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two-electrode voltage clamp (162) 162
animals (138) 138
index medicus (84) 84
xenopus laevis (72) 72
patch-clamp techniques (60) 60
xenopus oocytes (58) 58
oocytes - metabolism (56) 56
biochemistry & molecular biology (49) 49
female (49) 49
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two-electrode voltage-clamp (40) 40
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physiology (34) 34
electrophysiology (33) 33
xenopus oocyte (33) 33
xenopus laevis oocytes (30) 30
ion channels (27) 27
rats (27) 27
amino acid sequence (26) 26
expression (26) 26
molecular sequence data (25) 25
gaba (24) 24
kinetics (24) 24
dose-response relationship, drug (23) 23
oocytes - physiology (23) 23
two‐electrode voltage clamp (23) 23
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cells (16) 16
mutation (16) 16
gene expression (15) 15
activation (14) 14
analysis (14) 14
channel (14) 14
hydrogen-ion concentration (14) 14
nicotinic acetylcholine receptor (14) 14
subunits (14) 14
two electrode voltage clamp (14) 14
identification (13) 13
pharmacology (13) 13
potassium channels (13) 13
amphibians (12) 12
chemistry, medicinal (12) 12
neurons (12) 12
structure-activity relationship (12) 12
alcohol (11) 11
binding (11) 11
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glycine (11) 11
membrane potentials (11) 11
mutagenesis, site-directed (11) 11
picrotoxinin (11) 11
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receptors (11) 11
xenopus laevis oocyte (11) 11
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electric conductivity (10) 10
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glutamate (9) 9
modulation (9) 9
papers (9) 9
patch clamp (9) 9
plant sciences (9) 9
potassium channel blockers - pharmacology (9) 9
protein structure, tertiary (9) 9
receptors, gaba-a - metabolism (9) 9
recombinant proteins - metabolism (9) 9
sodium - metabolism (9) 9
xenopus-oocytes (9) 9
bilobalide (8) 8
currents (8) 8
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life sciences (8) 8
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1. Full Text Voltage clamp fluorometry: Combining fluorescence and electrophysiological methods to examine the structure–function of the Na +/K +-ATPase
by Dempski, Robert E and Friedrich, Thomas and Bamberg, Ernst
BBA - Bioenergetics, ISSN 0005-2728, 2009, Volume 1787, Issue 6, pp. 714 - 720
This paper summarizes our recent work investigating the conformational dynamics and structural arrangement of the Na /K -ATPase using voltage clamp fluorometry... 
Structural alignment | Sodium pump | Fluorescence resonance energy transfer | Two electrode voltage clamp | Conformational dynamics | RENAL NA,K-ATPASE | SITE | NA,K-ATPASE ALPHA-SUBUNIT | CRYOELECTRON MICROSCOPY | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOPHYSICS | NA+,K+-ATPASE | CALCIUM-PUMP | GAMMA-SUBUNIT | BETA-SUBUNIT | Index Medicus
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2. A Study of Electrogenic Transient and Steady-state Cotransporter Kinetics: Investigations with the Na+/Glucose Transporter SGLT1
by Krofchick, Daniel
06/2012
Significant advancements in the field of membrane protein crystallography have provided in recent years invaluable images of transporter structures. These... 
0786 | electrophysiology | 0487 | SGLT1 | membrane transport | two-electrode voltage-clamp | enzyme kinetics
Dissertation
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3. Full Text SUMO co-expression modifies K V 11.1 channel activity
by Steffensen, A.B and Andersen, M.N and Mutsaers, N and Mujezinovic, A and Schmitt, N
Acta Physiologica, ISSN 1748-1708, 03/2018, Volume 222, Issue 3
The voltage-gated potassium channel K 11.1 is the molecular basis for the I current, which plays an important role in cardiac physiology. Its malfunction is... 
sumoylation | K | 11.1 | two-electrode voltage-clamp electrophysiology
Journal Article
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4. Full Text HCN and K2P Channels in Anesthetic Mechanisms Research
by Riegelhaupt, Paul M and Tibbs, Gareth R and Goldstein, Peter A
Methods in Enzymology, ISSN 0076-6879, 01/2018, Volume 602, pp. 391 - 416
The ability of a diverse group of agents to produce general anesthesia has long been an area of intense speculation and investigation. Over the past century,... 
Anesthetic mechanisms | channel | Patch clamp | Two-electrode voltage clamp | HCN channel | Heterologous expression
Journal Article
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5. Full Text Inhibition of protein kinase C (PKC) response of voltage-gated calcium (Ca v )2.2 channels expressed in Xenopus oocytes by Ca v β subunits
by Rajagopal, S and Fields, B.L and Burton, B.K and On, C and Reeder, A.A and Kamatchi, G.L
Neuroscience, ISSN 0306-4522, 11/2014, Volume 280, pp. 1 - 9
Ca v 2.2 channels are a substrate for phosphorylation by protein kinase C (PKC) isozymes. The contribution of Ca v β, an auxiliary subunit of these channels,... 
Xenopus oocytes | Muscarinic receptor 1 | Two-electrode voltage clamp | Calcium channels | Protein kinase C | Subunits
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6. Full Text Characterization of heterologously expressed transporter genes by patch- and voltage-clamp methods: Application to cyclic nucleotide-dependent responses
by Lemtiri-Chlieh, Fouad and Ali, Rashid
Methods in Molecular Biology, ISSN 1064-3745, 2013, Volume 1016, pp. 67 - 93
The application of patch- and voltage-clamp methods to study ion transport can be limited by many -hurdles: the size of the cells to be patched and/or stabbed,... 
Xenopus oocytes | HEK-293 | Patch clamp | Two-electrode voltage clamp | Yeast protoplasts | Heterologous expression | Nucleotides, Cyclic - metabolism | Gene Expression | Microinjections | Oocytes - metabolism | Humans | Xenopus laevis | Electroporation | Saccharomyces cerevisiae - drug effects | Patch-Clamp Techniques - methods | Electrodes | Saccharomyces cerevisiae - metabolism | Animals | Transformation, Genetic - drug effects | Membrane Transport Proteins - genetics | Chlorides | Cloning, Molecular | Culture Media - pharmacology | HEK293 Cells | Oocytes - drug effects | Membrane Transport Proteins - metabolism
Conference Proceeding
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7. Full Text Suramin is a novel competitive antagonist selective to α1β2γ2 GABAA over ρ1 GABAC receptors
by Luo, Hui and Wood, Kristofer and Shi, Fu-Dong and Gao, Fenfei and Chang, Yongchang
Neuropharmacology, ISSN 0028-3908, 10/2018, Volume 141, pp. 148 - 157
GABA and GABA receptors are both GABA-gated chloride channels with distinct pharmacological properties, mainly in their sensitivity to bicuculline and... 
Suramin | GABAC receptor | Two-electrode voltage-clamp | GABAA receptor | Competitive antagonist
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8. Full Text Effects of bilobalide, ginkgolide B and picrotoxinin on GABAA receptor modulation by structurally diverse positive modulators
by Ng, Chiu Chin and Duke, Rujee K and Hinton, Tina and Johnston, Graham A.R
European Journal of Pharmacology, ISSN 0014-2999, 07/2017, Volume 806, pp. 83 - 90
Anxiolytics and anticonvulsants generally positively modulate the action of GABA, whereas many convulsants (including the chloride channel blocker... 
Bilobalide | Xenopus oocytes | Two-electrode voltage clamp | GABAA receptor | Picrotoxinin | Ginkgolides | receptor | GABA
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9. Full Text A challenge finding P2X1 and P2X4 ligands
by Beswick, Paul and Wahab, Ben and Honey, Mark A and Paradowski, Michael and Jiang, Ke and Lochner, Martin and Murrell-Lagnado, Ruth D and Thompson, Andrew J
Neuropharmacology, ISSN 0028-3908, 10/2019, Volume 157, p. 107674
Identifying novel small-molecule P2X1 and P2X4 ligands with sub-type specificity and high-affinity remains a pharmacological challenge. Here we use... 
Function | Two-electrode voltage clamp | Agonist | Ligand | Screen | Microplate | Antagonist | P2X4 | Ion channel | P2X1 | DRUG | DESIGN | RECEPTOR | NEUROSCIENCES | MEDICINAL CHEMISTRY | SURAMIN | CHANNEL | PHARMACOLOGY & PHARMACY
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10. Full Text GABAA receptor modulation by terpenoids from Sideritis extracts
by Kessler, Artur and Sahin‐Nadeem, Hilal and Lummis, Sarah C. R and Weigel, Ingrid and Pischetsrieder, Monika and Buettner, Andrea and Villmann, Carmen
Molecular Nutrition & Food Research, ISSN 1613-4125, 04/2014, Volume 58, Issue 4, pp. 851 - 862
Scope GABAA receptors are modulated by Sideritis extracts. The aim of this study was to identify single substances from Sideritis extracts responsible for... 
Volatile odorants | Terpene | Two‐electrode voltage clamp recordings | GABAA receptor | Patch clamp recordings | Two-electrode voltage clamp recordings | GATED ION-CHANNEL | DIAZEPAM | ESSENTIAL OILS | FOOD SCIENCE & TECHNOLOGY | BENZODIAZEPINES | BLOOD-BRAIN-BARRIER | AROMA COMPOUNDS | POTENTIATION | GABA(A) receptor | XENOPUS OOCYTES | BINDING | SUBUNIT | GABA | Terpenes
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11. Full Text INHIBITION OF PROTEIN KINASE C (PKC) RESPONSE OF VOLTAGE GATED CALCIUM (CA(v))2.2 CHANNELS EXPRESSED IN XENOPUS OOCYTES BY CA(v)beta SUBUNITS
by Rajagopal, S and Fields, BL and Burton, BK and On, C and Reeder, AA and Kamatchi, GL
NEUROSCIENCE, ISSN 0306-4522, 11/2014, Volume 280, pp. 1 - 9
Ca(v)2.2 channels are a substrate for phosphorylation by protein kinase C (PKC) isozymes. The contribution of Ca-v beta, an auxiliary subunit of these... 
Xenopus oocytes | N-TYPE | ACTIVATION | two-electrode voltage clamp | calcium channels | muscarinic receptor 1 | CA2+ CHANNELS | INSULIN-SECRETION | SYMPATHETIC NEURONS | CURRENTS | IDENTIFICATION | NEUROSCIENCES | subunits | PANCREATIC BETA-CELLS | SIGNALING COMPLEXES | protein kinase C | MODULATION
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12. Full Text Inhibition of protein kinase C (PKC) response of voltage-gated calcium (Cav )2.2 channels expressed in Xenopus oocytes by Cav β subunits
by Rajagopal, S and Fields, B.L and Burton, B.K and On, C and Reeder, A.A and Kamatchi, G.L
Neuroscience, ISSN 0306-4522, 2014, Volume 280, pp. 1 - 9
Highlights • Cav 2.2 currents expressed with Cav 2.2α1 subunits are potentiated by PKC isozymes. • Auxiliary Cav β subunits inhibit PKC potentiation of Cav 2.2... 
Neurology | subunits | Xenopus oocytes | two-electrode voltage clamp | calcium channels | muscarinic receptor 1 | protein kinase C | Membrane Potentials - drug effects | Calcium Channels, N-Type - genetics | Muscarinic Agonists - pharmacology | Xenopus laevis | Rats | Barium - metabolism | Calcium Channels, N-Type - metabolism | Membrane Potentials - physiology | Patch-Clamp Techniques | Animals | Oocytes - physiology | Isoenzymes - metabolism | Protein Kinase C - metabolism | Methacholine Chloride - pharmacology | Oocytes - drug effects | Mutation
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13. Full Text An odorant receptor mediates the attractiveness of cis‐jasmone to Campoletis chlorideae, the endoparasitoid of Helicoverpa armigera
by Sun, Y.‐L and Dong, J.‐F and Ning, C and Ding, P.‐P and Huang, L.‐Q and Sun, J.‐G and Wang, C.‐Z
Insect Molecular Biology, ISSN 0962-1075, 02/2019, Volume 28, Issue 1, pp. 23 - 34
Parasitic wasps rely on olfaction to locate their hosts in complex chemical environments. Odorant receptors (ORs) function together with well‐conserved odorant... 
behavioural assay | Xenopus expression system | two‐electrode voltage‐clamp recording | Campoletis chlorideae | odorant receptor | two-electrode voltage-clamp recording | DEFENSE | INDUCED PLANT VOLATILES | HYMENOPTERA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | ENTOMOLOGY | CHEMORECEPTOR SUPERFAMILY | EVOLUTION | RESISTANCE | MOLECULAR-BASIS | EXPRESSION | PREFERENCE | Larvae | Plants (botany) | Attraction | Bioassays | Cotton | Antennae | Gene expression | Odorant receptors | Organic chemistry | Receptors | Tobacco | Plant tissues | Olfaction | Parasitism | Adults | Receptor mechanisms | Parasitics (electronics)
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14. Full Text Functional characterization of Bacillus thuringiensis Cry toxin receptors explains resistance in insects
by Tanaka, Shiho and Endo, Haruka and Adegawa, Satomi and Kikuta, Shingo and Sato, Ryoichi
The FEBS Journal, ISSN 1742-464X, 12/2016, Volume 283, Issue 24, pp. 4474 - 4490
Bacillus thuringiensis produces Cry toxins, which are used as insecticides in sprays and in transgenic crops. However, little is known about the function of... 
cadherin‐like receptor | Bombyx mori | Bacillus thuringiensis | ABC transporter C2 | two‐electrode voltage clamp | two-electrode voltage clamp | cadherin-like receptor | MANDUCA-SEXTA | ALKALINE-PHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HELICOVERPA-ARMIGERA | PORE-FORMATION | BOMBYX-MORI | BT TOXINS | AMINOPEPTIDASE-N | BINDING | PLANAR LIPID-BILAYERS | Xenopus | Membrane Potentials - genetics | Drug Resistance, Bacterial | Bombyx - metabolism | ATP-Binding Cassette Transporters - genetics | Bacillus thuringiensis - genetics | Bacillus thuringiensis - metabolism | ATP-Binding Cassette Transporters - metabolism | Female | Multidrug Resistance-Associated Proteins - genetics | Bacillus thuringiensis - physiology | Insect Proteins - metabolism | Oocytes - metabolism | Bacterial Proteins - genetics | Insect Proteins - genetics | Receptors, Cell Surface - metabolism | Bombyx - genetics | Membrane Potentials - physiology | CD13 Antigens - metabolism | Patch-Clamp Techniques | Animals | CD13 Antigens - genetics | Oocytes - physiology | Bacterial Proteins - metabolism | Multidrug Resistance-Associated Proteins - metabolism | Insecta - microbiology | Receptors, Cell Surface - genetics | Insects | Genetic engineering | Insecticides | Genes | Bacteriology
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15. Full Text Identification of eugenol as the major determinant of GABAA-receptor activation by aqueous Syzygium aromaticum L. (clove buds) extract
by Sahin, Sümeyye and Eulenburg, Volker and Heinlein, Anja and Villmann, Carmen and Pischetsrieder, Monika
Journal of Functional Foods, ISSN 1756-4646, 10/2017, Volume 37, pp. 641 - 649
The spice L. (clove buds) exerts topical anesthetic and analgesic effects. Since GABA receptors are an emerging drug target for pain treatment, the effects of... 
Acetyleugenol | Two-electrode voltage clamp technique | GABAA receptor | Eugenol | Analgesic activity | Clove buds
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16. Full Text Mode of action of piperovatine, an insecticidal piperamide isolated from Piper piscatorum (Piperaceae), against voltage-gated sodium channels
by Suzuki, Tatsuya and Yamato, Seiji
Neurotoxicology, ISSN 0161-813X, 12/2018, Volume 69, pp. 288 - 295
Piperamides, which are secondary metabolites in the genus , have potent insecticidal activity, and have thus inspired the development of novel insecticides. In... 
Two-electrode voltage clamp | Piperamide | Xenopus oocyte | Piperovatine | Voltage-gated sodium channel | PHARMACOLOGY & PHARMACY | PYRETHROID INSECTICIDES | TOXICOLOGY | NEUROSCIENCES | COCKROACH | AMIDES | Insecticides - pharmacology | Sorbic Acid - isolation & purification | Sorbic Acid - pharmacology | Xenopus laevis | Plant Extracts - isolation & purification | Insecticides - isolation & purification | Sorbic Acid - metabolism | Neuromuscular Depolarizing Agents - metabolism | Neuromuscular Depolarizing Agents - isolation & purification | Action Potentials - physiology | Dose-Response Relationship, Drug | Plant Extracts - metabolism | Animals | Insecticides - metabolism | Female | Sorbic Acid - analogs & derivatives | Piper | Drosophila melanogaster | Action Potentials - drug effects | Cockroaches | Voltage-Gated Sodium Channels - metabolism | Neuromuscular Depolarizing Agents - pharmacology | Insecticides | Sensors | Plant metabolites | Biological activity | Channels | Oocytes | Mode of action | Depolarization | Secondary metabolites | Metabolites | Sodium | Natural products | Sodium channels (voltage-gated) | Organic chemicals | Conditioning | Conformation | Index Medicus
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17. Full Text Investigating glutamate receptor‐like gene co‐expression in Arabidopsis thaliana
by ROY, S. J and GILLIHAM, M and BERGER, B and ESSAH, P. A and CHEFFINGS, C and MILLER, A. J and DAVENPORT, R. J and LIU, L.‐H and SKYNNER, M. J and DAVIES, J. M and RICHARDSON, P and LEIGH, R. A and TESTER, M
Plant, Cell & Environment, ISSN 0140-7791, 06/2008, Volume 31, Issue 6, pp. 861 - 871
ABSTRACT There is increasing evidence of the important roles of glutamate receptors (GLRs) in plant development and in adaptation to stresses. However, the... 
Xenopus oocytes | single‐cell sampling | micro‐EXpression amplification | glutamate receptor‐like genes | AtGLR3.7 | two‐electrode voltage clamp | Single-cell sampling | Two-electrode voltage clamp | Glutamate receptor-like genes | Micro-EXpression amplification | GLYCINE | PHYSIOLOGY | two-electrode voltage clamp | glutamate receptor-like genes | PLANT SCIENCES | XENOPUS-OOCYTES | PLANTS | CHANNEL ALPHA-SUBUNIT | single-cell sampling | PROTEINS | CELL | EXPRESSION | micro-EXpression amplification | REVEALS | AGONIST | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Receptors, Glutamate - metabolism | Arabidopsis Proteins - genetics | Plant Leaves - metabolism | Receptors, Glutamate - genetics | Gene Expression Regulation, Plant - physiology | Arabidopsis - metabolism | Genetic research | Glutamate | Arabidopsis | Investigations | AtGLR.7 | twoelectrode voltage clamp | Xenopus oocytes.
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18. Full Text SUMO co-expression modifies K(V)11.1 channel activity
by Steffensen, AB and Andersen, MN and Mutsaers, N and Mujezinovic, A and Schmitt, N
ACTA PHYSIOLOGICA, ISSN 1748-1708, 03/2018, Volume 222, Issue 3
AimThe voltage-gated potassium channel K(V)11.1 is the molecular basis for the I-Kr current, which plays an important role in cardiac physiology. Its... 
PAS DOMAIN | PHYSIOLOGY | sumoylation | HERG POTASSIUM CHANNELS | UBIQUITIN | CARDIAC-ARRHYTHMIA | two-electrode voltage-clamp electrophysiology | SITES | K(V)11.1 | LONG-QT-SYNDROME | BETA-CELL | EXPRESSION | K+ CHANNELS
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19. Full Text Mutations in the extracellular domains of glutamate‐gated chloride channel α3 and β subunits from ivermectin‐resistant Cooperia oncophora affect agonist sensitivity
by Njue, Annete I and Hayashi, Jon and Kinne, Lyle and Feng, Xiao‐Peng and Prichard, Roger K
Journal of Neurochemistry, ISSN 0022-3042, 06/2004, Volume 89, Issue 5, pp. 1137 - 1147
Two full‐length glutamate‐gated chloride channel (GluCl) cDNAs, encoding GluClα3 and GluClβ subunits, were cloned from ivermectin‐susceptible (IVS) and... 
anthelmintic resistance | moxidectin | ivermectin | glutamate‐gated chloride channel | Cooperia oncophora | two‐electrode voltage clamp | Anthelmintic resistance | Two-electrode voltage clamp | Glutamate-gated chloride channel | Moxidectin | Ivermectin
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20. Full Text Suramin is a novel competitive antagonist selective to α1β2γ2 GABA A over ρ1 GABA C receptors
by Luo, Hui and Wood, Kristofer and Shi, Fu-Dong and Gao, Fenfei and Chang, Yongchang
Neuropharmacology, ISSN 0028-3908, 10/2018, Volume 141, pp. 148 - 157
GABA and GABA receptors are both GABA-gated chloride channels with distinct pharmacological properties, mainly in their sensitivity to bicuculline and... 
GABA | Suramin | receptor | Two-electrode voltage-clamp | Competitive antagonist | Xenopus | Brain Tissue Transplantation | Allosteric Regulation | Substrate Specificity | gamma-Aminobutyric Acid - pharmacology | Bicuculline - pharmacology | Pyridazines - pharmacology | Oocytes | GABA Antagonists - pharmacology | Binding, Competitive - drug effects | Dose-Response Relationship, Drug | Patch-Clamp Techniques | Animals | Receptors, GABA - metabolism | Mice | Receptors, GABA-A - metabolism | Protein Isoforms - antagonists & inhibitors | Suramin - pharmacology
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