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International Journal of Molecular Sciences, ISSN 1422-0067, 07/2019, Volume 20, Issue 15, p. 3637
Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II detoxification enzymes involved in glycosylation of lipophilic endobiotics and... 
Index Medicus | host adaptation | UDP-glucuronosyltransferase | nicotine tolerance | Myzus persicae
Journal Article
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 01/2006, Volume 34, Issue 1, pp. 121 - 130
The metabolism and disposition of varenicline ( 7,8,9,10-tetrahydro6,10-methano-6H-pyrazino[2,3-h][3]benzazepine), a partial agonist of the nicotinic... 
UDP-GLUCURONOSYLTRANSFERASE | MORTALITY | PHARMACOLOGY & PHARMACY | SMOKING | LIVER-MICROSOMES | INHIBITOR
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 07/2006, Volume 24, Issue 19, pp. 3061 - 3068
Purpose UGT1A1*28 polymorphism has been associated with decreased glucuronidation of SN38, the active metabolite of irinotecan. This could increase toxicity... 
UDP-GLUCURONOSYLTRANSFERASE | METABOLITES | SN-38 | UGT1A1 | CPT-11 | ONCOLOGY | DRUG-INTERACTIONS | PREDICT | GENETIC-VARIANTS | TOXICITY | FLUOROURACIL
Journal Article
International Journal of Legal Medicine, ISSN 0937-9827, 03/2019, Volume 133, Issue 2, pp. 365 - 372
We present a novel multiplex assay for the simultaneous detection of 12 polymorphisms within the UGT1A9 sequence, which codes for enzymes involved in phase II... 
Delta-THC | Cannabis | Personalised medicine | Biological assay | UDP-glucuronosyltransferase 1A9
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 09/2019, Volume 131, pp. 110542 - 110542
-equol, an active metabolite of the soy isoflavone daidzein, is mainly metabolized into glucuronide(s) by UDP-glucuronosyltransferase (UGT) enzymes in mammals.... 
Intestinal microsomes | Glucuronidation | Liver microsomes | UDP-Glucuronosyltransferase (UGT) | S-equol | Index Medicus
Journal Article
Pharmaceutics, ISSN 1999-4923, 07/2019, Volume 11, Issue 7, p. 355
Catalposide, an active component of Veronica species such as Catalpa ovata and Pseudolysimachion lingifolium, exhibits anti-inflammatory, antinociceptic,... 
carboxylesterase | sulfotransferase | in vitro human metabolism | UDP-glucuronosyltransferase | catalposide
Journal Article
Yaoxue Xuebao, ISSN 0513-4870, 05/2016, Volume 51, Issue 5, pp. 749 - 755
Journal Article
2018, ISBN 2889453855
Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact... 
POR | Pharmacogenetics | UGT | Biocatalysis | UDP-glucuronosyltransferase | Cytochrome P450 | Drug metabolism | Membrane-associated progesterone receptor | PXR | Steroids
eBook
2018, ISBN 9782889454914
Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact... 
POR | Pharmacogenetics | UGT | Biocatalysis | UDP-glucuronosyltransferase | Cytochrome P450 | Drug metabolism | Membrane-associated progesterone receptor | PXR | Steroids
eBook
Journal of Ethnopharmacology, ISSN 0378-8741, 08/2019, Volume 240, pp. 111913 - 111913
is a traditional herbal medicine and is reported to have various pharmacological actions. Despite many reports of previous studies, there is limited scientific... 
UDP-Glucuronosyltransferase | Gyejibokryeong-hwan | Subacute toxicity | Cytochrome P450 | Herbal formula | CHEMISTRY, MEDICINAL | KEISHI-BUKURYO-GAN | RATS | FORMULA | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | PLANTS | PHARMACOLOGY & PHARMACY
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 07/2019, Volume 47, Issue 7, pp. 743 - 752
The prevalence of cannabis use and the concentrations of the psychoactive cannabinoid in cannabis, (-)-∆ -tetrahydrocannabinol (THC), are rising.... 
Enzymes | Drug abuse | UDP-glucuronosyltransferase | Computer simulation | Cytochrome P450 | Liver | Pharmacology | Exposure | Parameter identification | Microsomes | Cannabis | Depletion | Metabolites | Modelling | Kinetics | Enzyme kinetics | Tetrahydrocannabinol | CYP2D6 protein | Glucuronosyltransferase
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 03/2019, Volume 368, Issue 3, pp. 363 - 381
Genes involved in drug absorption, distribution, metabolism, and excretion (ADME) are called ADME genes. Currently, 298 genes that encode phase I and II drug... 
UDP-GLUCURONOSYLTRANSFERASE | CANCER-CELLS | XENOBIOTIC METABOLISM | PROGRESSIVE STAGES | ALCOHOL-DEHYDROGENASE | PHARMACOLOGY & PHARMACY | HUMAN LIVER | TRANSCRIPTIONAL REGULATION | UP-REGULATION | EXPRESSION | P-GLYCOPROTEIN
Journal Article
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 05/2019, Volume 47, Issue 5, pp. 535 - 544
Integrase strand transfer inhibitor (INSTI)-based regimens dominate initial human immunodeficiency virus treatment. Most INSTIs are metabolized predominantly... 
UDP-GLUCURONOSYLTRANSFERASE ENZYMES | IN-VITRO | TROUGH CONCENTRATIONS | METABOLISM | DRUG-INTERACTIONS | RALTEGRAVIR MK-0518 | QUANTITATIVE PREDICTION | PHARMACOLOGY & PHARMACY | DOLUTEGRAVIR | UGT1A1 POLYMORPHISMS | HUMAN KIDNEY
Journal Article
RSC Advances, ISSN 2046-2069, 2018, Volume 8, Issue 72, pp. 41368 - 41375
Shogaols, mainly [6]-shogaol (6S), [8]-shogaol (8S) and [10]-shogaol (10S), the predominant and characteristic pungent phytochemicals in ginger, are... 
UDP-GLUCURONOSYLTRANSFERASE ENZYMES | METABOLITES | INHIBITION | REACTION-KINETICS | URINE | MOUSE | GINGER | 6-SHOGAOL | HUMAN LIVER-MICROSOMES | ZINGIBER-OFFICINALE | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 01/2019, Volume 47, Issue 1, pp. 38 - 44
UDP-glucuronosyltransferases (UGTs) catalyze the glucuronidation of numerous endogenous and exogenous compounds to facilitate their excretion from the body.... 
ORGANIZATION | PHARMACOLOGY & PHARMACY | GENE | METABOLISM | GLUCURONIDATION | Excretion | UDP-glucuronosyltransferase | Liver | Sex | Rats | Pharmacology | Gene expression | Small intestine | Sexes | Rodents | Isoforms | Pharmacokinetics | Glucuronosyltransferase | Quantitative analysis | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 09/2018, Volume 366, Issue 3, pp. 458 - 469
Previous evidence has suggested that puerarin may attenuate cardiac hypertrophy; however, the potential mechanisms have not been determined. Moreover, the use... 
TRANSCRIPTION FACTORS | BILIRUBIN | PRESSURE-OVERLOAD | MYOCARDIAL-INFARCTION | BETA-TRCP | HEART-FAILURE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | INDUCED CARDIOMYOCYTE HYPERTROPHY | INDUCTION | UDP-GLUCURONOSYLTRANSFERASE 1A1
Journal Article
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