X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (2442) 2442
Publication (264) 264
Book Chapter (3) 3
Magazine Article (2) 2
Book Review (1) 1
Conference Proceeding (1) 1
Dissertation (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
tyrphostins - pharmacology (1853) 1853
animals (1461) 1461
humans (1303) 1303
enzyme inhibitors - pharmacology (996) 996
phosphorylation (814) 814
index medicus (755) 755
protein-tyrosine kinases - antagonists & inhibitors (657) 657
mice (617) 617
rats (585) 585
tyrphostins (521) 521
cells, cultured (502) 502
male (499) 499
signal transduction (495) 495
signal transduction - drug effects (475) 475
biochemistry & molecular biology (472) 472
quinazolines (445) 445
cell biology (417) 417
nitriles - pharmacology (409) 409
expression (392) 392
female (390) 390
receptor, epidermal growth factor - metabolism (388) 388
activation (376) 376
cell line (365) 365
cell line, tumor (344) 344
oncology (342) 342
receptor, epidermal growth factor - antagonists & inhibitors (335) 335
protein-tyrosine kinases - metabolism (326) 326
phosphorylation - drug effects (322) 322
dose-response relationship, drug (300) 300
apoptosis (280) 280
quinazolines - pharmacology (261) 261
apoptosis - drug effects (255) 255
pharmacology & pharmacy (252) 252
blotting, western (244) 244
tumor cells, cultured (240) 240
stat3 transcription factor - metabolism (227) 227
tyrosine kinase (224) 224
rats, sprague-dawley (215) 215
antineoplastic agents - pharmacology (213) 213
cells (210) 210
protein kinase inhibitors - pharmacology (208) 208
genistein - pharmacology (196) 196
cell proliferation - drug effects (194) 194
catechols - pharmacology (187) 187
epidermal growth factor - pharmacology (186) 186
signal transduction - physiology (186) 186
genistein (185) 185
tyrosine - metabolism (185) 185
cell division - drug effects (179) 179
epidermal growth factor (179) 179
inhibition (177) 177
time factors (167) 167
cancer (165) 165
physiology (160) 160
signal-transduction (160) 160
receptor (158) 158
proliferation (153) 153
tyrosine (153) 153
enzyme activation (150) 150
flavonoids - pharmacology (147) 147
in-vitro (147) 147
research (147) 147
egf receptor (145) 145
janus kinase 2 (145) 145
proteins (142) 142
rna, messenger - metabolism (142) 142
janus kinase 2 - metabolism (141) 141
stat3 transcription factor - antagonists & inhibitors (141) 141
kinases (140) 140
stat3 (139) 139
immunology (138) 138
mitogen-activated protein kinases - metabolism (137) 137
kinetics (136) 136
pyridines - pharmacology (136) 136
transfection (136) 136
receptor, epidermal growth factor - genetics (135) 135
gene-expression (133) 133
tyrosine phosphorylation (133) 133
janus kinase 2 - antagonists & inhibitors (132) 132
enzyme activation - drug effects (130) 130
growth (129) 129
in vitro techniques (129) 129
isoflavones - pharmacology (129) 129
neurosciences (129) 129
growth-factor receptor (127) 127
calcium - metabolism (121) 121
mitogen-activated protein kinase 1 - metabolism (119) 119
epidermal growth factor receptor (118) 118
phosphatidylinositol 3-kinases - metabolism (117) 117
cell survival - drug effects (113) 113
egfr (113) 113
rats, wistar (113) 113
pathway (112) 112
reverse transcriptase polymerase chain reaction (112) 112
gene expression (111) 111
analysis (108) 108
protein (107) 107
tyrphostin (107) 107
biophysics (104) 104
research article (103) 103
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Psychopharmacology, ISSN 0033-3158, 12/2008, Volume 201, Issue 3, pp. 443 - 458
Fluoxetine has relatively high affinity for Gq/11 protein-coupled 5-HT2 receptors. Part of these receptors in brain are on astrocytes, where fluoxetine causes... 
Neurosciences | Biomedicine | Serotonin | Astrocytes | Fluoxetine | EGFR transactivation | fosB | c-fos | Pharmacology/Toxicology | Psychiatry | ERK | 5-HT 2B receptor | receptor | C-fos | FosB | 5-HT | SIGNALING PATHWAYS | PSYCHIATRY | TYROSINE KINASE | PHARMACOLOGICAL CHARACTERIZATION | CELL-PROLIFERATION | 5-HT2B receptor | NEUROSCIENCES | SEROTONIN REUPTAKE INHIBITORS | MESSENGER-RNA | TISSUE DISTRIBUTION | MECHANICAL-STRESS | CULTURED ASTROCYTES | PHARMACOLOGY & PHARMACY | R-FLUOXETINE | Receptor, Epidermal Growth Factor - genetics | Up-Regulation | Phosphorylation | Transcriptional Activation - genetics | Nitriles - pharmacology | Calcium - metabolism | Maleimides - pharmacology | Substrate Specificity | Extracellular Signal-Regulated MAP Kinases - metabolism | Quinazolines | Calcium - chemistry | Receptor, Serotonin, 5-HT2B - physiology | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Receptor, Epidermal Growth Factor - metabolism | Piperidines - pharmacology | Receptor, Serotonin, 5-HT2B - drug effects | Urea - analogs & derivatives | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Proto-Oncogene Proteins c-fos - antagonists & inhibitors | Astrocytes - drug effects | Fluoxetine - pharmacology | Butadienes - pharmacology | Gene Expression | Signal Transduction | Dipeptides - pharmacology | RNA, Messenger - genetics | Cells, Cultured | Proto-Oncogene Proteins c-fos - metabolism | Antidepressive Agents, Second-Generation - pharmacology | Protein Kinase C - antagonists & inhibitors | Tyrphostins - pharmacology | Chelating Agents - pharmacology | Antidepressive Agents, Second-Generation - antagonists & inhibitors | Fluoxetine - antagonists & inhibitors | Astrocytes - physiology | Animals | Egtazic Acid - pharmacology | Aminopyridines - pharmacology | Proto-Oncogene Proteins c-fos - genetics | Mice | Urea - pharmacology | Brain | Neurotransmitters | Antidepressants | Psychopharmacology | Cells
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 08/2003, Volume 93, Issue 4, pp. 311 - 320
ABSTRACT—Homocysteine (Hcy) is an independent risk factor for cardiovascular disease. Monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) are... 
Monocyte chemoattractant protein-1 | Monocytes | Homocysteine | Interleukin-8 | Atherosclerosis | homocysteine | atherosclerosis | monocytes | ENDOTHELIAL-CELL INJURY | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | OXIDANT STRESS | monocyte chemoattractant protein-1 | RISK FACTOR | PLASMA HOMOCYST(E)INE | interleukin-8 | VASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | ATHEROMATOUS PLAQUES | HEMATOLOGY | NF-KAPPA-B | T-LYMPHOCYTES | Interleukin-8 - genetics | Reactive Oxygen Species - metabolism | Chemokine CCL2 - secretion | Monocytes - cytology | Humans | Dimethyl Sulfoxide - pharmacology | Monocytes - metabolism | RNA, Messenger - metabolism | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Thiocarbamates - pharmacology | Chromans - pharmacology | Time Factors | Homocysteine - pharmacology | Indoles - pharmacology | Interleukin-8 - secretion | Flavonoids - pharmacology | RNA, Messenger - drug effects | RNA, Messenger - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Chemokine CCL2 - genetics | Imidazoles - pharmacology | Tyrphostins - pharmacology | Antioxidants - pharmacology | Onium Compounds - pharmacology | Sulfonamides - pharmacology | Naphthalenes - pharmacology | Gene Expression Regulation - drug effects | Monocytes - drug effects | Genistein - pharmacology | Pyridines - pharmacology | Thiazoles - pharmacology | Thiazolidinediones
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 12/2015, Volume 153, pp. 49 - 59
Heart tissue becomes zinc-depleted and the capacity to mobilize labile zinc is diminished, indicating zinc dyshomeostasis during ischemia/reperfusion (I/R).... 
Hypoxia | Reoxygenation | Proteolysis | Caspase-3 | Zinc | Apoptosis | ACTIVATION | RAT | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | CARDIOMYOPATHY | CARDIAC-CELLS | DEATH | INTRACELLULAR ZINC | CHEMISTRY, INORGANIC & NUCLEAR | ACUTE MYOCARDIAL-INFARCTION | Receptor, Epidermal Growth Factor - genetics | Caspase Inhibitors - pharmacology | Phosphorylation | Receptor, ErbB-2 - genetics | Protein Multimerization | Caspase 3 - metabolism | Receptor, ErbB-2 - metabolism | RNA, Messenger - metabolism | Cell Hypoxia | Receptor, Epidermal Growth Factor - metabolism | Zinc Compounds - pharmacology | Amino Acid Chloromethyl Ketones - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Benzothiazoles - pharmacology | Chlorides - pharmacology | Down-Regulation | RNA, Messenger - genetics | Rats | Tyrphostins - pharmacology | Cardiotonic Agents - pharmacology | Leupeptins - pharmacology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Thiones - pharmacology | Quinazolines - pharmacology | Organometallic Compounds - pharmacology | Proteins | Membrane lipids | Inositol | RNA | Antifungal agents | Permeability | Antibacterial agents | Phosphotransferases | Tyrosine | Cell death
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2009, Volume 296, Issue 2, pp. 470 - 479
Bacterial endotoxin lipopolysaccharide (LPS) is responsible for the multiorgan dysfunction that characterizes septic shock and is causal in the myocardial... 
Green fluorescent protein- Microtubule-associated protein light chain 3 | Lipopolysaccharide | Oxidative stress | Hl-1 cardiac myocyte | TRANSCRIPTIONAL ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | HL-1 cardiac myocyte | CARDIAC MYOCYTES | NECROSIS-FACTOR-ALPHA | MYOCARDIAL DEPRESSION | PROGRAMMED CELL-DEATH | ENDOTOXEMIC RATS | SCAVENGER RECEPTOR | green fluorescent protein-microtubule-associated protein light chain 3 | SEPTIC SHOCK | PERIPHERAL VASCULAR DISEASE | TNF-ALPHA | lipopolysaccharide | NF-KAPPA-B | oxidative stress | Tumor Necrosis Factor-alpha - metabolism | Mitochondria, Heart - metabolism | Glutathione - metabolism | Mitochondria, Heart - pathology | Nitric Oxide Synthase - antagonists & inhibitors | omega-N-Methylarginine - pharmacology | Mitochondria, Heart - drug effects | Nitroprusside - pharmacology | Autophagy - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Nitric Oxide Donors - pharmacology | Cytoprotection | Animals, Newborn | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Mice, Transgenic | Imidazoles - pharmacology | Tyrphostins - pharmacology | Antioxidants - pharmacology | Sirolimus - pharmacology | Hydrogen Peroxide - metabolism | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Acetylcysteine - pharmacology | Lipopolysaccharides - pharmacology | Myocytes, Cardiac - metabolism | Mice | Nitric Oxide Synthase - metabolism | Pyridines - pharmacology | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Index Medicus
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 07/2005, Volume 16, Issue 6, pp. 601 - 607
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 10/2007, Volume 85, Issue 7, pp. 558 - 566
It has been recognized that protease‐activated receptors (PARs), interleukin (IL)‐4 and IL‐6 are involved in the pathogenesis of allergic diseases, and that... 
mast cell | IL‐4 | IL‐12 | trypsin | protease‐activated receptor | tryptase | IL-4 | Trypsin | Mast cell | Protease-activated receptor | IL-12 | Tryptase | SERINE PROTEINASES | THROMBIN RECEPTORS | HISTAMINE-RELEASE | INDUCTION | IMMUNOLOGY | HUMAN AIRWAYS | CELL BIOLOGY | SMOOTH-MUSCLE | INTERFERON-GAMMA | IN-VIVO | protease-activated receptor | VASCULAR ENDOTHELIAL-CELLS | INFLAMMATORY MEDIATORS | Receptors, Proteinase-Activated - metabolism | Nitriles - pharmacology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Receptors, Proteinase-Activated - genetics | Trypsin - pharmacology | Mast Cells - metabolism | Flavonoids - pharmacology | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-12 - pharmacology | Butadienes - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Imidazoles - pharmacology | Tyrphostins - pharmacology | Mast Cells - drug effects | Gene Expression Regulation - drug effects | Interleukin-4 - secretion | Animals | Tryptases - pharmacology | Mice | Pyridines - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Tyrphostins, pharmacology | Up-Regulation | Chromones, pharmacology | Trypsin, pharmacology | Humans | Imidazoles, pharmacology | Tryptases, pharmacology | Oligopeptides, pharmacology | Interleukin-12, pharmacology | Flow Cytometry | Pyridines, pharmacology | Polymerase Chain Reaction | Receptor, PAR-1, drug effects | Morpholines, pharmacology | RNA, Messenger, metabolism | Flavonoids, pharmacology | Receptor, PAR-2, drug effects | Receptors, Thrombin, drug effects | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Butadienes, pharmacology | Down-Regulation | Mast Cells, drug effects | Interleukin-6, secretion | Nitriles, pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-4, secretion | Fluorescent Antibody Technique
Journal Article
Neoplasia, ISSN 1476-5586, 2015, Volume 17, Issue 7, pp. 564 - 573
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2013, Volume 288, Issue 32, pp. 22942 - 22960
TGR5 is a G protein-coupled receptor that mediates bile acid (BA) effects on energy balance, inflammation, digestion, and sensation. The mechanisms and... 
GROWTH-FACTOR RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | GPBAR1 TGR5 | DEPENDENT ENDOCYTOSIS | PROTEIN-COUPLED RECEPTORS | RESONANCE ENERGY-TRANSFER | KINASE ACTIVATION | MU-OPIOID RECEPTOR | BETA-ADRENERGIC RECEPTOR | ACTIVATED RECEPTOR-2 | EGF RECEPTOR | Cholagogues and Choleretics - pharmacology | Phenylalanine - analogs & derivatives | Receptors, G-Protein-Coupled - metabolism | Membrane Microdomains - metabolism | Phenylalanine - pharmacology | Humans | ErbB Receptors - genetics | Oleanolic Acid - pharmacology | Arrestins - genetics | Protein Transport - physiology | Protein Transport - drug effects | G-Protein-Coupled Receptor Kinase 2 - genetics | G-Protein-Coupled Receptor Kinase 2 - metabolism | Arrestins - metabolism | beta-Cyclodextrins - pharmacology | Endosomes - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Antineoplastic Agents - pharmacology | Cyclic AMP - genetics | Cyclic AMP - metabolism | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Endosomes - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Thiophenes - pharmacology | Tyrphostins - pharmacology | Endocytosis - physiology | Arrestins - antagonists & inhibitors | G-Protein-Coupled Receptor Kinase 5 - metabolism | Deoxycholic Acid - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | beta-Arrestin 2 | beta-Arrestin 1 | beta-Arrestins | Receptors, G-Protein-Coupled - genetics | Quinazolines - pharmacology | G-Protein-Coupled Receptor Kinase 5 - genetics | Membrane Microdomains - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Lipid Raft | Bile Acid | Endocytosis | G Protein-coupled Receptors (GPCR) | Arrestin | Signal Transduction
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 06/2004, Volume 18, Issue 9, pp. 1309 - 1309
Accumulation of inflammatory mononuclear phagocytes in Alzheimer's senile plaques, a hallmark of the innate immune response to beta-amyloid fibrils, can... 
ACTIVATION | G-protein coupled receptors | Alzheimer disease | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | immunosuppression | NEUTROPHILS | sphingosine-1-phosphate receptors | MESSENGER | PEPTIDE | CELL BIOLOGY | FIBRILS | MICROGLIA | SPHINGOSINE-1-PHOSPHATE | BIOLOGY | leukocytes | T-CELL CHEMOTAXIS | 1-PHOSPHATE | Phosphotransferases (Alcohol Group Acceptor) - physiology | Amyloid beta-Peptides - pharmacology | Humans | Maleimides - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Bombesin - pharmacology | Chemotaxis, Leukocyte - drug effects | Protein Processing, Post-Translational - drug effects | Vasoactive Intestinal Peptide - pharmacology | Neuropeptides - pharmacology | N-Formylmethionine Leucyl-Phenylalanine - pharmacology | Receptors, Lysosphingolipid - genetics | Indoles - pharmacology | Cholera Toxin - pharmacology | Heterotrimeric GTP-Binding Proteins - physiology | Phosphorylation - drug effects | Drug Evaluation, Preclinical | Pertussis Toxin - pharmacology | Propylene Glycols - pharmacology | Leukocytes, Mononuclear - drug effects | Calcitonin Gene-Related Peptide - pharmacology | Enzyme Inhibitors - pharmacology | Secretogranin II | Fingolimod Hydrochloride | Receptors, Lysosphingolipid - physiology | Tyrphostins - pharmacology | 1-Methyl-3-isobutylxanthine - pharmacology | Gene Expression Regulation - drug effects | Sphingosine - pharmacology | Cell Movement - drug effects | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Sphingosine - analogs & derivatives | Androstadienes - pharmacology | Receptors, Lysosphingolipid - agonists | Leukocytes, Mononuclear - cytology | Protein Kinase Inhibitors - pharmacology | Immunologic Factors - pharmacology | Receptors, Lysosphingolipid - biosynthesis | Staurosporine - pharmacology | Amyloid beta-Protein Precursor - pharmacology
Journal Article
Circulation, ISSN 0009-7322, 04/2004, Volume 109, Issue 14, pp. 1795 - 1801
Background - Isoforms of the NADPH oxidase contribute to vascular superoxide anion (.O-2(-)) formation and limit NO bioavailability. We hypothesized that the... 
Hypertension | Stress, oxidative | Angiotensin | Endothelium | endothelium | PROTEIN-KINASE-C | CARDIAC & CARDIOVASCULAR SYSTEMS | stress, oxidative | SUPEROXIDE-PRODUCTION | INVOLVEMENT | ANGIOTENSIN-II | DEFICIENT MICE | NAD(P)H OXIDASE | DISEASE | angiotensin | TETRAHYDROBIOPTERIN | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | hypertension | EXPRESSION | SMOOTH-MUSCLE CELLS | Angiotensin II - blood | Male | 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt - pharmacology | Hypertension, Renovascular - physiopathology | Quinazolines | Endothelium, Vascular - enzymology | Glycoproteins - pharmacology | Cytochromes b - deficiency | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Superoxides - metabolism | Aorta | Indoles - pharmacology | Membrane Glycoproteins | Cardiomyopathy, Hypertrophic - etiology | Organ Culture Techniques | Disease Models, Animal | Polyethylene Glycols - pharmacology | NADPH Oxidases | Superoxide Dismutase - pharmacology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Hypertension, Renovascular - enzymology | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Protein Kinase C - antagonists & inhibitors | Tyrphostins - pharmacology | Antioxidants - pharmacology | NADPH Oxidase 2 | Mice, Knockout | Proto-Oncogene Proteins c-akt | Animals | Hypertension, Renovascular - complications | Bacterial Toxins - pharmacology | Cytochromes b - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Vasodilation - drug effects | Nitric Oxide - metabolism | Cytochromes b - physiology
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 717 - 726
Journal Article