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udca (178) 178
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1. Full Text Ursodeoxycholic acid in pregnancy?
by de Vries, Elsemieke and Beuers, Ulrich
Journal of hepatology, ISSN 0168-8278, 12/2019, Volume 71, Issue 6, pp. 1237 - 1245
PBC | PSC | Lactation | Stillbirth | Primary biliary cholangitis | Primary sclerosing cholangitis | UDCA | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Pregnancy | Breastfeeding & lactation | Cholangitis | Bile | Ursodeoxycholic acid | Index Medicus
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2. Full Text Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human β‐defensin‐1 and ‐2 secretion by colonic epithelial cells
by Lajczak, Natalia K and Saint‐Criq, Vinciane and O’Dwyer, Aoife M and Perino, Alessia and Adorini, Luciano and Schoonjans, Kristina and Keely, Stephen J
The FASEB journal, ISSN 0892-6638, 09/2017, Volume 31, Issue 9, pp. 3848 - 3857
UDCA | epithelium | HβD | innate immunity | Innate immunity | HbD | Epithelium | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Colon - cytology | Cell Line | Ursodeoxycholic Acid - administration & dosage | beta-Defensins - genetics | Receptors, G-Protein-Coupled - metabolism | Tissue Culture Techniques | Humans | RNA, Messenger - genetics | NF-kappa B - metabolism | Epithelial Cells | beta-Defensins - secretion | RNA, Messenger - metabolism | Mice, Knockout | Dose-Response Relationship, Drug | Intestinal Mucosa - cytology | Ursodeoxycholic Acid - pharmacology | Animals | Deoxycholic Acid - pharmacology | NF-kappa B - genetics | Deoxycholic Acid - administration & dosage | Mice | Receptors, G-Protein-Coupled - genetics | beta-Defensins - metabolism | NF-κB protein | Phosphorylation | G protein-coupled receptors | Bile acids | Epithelial cells | Secretion | Mucosa | Ursodeoxycholic acid | Deoxycholic acid | Acids | Defensins | Intestine | Animal tissues | Colon | Inhibition | Bile | Index Medicus | Life Sciences
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3. Full Text Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity
by Mueller, Michaela and Thorell, Anders and Claudel, Thierry and Jha, Pooja and Koefeler, Harald and Lackner, Carolin and Hoesel, Bastian and Fauler, Guenter and Stojakovic, Tatjana and Einarsson, Curt and Marschall, Hanns-Ulrich and Trauner, Michael and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
Journal of hepatology, ISSN 0168-8278, 2015, Volume 62, Issue 6, pp. 1398 - 1404
Gastroenterology and Hepatology | 3-hydroxy-3-methylglutaryl-CoA reductase | Stearoyl-CoA desaturase | Non-alcoholic fatty liver disease | Lipogenesis | FGF19 | 3-hydroxy-3-methylglutaryl- CoA reductase | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Ursodeoxycholic Acid - administration & dosage | Oleic Acid - metabolism | Bile Acids and Salts - biosynthesis | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Intra-Abdominal Fat - metabolism | Obesity, Morbid - drug therapy | Non-alcoholic Fatty Liver Disease - drug therapy | Ursodeoxycholic Acid - pharmacology | Stearoyl-CoA Desaturase - biosynthesis | Liver - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Lipid Metabolism - drug effects | Intra-Abdominal Fat - drug effects | Obesity, Morbid - metabolism | Physiological aspects | Obesity | Ursodiol | Deoxycholic acid | Index Medicus | BAs, bile acids | nCEH, neutral cholesterol ester hydrolase | ApoB, apolipoprotein B | LDLR, low density lipoprotein receptor | FGF19, fibroblast growth factor 19 | VLDL, very low density lipoproteins | ABC, ATP-binding cassette | TGs, triglycerides | NAFLD, non-alcoholic fatty liver disease | OA, oleic acid | C4, 7α-hydroxy-4-cholesten-3-one | SHP, small heterodimer partner | SREBP1c, sterol regulatory element-binding protein-1c | CA, cholic acid | PA, palmitic acid | FATP1, fatty acid transport protein 1 | UDCA, ursodeoxycholic acid | FAs, fatty acides | HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase | vWAT, visceral white adipose tissue | SCD, stearoyl-Coa desaturase | CYP7A1, cholesterol 7α-hydroxylase | NASH, non-alcoholic steatohepatitis | FXR, farnesoid X receptor | CDCA, chenodeoxycholic acid | MA, myristic acid | FASN, fatty acid synthase | MTTP, microsomal triglyceride transfer protein | SA, stearic acid | NONALCOHOLIC | FATTY LIVER-DISEASE | NUCLEAR RECEPTOR | CHOLESTEROL-METABOLISM | TRANSPORT | Endokrinologi och diabetes | FEEDBACK-REGULATION | STEATOHEPATITIS | PLACEBO-CONTROLLED TRIAL | COA DESATURASE | EXPRESSION | Endocrinology and Diabetes | ADIPOSE-TISSUE | Medicin och hälsovetenskap
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4. Full Text Ursodeoxycholic acid protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis in MPTP/MPP+-induced Parkinson’s disease
by Qi, Huiping and Shen, Dongfang and Jiang, Chenggong and Wang, Huan and Chang, Mingxiu
Neuroscience letters, ISSN 0304-3940, 01/2021, Volume 741, pp. 135493 - 135493
UDCA | Mitochondrial dysfunction | MPTP/MPP | Autophagy | Parkinson’s disease | Apoptosis | Index Medicus
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5. Full Text Ursodeoxycholic acid alleviates experimental liver fibrosis involving inhibition of autophagy
by Ye, Hui-Lan and Zhang, Ji-Wang and Chen, Xing-Zhou and Wu, Peng-Bo and Chen, Li and Zhang, Guo
Life sciences (1973), ISSN 0024-3205, 02/2020, Volume 242, pp. 117175 - 117175
Hepatic stellate cells (HSC) | Ursodeoxycholic acid (UDCA) | Liver fibrosis | Autophagy | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cell Line | Liver Cirrhosis - drug therapy | Humans | Hydroxyproline - metabolism | Rats | Male | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Autophagy - drug effects | Blotting, Western | Ursodeoxycholic Acid - therapeutic use | Animals | Hydroxychloroquine - pharmacology | Transforming Growth Factor beta1 - pharmacology | Disease Models, Animal | Cell proliferation | Animal models | Liver | Carbon tetrachloride | Hydroxyproline | Collagens | Phagosomes | Fluorescence | Cell viability | Western blotting | Ursodeoxycholic acid | Transfection | Inhibition | Cellular manufacture | Cholangitis | Rapamycin | Gene expression | Signaling | Hydroxychloroquine | Collagen | Fibrosis | In vivo methods and tests | Aggradation | Phagocytosis | Bile | Index Medicus
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6. Full Text Ursodeoxycholic acid therapy and liver transplant-free survival in patients with primary biliary cholangitis
by Harms, Maren H and van Buuren, Henk R and Corpechot, Christophe and Thorburn, Douglas and Janssen, Harry L.A and Lindor, Keith D and Hirschfield, Gideon M and Parés, Albert and Floreani, Annarosa and Mayo, Marlyn J and Invernizzi, Pietro and Battezzati, Pier Maria and Nevens, Frederik and Ponsioen, Cyriel Y and Mason, Andrew L and Kowdley, Kris V and Lammers, Willem J and Hansen, Bettina E and van der Meer, Adriaan J
Journal of hepatology, ISSN 0168-8278, 08/2019, Volume 71, Issue 2, pp. 357 - 365
Clinical trials | Treatment | Patient management | UDCA, transplantation | Mortality | Cholestasis | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Statistical analysis | Syngeneic grafts | Liver | Cholangitis | Survival | Patients | Ursodeoxycholic acid | Allografts | Acids | Death | Bile | Liver transplantation | Index Medicus
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7. Full Text 24- nor -ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis
by Sombetzki, Martina and Fuchs, Claudia D and Fickert, Peter and Österreicher, Christoph H and Mueller, Michaela and Claudel, Thierry and Loebermann, Micha and Engelmann, Robby and Langner, Cord and Sahin, Emine and Schwinge, Dorothee and Guenther, Nina D and Schramm, Christoph and Mueller-Hilke, Brigitte and Reisinger, Emil C and Trauner, Michael
Journal of hepatology, ISSN 0168-8278, 2014, Volume 62, Issue 4, pp. 871 - 878
Gastroenterology and Hepatology | Schistosoma mansoni infection | Bile acids | Liver fibrosis | Anti-inflammatory/anti-fibrotic therapy | Hepatic granulomas | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Immunohistochemistry | Inflammation - pathology | Liver Cirrhosis - immunology | Cholagogues and Choleretics - pharmacology | Ursodeoxycholic Acid - analogs & derivatives | Schistosomiasis mansoni - immunology | Inflammation - drug therapy | T-Lymphocytes - drug effects | Disease Models, Animal | Schistosomiasis mansoni - physiopathology | Liver Cirrhosis - drug therapy | Liver Cirrhosis - etiology | Cholagogues and Choleretics - metabolism | Schistosomiasis mansoni - complications | Treatment Outcome | Inflammation - immunology | Granuloma - pathology | Ursodeoxycholic Acid - pharmacology | Animals | Lymphocyte Activation - drug effects | Liver Cirrhosis - pathology | Granuloma - drug therapy | Granuloma - immunology | T-Lymphocytes - immunology | Mice | Liver Cirrhosis - physiopathology | Schistosomiasis mansoni - pathology | Ursodeoxycholic Acid - metabolism | Drug Monitoring | Ursodiol | Liver diseases | Index Medicus | ALT, alanine aminotransferase | HP, hydroxyproline | Mdr2, canalicular phospholipid export pump | BMDC, bone marrow derived dendritic cells | BMDM, bone marrow derived macrophages | M-CSF, macrophage colony-stimulating factor | multidrug resistance protein 2 | norUDCA, 24-nor-ursodeoxycholic acid | anti-fibrotic therapy | Abcb4 | B. glabrata, Biomphalaria glabrata | UDCA, ursodeoxycholic acid | S. mansoni, Schistosoma mansoni | Anti-inflammatory | AP, alkaline phosphatase
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8. Full Text miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
by Castro, Rui E and Ferreira, Duarte M.S and Afonso, Marta B and Borralho, Pedro M and Machado, Mariana V and Cortez-Pinto, Helena and Rodrigues, Cecília M.P
Journal of hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 119 - 125
Gastroenterology and Hepatology | NAFLD | UDCA | miRNAs | SIRT1 | Apoptosis | p53 | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Sirtuin 1 - metabolism | Transcription, Genetic - drug effects | Liver - pathology | Apoptosis - drug effects | Fatty Liver - pathology | Humans | Hepatocytes - pathology | Male | MicroRNAs - metabolism | Hepatocytes - metabolism | Sirtuin 1 - genetics | Tumor Suppressor Protein p53 - genetics | Obesity, Morbid - genetics | Non-alcoholic Fatty Liver Disease | Obesity, Morbid - metabolism | Obesity, Morbid - pathology | Fatty Liver - genetics | Severity of Illness Index | Fatty Liver - metabolism | Liver - metabolism | Tumor Suppressor Protein p53 - metabolism | Rats | Rats, Sprague-Dawley | Ursodeoxycholic Acid - pharmacology | Transcription, Genetic - physiology | Animals | Signal Transduction - drug effects | Biopsy | Signal Transduction - physiology | MicroRNAs - genetics | Apoptosis - physiology | Primary Cell Culture | Ursodeoxycholic Acid - metabolism | Ursodiol | Fatty liver | MicroRNA | Universities and colleges | Tumor proteins | Fatty acids | Index Medicus
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9. Full Text Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease
by Munoz-Garrido, Patricia and Marin, José J.G and Perugorria, María J and Urribarri, Aura D and Erice, Oihane and Sáez, Elena and Úriz, Miriam and Sarvide, Sarai and Portu, Ainhoa and Concepcion, Axel R and Romero, Marta R and Monte, María J and Santos-Laso, Álvaro and Hijona, Elizabeth and Jimenez-Agüero, Raúl and Marzioni, Marco and Beuers, Ulrich and Masyuk, Tatyana V and LaRusso, Nicholas F and Prieto, Jesús and Bujanda, Luis and Drenth, Joost P.H and Banales, Jesús M
Journal of hepatology, ISSN 0168-8278, 2015, Volume 63, Issue 4, pp. 952 - 961
Gastroenterology and Hepatology | Cholangiocyte | Therapy | Ursodeoxycholic acid (UDCA) | Cystogenesis | Polycystic liver diseases (PLDs) | Intracellular calcium | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Cysts - drug therapy | Cholagogues and Choleretics - pharmacology | Liver - pathology | Bile Ducts - metabolism | Calcium - metabolism | Liver - metabolism | Cells, Cultured | Liver Diseases - pathology | Rats | Bile Acids and Salts - metabolism | Cysts - pathology | Cysts - metabolism | Tandem Mass Spectrometry | Ursodeoxycholic Acid - pharmacology | Animals | Liver - drug effects | Cell Proliferation - drug effects | Liver Diseases - drug therapy | Liver Diseases - metabolism | Bile Ducts - pathology | Apoptosis | Disease Models, Animal | Ursodiol | Models | Liver diseases | Index Medicus | cholangiocyte | intracellular calcium | ursodeoxycholic acid (UDCA) | therapy | cystogenesis
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