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by Chu, Y and Yang, X
Oncogene, ISSN 0950-9232, 03/2011, Volume 30, Issue 9, pp. 1108 - 1116
SUMOylation governs numerous cellular processes and is essential to most eukaryotic life. Despite increasing recognition of the importance of this process, an... 
Mdm2 | TRIM proteins | sumoylation | SUMOE3 ligase | PML | p53 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PML NUCLEAR-BODIES | DNA-DAMAGE | REGULATES P53 | FAMILY PROTEINS | SUMO E3 ligase | UBIQUITIN LIGASES | CELL BIOLOGY | RET FINGER PROTEIN | ONCOLOGY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | C-JUN | Immunoprecipitation | Transcription Factors - chemistry | Humans | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - genetics | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Animals | Small Ubiquitin-Related Modifier Proteins - chemistry | Ubiquitin-Conjugating Enzymes - metabolism | Protein Binding | Sumoylation | RNA, Small Interfering | Ubiquitin-Protein Ligases - genetics | Microscopy, Fluorescence | Promyelocytic Leukemia Protein | Physiological aspects | Tumor suppressor genes | Research | Tumor proteins | Ligases | Proteins | Enzymes | Biochemistry | Cellular biology | Gene expression
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 07/2016, Volume 23, Issue 7, pp. 647 - 655
The opposing activities of 53BP1 and BRCA1 influence pathway choice in DNA double-strand-break repair. How BRCA1 counteracts the inhibitory effect of 53BP1 on... 
STRAND BREAK REPAIR | RING-RING COMPLEX | TUMOR SUPPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPAIR PATHWAY CHOICE | BRCA1 | REMODELING ENZYME | CELL BIOLOGY | E3 LIGASE | BIOPHYSICS | END RESECTION | HOMOLOGOUS RECOMBINATION | FUN30 | Chromatin - metabolism | DNA, Neoplasm - metabolism | Humans | Gene Expression Regulation, Neoplastic | Ubiquitin - metabolism | DNA Breaks, Double-Stranded | Ubiquitination - drug effects | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - genetics | Cloning, Molecular | Escherichia coli - metabolism | Binding Sites | Chromatin - drug effects | DNA Helicases - genetics | Chromatin - chemistry | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinant Proteins - metabolism | Gene Expression | Recombinational DNA Repair | Tumor Suppressor Proteins - metabolism | Tumor Suppressor p53-Binding Protein 1 - genetics | Signal Transduction | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Proteins - genetics | Ubiquitin - genetics | Piperazines - pharmacology | DNA Cleavage - drug effects | BRCA1 Protein - genetics | DNA Helicases - metabolism | Phthalazines - pharmacology | Histones - genetics | Escherichia coli - genetics | Protein Binding | DNA, Neoplasm - genetics | HeLa Cells | Histones - metabolism | Ubiquitin-Protein Ligases - genetics | Camptothecin - pharmacology | Breast cancer | BRCA mutations | DNA repair | Analysis | Risk factors | Enzymes | Protein expression | Chromatin | DNA damage
Journal Article
Journal Article
Science, ISSN 0036-8075, 10/2011, Volume 334, Issue 6055, pp. 525 - 528
Germline mutations of the breast cancer 1 (BRCA1) gene are a major cause of familial breast and ovarian cancer. The BRCA1 protein displays E3 ubiquitin ligase... 
Research fellowships | Proteins | Kaplan Meier estimator | Phosphoproteins | DNA damage | REPORTS | Breast cancer | Mice | Genetic mutation | Tumors | Cancer | BREAST-CANCER | BACH1 PHOSPHOPEPTIDE | COMPLEX | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | MUTATION | PHOSPHOPEPTIDE RECOGNITION | BRCA1/BARD1 HETERODIMER | MICE | IDENTIFICATION | TUMORIGENESIS | Embryonic Stem Cells - metabolism | Basic-Leucine Zipper Transcription Factors - metabolism | Pancreatic Neoplasms - metabolism | Protein Multimerization | Mammary Neoplasms, Experimental - metabolism | Phosphoproteins - metabolism | RING Finger Domains | Mammary Neoplasms, Experimental - genetics | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - chemistry | Protein Interaction Domains and Motifs | Genes, BRCA1 | BRCA1 Protein - chemistry | Disease Models, Animal | Tumor Suppressor Proteins - metabolism | Cells, Cultured | Mutant Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Mutant Proteins - metabolism | Pancreatic Neoplasms - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Ubiquitin-Protein Ligases - chemistry | Animals | Mutant Proteins - chemistry | Protein Binding | Ligands | Ligases | Physiological aspects | Tumor suppressor genes | Genetic aspects | Research | Health aspects | Protein binding | Biochemistry | Mutation | Binding sites
Journal Article
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