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by Chu, Y and Yang, X
Oncogene, ISSN 0950-9232, 03/2011, Volume 30, Issue 9, pp. 1108 - 1116
SUMOylation governs numerous cellular processes and is essential to most eukaryotic life. Despite increasing recognition of the importance of this process, an... 
Mdm2 | TRIM proteins | sumoylation | SUMOE3 ligase | PML | p53 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PML NUCLEAR-BODIES | DNA-DAMAGE | REGULATES P53 | FAMILY PROTEINS | SUMO E3 ligase | UBIQUITIN LIGASES | CELL BIOLOGY | RET FINGER PROTEIN | ONCOLOGY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | C-JUN | Immunoprecipitation | Transcription Factors - chemistry | Humans | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - genetics | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Animals | Small Ubiquitin-Related Modifier Proteins - chemistry | Ubiquitin-Conjugating Enzymes - metabolism | Protein Binding | Sumoylation | RNA, Small Interfering | Ubiquitin-Protein Ligases - genetics | Microscopy, Fluorescence | Promyelocytic Leukemia Protein | Physiological aspects | Tumor suppressor genes | Research | Tumor proteins | Ligases | Proteins | Enzymes | Biochemistry | Cellular biology | Gene expression | Index Medicus
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 01/2015, Volume 17, Issue 1, pp. 95 - 103
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7413, pp. 665 - 669
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the... 
IN-VITRO | INHIBITION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | UBIQUITYLATION | SMALL-INTESTINE | COLON | BETA-CATENIN | LGR5 | CANCER | NEGATIVE REGULATOR | Oncogene Proteins - genetics | Receptors, Wnt - antagonists & inhibitors | Cell Proliferation | Receptors, G-Protein-Coupled - metabolism | Humans | Ubiquitin - metabolism | Paneth Cells - pathology | Stem Cells - cytology | Receptors, Wnt - metabolism | Stem Cells - metabolism | DNA-Binding Proteins - deficiency | Adenoma - metabolism | DNA-Binding Proteins - metabolism | Endocytosis | Ubiquitination | Lysosomes - metabolism | Stem Cells - enzymology | Tumor Suppressor Proteins - deficiency | Organoids - metabolism | Tumor Suppressor Proteins - genetics | HEK293 Cells | Colorectal Neoplasms - metabolism | Paneth Cells - metabolism | Tumor Suppressor Proteins - metabolism | Organoids - pathology | Oncogene Proteins - metabolism | Organoids - cytology | Ubiquitin-Protein Ligases - metabolism | Frizzled Receptors - metabolism | DNA-Binding Proteins - genetics | beta Catenin - metabolism | Animals | Wnt Signaling Pathway - drug effects | Adenoma - pathology | Ubiquitin-Protein Ligases - deficiency | Oncogene Proteins - deficiency | Mice | Receptors, G-Protein-Coupled - genetics | Colorectal Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Colorectal cancer | Physiological aspects | Development and progression | Research | Gene expression | Risk factors | Proteins | Epidermal growth factor | Mutation | Kinases | Rodents | Stem cells | Index Medicus
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 02/2012, Volume 19, Issue 2, pp. 201 - 206
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7493, pp. 508 - 512
Tumour metastasis is the primary cause of mortality in cancer patients and remains the key challenge for cancer therapy(1). New therapeutic approaches to block... 
ACTIVATION | MOUSE NK CELLS | WARFARIN | AXL | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | TYROSINE KINASES | IDENTIFICATION | CELLULAR TARGETS | Mammary Neoplasms, Experimental - immunology | Proto-Oncogene Proteins c-cbl - metabolism | Melanoma, Experimental - drug therapy | Male | Mammary Neoplasms, Experimental - genetics | Warfarin - pharmacology | Warfarin - therapeutic use | Ubiquitination | Melanoma, Experimental - immunology | Neoplasm Metastasis - drug therapy | Neoplasm Metastasis - immunology | Neoplasm Metastasis - prevention & control | c-Mer Tyrosine Kinase | Mammary Neoplasms, Experimental - pathology | Killer Cells, Natural - immunology | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-cbl - deficiency | Mammary Neoplasms, Experimental - drug therapy | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins c-cbl - genetics | Proto-Oncogene Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Ubiquitin-Protein Ligases - metabolism | Melanoma, Experimental - pathology | Anticoagulants - therapeutic use | Receptor Protein-Tyrosine Kinases - metabolism | Animals | Melanoma, Experimental - genetics | Adaptor Proteins, Signal Transducing - deficiency | Anticoagulants - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Ubiquitin-Protein Ligases - deficiency | Killer Cells, Natural - drug effects | Mice | Mice, Inbred BALB C | Killer Cells, Natural - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Cell receptors | Killer cells | Ligases | Physiological aspects | Development and progression | Genetic aspects | Metastasis | Research | Proteins | Lungs | Rodents | Melanoma | Cytotoxicity | Ligands | Kinases | Immune system | Tumors | Cancer | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 2010, Volume 65, Issue 3, pp. 341 - 357
Regulated protein degradation via the ubiquitin-proteasome system (UPS) plays a central role in building synaptic connections, yet little is known about either... 
DEVBIO | MOLNEURO | SIGNALING | RETINAL GROWTH CONES | UBIQUITIN LIGASE | IN-VIVO | RETINOTECTAL SYNAPTIC CONNECTIVITY | XENOPUS EMBRYOS | TUMOR-SUPPRESSOR | VISUAL-SYSTEM | PROTEIN-SYNTHESIS | NEUROSCIENCES | ZEBRAFISH RETINA | CHEMOTROPIC RESPONSES | Xenopus | Humans | Gene Expression Regulation, Developmental - genetics | Axons - physiology | Green Fluorescent Proteins - genetics | Phosphatidylinositol 3-Kinases - metabolism | Retinal Ganglion Cells - cytology | Retina - cytology | Arginine - genetics | Nedd4 Ubiquitin Protein Ligases | Transduction, Genetic - methods | Gene Expression Regulation, Developmental - physiology | Growth Cones - physiology | PTEN Phosphohydrolase - genetics | Retinal Ganglion Cells - physiology | Immunoprecipitation - methods | Tissue Culture Techniques | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | PTEN Phosphohydrolase - metabolism | Signal Transduction - genetics | Ubiquitin - genetics | Xenopus Proteins | Electroporation - methods | Mutation - genetics | Microscopy, Confocal - methods | Down-Regulation - genetics | Down-Regulation - physiology | Lysine - genetics | Animals | Embryo, Nonmammalian | Superior Colliculi - cytology | Signal Transduction - physiology | Ubiquitin-Protein Ligases - genetics | Cell Line, Transformed | Ubiquitin | Physiological aspects | Neurosciences | Proteolysis | Neurons | Ligases | Proteins | Enzymes | Insects | Kinases | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2005, Volume 102, Issue 21, pp. 7760 - 7765
Journal Article