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humans (1010) 1010
twist-related protein 1 - metabolism (873) 873
twist-related protein 1 - genetics (679) 679
nuclear proteins - metabolism (677) 677
animals (654) 654
nuclear proteins - genetics (581) 581
female (544) 544
epithelial-mesenchymal transition (446) 446
cell line, tumor (414) 414
expression (400) 400
mice (388) 388
metastasis (377) 377
oncology (360) 360
male (346) 346
cell biology (320) 320
twist (320) 320
gene expression regulation, neoplastic (296) 296
cancer (272) 272
transcription factors - metabolism (251) 251
middle aged (232) 232
gene expression (225) 225
twist1 (217) 217
transcription factors - genetics (209) 209
transcription factors (203) 203
up-regulation (201) 201
biochemistry & molecular biology (195) 195
signal transduction (192) 192
cadherins - metabolism (190) 190
stem cells (184) 184
aged (182) 182
e-cadherin (180) 180
adult (179) 179
snail family transcription factors (174) 174
neoplasm invasiveness (172) 172
animal structures (165) 165
research (161) 161
immunohistochemistry (160) 160
proteins (160) 160
cell movement (157) 157
prognosis (157) 157
developmental biology (153) 153
genetic aspects (144) 144
gene-expression (143) 143
emt (140) 140
tumors (140) 140
cells (137) 137
breast neoplasms - pathology (136) 136
twist-related protein 1 (136) 136
invasion (134) 134
breast cancer (133) 133
epithelial-mesenchymal transition - genetics (133) 133
analysis (132) 132
cell proliferation (131) 131
apoptosis (128) 128
activation (126) 126
breast-cancer (120) 120
breast neoplasms - metabolism (119) 119
cadherins - genetics (119) 119
twist-related protein 1 - biosynthesis (118) 118
snail (114) 114
protein (113) 113
reverse transcriptase polymerase chain reaction (113) 113
gene expression regulation, developmental (112) 112
research article (110) 110
differentiation (109) 109
progression (109) 109
down-regulation (106) 106
gene (106) 106
growth (106) 106
mice, nude (105) 105
neoplasm metastasis (105) 105
genes (104) 104
transfection (104) 104
phenotype (103) 103
rna interference (103) 103
breast neoplasms - genetics (100) 100
blotting, western (99) 99
cell differentiation (99) 99
rna, messenger - genetics (99) 99
carcinoma (97) 97
development and progression (97) 97
rna, messenger - metabolism (97) 97
cell line (95) 95
nuclear proteins - biosynthesis (95) 95
genetics & heredity (93) 93
multidisciplinary sciences (93) 93
cells, cultured (90) 90
molecular sequence data (90) 90
repressor proteins - metabolism (90) 90
biomarkers, tumor - metabolism (89) 89
mesenchyme (88) 88
repressor proteins - genetics (88) 88
base sequence (86) 86
micrornas - genetics (86) 86
phosphorylation (86) 86
mutation (82) 82
physiological aspects (80) 80
medicine (79) 79
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promoter regions, genetic (79) 79
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PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 7, p. e0177962
.... We performed comparative analyses in terms of gene and protein expression as well as functional characterizations... 
PROGENITOR CELLS | MESENCHYMAL STROMAL CELLS | STEM-CELLS | TRUNK | MULTIDISCIPLINARY SCIENCES | PERIODONTAL-LIGAMENT | ONTOGENY | GENERATION | SKIN-DERIVED PRECURSORS | DIFFERENTIATION | MELANOCYTES | RNA-Binding Proteins - genetics | Humans | Adipose Tissue - cytology | Melanocytes - metabolism | Neurons - cytology | Receptors, Nerve Growth Factor - metabolism | Neural Stem Cells - cytology | Schwann Cells - cytology | Neural Crest - metabolism | Adipose Tissue - metabolism | Mesenchymal Stromal Cells - cytology | Snail Family Transcription Factors - genetics | Melanocytes - cytology | Nestin - genetics | Adult | Female | Cell Differentiation | Neurons - metabolism | Dermis - cytology | Nuclear Proteins - genetics | Biomarkers - metabolism | SOX9 Transcription Factor - metabolism | Gene Expression | Neural Crest - cytology | Dermis - metabolism | Snail Family Transcription Factors - metabolism | Microinjections | Bone Marrow Cells - cytology | Neural Crest - growth & development | Mesenchymal Stromal Cells - metabolism | Nuclear Proteins - metabolism | Schwann Cells - metabolism | Transcription Factor Brn-3A - metabolism | Chick Embryo | Nerve Tissue Proteins - genetics | Receptors, Nerve Growth Factor - genetics | Nerve Tissue Proteins - metabolism | Nestin - metabolism | Animals | Transcription Factor Brn-3A - genetics | Twist-Related Protein 1 - genetics | Twist-Related Protein 1 - metabolism | Neural Stem Cells - metabolism | SOX9 Transcription Factor - genetics | Bone Marrow Cells - metabolism | Mesenchymal Stem Cell Transplantation | RNA-Binding Proteins - metabolism | Adipose tissues | Comparative analysis | Skin | Neurosciences | Nestin | Adipose tissue | Leukocyte migration | Laboratories | Sox9 protein | Dermis | Melanocytes | Nervous system | Human tissues | Regeneration (physiology) | Cell adhesion & migration | Msi1 protein | Plasticity (neural) | Ethics | Immunology | Pathways | Surgery | Bone marrow | Hair | Hematology | Neurons | Tissue engineering | Schwann cells | Brn-3 protein | Gene expression | Embryos | Neural crest | Medicine | Regeneration | Human performance | Stromal cells | Stem cells | Cell migration | Dental pulp
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2010, Volume 285, Issue 47, pp. 36721 - 36735
Dysregulation of microRNAs is observed in many cancers, including breast cancer. In particular, miR-10b appears to play an important role in tumor cell... 
MIGRATION | CD44 INTERACTION | STRESS FIBERS | METASTASIS | CANCER CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | TYROSINE KINASES | HYALURONIC-ACID | FOCAL ADHESIONS | RNA, Small Interfering - genetics | Cell Proliferation | src-Family Kinases | Protein-Tyrosine Kinases - metabolism | Homeodomain Proteins - metabolism | Humans | MicroRNAs - metabolism | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Immunoenzyme Techniques | Breast Neoplasms - metabolism | Protein-Tyrosine Kinases - genetics | Chromatin Immunoprecipitation | rho-Associated Kinases - metabolism | Adjuvants, Immunologic - metabolism | Hyaluronan Receptors - metabolism | Female | Tumor Cells, Cultured | Nuclear Proteins - genetics | Twist-Related Protein 1 - antagonists & inhibitors | Neoplasm Invasiveness | rho GTP-Binding Proteins - genetics | RNA, Messenger - genetics | rho-Associated Kinases - genetics | Nuclear Proteins - metabolism | rhoC GTP-Binding Protein | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Hyaluronan Receptors - genetics | Blotting, Western | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Hyaluronic Acid - metabolism | Nuclear Proteins - antagonists & inhibitors | rho GTP-Binding Proteins - metabolism | Fluorescent Antibody Technique | Twist-Related Protein 1 - genetics | Cytoskeleton - metabolism | MicroRNAs - genetics | Twist-Related Protein 1 - metabolism | Apoptosis | Cell Movement | Cytoskeleton | MicroRNA | Cell Surface Receptor | Signal Transduction | Hyaluronate | Breast Cancer
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 463, Issue 7283, pp. 958 - 962
...) member CHD7, an ATP-dependent chromatin remodeller homologous to the Drosophila trithorax-group protein Kismet(1,2... 
NETWORK | COMPLEX | PROTEIN | CHROMATIN | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | TRANSCRIPTION | POLYMERASE-II | MUTATIONS | EXPRESSION | CHARGE-SYNDROME | Embryonic Stem Cells - metabolism | Embryo, Nonmammalian - cytology | Embryonic Stem Cells - cytology | Xenopus Proteins - genetics | Humans | Multipotent Stem Cells - metabolism | Embryo, Nonmammalian - metabolism | Embryo, Nonmammalian - embryology | DNA-Binding Proteins - deficiency | Neural Crest - metabolism | Xenopus Proteins - chemistry | DNA-Binding Proteins - metabolism | Gene Expression Regulation, Developmental | Transcription, Genetic | Cell Differentiation | Xenopus laevis - genetics | DNA Helicases - genetics | Snail Family Transcription Factors | SOX9 Transcription Factor - metabolism | Cell Line | DNA Helicases - chemistry | Neural Crest - cytology | Xenopus laevis - embryology | Chromosomal Proteins, Non-Histone - metabolism | DNA Helicases - deficiency | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Syndrome | Chromosomal Proteins, Non-Histone - genetics | Transcription Factors - metabolism | Cell Lineage | DNA Helicases - metabolism | Animals | Xenopus Proteins - deficiency | Multipotent Stem Cells - cytology | Neural Crest - embryology | Xenopus laevis - metabolism | Twist-Related Protein 1 - genetics | Protein Binding | Xenopus Proteins - metabolism | Enhancer Elements, Genetic - genetics | Twist-Related Protein 1 - metabolism | SOX9 Transcription Factor - genetics | Cell Movement | Chromatin | Drosophila | Polybrominated biphenyls | Physiological aspects | Genetic aspects | Research | Structure | Embryonic stem cells | Helicases | Proteins | Labeling | Evacuations & rescues | Cell adhesion & migration | Human | Peripheral nervous system | Genes | Charge | Bones | Activation | Numerical control | Gene expression
Journal Article
Cancer Research, ISSN 0008-5472, 12/2012, Volume 72, Issue 24, pp. 6382 - 6392
...)1/2 signaling, which is hyperactive in the majority of melanomas. We show that TWIST1 protein levels are especially high in melanoma cell lines generated from invasive, premetastatic stage tumors... 
RNA INTERFERENCE | TARGET GENES | ONCOLOGY | MATRIX METALLOPROTEINASE-1 | BRAF MUTATION | TUMOR-METASTASIS | GROWTH | EPITHELIAL-MESENCHYMAL TRANSITIONS | MELANOCYTIC NEVI | UP-REGULATION | CANCER | Gene Expression Regulation, Enzymologic - drug effects | MAP Kinase Signaling System - physiology | Humans | Spheroids, Cellular - pathology | Matrix Metalloproteinase 1 - physiology | Spheroids, Cellular - physiology | MAP Kinase Signaling System - genetics | Melanoma - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Nuclear Proteins - genetics | Matrix Metalloproteinase 1 - genetics | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | Mitogen-Activated Protein Kinase 3 - genetics | Twist-Related Protein 1 - antagonists & inhibitors | Neoplasm Invasiveness | RNA, Small Interfering - pharmacology | Spheroids, Cellular - metabolism | Nuclear Proteins - metabolism | Melanoma - pathology | Skin Neoplasms - metabolism | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Proto-Oncogene Proteins B-raf - genetics | Nuclear Proteins - antagonists & inhibitors | Skin Neoplasms - genetics | Twist-Related Protein 1 - physiology | Twist-Related Protein 1 - genetics | Cell Proliferation - drug effects | Nuclear Proteins - physiology | Matrix Metalloproteinase 1 - metabolism | Twist-Related Protein 1 - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | TWIST1 | melanoma | invasion | MMP-1 | ERK
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 8, p. e0135851
Overexpression of Twist, a highly conserved basic helix-loop-helix transcription factor, is associated with epithelial-mesenchymal transition (EMT) and... 
TRANSCRIPTION FACTORS | METASTASIS | PROTEIN | LOCAL RECURRENCE | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | RESISTANCE | BETA-CATENIN | CONSERVING THERAPY | CARCINOMA | Carcinoma, Ductal, Breast - genetics | Prognosis | Cadherins - metabolism | Receptor, ErbB-2 - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Ki-67 Antigen - metabolism | Receptors, Progesterone - genetics | Epithelial-Mesenchymal Transition - genetics | Carcinoma, Ductal, Breast - mortality | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Receptors, Progesterone - metabolism | Neoplasm Grading | Biomarkers, Tumor - metabolism | Adult | Carcinoma, Ductal, Breast - pathology | Estrogen Receptor alpha - metabolism | Female | Cadherins - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Lymphatic Metastasis | Carcinoma, Ductal, Breast - diagnosis | Vascular Endothelial Growth Factor C - genetics | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Ki-67 Antigen - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Breast Neoplasms - pathology | Vascular Endothelial Growth Factor C - metabolism | Survival Analysis | Twist-Related Protein 1 - genetics | Cell Line, Tumor | Breast Neoplasms - mortality | Biomarkers, Tumor - genetics | Breast Neoplasms - diagnosis | Neoplasm Staging | Twist-Related Protein 1 - metabolism | Transcription factors | Physiological aspects | Breast cancer | Genetic aspects | Research | Gene expression | Immunohistochemistry | Mesenchyme | Laboratories | Estrogens | Estrogen receptors | AKT protein | Activation | Metastasis | Kinases | Cancer therapies | E-cadherin | Proteins | Signal transduction | Tumorigenesis | Helix-loop-helix proteins | Vascular endothelial growth factor | Medical research | Immunoglobulins | Invasiveness | Extracellular signal-regulated kinase | Mammography | Patients | ErbB-2 protein | Hospitals | Protein kinase | Biomarkers | Progesterone | Prostate | Cell migration | Cancer
Journal Article
PLoS genetics, ISSN 1553-7404, 2012, Volume 8, Issue 5, p. e1002723
.... Supporting oncogenic activity within primary lesions, the TWIST and ZEB proteins can prevent cells from undergoing oncogene-induced senescence and apoptosis by abolishing both p53- and RB-dependent pathways... 
MIDDLE-T | TO-MESENCHYMAL TRANSITION | GENE | GROWTH | GENETICS & HEREDITY | PROTEIN PHOSPHATASE 2A | IDENTIFICATION | EXPRESSION | CANCER STEM-CELLS | TWIST | SNAIL | Epithelial Cells - metabolism | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Epithelial-Mesenchymal Transition - genetics | Mammary Glands, Human - metabolism | Breast Neoplasms - metabolism | Claudins - metabolism | Cell Transformation, Neoplastic - genetics | Female | Telomerase - metabolism | Cell Differentiation | Epithelial Cells - cytology | Cell Line | Claudins - genetics | Mammary Glands, Human - cytology | Protein Phosphatase 2 - antagonists & inhibitors | Retinoblastoma Protein - metabolism | Tumor Suppressor Protein p53 - metabolism | Mice, Transgenic | Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Homeodomain Proteins - genetics | Mammary Glands, Animal - cytology | Transcription Factors - metabolism | Animals | Breast Neoplasms - genetics | Mammary Glands, Animal - metabolism | Protein Phosphatase 2 - metabolism | Twist-Related Protein 1 - genetics | Mice | Genes, ras | Twist-Related Protein 1 - metabolism | Zinc Finger E-box-Binding Homeobox 1 | Transcription factors | Physiological aspects | Development and progression | Breast cancer | Genetic aspects | Research | Cell differentiation | Risk factors | Proteins | Rodents | Colonies & territories | Gene expression | Experiments | Tumors | Apoptosis | Life Sciences | Cancer
Journal Article
Cancer cell, ISSN 1535-6108, 2008, Volume 14, Issue 1, pp. 79 - 89
.... Both proteins override oncogene-induced premature senescence by abrogating key regulators of the p53- and Rb-dependent pathways... 
CELLBIO | HUMDISEASE | SIGNALING | BREAST-CANCER | TRANSFORMATION | DORSOVENTRAL PATTERN | ONCOGENIC RAS | ONCOLOGY | IN-VIVO | ZYGOTIC GENE | SUPPRESSION | EXPRESSION | TUMORIGENESIS | CELL IMMORTALIZATION | Neoplasms - metabolism | Up-Regulation | Fibroblasts - enzymology | Epithelial Cells - metabolism | Humans | Gene Expression Regulation, Neoplastic | ras Proteins - metabolism | Transplantation, Heterologous | Cell Transdifferentiation - genetics | Mammary Glands, Human - metabolism | Transfection | Neoplasms - genetics | RNA Interference | Cell Transformation, Neoplastic - genetics | Mice, Inbred DBA | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Fibroblasts - metabolism | Cell Line | Cellular Senescence - genetics | Neoplasm Invasiveness | Mice, Inbred C57BL | Retinoblastoma Protein - metabolism | Tumor Suppressor Protein p53 - metabolism | Neoplasms - enzymology | Repressor Proteins - genetics | Epithelial Cells - pathology | Mice, Transgenic | Nuclear Proteins - metabolism | Fibroblasts - pathology | Cell Transformation, Neoplastic - metabolism | Animals | Mice, Nude | Dogs | Epithelial Cells - enzymology | Twist-Related Protein 1 - genetics | Mice | Enzyme Activation | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Twist-Related Protein 1 - metabolism | Tumor proteins | Stem cells | Tumors
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 12/2012, Volume 10, Issue 12, pp. 1597 - 1606
To understand the mechanisms leading to trastuzumab resistance in HER2-overexpressing breast tumors, we created trastuzumab-insensitive cell lines (SKBR3/100-8... 
MIGRATION | STEM-CELLS | INVASION | GROWTH-FACTOR-RECEPTOR | MECHANISM | LIGANDS | ONCOLOGY | HERCEPTIN | MESENCHYMAL TRANSITION | BETA-CATENIN | CONTRIBUTES | CELL BIOLOGY | Receptor, Epidermal Growth Factor - genetics | Cadherins - metabolism | Receptor, ErbB-2 - genetics | Humans | Transcriptional Activation | Receptor, ErbB-2 - metabolism | Drug Resistance, Neoplasm | Cadherins - biosynthesis | Wnt3 Protein - genetics | Breast Neoplasms - metabolism | Wnt3 Protein - biosynthesis | beta Catenin - biosynthesis | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Nuclear Proteins - biosynthesis | Antibodies, Monoclonal, Humanized - pharmacology | Female | Wnt3 Protein - metabolism | Twist-Related Protein 1 - biosynthesis | Cadherins - genetics | Nuclear Proteins - genetics | Snail Family Transcription Factors | Wnt Signaling Pathway | Receptor, Epidermal Growth Factor - biosynthesis | Receptor, ErbB-2 - biosynthesis | Organic Cation Transport Proteins - metabolism | Nuclear Proteins - metabolism | Transcription Factors - biosynthesis | Transcription Factors - genetics | Organic Cation Transport Proteins - biosynthesis | beta Catenin - metabolism | beta Catenin - genetics | Transcription Factors - metabolism | Phenotype | Breast Neoplasms - genetics | Twist-Related Protein 1 - genetics | Cell Line, Tumor | Organic Cation Transport Proteins - genetics | Twist-Related Protein 1 - metabolism | Trastuzumab | trastuzumab | β-catenin | EMT | Breast Cancer | Wnt3
Journal Article
Seminars in Cancer Biology, ISSN 1044-579X, 2015, Volume 36, pp. 71 - 79
Abstract F-box proteins are the key recognition subunit of multimeric E3 ubiquitin ligase complexes that participate in the proteasome degradation of specific substrates... 
Hematology, Oncology and Palliative Medicine | Twist | Ubiquitination | F-box | Zeb | Snail | EMT | Proteasome | Cancer | C-MYC | SCF-BETA-TRCP | BREAST-CANCER | ONCOLOGY | CELL-MIGRATION | TRANSCRIPTION FACTORS SNAIL | TUMOR-SUPPRESSOR | PHOSPHORYLATION-DEPENDENT DEGRADATION | NF-KAPPA-B | FBW7 UBIQUITIN LIGASE | E-CADHERIN REPRESSION | Neoplasms - metabolism | Neoplasms - etiology | Humans | Multiprotein Complexes | Intracellular Signaling Peptides and Proteins - metabolism | Epithelial-Mesenchymal Transition - genetics | Zinc Finger E-box-Binding Homeobox 1 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cullin Proteins - metabolism | Protein Interaction Domains and Motifs | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Snail Family Transcription Factors - metabolism | F-Box Proteins - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Cullin Proteins - chemistry | Cullin Proteins - genetics | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Twist-Related Protein 1 - metabolism | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Ubiquitin | DNA binding proteins | Ligases | Stem cells
Journal Article
Nature cell biology, ISSN 1476-4679, 2014, Volume 16, Issue 9, pp. 864 - 875
Journal Article