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06/2014
The HECT E3 ubiquitin ligase Nedd4-1 was previously shown to regulate diverse processes such as cell and animal growth, insulin signaling, and lysosomal... 
0379 | Ubiquitin ligase | Angiomotin | biochemistry | Nedd4
Dissertation
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 514, Issue 1, pp. 344 - 350
The bestrophin family comprises well-known Ca -activated chloride channels (CaCC) that are expressed in a variety tissues including the brain, eye,... 
Chloride channel | NEDD4L | E3 ubiquitin ligase | BEST1
Journal Article
03/2011
Drosophila Nedd4 (DNedd4), an E3 ubiquitin ligase, is known to be involved in neuromuscular (NM) synaptogenesis during embryogenesis. To further elucidate its... 
0487 | neuromuscular synaptogenesis | Nedd4 | E3 ubiquitin ligase
Dissertation
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 104 - 109
The effective use of targeted therapy is highly dependent on the identification of responder patient populations. Loss of FBW7, which encodes a... 
COMPLEX | PROTEIN | CANCERS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | DEGRADATION | DIFFERENTIATION | FBW7 UBIQUITIN LIGASE
Journal Article
Genes and Cancer, ISSN 1947-6019, 2010, Volume 1, Issue 7, pp. 764 - 778
The endoplasmic reticulum (ER) is an essential organelle involved in many cellular functions including protein folding and secretion, lipid biosynthesis and... 
Senescence | gp78 | Metastasis | Ubiquitin ligase | ubiquitin ligase | senescence | metastasis | Monographs
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 05/2014, Volume 15, Issue 5, pp. 457 - 457
SGK1 is an AGC kinase that regulates the expression of membrane sodium channels in renal tubular cells in a manner dependent on the metabolic checkpoint kinase... 
CHANNEL | UBIQUITIN LIGASE | PHOSPHORYLATION | INFLAMMATION | ASTHMA | RICTOR | MICE | IMMUNOLOGY | SELECTIVE ACTIVATION | EXPRESSION | T-CELLS
Journal Article
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, ISSN 1943-0264, 10/2009, Volume 1, Issue 4, pp. 5 - 18
Nuclear factor-kappa B (NF-kappa B) consists of a family of transcription factors that play critical roles in inflammation, immunity, cell proliferation,... 
KINASE-ALPHA | DNA-BINDING | BETA-TRCP | UBIQUITIN LIGASE | CRYSTAL-STRUCTURE | INDUCIBLE NUCLEAR-PROTEIN | GENE-EXPRESSION | IKK-ALPHA | SIGNALING MODULE | DEPENDENT DEGRADATION | CELL BIOLOGY | 040
Journal Article
Journal of Biochemistry, ISSN 0021-924X, 02/2017, Volume 161, Issue 2, pp. 135 - 144
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 462 - 481
The bromodomain and extra-terminal (BET) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT members, are epigenetic "readers" and play a... 
CHEMISTRY, MEDICINAL | REACTIVATION | INFLAMMATION | STRATEGY | I-BET762 | DEGRADATION | PROTACS | INHIBITOR OTX015 | CANCER | E3 UBIQUITIN LIGASE | BRD4 | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2009, Volume 36, Issue 6, pp. 1095 - 1102
In E1-E2-E3 ubiquitin (Ub) conjugation cascades, the E2 first forms a transient E2∼Ub covalent complex and then interacts with an E3 for Ub transfer. For... 
PROTEINS | Ubiquitin | UbcH5B | NEDD4-2 | NEDD4L | Ubiquitin ligase | HECT
Journal Article
06/2010
The p53 tumour suppressor gene is inactivated by mutation in over 50% of all human cancers. The p53 protein is activated and stabilized through several... 
0992 | ubiquitination | E3 ubiquitin ligase | Pirh2 | 0307 | p53
Dissertation
NATURE, ISSN 0028-0836, 08/2007, Volume 448, Issue 7154, pp. 661 - U2
Jasmonate and related signalling compounds have a crucial role in both host immunity and development in plants, but the molecular details of the signalling... 
DEFENSE RESPONSES | ACID | METHYL JASMONATE | OXYLIPIN SIGNAL | MULTIDISCIPLINARY SCIENCES | PLANT DEFENSE | MALE-STERILE | GENE-EXPRESSION | UBIQUITIN-LIGASE | ARABIDOPSIS | REGULATED DEFENSE
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 453 - 461
Proteolysis targeting chimeras (PROTACs) are bispecific molecules containing a target protein binder and an ubiquitin ligase binder connected by a linker. By... 
DESIGN | CHEMISTRY, MEDICINAL | INHIBITION | MECHANISM | ALPHA | PROTACS | THALIDOMIDE | CEREBLON | E3 UBIQUITIN LIGASE | BRD4 | Index Medicus
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 12/2007, Volume 8, Issue 12, pp. 970 - 982
Ligands of the transforming growth factor-beta (TGF beta) superfamily of growth factors initiate signal transduction through a bewildering complexity of... 
CYCLIN-DEPENDENT KINASES | NUCLEAR IMPORT | TRANSCRIPTION FACTORS | GROWTH-FACTOR-BETA | INTERACTION MOTIF | UBIQUITIN LIGASE | ACTIVIN RECEPTORS | MORPHOGEN GRADIENT INTERPRETATION | DROSOPHILA EMBRYO | SPEMANN ORGANIZER | CELL BIOLOGY
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 02/2019, Volume 56, Issue 2, pp. 1293 - 1309
The G protein-coupled GABA receptors, constituted from GABA and GABA subunits, are important regulators of neuronal excitability by mediating long-lasting... 
GABA receptor | Protein degradation | Ubiquitination | E3 ubiquitin ligase | CaMKII | Lysosome
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 2, pp. 448 - 466
Human murine double minute 2 (MDM2) protein is a primary endogenous cellular inhibitor of the tumor suppressor p53 and has been pursued as an attractive cancer... 
CHEMISTRY, MEDICINAL | PROTEIN-DEGRADATION | MDM2 INHIBITOR | CLINICAL-TRIALS | CANCER | E3 UBIQUITIN LIGASE | P53
Journal Article
11/2012
Skeletal muscle (SM) atrophy complicates many illnesses, diminishing quality of life and increasing disease morbidity, health resource utilization and health... 
0379 | Ubiquitin ligase | skeletal muscle atrophy | Nedd4 | 0719 | 0307 | skeletal muscle
Dissertation
Nature Immunology, ISSN 1529-2908, 03/2008, Volume 9, Issue 3, pp. 263 - 271
The paracaspase MALT1 mediates T cell antigen receptor-induced signaling to the transcription factor NF-kappa B and is indispensable for T cell activation and... 
ACTIVATION | CYTOKINE PRODUCTION | SIGNALING PATHWAY | UBIQUITIN LIGASE | CARMA1 | LIPID RAFTS | LYMPHOMA | BCL10 | IMMUNOLOGY | DEPENDENT GENE-EXPRESSION | CHROMOSOMAL TRANSLOCATION
Journal Article
by Zheng, QL and Hou, J and Zhou, Y and Li, ZY and Cao, XT
NATURE IMMUNOLOGY, ISSN 1529-2908, 10/2017, Volume 18, Issue 10, pp. 1094 - 1094
DEAD-box (DDX) helicases are vital for the recognition of RNA and metabolism and are critical for the initiation of antiviral innate immunity. Modification of... 
NONCODING RNA | PROTEIN INTERACTIONS | STEM-CELLS | MESSENGER-RNA | DENDRITIC CELLS | NUCLEOTIDE RESOLUTION | UBIQUITIN LIGASE | RETENTION | GENE-EXPRESSION | RIG-I | IMMUNOLOGY
Journal Article
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