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European Journal of Immunology, ISSN 0014-2980, 11/2016, Volume 46, Issue 11, pp. 2639 - 2649
Journal Article
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7414, pp. 155 - 159
The identification of somatic activating mutations in JAK2 (refs 1-4) and in the thrombopoietin receptor gene (MPL)(5) in most patients with myeloproliferative... 
MYELOFIBROSIS | LUNG-CANCER | POLYCYTHEMIA-VERA | GEFITINIB | MYELOPROLIFERATIVE DISORDERS | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | MUTATION | RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Myeloproliferative Disorders - enzymology | Phosphorylation | Protein Biosynthesis | Humans | Protein Multimerization | STAT Transcription Factors - metabolism | TYK2 Kinase - metabolism | Janus Kinase 1 - deficiency | TYK2 Kinase - deficiency | Myeloproliferative Disorders - pathology | Janus Kinase 1 - biosynthesis | Gene Knockdown Techniques | Janus Kinase 2 - deficiency | Janus Kinase 1 - metabolism | Granulocytes - drug effects | RNA Interference | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Myeloproliferative Disorders - metabolism | Granulocytes - metabolism | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Cell Line | Janus Kinase 2 - genetics | Myeloproliferative Disorders - drug therapy | Enzyme Activation - drug effects | TYK2 Kinase - biosynthesis | Granulocytes - enzymology | Animals | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Mice | TYK2 Kinase - genetics | Drug Resistance, Neoplasm - drug effects | Enzyme inhibitors | Gene mutations | Cancer cells | Dosage and administration | Genetic aspects | Cellular signal transduction | Identification and classification | Physiological aspects | Care and treatment | Research | Myeloproliferative disorders | Cancer | tyrosine kinase inhibitors | persistence | MPN | JAK2 | resistance
Journal Article
Cancer, ISSN 0008-543X, 04/2017, Volume 123, Issue 7, pp. 1194 - 1201
BACKGROUND Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise at an estimated frequency of 8% to 13% in individuals with... 
ROS proto‐oncogene 1 (ROS1) | cancer predisposition | neurofibromatosis | tyrosine kinase 2 (TYK2) | sarcoma | ROS proto-oncogene 1 (ROS1) | CELLS | PROTEIN | VARIANTS | KINASE | MISSENSE MUTATIONS | MOUSE MODELS | CANCER GENOMICS | ONCOLOGY | PATHWAY | ACUTE LYMPHOBLASTIC-LEUKEMIA | SEQUENCING DATA | Immunohistochemistry | Tissue Array Analysis | Humans | Middle Aged | TYK2 Kinase - metabolism | Male | Gene Expression Profiling | TYK2 Kinase - chemistry | Biomarkers, Tumor | Neurofibromatosis 1 - therapy | Young Adult | Neoplasm Metastasis | DNA Mutational Analysis | Adult | Female | Neurofibromatosis 1 - genetics | Amino Acid Sequence | Gene Expression | Nerve Sheath Neoplasms - diagnosis | Neurofibromatosis 1 - diagnosis | Combined Modality Therapy | Tumor Burden | Nerve Sheath Neoplasms - etiology | Neurofibromatosis 1 - complications | Mutation | TYK2 Kinase - genetics | Nerve Sheath Neoplasms - therapy | Amino Acid Substitution | Usage | Sarcoma | Neurofibromatosis | Genetic aspects | DNA testing | Research | Diagnosis | Gene expression | Protein kinases | Mutation (Biology) | Tyk2 protein | Profiling | p53 Protein | Genes | Neurofibromin 1 | Malignancy | Surgery | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tyrosine | Genomic analysis | Young adults | Melanoma | Radiation therapy | Recklinghausen's disease | Neural crest | Chemotherapy | DNA microarrays | Men | Biomarkers | Adults | Tumors | Cancer
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 10, pp. 1641 - 1662
Journal Article
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 03/2019, Volume 10, Issue 3, pp. 383 - 388
In sharp contrast to a previously reported series of 6-anilino imidazopyridazine based Tyk2 JH2 ligands, 64(2oxo-Nl -substituted-1,2-dihydropyridin-3-y1)... 
ACTIVATION | CHEMISTRY, MEDICINAL | EFFICACY | USTEKINUMAB | Tyk2 JH2 inhibitor(s) | TYROSINE KINASE 2 | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | Tyk2 JH2 ligand(s) | RESPONSES | IN-VITRO | Tyk2 pseudokinase ligand(s) | PSORIASIS LESIONS | Tyk2 pseudokinase inhibitor(s) | INTERFERONS | EXPRESSION
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2015, Volume 195, Issue 10, pp. 5011 - 5024
Journal Article
Cancer Discovery, ISSN 2159-8274, 05/2013, Volume 3, Issue 5, pp. 564 - 577
Journal Article
Journal Article