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Immunological reviews, ISSN 1600-065X, 2009, Volume 228, Issue 1, pp. 58 - 73
Bruton’s agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase important in B‐lymphocyte development, differentiation, and signaling. Btk... 
bone marrow tyrosine kinase gene on chromosome X | IL‐2 inducible tyrosine kinase (Itk) | nuclear factor κB | peptidyl‐prolyl cis–trans isomerase (Pin 1) | X‐linked agammaglobulinemia | Tec protein tyrosine kinase (Tec) | IL-2 inducible tyrosine kinase (Itk) | Bone marrow tyrosine kinase gene on chromosome X | X-linked agammaglobulinemia | Nuclear factor κB | Peptidyl-prolyl cis-trans isomerase (Pin 1) | B-CELL RECEPTOR | TRANSCRIPTION FACTOR BRIGHT | PROLINE-RICH SEQUENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | X-LINKED AGAMMAGLOBULINEMIA | PLECKSTRIN HOMOLOGY DOMAIN | FACTOR-KAPPA-B | T-CELL | IMMUNOLOGY | TEC FAMILY KINASES | SH3 DOMAIN | Neoplasms - metabolism | Protein Structure, Tertiary | Agammaglobulinemia - immunology | Animals | Protein-Tyrosine Kinases - metabolism | Humans | Protein-Tyrosine Kinases - chemistry | Mutation | X-Linked Combined Immunodeficiency Diseases - immunology | Protein-Tyrosine Kinases - immunology | Proteins | Tyrosine | Oncology, Experimental | Phenols | Research | Universities and colleges | T cells | Protein kinases | Cancer | Neoplasms: metabolism | Basic Medicine | Protein-Tyrosine Kinases: metabolism | Medical and Health Sciences | Medicin och hälsovetenskap | Protein-Tyrosine Kinases: chemistry | X-Linked Combined Immunodeficiency Diseases: immunology | Medicinska och farmaceutiska grundvetenskaper | Protein-Tyrosine Kinases: immunology | Agammaglobulinemia: immunology | Immunologi inom det medicinska området | Immunology in the medical area
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 4, p. e10290
Stat3 is initially dephosphorylated in murine keratinocytes in response to UVB irradiation. Treatment with Na3VO4 desensitized keratinocytes to UVB-induced... 
GROWTH-FACTOR RECEPTOR | ACTIVATION | TRANSCRIPTION 3 | PROMOTION STAGES | EPITHELIAL CARCINOGENESIS | SUBSTRATE | BIOLOGY | SKIN CARCINOGENESIS | PROLIFERATION | SIGNAL TRANSDUCER | NEGATIVE REGULATOR | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - radiation effects | Apoptosis - radiation effects | Keratinocytes - radiation effects | RNA, Small Interfering - pharmacology | Cells, Cultured | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - physiology | STAT3 Transcription Factor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - physiology | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Protein Tyrosine Phosphatases, Non-Receptor - physiology | Ultraviolet Rays - adverse effects | Protein Tyrosine Phosphatases, Non-Receptor - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - radiation effects | Phosphorylation - radiation effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - physiology | Animals | Keratinocytes - metabolism | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | STAT3 Transcription Factor - metabolism | Tyrosine | Phenols | Skin | Phosphatases | Apoptosis | Pediatrics | Phosphorylation | Transcription factors | SHP-1 protein | c-Myc protein | Genomes | Myc protein | Dephosphorylation | Cyclin D1 | Phosphatase | Experiments | Carcinogenesis | Proteins | Signal transduction | Carcinogens | Toxicology | Cell growth | Epidermal growth factor | Rodents | Cell cycle | Translocation | Desensitization | U.V. radiation | RNA-mediated interference | Stat3 protein | Keratinocytes | Epidermis | siRNA | Nuclear transport | Studies | Irradiation | Diabetes | Endoplasmic reticulum | Cytoplasm | Protein-tyrosine-phosphatase | Tumors | Cancer
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2018, Volume 140, Issue 41, pp. 13253 - 13259
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2007, Volume 402, Issue 1, pp. 1 - 15
It is now well established that the members of the PTP (protein tyrosine phosphatase) superfamily play critical roles in fundamental biological processes.... 
Substrate identification | Tyrosine phosphorylation | Protein tyrosine phosphatase (PTP) | Substrate-trapping | KINASE-ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR RECEPTOR | NEGATIVE REGULATOR | SIGNAL-TRANSDUCTION | INSULIN-RECEPTOR | protein tyrosine phosphatase (PTP) | EPIDERMAL-GROWTH-FACTOR | IN-VIVO | HELICOBACTER-PYLORI CAGA | substrate-trapping | tyrosine phosphorylation | PTP-PEST | substrate identification | T-CELLS | Protein Structure, Tertiary | Phosphorylation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Humans | Substrate Specificity | Protein Tyrosine Phosphatases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Protein Tyrosine Phosphatases - genetics | Tyrosine - metabolism | Animals | Models, Biological | Protein Tyrosine Phosphatase, Non-Receptor Type 1 | Binding Sites | serine | SH, Src homology | CSK, C-terminal Src kinase | RNAi, RNA interference | PTK, protein tyrosine kinase | MKP, MAPK phosphatase | IRS, IR substrate | CSF-1, colony-stimulating factor 1 | SHP, SH2-domain-containing protein tyrosine phosphatase | ERK, extracellular-signal-regulated kinase | PIR-B, paired immunoglobulin-like receptor B | ZAP-70, ζ-chain-associated protein kinase of 70 kDa | KIM, kinase-interacting motif | FAK, focal adhesion kinase | EGFR, epidermal growth factor receptor | STEP, striatal-enriched PTP | LYP, lymphoid phosphatase | MAPK, mitogen-activated protein kinase | PTP, protein tyrosine phosphatase | SNARE, NSF-attachment protein receptor | TCR, T-cell receptor | PI3K, phosphoinositide 3-kinase | Gab1, Grb2-associated binder-1 | PAG, phosphoprotein associated with glycosphingolipid-enriched membrane microdomains | Cbp, C-terminal Src kinase-binding protein | SNP, single-nucleotide polymorphism | Review | WASP, Wiskott–Aldrich syndrome protein | NSF, N-ethylmaleimide-sensitive factor | PDGFR, platelet-derived growth factor receptor | AP-1, activator protein 1 | PEP, PEST (Pro-Glu-Ser-Thr) domain phosphatase | SFK, Src family kinase | DSP, dual-specificity phosphatase | PSTPIP, proline | NS, Noonan syndrome | IR, insulin receptor | IFN, interferon | STAT, signal transducer and activator of transcription | NFAT, nuclear factor of activated T-cells | IGF-1, insulin-like growth factor 1 | BIT, brain immunoglobulin-like molecule with tyrosine-based activation motifs | threonine-phosphatase-interacting protein | TCPTP, T-cell PTP | JAK, Janus kinase | MEF, mouse embryonic fibroblast | BCR, B-cell receptor | GAP, GTPase-activating protein | HGF, hepatocyte growth factor
Journal Article
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 3, p. 569
Protein tyrosine phosphatases (PTPs), of the receptor and non-receptor classes, are key signaling molecules that play critical roles in cellular regulation... 
Phosphorylation | Disease | Tyrosine phosphatase | Receptor | Biotherapeutic | Inhibitor | Biological | Ectodomain | GAMMA | disease | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCLONAL-ANTIBODY | PROTEOGLYCAN | CHEMISTRY, MULTIDISCIPLINARY | biotherapeutic | PTP-SIGMA | tyrosine phosphatase | receptor | INHIBITION | inhibitor | STRUCTURAL BASIS | biological | DIABETIC MACULAR EDEMA | CD148 | STEM-CELL TRANSPLANTATION | PLATELET ACTIVATION | phosphorylation | ectodomain | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - chemistry | Ribosome Inactivating Proteins, Type 1 - chemistry | Humans | Receptor-Like Protein Tyrosine Phosphatases - chemistry | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - genetics | Enzyme Inhibitors - chemical synthesis | Molecular Targeted Therapy | Immunoconjugates - pharmacology | Neoplasms - genetics | Arthritis, Rheumatoid - drug therapy | Protein Domains | Receptor-Like Protein Tyrosine Phosphatases - genetics | Immunotoxins - chemistry | Receptor-Like Protein Tyrosine Phosphatases - antagonists & inhibitors | Signal Transduction | Asthma - enzymology | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Neoplasms - enzymology | Receptor-Like Protein Tyrosine Phosphatases - metabolism | Antibodies, Neutralizing - pharmacology | Arthritis, Rheumatoid - enzymology | Asthma - drug therapy | Immunoconjugates - chemistry | Asthma - genetics | Arthritis, Rheumatoid - pathology | Neoplasms - drug therapy | Arthritis, Rheumatoid - genetics | Animals | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - metabolism | Neoplasms - pathology | Asthma - pathology | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - antagonists & inhibitors | Tyrosine | Proteins | Signaling | Medical treatment | Monoclonal antibodies | Pharmacology | Drug delivery | Phosphatase | CD45 antigen | Protein-tyrosine-phosphatase
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2012, Volume 448, Issue 2, pp. 213 - 220
To investigate the range of autoinhibitory mechanisms used by TKDs (tyrosine kinase domains) from the insulin receptor family of RTKs (receptor tyrosine... 
X-ray crystallography | Insulin receptor kinase | Autoinhibition | Receptor tyrosine kinase (RTK) | Receptor tyrosine kinase-like orphan receptor 2 (Ror2) | Tropomyosin receptor kinase A (TrkA) | ALK | ACTIVATION | CRYSTAL-STRUCTURE | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC DOMAIN | autoinhibition | receptor tyrosine kinase-like orphan receptor 2 (Ror2) | CANCER | ANAPLASTIC LYMPHOMA KINASE | insulin receptor kinase | receptor tyrosine kinase (RTK) | MUTATIONS | INHIBITOR | tropomyosin receptor kinase A (TrkA) | EGF RECEPTOR | Neoplasms - metabolism | Humans | Receptor, trkA - antagonists & inhibitors | Crystallography, X-Ray | Antigens, CD - genetics | Antigens, CD - metabolism | Neoplasms - genetics | Receptor, Insulin - genetics | Protein Structure, Quaternary | Antigens, CD - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Recombinant Proteins - antagonists & inhibitors | Receptor Tyrosine Kinase-like Orphan Receptors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Receptor, Insulin - antagonists & inhibitors | Amino Acid Motifs | Receptor Tyrosine Kinase-like Orphan Receptors - antagonists & inhibitors | Receptor Tyrosine Kinase-like Orphan Receptors - chemistry | Receptor, trkA - metabolism | Receptor, Insulin - chemistry | Receptor, trkA - chemistry | Receptor, trkA - genetics | Receptor Tyrosine Kinase-like Orphan Receptors - genetics | Receptor, Insulin - metabolism | Mutation | Enzyme Activation - genetics | In Vitro Techniques | ALK, anaplastic lymphoma kinase | FGFR, fibroblast growth factor receptor | Trk, tropomyosin receptor kinase | C-lobe, C-terminal lobe | EGFR, epidermal growth factor receptor | TKD, tyrosine kinase domain | DTT, dithiothreitol | NSCLC, non-small-cell lung cancer | TCEP, tris-(2-carboxyethyl)phosphine | COSMIC, Catalogue Of Somatic Mutations In Cancer | Ni-NTA, Ni2+-nitrilotriacetate | N-lobe, N-terminal lobe | RTK, receptor tyrosine kinase | CDK, cyclin-dependent kinase | IGF1R, insulin-like growth factor 1 receptor | MuSK, muscle-specific kinase | IRK, insulin receptor kinase | Ror, receptor tyrosine kinase-like orphan receptor
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 06/2013, Volume 33, Issue 11, pp. 2188 - 2201
Journal Article
Environmental science and pollution research international, ISSN 1614-7499, 2019, Volume 26, Issue 8, pp. 8312 - 8324
Protein tyrosine phosphatase (PTPs) and protein tyrosine kinase (PTKs) genes are responsible for the regulation of insect insulin-like pathway (ILP), cells... 
Environmental Health | Ecotoxicology | Protein tyrosine phosphatase | Protective enzyme | Insulin-like signalling pathway | Oedaleus asiaticus | Environment, general | Protein tyrosine kinase, insect descriptive parameters | Environment | Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution | Performance | Environmental Chemistry | Atmospheric Protection/Air Quality Control/Air Pollution | INSECT HERBIVORES | RECEPTOR SUBSTRATE | PROTEIN-TYROSINE PHOSPHATASES | INNER-MONGOLIA | DROSOPHILA | ENVIRONMENTAL SCIENCES | METABOLISM | insect descriptive parameters | GROWTH | Protein tyrosine kinase | RESISTANCE | CELL | MOLECULAR-MECHANISMS | Phosphorylation | Protein Tyrosine Phosphatase, Non-Receptor Type 4 - genetics | Signal Transduction | Grasshoppers - metabolism | Protein-Tyrosine Kinases - metabolism | Larva - metabolism | Insect Proteins - genetics | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Insulin - metabolism | Protein-Tyrosine Kinases - genetics | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 4 - metabolism | Gene Expression Regulation, Developmental | Receptor, Insulin - genetics | Grasshoppers - growth & development | Larva - growth & development | Receptor, Insulin - metabolism | Larva - genetics | Grasshoppers - genetics | Proto-Oncogene Proteins c-akt - metabolism | Insect Proteins - metabolism | Oxidases | Tyrosine | Insect pests | Phosphatases | Physiological aspects | Cellular signal transduction | Genetic transcription | Protein kinases | Water treatment | Reactive oxygen species | Growth rate | Genes | AKT protein | Kinases | Proteins | Signal transduction | Enzymatic activity | Catalase | Forkhead protein | Protein-tyrosine kinase | Immune system | Immune response | Double-stranded RNA | Detoxification | Exposure | Metabolism | Gene expression | Insulin | Substrates | 1-Phosphatidylinositol 3-kinase | Signaling | Insects | Body mass | Phenols | Transduction | Phenol oxidase | Cellular stress response | Protein-tyrosine-phosphatase
Journal Article