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Journal Article
PLoS One, ISSN 1932-6203, 2017, Volume 12, Issue 10, pp. e0186317 - e0186317
Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays a key role in maintainingimmune homeostasis. IL-10-mediated responses are triggered upon... 
INTERLEUKIN-10 RECEPTOR COMPLEX | SOCS3 | HUMAN NEUTROPHILS | PATHWAY | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | MECHANISMS | MODEL | EXPRESSION | BINDING | T-CELLS | Dendritic Cells - immunology | Tumor Necrosis Factor-alpha - genetics | TYK2 Kinase - deficiency | TYK2 Kinase - immunology | Signal Transduction - immunology | Bone Marrow Cells - immunology | Cloning, Molecular | Tumor Necrosis Factor-alpha - immunology | Bone Marrow Cells - drug effects | Dendritic Cells - drug effects | Protein Interaction Domains and Motifs | Protein Isoforms - deficiency | Suppressor of Cytokine Signaling 3 Protein - immunology | Macrophages - immunology | STAT3 Transcription Factor - genetics | Receptors, Interleukin-10 - immunology | Recombinant Proteins - metabolism | Mast Cells - immunology | Gene Expression | Bone Marrow Cells - cytology | Tobacco - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Suppressor of Cytokine Signaling 3 Protein - genetics | Macrophages - cytology | Organ Specificity | Mast Cells - drug effects | Mice, Knockout | Animals | Tobacco - genetics | Interleukin-10 - genetics | Lipopolysaccharides - pharmacology | Mast Cells - cytology | Protein Binding | Macrophages - drug effects | Dendritic Cells - cytology | Mice | Primary Cell Culture | Receptors, Interleukin-10 - deficiency | STAT3 Transcription Factor - immunology | TYK2 Kinase - genetics | Protein Isoforms - immunology | Interleukin-10 - immunology | Interleukin-10 - pharmacology | Protein Isoforms - genetics | Receptors, Interleukin-10 - genetics | Homeostasis | Research | Interleukin-10 | Dendritic cells | Tyk2 protein | Laboratories | Interleukin | Intracellular signalling | Activation | Kinases | Macrophages | Experiments | Lipopolysaccharides | Bone marrow | Janus kinase | Plant sciences | Antigens | Cytokines | Neutrophils | Stat3 protein | Inflammation | Tumor necrosis factor-α | Biological activity | Studies | Molecular modelling | Interleukin 10 | Mast cells | Bone | Intracellular | Index Medicus | Laboratorium voor Nematologie | Laboratory of Nematology | EPS | PE&RC
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4285 - 13
Journal Article
Cellular Signalling, ISSN 0898-6568, 03/2014, Volume 26, Issue 3, pp. 619 - 628
New negative regulators of interferon (IFN) signaling, preferably with tissue specificity, are needed to develop therapeutic means to enhance the efficacy of... 
Interferon | SHP-2 | Luteolin | PKA | Phosphodiesterase | INDUCED APOPTOSIS | STAT1 | MOTIF-CONTAINING PROTEIN | RECEPTOR | CELL BIOLOGY | JAK/STAT PATHWAY | FLAVONOID LUTEOLIN | DEGRADATION | EXPRESSION | CAMP | IFN-ALPHA | Interferon-alpha - pharmacology | Adjuvants, Immunologic - pharmacology | STAT2 Transcription Factor - immunology | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | TYK2 Kinase - metabolism | Receptors, Cell Surface | TYK2 Kinase - immunology | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | Neoplasm Proteins | HEK293 Cells | Receptors for Activated C Kinase | Antibodies - immunology | Phosphorylation - drug effects | Receptor, Interferon alpha-beta - chemistry | Cyclic AMP - metabolism | Receptor, Interferon alpha-beta - metabolism | Phosphoric Diester Hydrolases - metabolism | Cell Survival | Colforsin - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Phosphodiesterase Inhibitors - pharmacology | Janus Kinase 1 - antagonists & inhibitors | Luteolin - pharmacology | STAT1 Transcription Factor - antagonists & inhibitors | Janus Kinase 1 - immunology | STAT1 Transcription Factor - immunology | Hep G2 Cells | Interferon-beta - pharmacology | STAT2 Transcription Factor - antagonists & inhibitors | Signal Transduction - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | STAT2 Transcription Factor - metabolism | GTP-Binding Proteins | HeLa Cells | Immunologic Factors - pharmacology | Index Medicus | Proteins | Transducers | Pathways | Partial differential equations | Activation | Inhibition | Kinases
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, pp. e70536 - e70536
Journal Article
The Journal of Immunology, ISSN 0022-1767, 09/1997, Volume 159, Issue 5, pp. 2212 - 2221
IL-6 mediates growth of some human multiple myeloma (MM) cells and IL-6-dependent cell lines, Although three IL-6 signaling pathways (STAT1, STAT3, and... 
JAK-TYK KINASES | INTERLEUKIN-6 FAMILY | TYROSINE PHOSPHORYLATION | STAT FAMILY | K NI IMMUNOLOGY | SIGNAL TRANSDUCER GP130 | IMMUNOLOGY | MALIGNANT PLASMA-CELLS | PHASE RESPONSE FACTOR | HUMAN MULTIPLE-MYELOMA | MARROW STROMAL CELLS | CYTOKINE RECEPTORS | Membrane Glycoproteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Neoplasm Proteins - physiology | Adaptor Proteins, Vesicular Transport | Antigens, CD - metabolism | TYK2 Kinase | DNA-Binding Proteins - metabolism | Janus Kinase 2 | JNK Mitogen-Activated Protein Kinases | Proto-Oncogene Proteins | SOS1 Protein | p38 Mitogen-Activated Protein Kinases | ras Proteins - physiology | Repressor Proteins - metabolism | Shc Signaling Adaptor Proteins | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Mitogen-Activated Protein Kinases | STAT2 Transcription Factor | Oligonucleotides, Antisense - pharmacology | Cytokine Receptor gp130 | Tumor Cells, Cultured - drug effects | Cell Division - drug effects | Janus Kinase 1 | Adaptor Proteins, Signal Transducing | Multiple Myeloma - pathology | Proteins - metabolism | Src Homology 2 Domain-Containing, Transforming Protein 1 | Interleukin-6 - pharmacology | Signal Transduction - drug effects | Protein Kinases - physiology | STAT1 Transcription Factor | Signal Transduction - physiology | Trans-Activators - metabolism | Mitogen-Activated Protein Kinase 1 | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinase 3 | Fungal Proteins - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 06/1997, Volume 387, Issue 6636, pp. 924 - 929
The signalling pathway that comprises JAK kinases and STAT proteins (for signal transducer and activator of transcription) is important for relaying signals... 
SIGNAL-TRANSDUCTION | PATHWAYS | ACTIVATION | TYROSINE PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GP130 | K RO MULTIDISCIPLINARY SCIENCES | IL-3 | INTERLEUKIN-6 | TRANSCRIPTION FACTOR | CYTOKINE RECEPTORS | FAMILY | Membrane Glycoproteins - metabolism | Protein-Tyrosine Kinases - metabolism | Repressor Proteins | Suppressor of Cytokine Signaling 1 Protein | Suppressor of Cytokine Signaling Proteins | Cytokines - physiology | Antigens, CD - metabolism | TYK2 Kinase | Trans-Activators - physiology | Proteins | Base Sequence | Immediate-Early Proteins - chemistry | Interleukin-6 - physiology | Macrophages - physiology | Amino Acid Sequence | DNA-Binding Proteins - physiology | DNA-Binding Proteins - antagonists & inhibitors | Cytokine Receptor gp130 | Signal Transduction | Carrier Proteins - antagonists & inhibitors | Tyrosine - metabolism | Immediate-Early Proteins - genetics | Mice | COS Cells | RNA, Messenger | DNA, Complementary | Protein-Tyrosine Kinases - antagonists & inhibitors | Enzyme Inhibitors | Phosphorylation | Molecular Sequence Data | Janus Kinase 2 | Transfection | Cloning, Molecular | Trans-Activators - genetics | Carrier Proteins - chemistry | Proto-Oncogene Proteins | Tumor Cells, Cultured | Cell Differentiation - physiology | Carrier Proteins - physiology | Immediate-Early Proteins - physiology | Cells, Cultured | Gene Expression Regulation | Macrophages - cytology | DNA-Binding Proteins - genetics | src Homology Domains | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Cell research | Cell receptors | Research | Cytokines | Observations | Cellular biology | Clones | Transducers | Inhibitors | Pathways | Cloning | Stimulation | Activation | Kinases | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 01/2010, Volume 6, Issue 1, pp. e1000721 - e1000721
Previous studies have demonstrated that Marburg viruses (MARV) and Ebola viruses (EBOV) inhibit interferon (IFN)-alpha/beta signaling but utilize different... 
I-INTERFERON | VP35 PROTEIN | MICROBIOLOGY | NUCLEAR ACCUMULATION | SIGNAL-TRANSDUCTION | ANTIVIRAL RESPONSE | VIROLOGY | TYROSINE KINASE JAK1 | VESICULAR STOMATITIS-VIRUS | MATRIX PROTEIN VP40 | NF-KAPPA-B | V-PROTEIN | PARASITOLOGY | Cell Line | Enzyme-Linked Immunosorbent Assay | Marburg Virus Disease - immunology | Humans | Interferons - immunology | Blotting, Western | Ebolavirus - immunology | Janus Kinase 1 - immunology | Janus Kinase 1 - metabolism | Signal Transduction - immunology | Animals | Transfection | Fluorescent Antibody Technique | Polymerase Chain Reaction | Marburgvirus - immunology | Hemorrhagic Fever, Ebola - immunology | Viral Matrix Proteins - immunology | Marburg Virus Disease - metabolism | Marburgvirus - metabolism | Immune Evasion - immunology | Cytokines - immunology | Physiological aspects | RNA viruses | Cellular signal transduction | Interferon | Research | Health aspects | Index Medicus | VP24 protein | b-Interferon | Phosphorylation | Tyk2 protein | VP40 protein | Hemorrhagic disease | Interleukin 6 | Signal transduction | Janus kinase | Stat1 protein | Stat protein | Tyrosine | Pathogens | Antiviral state | Immune response | Cytokines | g-Interferon | Stat3 protein | Data processing | Gene expression | a-Interferon | Nuclear transport | Infection | Overexpression | Mutation | matrix protein | Budding | Proteins | Enzymes | Kinases | Immune system
Journal Article
Oncogene, ISSN 0950-9232, 10/1999, Volume 18, Issue 42, pp. 5727 - 5737
We have examined the effects of human papilloma virus (HPV) E6 proteins on interferon (IFN) signaling. Here we show that expression of the 'malignant' HPV-18... 
Human papilloma virus | Interferon | Oncoproteins | Protein phosphorylation | Cell signaling | DNA-binding | CELLS | TRANSCRIPTIONAL ACTIVATION | PROTEIN | TYROSINE KINASE | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | human papilloma virus | protein phosphorylation | interferon | CELL BIOLOGY | BETA RECEPTOR | ONCOLOGY | ANOGENITAL HUMAN PAPILLOMAVIRUS | cell signaling | GENETICS & HEREDITY | GENE-EXPRESSION | BINDING | oncoproteins | SUBUNIT | Protein-Tyrosine Kinases - isolation & purification | Phosphorylation | Protein-Tyrosine Kinases - metabolism | Humans | Interferon-Stimulated Gene Factor 3, gamma Subunit | Proteins - isolation & purification | TYK2 Kinase | Trans-Activators - physiology | Janus Kinase 2 | Protein-Tyrosine Kinases - physiology | Interferon-alpha - genetics | Protein-Tyrosine Kinases - chemistry | Interferon-Stimulated Gene Factor 3 | Proto-Oncogene Proteins | Interferon-gamma - genetics | Tumor Cells, Cultured | Papillomaviridae - physiology | Oncogene Proteins, Viral - physiology | Cell Line | Proteins - physiology | STAT2 Transcription Factor | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Interferon-gamma - physiology | Proteins - metabolism | Multienzyme Complexes - physiology | STAT1 Transcription Factor | Signal Transduction - physiology | Enzyme Activation | Proteins - chemistry | Interferon-alpha - physiology | Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 03/2019, Volume 33, Issue 3, pp. 696 - 709
TYK2 is a member of the JAK family of tyrosine kinases that is involved in chromosomal translocation-induced fusion proteins found in anaplastic large cell... 
NPM-ALK | ACTIVATION | FUSION | CYTOKINE RESPONSES | GENE | ONCOLOGY | STAT1 | TYROSINE KINASE | T-CELL | TYK2 | HEMATOLOGY | EXPRESSION | Apoptosis - drug effects | Humans | Cell Survival - genetics | Apoptosis - genetics | Translocation, Genetic - drug effects | Anaplastic Lymphoma Kinase - genetics | Phosphorylation - genetics | Protein-Tyrosine Kinases - genetics | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | Lymphoma, Large-Cell, Anaplastic - genetics | Cell Survival - drug effects | Signal Transduction - genetics | STAT1 Transcription Factor - genetics | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Animals | Signal Transduction - drug effects | Lymphoma, Large-Cell, Anaplastic - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | TYK2 Kinase - genetics | Translocation, Genetic - genetics | Non-Hodgkin's lymphomas | Research | Drug therapy | Gene expression | Tyk2 protein | Phosphorylation | Interleukin 22 | Kinases | Proteins | Receptors | Cell activation | Dependence | Autocrine signalling | Stat1 protein | Protein-tyrosine kinase | Tyrosine | Translocation | Cell survival | Stat3 protein | Survival | Lymphoma | Mcl-1 protein | Inhibitors | Cell lines | Interleukin 10 | Lymphomas | Anaplastic large-cell lymphoma | Tumors | Apoptosis | Index Medicus
Journal Article