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09/2013
Background: Drug-metabolizing enzymes (DMEs) inhibition based drug-drug interaction and herb-drug interaction severely challenge the R&D process of drugs or... 
UDP-glucuronosyltransferases (UGTs) | drug-drug interaction (DDI) | wogonin
Web Resource
British Journal of Clinical Pharmacology, ISSN 0306-5251, 04/2019, Volume 85, Issue 4, pp. 859 - 860
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 01/2019, Volume 105, Issue 1, pp. 131 - 141
The ontogeny of hepatic uridine diphosphate‐glucuronosyltransferases (UGTs) was investigated by determining their protein abundance in human liver microsomes... 
UDP-GLUCURONOSYLTRANSFERASES | MESSENGER-RNA | UGT1A1 | ZIDOVUDINE | MORPHINE | INTERINDIVIDUAL VARIABILITY | POPULATION PHARMACOKINETICS | GLUCURONIDATION | PHARMACOLOGY & PHARMACY | DRUG-METABOLIZING-ENZYMES | DEVELOPMENTAL EXPRESSION
Journal Article
Chemosphere, ISSN 0045-6535, 01/2020, Volume 238, pp. 124645 - 124645
Bromophenols (BPs) are important organic compounds which have become dominant pollutants during these years. Our present study investigated the potential... 
Human UDP-Glucuronosyltransferases (UGTs) | Bromophenols (BPs) | Bromine substituent | Inhibition | In vitro-in vivo extrapolation (IVIVE) | Index Medicus
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2018, Volume 104, Issue 3, pp. 515 - 524
This work revises and complements existing findings on the distribution of drug‐metabolizing enzymes in the first‐pass effect organs. We explored gene... 
UDP-GLUCURONOSYLTRANSFERASES | GLUCURONOSYL TRANSFERASE 1A | CYTOCHROME-P450 ENZYMES | IN-VIVO EXTRAPOLATION | SAMPLE PREPARATION | SYSTEMIC EXPOSURE | PHARMACOLOGY & PHARMACY | P-GLYCOPROTEIN EXPRESSION | TANDEM MASS-SPECTROMETRY | TARGETED PROTEOMICS | 1ST-PASS METABOLISM
Journal Article
by Chen, DW and Du, Z and Zhang, CZ and Zhang, WH and Cao, YF and Sun, HZ and Zhu, ZT and Yang, K and Liu, YZ and Zhao, ZW and Fu, ZW and Gu, WQ and Yu, Y and Fang, ZZ
XENOBIOTICA, ISSN 0049-8254, 2018, Volume 48, Issue 3, pp. 250 - 257
1. UDP-glucuronosyltransferases (UGTs) are important drug-metabolizing enzymes (DMEs) catalyzing the glucuronidation elimination of various xenobiotics and... 
thyroxine | ACIDS | triiodothyronine | GLUCURONIDATION | RATIO | THYROTOXICOSIS | PARAMETERS | HYPOTHYROIDISM | THYROIDITIS | UDP-glucuronosyltransferases | ENZYMES | Enzyme inhibition | PHARMACOLOGY & PHARMACY | TOXICOLOGY | UGT2B7
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 08/2018, Volume 61, Issue 16, pp. 7273 - 7288
Studies on indole-3-carboxylic acid derivatives as direct activators of human adenosine monophosphate-activated protein kinase (AMPK) alpha 1 beta 1 gamma 1... 
IN-VITRO | CHEMISTRY, MEDICINAL | UDP-GLUCURONOSYLTRANSFERASES | HEPATIC DISPOSITION | HIGH-FAT DIET | COVALENT BINDING | NMR-SPECTROSCOPY | CHOLESTEROL ABSORPTION INHIBITOR | CHEMICAL-SYNTHESIS | DRUG METABOLITES | MASS-SPECTROMETRY
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2008, Volume 36, Issue 8, pp. 1461 - 1464
UDP-glucuronosyltransferases (UGTs) are major phase II drug metabolism enzymes that catalyze the glucuronidation of numerous endogenous and exogenous... 
UDP-GLUCURONOSYLTRANSFERASES | METABOLISM | GLUCURONIDATION | ESTRADIOL | DISEASE | PHARMACOLOGY & PHARMACY | CANCER | ESTROGEN-RECEPTOR | Glucuronosyltransferase - genetics | Glucuronosyltransferase - metabolism | Isoenzymes - genetics | Isoenzymes - metabolism | Humans | RNA, Messenger - genetics | Cell Line, Tumor | Index Medicus
Journal Article
ENDOCRINOLOGY, ISSN 0013-7227, 06/2014, Volume 155, Issue 6, pp. 2052 - 2063
25-Hydroxyvitamin D-3 (25OHD(3)) is used as a clinical biomarker for assessment of vitamin D status. Blood levels of 25OHD(3) represent a balance between its... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | VITAMIN-D | UDP-GLUCURONOSYLTRANSFERASES | PLASMA | ENDOCRINOLOGY & METABOLISM | ENZYMATIC-HYDROLYSIS | TANDEM MASS-SPECTROMETRY | CYP3A4 | IN-VITRO GLUCURONIDATION | D-3-1-ALPHA-HYDROXYLASE | PREGNANCY
Journal Article
Environmental Pollution, ISSN 0269-7491, 11/2019, Volume 254, pp. 113093 - 113093
Per- and polyfluoroalkyl substances (PFASs) are a large group of chemicals and can be detected in environmental and human samples all over the world. Toxicity... 
Inhibition type | Per- and polyfluoroalkyl substances (PFASs) | UDP-Glucuronosyltransferases (UGTs) | In vitro-in vivo extrapolation (IVIVE) | Inhibition kinetic parameters (Ki) | Half inhibition concentration (IC50) | Index Medicus
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 05/2019, Volume 369, Issue 2, pp. 234 - 243
UDP-glucuronosyltransferase (UGT) 2A1 is an important enzyme in the detoxification of polycyclic aromatic hydrocarbons found in cigarette smoke. This enzyme is... 
LUNG-CANCER | UDP-GLUCURONOSYLTRANSFERASES | POLYCYCLIC AROMATIC-HYDROCARBONS | ENZYMES | GENES | VALIDATION | PHARMACOLOGY & PHARMACY | MICRORNAS | IDENTIFICATION | EXPRESSION | VARIANT | Metabolism, Transport, and Pharmacogenomics
Journal Article
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, ISSN 1055-9965, 9/2011, Volume 20, Issue 9, pp. 1937 - 1943
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 02/2019, Volume 368, Issue 2, pp. 308 - 316
A potential CYP4B1 suicide gene application in engineered T-cell treatment of blood cancers has revived interest in the use of 4-ipomeanol (IPO) in... 
KIDNEY MICROSOMES | DOSE SCHEDULE | GREEN FLUORESCENT PROTEIN | IN-VITRO | UDP-GLUCURONOSYLTRANSFERASES | PHARMACOLOGY & PHARMACY | METABOLIC-ACTIVATION | SWEET-POTATO | PRODRUG-ACTIVATING GENE | CYTOCHROME-P450 4B1 | DRUG-METABOLISM
Journal Article
ACS CHEMICAL BIOLOGY, ISSN 1554-8929, 03/2019, Volume 14, Issue 3, pp. 348 - 355
Cancer therapies are plagued by resistance. Previously, we discovered a novel form of cancer drug resistance where the Glioma-associated protein 1 (GLI1)... 
REGULATOR | CELLS | UDP-GLUCURONOSYLTRANSFERASES | INHIBITION | RAT HEPATOCYTES | METABOLISM | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RISK | GLI1 | EXPRESSION
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2019, Volume 161, pp. 89 - 97
Circadian clock is known to modulate phase I metabolism, however whether and how the phase II enzymes UDP-glucuronosyltransferases (UGTs) are regulated by... 
Circadian clock | Morphine | UGT | Pharmacokinetics | Rev-erbα | HEPATIC EXPRESSION | Rev-erb alpha | GLUCURONIDATION | TRANSCRIPTION | MORPHINE-6-GLUCURONIDE | CROSS-TALK | UDP-GLUCURONOSYLTRANSFERASES | METABOLISM | GENE | PHARMACOLOGY & PHARMACY
Journal Article
FEBS Letters, ISSN 0014-5793, 06/2018, Volume 592, Issue 11, pp. 1837 - 1846
Uridine diphosphate‐glucuronosyltransferases ( UGT s) are the most important phase II enzymes in human drug metabolism. Using permeabilized recombinant fission... 
polymorphism | UGT | 1A5 | drug metabolism | UGT1A5 | FISSION YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLUCURONIDATION | UGT2B28 | CELL BIOLOGY | UDP-GLUCURONOSYLTRANSFERASES | BIOPHYSICS | GENES | FORCE-FIELD | DRUG-METABOLISM | Index Medicus
Journal Article
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 11/2018, Volume 46, Issue 11, pp. 1497 - 1506
Cell models to investigate intestinal absorption functions, such as those of transporters and metabolic enzymes, are essential for oral drug discovery and... 
CYTOCHROME-P450 | IN-VITRO | UDP-GLUCURONOSYLTRANSFERASES | PARACELLULAR PATHWAY | CARBOXYLESTERASE | PERMEABILITY | METABOLISM | ORAL BIOAVAILABILITY | ENTEROCYTE-LIKE CELLS | PHARMACOLOGY & PHARMACY | P-GLYCOPROTEIN
Journal Article
by Garcia-Closas, M and Chatterjee, N and Malats, N and Wu, X and Figueroa, J.D and Real, F.X and Berg, D. Van den and Matullo, G and Baris, D and Thun, M and Kiemeney, L.A.L.M and Vilneis, P and De Vivo, I and Albanes, D and Purdue, M and Rafnar, T and Hildebrandt, M.A.T and Kiltie, A.E and Cussenot, O and Golka, K and Kumar, R and Taylor, J.A and Mayordomo, J.I and Jacobs, K.B and Kogevinas, M and Hutchinson, A and Wang, Z and Fu, Y and Prokunina-Olsson, L and Burdett, L and Yeager, M and Wheeler, W and Tardon, A and Serra, C and Carrato, A and Garcia-Closas, R and Lloreta, J and Johnson, A and Schwenn, M and Karagas, M.R and Schned, A and Aniole, G.L and Grubb, R and Black, A and Jacobs, E.J and Diver, W.R and Gapstur, S.M and Weinstein, S.J and Virtamo, J and Cortessis, V.K and Gago-Dominguez, M and Pike, M.C and Stern, M.C and Yuan, J.M and Hunter, D.J and McGrath, M and Dinney, C.P and Czerniak, B and Chen, M and Yang, H and Vermeulen, S and Aben, K.K.H and Witjes, J.A and Makkinje, R.R and Sulem, P and Besenbacher, S and Riboli, E and Brennan, P and Panico, S and Navarro, C and Allen, N.E and Bueno-De-Mesquita, H.B and Trichopoulos, D and Caporaso, N and Landi, M.T and Canzian, F and Ljungberg, B and Tjonneland, A and Clavel-Chapelon, F and Bishop, D.T and Teo, M.T and Knowles, M.A and Guarrera, S and Polidoro, S and Ricceri, F and Sacerdote, C and Allione, A and Cancel-Tassin, G and Selinski, S and Hengstler, J.G and Dietrich, H and Fletcher, T and Rudnai, P and Gurzau, E and Koppova, K and Bolick, S.C and Godfrey, A and Xu, Z and Medicinska fakulteten and Urologi och andrologi and Institutionen för kirurgisk och perioperativ vetenskap and Umeå universitet
Nature Genetics, ISSN 1061-4036, 2010, Volume 42, Issue 11, pp. 978 - 984
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120... 
CONFERS SUSCEPTIBILITY | CHROMOSOME 8Q24 | COMMON VARIANTS | UDP-GLUCURONOSYLTRANSFERASES | SEQUENCE VARIANT | TELOMERASE MUTATIONS | GENETICS & HEREDITY | DOWN-REGULATION | RECOMBINATION HOTSPOTS | PULMONARY-FIBROSIS | CELL-CARCINOMA | Smoking - adverse effects | United States - epidemiology | Arylamine N-Acetyltransferase - metabolism | Humans | Male | Incidence | Chromosomes, Human, Pair 2 - genetics | Chromosomes, Human, Pair 22 - genetics | Urinary Bladder Neoplasms - genetics | Chromosome Mapping - methods | Urinary Bladder Neoplasms - pathology | Female | Urinary Bladder Neoplasms - epidemiology | Genetic Predisposition to Disease | Genome-Wide Association Study | Risk Assessment | Risk Factors | Europe - epidemiology | Sex Characteristics | Spain - epidemiology | Family | Arylamine N-Acetyltransferase - genetics | Polymorphism, Single Nucleotide | Chromosomes, Human, Pair 18 - genetics | Neoplasm Staging | Quantitative trait loci | Genetic aspects | Disease susceptibility | Research | Bladder cancer | Studies | Genotype & phenotype | Family medical history | Chromosomes | Cancer | Tumors | Index Medicus | Genome-wide association studies | Psychology | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | confers susceptibility; udp-glucuronosyltransferases; recombination hotspots; telomerase mutations; pulmonary-fibrosis; sequence variant; common variants; chromosome 8q24; down-regulation; cell-carcinoma
Journal Article