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International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 05/2012, Volume 121, Issue 3, pp. 343 - 348
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2010, Volume 400, Issue 2, pp. 252 - 257
Journal Article
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 07/2004, Volume 173, Issue 2, pp. 1151 - 1157
Receptor for activated C kinase (Rack)-1 is a protein kinase C-interacting protein, and contains a WD repeat but has no enzymatic activity. In addition to... 
Protein Structure, Tertiary | Phosphorylation | Tyrosine - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Receptors for Activated C Kinase | Receptors, Cell Surface - metabolism | Amino Acid Motifs | TYK2 Kinase
Journal Article
Cancer, ISSN 0008-543X, 04/2017, Volume 123, Issue 7, pp. 1194 - 1201
BACKGROUND Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise at an estimated frequency of 8% to 13% in individuals with... 
ROS proto‐oncogene 1 (ROS1) | cancer predisposition | neurofibromatosis | tyrosine kinase 2 (TYK2) | sarcoma | ROS proto-oncogene 1 (ROS1) | CELLS | PROTEIN | VARIANTS | KINASE | MISSENSE MUTATIONS | MOUSE MODELS | CANCER GENOMICS | ONCOLOGY | PATHWAY | ACUTE LYMPHOBLASTIC-LEUKEMIA | SEQUENCING DATA | Immunohistochemistry | Tissue Array Analysis | Humans | Middle Aged | TYK2 Kinase - metabolism | Male | Gene Expression Profiling | TYK2 Kinase - chemistry | Biomarkers, Tumor | Neurofibromatosis 1 - therapy | Young Adult | Neoplasm Metastasis | DNA Mutational Analysis | Adult | Female | Neurofibromatosis 1 - genetics | Amino Acid Sequence | Gene Expression | Nerve Sheath Neoplasms - diagnosis | Neurofibromatosis 1 - diagnosis | Combined Modality Therapy | Tumor Burden | Nerve Sheath Neoplasms - etiology | Neurofibromatosis 1 - complications | Mutation | TYK2 Kinase - genetics | Nerve Sheath Neoplasms - therapy | Amino Acid Substitution | Usage | Sarcoma | Neurofibromatosis | Genetic aspects | DNA testing | Research | Diagnosis | Gene expression | Protein kinases | Mutation (Biology) | Tyk2 protein | Profiling | p53 Protein | Genes | Neurofibromin 1 | Malignancy | Surgery | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tyrosine | Genomic analysis | Young adults | Melanoma | Radiation therapy | Recklinghausen's disease | Neural crest | Chemotherapy | DNA microarrays | Men | Biomarkers | Adults | Tumors | Cancer
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2017, Volume 76, Issue Suppl 2, p. 859
Journal Article
PLoS ONE, ISSN 1932-6203, 2015, Volume 10, Issue 4, p. e0122271
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 06/2018, Volume 19, Issue 6, p. 1665
Interleukin-34 (IL-34) is a newly recognized cytokine with functions similar to macrophage colony-stimulating factor 1. It is expressed in macrophages and... 
Chicken | Cytokines | Signaling pathway | Interleukin-34 | CSF-1R | RHEUMATOID-ARTHRITIS | chicken | BIOCHEMISTRY & MOLECULAR BIOLOGY | signaling pathway | PROINFLAMMATORY CYTOKINES | CHEMISTRY, MULTIDISCIPLINARY | TYROSINE-PHOSPHATASE | interleukin-34 | EPITHELIAL-CELLS | FUNCTIONAL ANALYSES | cytokines | MOLECULAR-CLONING | MONOCLONAL-ANTIBODIES | CHRONIC INFLAMMATION | NECROTIC ENTERITIS | NF-KAPPA-B | Protein Binding - genetics | Macrophages - pathology | Signal Transduction | Gene Expression Regulation - genetics | Receptor, Macrophage Colony-Stimulating Factor - genetics | Fibroblasts - pathology | Th1 Cells - immunology | Receptor, Macrophage Colony-Stimulating Factor - metabolism | Immunity, Innate - immunology | Interleukins - genetics | Animals | Chickens | Interleukins - immunology | Th17 Cells - immunology | Fibroblasts - immunology | Ligands | Cytokines - biosynthesis | Macrophages - immunology | Cytokines - immunology | Biotechnology | Tyk2 protein | Phosphorylation | Transcription | Interleukin | Helper cells | SHP-2 protein | Homology | Lymphocytes T | Kinases | Macrophages | Immunity | Proteins | Signal transduction | Pathways | Fibroblasts | Janus kinase | Colony-stimulating factor | Protein-tyrosine kinase | Tyrosine | NF-κB protein | Colonies | TAK1 protein | Stat3 protein | Macrophage colony-stimulating factor | Extracellular signal-regulated kinase | MAP kinase | Adaptive immunity | SOCS-1 protein | Signaling | Cell lines | MyD88 protein | Transduction | Protein-tyrosine-phosphatase
Journal Article