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PloS one, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e81618
Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms... 
CAPSAICIN RECEPTOR | 2-ARACHIDONOYLGLYCEROL | RAT | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | CANNABINOID CB1 RECEPTOR | CHANNELS | LIPASE | ENDOCANNABINOID METABOLISM | VANILLOID RECEPTOR-1 | SENSORY NERVES | Monoglycerides - biosynthesis | Humans | Rats | Type C Phospholipases - metabolism | Male | Ganglia, Spinal - cytology | Glycerides - biosynthesis | Monoglycerides - metabolism | Arachidonic Acids - biosynthesis | TRPV Cation Channels - metabolism | Animals | Sensory Receptor Cells - cytology | Sensory Receptor Cells - drug effects | Piperidines - pharmacology | HEK293 Cells | Nociception - drug effects | Endocannabinoids - biosynthesis | Female | Mice | Sensory Receptor Cells - metabolism | Ganglia, Spinal - drug effects | Benzodioxoles - pharmacology | Ganglia, Spinal - metabolism | Physiological aspects | Ion channels | Research | Phospholipases | Monoglycerides | Deuterium | Protons | Brain | Neurosciences | Laboratories | Calcineurin | Diacylglycerol | Capsaicin receptors | 2-Arachidonoylglycerol | Activation | Lipoprotein lipase | Phosphatidylinositol 4,5-diphosphate | Kinases | Lipase | Arteries | Fibers | Receptors | Pain | Dorsal root ganglia | Metabolites | Rodents | Bradykinin | Sensory neurons | Physiology | Inositol 1,4,5-trisphosphate | Adenosine triphosphate | Inositol 1,4,5-trisphosphate receptors | Pain perception | Palmitoylethanolamide | Metabolism | Biological assays | Fatty acids | Capsazepine | Ganglia | Phospholipase C | Medicine | Phospholipase | Histamine | Signaling | Brain research | Inhibitors | Insects | Ligands | ATP | Veins & arteries | Medicinal Chemistry | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Farmakologi och toxikologi | Pharmacology and Toxicology | Läkemedelskemi
Journal Article
Journal Article
The Journal of cell biology, ISSN 0021-9525, 2/2009, Volume 184, Issue 3, pp. 451 - 462
Journal Article
Molecular cell, ISSN 1097-2765, 2008, Volume 31, Issue 3, pp. 383 - 394
Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPases to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and inositol 1,4,5-trisphosphate... 
SIGNALING | ACTIVATION | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | STRUCTURAL REQUIREMENTS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLECKSTRIN HOMOLOGY DOMAIN | HIGH-AFFINITY | PHOSPHOLIPASE-C-BETA | MOLECULAR-CLONING | CA2+ OSCILLATIONS | Y-DOMAIN | CELL BIOLOGY | Sequence Deletion | Phospholipase C beta - isolation & purification | Humans | Cercopithecus aethiops | Molecular Sequence Data | Crystallography, X-Ray | Isoenzymes - chemistry | Type C Phospholipases - antagonists & inhibitors | Phospholipase C beta - antagonists & inhibitors | Phospholipase C beta - chemistry | Phospholipase C delta - antagonists & inhibitors | Phosphoinositide Phospholipase C - metabolism | Phosphoinositide Phospholipase C - chemistry | Binding Sites | Phosphoinositide Phospholipase C - antagonists & inhibitors | Phospholipase C beta - metabolism | Amino Acid Sequence | Protein Structure, Secondary | Models, Molecular | Type C Phospholipases - chemistry | Animals | Phospholipase C delta - metabolism | Phospholipase C delta - chemistry | Enzyme Activation | COS Cells | Isoenzymes - antagonists & inhibitors | GTP-Binding Proteins - metabolism | Isoenzymes | G proteins | CAPACITY | GTP-ASES | REMOVAL | MEMBRANES | STIMULI | CRYSTAL STRUCTURE | MATERIALS SCIENCE | REGULATIONS | PROTEINS | INOSITOL
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Journal Article