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Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 6/2011, Volume 67, Issue 6, pp. 1225 - 1237
Journal Article
Oncotarget, ISSN 1949-2553, 05/2018, Volume 9, Issue 39, pp. 25458 - 25473
Acute myeloid leukemia (AML) is characterized by uncontrolled proliferation and accumulation of immature myeloblasts, which impair normal hematopoiesis. While... 
AML | Personalized medicine | Mitosis | UCN-01 | STK3
Journal Article
RSC Advances, ISSN 2046-2069, 2018, Volume 8, Issue 65, pp. 37492 - 37502
Herein, graphene oxide (GO) has been attached with core -shell upconversion-silica (UCN-SiO2) nanoparticles (NPs) to form a GO-UCN-SiO2 hybrid nanocomposite... 
GRAPHENE OXIDE | PHOTODYNAMIC THERAPY | DRUG-DELIVERY | PHOTOSENSITIZER | ER3 | UP-CONVERSION NANOPARTICLES | IONS | SUSTAINED DELIVERY | NANOCAPSULES | CHEMISTRY, MULTIDISCIPLINARY | UCN-01
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 05/2007, Volume 6, Issue 5, pp. 1501 - 1508
NK314 is a novel synthetic benzo[ c ]phenanthridine alkaloid that has recently entered clinical trials as an antitumor compound, based on impressive activities... 
Etoposide | Checkpoint | Leukemia | UCN-01 | Topoisomerase II
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 03/2015, Volume 33, Issue 9, pp. 1060 - 1066
Journal Article
CELL CYCLE, ISSN 1538-4101, 06/2008, Volume 7, Issue 11, pp. 1668 - 1677
Checkpoint kinases Chk1 and Chk2 are two key components in the DNA damage-activated checkpoint signaling pathways. To distinguish the roles of Chk1 and Chk2 in... 
PHOSPHORYLATION | DNA damage | 7-HYDROXYSTAUROSPORINE UCN-01 | PROTEIN-KINASE | Chk1 | PREMATURE MITOSIS | Chk2 | UCN-01 | P53 | CELL BIOLOGY | CDS1 CHK2 | CELL-CYCLE CHECKPOINT | MAPKAPK2 | cell cycle checkpoints | TUMOR-SUPPRESSOR | RADIOSENSITIZING AGENT | Cdc25A | ATR
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 33, pp. 34846 - 34858
Enhanced rRNA synthesis is a downstream effect of many of the signaling pathways that are aberrantly activated in cancer, such as the PI3K/mTOR and MAP kinase... 
RRNA synthesis | MAP kinase | Acute lymphoblastic leukemia | CX-5461 | UCN-01 | CANCER THERAPEUTICS | APOPTOSIS | 7-HYDROXYSTAUROSPORINE UCN-01 | HUMAN NUCLEOLUS | DNA-DAMAGE | TRANSCRIPTION | CHRONIC MYELOID-LEUKEMIA | P53 | CELL BIOLOGY | acute lymphoblastic leukemia | rRNA synthesis | PROTEOMIC ANALYSIS | POLYMERASE-I | Index Medicus
Journal Article
Tetrahedron, ISSN 0040-4020, 2006, Volume 62, Issue 33, pp. 7838 - 7845
The syntheses of new nitrile and amide analogues of 7-keto Gö6976 are described. The amide analogue was formed via the condensation with a new functionalized... 
Checkpoint inhibitors | Indolocarbazoles | Gö6976 | Bisindolylmaleimide | UCN-01 | PROTEIN-KINASE-C | 7-HYDROXYSTAUROSPORINE UCN-01 | CHEMISTRY, ORGANIC | bisindolylmaleimide | CELL-CYCLE CHECKPOINTS | ARREST | Go6976 | SELECTIVE INHIBITORS | ANHYDRIDES | INDUCED S | ISOGRANULATIMIDE | indolocarbazoles | CYTOTOXICITY | checkpoint inhibitors | REBECCAMYCIN | Heterocyclic compounds | Condensation
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 01/2003, Volume 63, Issue 1, pp. 31 - 35
In response to DNA damage, cells arrest progression through the cell cycle at either G(1), S, or G(2). We have reported that UCN-01 (7-hydroxy-staurosporine)... 
PATHWAYS | APOPTOSIS | ACTIVATION | ONCOLOGY | PHOSPHORYLATION | 7-HYDROXYSTAUROSPORINE UCN-01 | ABROGATION | ENHANCEMENT | CAFFEINE | RADIOSENSITIZING AGENT | CYTOTOXICITY
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2008, Volume 7, Issue 9, pp. 2955 - 2966
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2012, Volume 11, Issue 9, pp. 1818 - 1826
DNA damage induces cell cycle arrest through both Chk1 and the p53 tumor suppressor protein, the latter arresting cells through induction of p21 waf1 protein.... 
MK-8776 | waf1 | p53 response | cell cycle checkpoints | Chk1 | p21 | UCN-01
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1541 - 1552
Patients with triple-negative breast cancer (TNBC) - defined by lack of estrogen receptor and progesterone receptor expression as well as lack of human... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | P53 MUTATION | CHECKPOINT KINASE-1 | PATHWAY | PROTEIN-KINASE | 7-HYDROXYSTAUROSPORINE UCN-01 | DNA-DAMAGE | S-PHASE | PREDICTIVE-VALUE | CDC25A PHOSPHATASE | Thiophenes - therapeutic use | Apoptosis - drug effects | Humans | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Receptors, Progesterone - genetics | Receptors, Progesterone - analysis | Breast Neoplasms - chemistry | Camptothecin - administration & dosage | Antineoplastic Agents, Phytogenic - therapeutic use | Camptothecin - analogs & derivatives | Thiophenes - pharmacology | Tumor Suppressor Protein p53 - deficiency | Breast Neoplasms - drug therapy | DNA, Neoplasm - drug effects | Protein Kinase Inhibitors - administration & dosage | Urea - therapeutic use | Mice, Inbred NOD | Mice | DNA Damage | Cell Cycle - drug effects | Genes, cdc | Staurosporine - pharmacology | Urea - pharmacology | Staurosporine - administration & dosage | Neoplasm Proteins - physiology | Staurosporine - analogs & derivatives | Cell Line, Tumor - transplantation | Receptors, Estrogen - analysis | Thiophenes - administration & dosage | Molecular Targeted Therapy | Genes, p53 | Urea - analogs & derivatives | Female | Antineoplastic Agents - pharmacology | Cell Line, Tumor - metabolism | Urea - administration & dosage | Protein Kinases - drug effects | Receptors, Estrogen - genetics | Camptothecin - therapeutic use | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Genes, erbB-2 | Protein Kinase Inhibitors - therapeutic use | Staurosporine - therapeutic use | Protein Kinases - physiology | Checkpoint Kinase 1 | Neoplasm Proteins - analysis | Protein Kinase Inhibitors - pharmacology | Breast cancer | Genetic aspects | Research | Gene mutations | Health aspects | DNA damage | Index Medicus | Abridged Index Medicus | Estrogen | Càncer de mama | Ratolins (Animals de laboratori) | Apoptosi | Receptors d'hormones | Hormone receptors | Chemotherapy | Mice (Laboratory animals) | Progesterone | Quimioteràpia | Progesterona | Estrògens | Apoptosis
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 05/2011, Volume 17, Issue 10, pp. 3431 - 3442
Purpose: Two phase I dose-escalation studies were conducted to determine the maximum tolerated dose (MTD) and safety profile of the G(2) checkpoint abrogator... 
CHK1 | ONCOLOGY | PLATINUM RESISTANCE | KINASE | RAT MAST-CELLS | HISTAMINE-RELEASE | 14-3-3 PROTEIN-BINDING | DNA-REPAIR PATHWAYS | RADIOSENSITIZING AGENT | CANCER | UCN-01
Journal Article
Cancer Cell, ISSN 1535-6108, 2007, Volume 11, Issue 2, pp. 175 - 189
In response to DNA damage, eukaryotic cells activate ATM-Chk2 and/or ATR-Chk1 to arrest the cell cycle and initiate DNA repair. We show that, in the absence of... 
SIGNALING | CANCER-CELLS | ONCOLOGY | 7-HYDROXYSTAUROSPORINE UCN-01 | MITOTIC CATASTROPHE | SECKEL-SYNDROME | MAPKAP KINASE-2 | NUCLEAR EXPORT | INDUCED CYTOTOXICITY | 14-3-3 PROTEIN-BINDING | RADIOSENSITIZING AGENT | PHOSPHORYLATION SITES | Protein Kinases - genetics | Antibiotics, Antineoplastic - pharmacology | Humans | DNA Repair - radiation effects | Staurosporine - analogs & derivatives | Bone Neoplasms - pathology | G2 Phase - drug effects | Bone Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Neoplasms, Experimental - pathology | Tumor Suppressor Protein p53 - physiology | Ultraviolet Rays | Antineoplastic Agents - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | cdc25 Phosphatases - metabolism | Osteosarcoma - metabolism | Protein-Serine-Threonine Kinases - metabolism | DNA Damage - drug effects | DNA Repair - drug effects | Tumor Suppressor Proteins - metabolism | Mitosis - radiation effects | G2 Phase - radiation effects | Signal Transduction | Cell Survival | Cell Cycle Proteins - metabolism | Cells, Cultured | Cell Division - radiation effects | Intracellular Signaling Peptides and Proteins | Protein Kinase C - antagonists & inhibitors | Ataxia Telangiectasia Mutated Proteins | Cisplatin - pharmacology | Cell Division - drug effects | Mice, Knockout | Phosphorylation - radiation effects | S Phase - radiation effects | Animals | Mitosis - drug effects | Mice, Nude | Protein Kinases - physiology | Mice | S Phase - drug effects | Neoplasms, Experimental - metabolism | DNA Damage - radiation effects | Doxorubicin - pharmacology | Osteosarcoma - pathology | Staurosporine - pharmacology | DNA | Index Medicus
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2012, Volume 18, Issue 24, pp. 6723 - 6731
Journal Article