Genomic Imprinting - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Models, Biological | Twist-Related Protein 1 - genetics | Cell Line, Tumor | MicroRNAs - genetics | Twist-Related Protein 1 - metabolism | Index Medicus | Molecular Bases of Disease | MicroRNA | Ataxia Telangiectasia Mutated | DLKI-DIO3 | Tumor Metastases | Epithelial to Mesenchymal Transition | Breast Cancer | EMT | TWIST
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0135851 - e0135851
Overexpression of Twist, a highly conserved basic helix-loop-helix transcription factor, is associated with epithelial-mesenchymal transition (EMT) and... 
TRANSCRIPTION FACTORS | METASTASIS | PROTEIN | LOCAL RECURRENCE | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | RESISTANCE | BETA-CATENIN | CONSERVING THERAPY | CARCINOMA | Carcinoma, Ductal, Breast - genetics | Prognosis | Cadherins - metabolism | Receptor, ErbB-2 - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Ki-67 Antigen - metabolism | Receptors, Progesterone - genetics | Epithelial-Mesenchymal Transition - genetics | Carcinoma, Ductal, Breast - mortality | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Receptors, Progesterone - metabolism | Neoplasm Grading | Biomarkers, Tumor - metabolism | Adult | Carcinoma, Ductal, Breast - pathology | Estrogen Receptor alpha - metabolism | Female | Cadherins - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Lymphatic Metastasis | Carcinoma, Ductal, Breast - diagnosis | Vascular Endothelial Growth Factor C - genetics | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Ki-67 Antigen - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Breast Neoplasms - pathology | Vascular Endothelial Growth Factor C - metabolism | Survival Analysis | Twist-Related Protein 1 - genetics | Cell Line, Tumor | Breast Neoplasms - mortality | Biomarkers, Tumor - genetics | Breast Neoplasms - diagnosis | Neoplasm Staging | Twist-Related Protein 1 - metabolism | Transcription factors | Physiological aspects | Breast cancer | Genetic aspects | Research | Gene expression | Immunohistochemistry | Mesenchyme | Laboratories | Estrogens | Estrogen receptors | AKT protein | Activation | Metastasis | Kinases | Cancer therapies | E-cadherin | Proteins | Signal transduction | Tumorigenesis | Bioindicators | Helix-loop-helix proteins | Vascular endothelial growth factor | Medical research | Immunoglobulins | Invasiveness | Extracellular signal-regulated kinase | Mammography | Patients | ErbB-2 protein | Hospitals | Protein kinase | Biomarkers | Breast | Progesterone | Prostate | Cell migration | Cancer | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 47, pp. 36721 - 36735
Dysregulation of microRNAs is observed in many cancers, including breast cancer. In particular, miR-10b appears to play an important role in tumor cell... 
MIGRATION | CD44 INTERACTION | STRESS FIBERS | METASTASIS | CANCER CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | TYROSINE KINASES | HYALURONIC-ACID | FOCAL ADHESIONS | RNA, Small Interfering - genetics | Cell Proliferation | src-Family Kinases | Protein-Tyrosine Kinases - metabolism | Homeodomain Proteins - metabolism | Humans | MicroRNAs - metabolism | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Immunoenzyme Techniques | Breast Neoplasms - metabolism | Protein-Tyrosine Kinases - genetics | Chromatin Immunoprecipitation | rho-Associated Kinases - metabolism | Adjuvants, Immunologic - metabolism | Hyaluronan Receptors - metabolism | Female | Tumor Cells, Cultured | Nuclear Proteins - genetics | Twist-Related Protein 1 - antagonists & inhibitors | Neoplasm Invasiveness | rho GTP-Binding Proteins - genetics | RNA, Messenger - genetics | rho-Associated Kinases - genetics | Nuclear Proteins - metabolism | rhoC GTP-Binding Protein | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Hyaluronan Receptors - genetics | Blotting, Western | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Hyaluronic Acid - metabolism | Nuclear Proteins - antagonists & inhibitors | rho GTP-Binding Proteins - metabolism | Fluorescent Antibody Technique | Twist-Related Protein 1 - genetics | Cytoskeleton - metabolism | MicroRNAs - genetics | Twist-Related Protein 1 - metabolism | Apoptosis | Cell Movement | Index Medicus | Cytoskeleton | MicroRNA | Cell Surface Receptor | Signal Transduction | Hyaluronate | Breast Cancer
Journal Article
Nature Cell Biology, ISSN 1465-7392, 05/2015, Volume 17, Issue 5, pp. 678 - 688
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 9, pp. 864 - 875
Journal Article
Cancer Research, ISSN 0008-5472, 03/2011, Volume 71, Issue 6, pp. 2328 - 2338
Pancreatic cancer is an exceptionally aggressive disease in great need of more effective therapeutic options. Epithelial-mesenchymal transition (EMT) plays a... 
INITIATING CELLS | ONCOLOGY | GROWTH | GENES | NOTCH | ACUTE MYELOID-LEUKEMIA | IDENTIFICATION | EXPRESSION | PROGRESSION | CANCER STEM-CELLS | BRAIN-TUMORS | Immunohistochemistry | ras Proteins - genetics | Pancreatic Neoplasms - metabolism | Exoribonucleases | Vimentin - metabolism | Humans | ras Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Epithelial-Mesenchymal Transition - genetics | Zinc Finger E-box Binding Homeobox 2 | RNA Interference | Biomarkers, Tumor - metabolism | Exonucleases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Pancreatic Neoplasms - pathology | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Mice, Transgenic | Pancreatic Neoplasms - genetics | Receptor, Notch1 - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Proto-Oncogene Proteins c-myc - metabolism | Homeodomain Proteins - genetics | 14-3-3 Proteins - metabolism | Animals | Twist-Related Protein 1 - genetics | Cell Line, Tumor | Mice | MicroRNAs - genetics | Proto-Oncogene Proteins c-myc - genetics | Mutation | Receptor, Notch1 - genetics | Zinc Finger E-box-Binding Homeobox 1 | Index Medicus | epithelial-mesenchymal transition (EMT) | pancreatic intraepithelial neoplasia (PanIN) | Cancer Stem Cell Marker | miR-144 | 14-3-3 σ | Let-7a | vimentin | miR-200a | DCAMKL-1 | Dclk-1 | Notch-1
Journal Article
Cancer Research, ISSN 0008-5472, 12/2012, Volume 72, Issue 24, pp. 6382 - 6392
Tumor cells often use developmental processes to progress toward advanced disease. The E-box transcription factor TWIST1 is essential to epithelial-mesenchymal... 
RNA INTERFERENCE | TARGET GENES | ONCOLOGY | MATRIX METALLOPROTEINASE-1 | BRAF MUTATION | TUMOR-METASTASIS | GROWTH | EPITHELIAL-MESENCHYMAL TRANSITIONS | MELANOCYTIC NEVI | UP-REGULATION | CANCER | Gene Expression Regulation, Enzymologic - drug effects | MAP Kinase Signaling System - physiology | Humans | Spheroids, Cellular - pathology | Matrix Metalloproteinase 1 - physiology | Spheroids, Cellular - physiology | MAP Kinase Signaling System - genetics | Melanoma - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Nuclear Proteins - genetics | Matrix Metalloproteinase 1 - genetics | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Twist-Related Protein 1 - antagonists & inhibitors | Neoplasm Invasiveness | RNA, Small Interfering - pharmacology | Spheroids, Cellular - metabolism | Nuclear Proteins - metabolism | Melanoma - pathology | Skin Neoplasms - metabolism | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Proto-Oncogene Proteins B-raf - genetics | Nuclear Proteins - antagonists & inhibitors | Skin Neoplasms - genetics | Twist-Related Protein 1 - physiology | Twist-Related Protein 1 - genetics | Cell Proliferation - drug effects | Nuclear Proteins - physiology | Matrix Metalloproteinase 1 - metabolism | Twist-Related Protein 1 - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | TWIST1 | melanoma | invasion | MMP-1 | ERK
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 3, pp. 372 - 386
The Twist1 transcription factor is known to promote tumor metastasis and induce Epithelial-Mesenchymal Transition (EMT). Here, we report that Twist1 is capable... 
BREAST-CANCER | EPITHELIAL PLASTICITY | ONCOLOGY | MOUSE EMBRYOGENESIS | PDGFR-ALPHA | TRANSCRIPTION FACTOR SNAIL | GENE-EXPRESSION | EXTRACELLULAR-MATRIX DEGRADATION | E-CADHERIN | PODOSOME FORMATION | TRANSFORMED-CELLS | CELL BIOLOGY | Neoplasms - metabolism | Epithelial-Mesenchymal Transition - physiology | Humans | Adaptor Proteins, Vesicular Transport - genetics | src Homology Domains - genetics | Epithelial-Mesenchymal Transition - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Breast Neoplasms - metabolism | Neoplasm Metastasis | RNA Interference | Base Sequence | HEK293 Cells | Female | Neoplasms - physiopathology | Nuclear Proteins - genetics | Cell Line | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Cell Surface Extensions - metabolism | Electrophoresis, Polyacrylamide Gel | Nuclear Proteins - metabolism | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mice, Nude | Receptor, Platelet-Derived Growth Factor alpha - genetics | Twist-Related Protein 1 - physiology | Twist-Related Protein 1 - genetics | Cell Line, Tumor | Signal Transduction - physiology | Mice | Nuclear Proteins - physiology | Neoplasms - pathology | Twist-Related Protein 1 - metabolism | Cell Movement | Cell Surface Extensions - physiology | Medical colleges | Metastasis | Index Medicus
Journal Article