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03/2010
The whole body UCP2 knockout (UCP2−/−) have enhanced insulin secretion and higher ATP content. However, these changes could be due to indirect effects of... 
UCP2 | 0719 | diabetes
Dissertation
Nuclear Medicine and Biology, ISSN 0969-8051, 10/2016, Volume 43, Issue 10, pp. 587 - 592
Compounds that modulate cancer cell glucose metabolism could open new opportunities for antitumor therapy and for monitoring response using F-FDG PET. Genipin,... 
Uncoupling | MMP | UCP2 | ROS | Genipin
Journal Article
Genetics and molecular biology, ISSN 1415-4757, 09/2019
Uncoupling protein 2 (UCP2) decreases reactive oxygen species (ROS) formation by mitochondria. ROS overproduction is a key contributor to the pathogenesis of... 
diabetic kidney disease | polymorphisms | UCP2
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2019, Volume 593, Issue 18, pp. 2525 - 2534
Mitochondria are the primary sites for ATP synthesis and free radical generation in organisms. Abnormal mitochondrial metabolism contributes to many diseases,... 
cancer | polymorphism | diabetes | mitochondria | obesity | UCP2 | Index Medicus
Journal Article
Molecular Metabolism, ISSN 2212-8778, 07/2017, Volume 6, Issue 7, pp. 760 - 769
Upregulation of uncoupling protein 2 (UCP2) is associated with impaired glucose-stimulated insulin secretion (GSIS), which is thought to be an important... 
Glucose tolerance | Glucose-stimulated insulin secretion | Pancreatic islets | Uncoupling protein 2 | β cells | OBESE SUBJECTS | ACID | RAT ISLETS | OVEREXPRESSION | GLUCOSE-HOMEOSTASIS | UCP2 | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | DYSFUNCTION | EXPRESSION | CLOCK | beta cells
Journal Article
Journal Article
한국식품영양학회지, ISSN 1225-4339, 2017, Volume 30, Issue 3, pp. 531 - 538
This study was performed to investigate the effects of garlic on uncoupling protein 2 (UCP2) transcriptional regulation of UCP2- luciferase transgenic mice fed... 
UCP2 transgenic mouse | garlic | transcriptional regulation | obesity | UCP2 | 식품과학
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2010, Volume 12, Issue 5, pp. 545 - 552
Blood glucose levels are tightly controlled, a process thought to be orchestrated primarily by peripheral mechanisms (insulin secretion by β cells, and insulin... 
KATP channel | glucose sensing | MCH neurons | UCP2
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2019, Volume 854, pp. 328 - 337
Cancer metabolism is an attractive target of the therapeutic strategy for cancer. The present study identified bouchardatine ( ) as a potent suppressor of... 
Energy metabolism | PGC-1α | Bouchardatine | SIRT1 | UCP2 | REGULATOR | PGC-1 alpha | LACTATE | PHARMACOLOGY & PHARMACY | UNCOUPLING PROTEIN-2
Journal Article
BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 10/2018, Volume 119, Issue 8, pp. 994 - 1008
BACKGROUND: The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer... 
ACTIVATION | INHIBITION | ONCOLOGY | UCP2 | PGC-1 | CHRONIC LYMPHOCYTIC-LEUKEMIA | CHEMORESISTANCE | PROTEINS | RECEPTOR-GAMMA COACTIVATOR-1-ALPHA | EXPRESSION | GAIN
Journal Article
GENE, ISSN 0378-1119, 02/2013, Volume 514, Issue 1, pp. 41 - 47
-866G/A polymorphism in the promoter of UCP2 gene has been reported to be associated with obesity, but the results remain inconclusive. To assess the relation... 
866G/A | Obesity | VARIANTS | UCP2 GENE | UCP2 | GENETICS & HEREDITY | UNCOUPLING PROTEIN-2 GENE | BODY-MASS INDEX | RISK | Meta-analysis | Polymorphism
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association, ISSN 1079-5642, 05/2004, Volume 24, Issue 5, pp. 864 - 870
OBJECTIVE—Uncoupling protein 2 (UCP2) belongs to the mitochondrial anion carrier family and regulates production of reactive oxygen species in macrophages.... 
Monocytes | Adhesion | Atherosclerosis | UCP2 | Integrins
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 5/2015, Volume 35, Issue 5, pp. 1166 - 1178
Journal Article
PLoS Genetics, ISSN 1553-7390, 2014, Volume 10, Issue 6, p. e1004385
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2014, Volume 111, Issue 3, pp. 960 - 965
Journal Article
by Jiang, L and Qiu, WJ and Zhou, Y and Wen, P and Fang, L and Cao, HD and Zen, K and He, WC and Zhang, CY and Dai, CS and Yang, JW
KIDNEY INTERNATIONAL, ISSN 0085-2538, 08/2013, Volume 84, Issue 2, pp. 285 - 296
Mitochondria dysfunction has been reported in various kidney diseases but how it leads to kidney fibrosis and how this is regulated is unknown. Here we found... 
tubular epithelial cell | mitochondria | INSULIN-SECRETION | renal fibrosis | MESENCHYMAL TRANSITION | OBESITY | GENE | UCP2 | DISEASE | UROLOGY & NEPHROLOGY | microRNA | MICE | DYSFUNCTION | EXPRESSION
Journal Article