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Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 2, pp. 523 - 540
Reactive oxygen and nitrogen species change cellular responses through diverse mechanisms that are now being defined. At low levels, they are signalling... 
Mitochondrion | Oxidative stress | Redox signalling | Neurodegeneration | Autophagy | Nitrative stress | autophagy | CHAPERONE-MEDIATED AUTOPHAGY | ANTIOXIDANT RESPONSIVE ELEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPOFUSCINOSES BATTEN-DISEASE | neurodegeneration | AMYOTROPHIC-LATERAL-SCLEROSIS | mitochondrion | redox signalling | MOTOR-NEURON DEGENERATION | MANGANESE SUPEROXIDE-DISMUTASE | nitrative stress | SMOOTH-MUSCLE-CELLS | PATHOGENIC DJ-1 MUTATIONS | HYPOXIA-INDUCED AUTOPHAGY | oxidative stress | COMPLEX-I DEFICIENCY | Protein Kinases - metabolism | Transcription, Genetic - drug effects | Cardiovascular Diseases - physiopathology | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Humans | Oxidative Stress - physiology | Hydrogen Peroxide - pharmacology | Oncogene Proteins - metabolism | Nitric Oxide - physiology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Parkinson Disease - physiopathology | Lysosomes - physiology | Protein Deglycase DJ-1 | Animals | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Neoplasms - physiopathology | AMPK, 5′-AMP-activated protein kinase | NBR1, neighbour of BRCA1 (breast cancer early-onset 1) | NGF, nerve growth factor | LC3, light chain 3 | NOX, NADPH oxidase | EM, electron microscopy | TOR, target of rapamycin | ULK, unc (unco-ordinated family member)-51-like kinase | mtDNA, mitochondrial DNA | mTOR, mammalian target of rapamycin | IKKβ, IκB kinase β | LRRK2, leucine-rich repeat kinase 2 | NAC, N-acetyl-L-cysteine | Nrf2, nuclear factor-erythroid 2-related factor 2 | PI3P, phosphatidylinositol 3-phosphate | ECH, enoyl-CoA hydratase | BNIP3L, BNIP3-like | Drp1, dynamin-related protein 1 | tfLC3, tandem fluorescently tagged LC3 | NF-κB, nuclear factor κB | BAG, Bcl-2-associated athanogene | Keap1, Kelch-like ECH-associated protein 1 | PE, phosphatidylethanolamine | 3-MA, 3-methyladenine | UCP, uncoupling protein | IκB, inhibitor of nuclear factor κB | FIP200, focal adhesion kinase family-interacting protein of 200 kDa | PI3K, phosphoinositide 3-kinase | HNE, 4-hydroxynonenal | Review | ALS, amyotrophic lateral sclerosis | ATG, AuTophaGy-related | adenovirus E18 19-kDa-interacting protein | Tzb, trastuzumab | mETC, mitochondrial electron-transport chain | Rubicon, RUN domain- and cysteine-rich domain-containing beclin-1-interacting protein | VDAC, voltage-dependent anion channel | IP3, inositol 1,4,5-trisphosphate | RFP, red fluorescent protein | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1 | GFP, green fluorescent protein | LAMP, lysosome-associated membrane protein | JNK1, c-Jun N-terminal kinase 1 | TAC, transverse aortic constriction | GABARAP, GABAA (γ-aminobutyric acid type A)-receptor-associated protein | HIF-1, hypoxia-inducible factor 1 | NOS, nitric oxide synthase | siRNA, small interfering RNA | SOD, superoxide dismutase | RLS, reactive lipid species | RNS, reactive nitrogen species | ER, endoplasmic reticulum | TIGAR, TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator | Vps34, vacuolar protein sorting 34 | BNIP, Bcl-2
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2006, Volume 398, Issue 2, pp. 153 - 168
Adipose tissue is a major endocrine organ that exerts a profound influence on whole-body homoeostasis. Two types of adipose tissue exist in mammals: WAT (white... 
Brown adipose tissue (BAT) | White adipose tissue (WAT) | Transcription | Signalling | Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) | Ion Channels | Signal Transduction | Membrane Proteins - genetics | Humans | Gene Expression Regulation | Adipose Tissue - cytology | Mitochondrial Proteins | Adipose Tissue - metabolism | Carrier Proteins - genetics | Adipose Tissue, Brown - cytology | Animals | Carrier Proteins - metabolism | Adipose Tissue, Brown - metabolism | Cell Differentiation | Membrane Proteins - metabolism | Uncoupling Protein 1 | transcription | NRF, nuclear respiratory factor | brown adipose tissue (BAT) | T3, 3,5,3′-tri-iodothyronine | RXR, retinoid X receptor | Cidea, cell death-inducing DFF45-like effector A | SRC-1, steroid receptor co-activator 1 | ChIP, chromatin immunoprecipitation | PKB, protein kinase B | ES, embryonic stem | FABP, fatty acid-binding protein | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | 4E-BP1, 4E-binding protein 1 | SV40, simian virus 40 | TAg, large T antigen | PRMT1, protein arginine methyltransferase 1 | AR, adrenergic receptor | SREBP-1, sterol regulatory element-binding protein 1 | peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) | PKA, cAMP-dependent protein kinase | RIP140, receptor interacting protein 140 | T4, thyroxine | Dio2, type 2 iodothyronine deiodinase | eNOS, epithelial NO synthase | LRH-1, liver receptor homologue 1 | SNS, sympathetic nervous system | NCoR, nuclear receptor co-repressor | UCP1, uncoupling protein 1 | WAT, white adipose tissue | white adipose tissue (WAT) | ERR, oestrogen-related receptor | LXR, liver X receptor | TR, thyroid hormone receptor | Tfam, mitochondrial transcription factor A | CIP, p300 | pRB, retinoblastoma protein | MAPK, mitogen-activated protein kinase | IRS, insulin receptor substrate | co-integrator-associated protein | PPAR, peroxisome proliferator-activated receptor | SIRT, sirtuin | SV, stromal-vascular | Review | CBP | IGF-1R, IGF-1 receptor | NO, nitric oxide | SHP, small heterodimer partner | Rb, retinoblastoma gene | PGC-1, PPARγ co-activator 1 | S6K, S6 kinase | TZD, thiazolidinedione | CPT-1b, carnitine palmitoyltransferase 1b | signalling | enhancer-binding protein | PRC, PGC-1-related co-activator | BAT, brown adipose tissue | EBP, CCAAT | CREB, cAMP response element-binding protein | Foxc2, forkhead box C2 | SPPARM, selective PPARγ modulator | CBP, CREB-binding protein | TIF2, transcriptional intermediary factor 2 | GABP, GA-binding protein | MEF, mouse embryo fibroblast
Journal Article
Nutrition, ISSN 0899-9007, 2016, Volume 36, pp. 8 - 16
Abstract Objectives Branched-chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), are key regulators of protein synthesis in... 
Gastroenterology and Hepatology | Branched-chain amino acid ratio | Protein metabolism | Proliferation and differentiation | mTORC1 | Myocyte | ADIPOCYTES | TRANSPORTER EXPRESSION | ATROPHY | UBIQUITIN LIGASES | TOR SIGNALING NETWORK | SUPPLEMENTATION | NUTRITION & DIETETICS | SKELETAL-MUSCLE CELLS | MTORC1 ACTIVATION | GROWTH | L-LEUCINE AVAILABILITY | Up-Regulation | Protein Biosynthesis | TOR Serine-Threonine Kinases - metabolism | SKP Cullin F-Box Protein Ligases - genetics | Uncoupling Protein 3 - genetics | Muscle Cells - drug effects | Multiprotein Complexes - genetics | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | RNA, Messenger - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Muscle Proteins - metabolism | Cell Survival - drug effects | Uncoupling Protein 3 - metabolism | Down-Regulation | RNA, Messenger - genetics | Muscle Cells - metabolism | Ubiquitin-Protein Ligases - metabolism | Tripartite Motif Proteins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | Muscle Proteins - genetics | Animals | Cell Differentiation - drug effects | Amino Acids, Branched-Chain - pharmacology | Cell Line, Tumor | Muscle Fibers, Skeletal - cytology | Cell Proliferation - drug effects | Mice | Tripartite Motif Proteins - metabolism | Ubiquitin-Protein Ligases - genetics | Physiological aspects | Protein biosynthesis | Livestock | Branched chain amino acids | Sensors | Ubiquitin | Energy metabolism | Regulators | Interleukin | Chain branching | Amino acids | Chains | Myocytes | Leucine | Kinases | Protein turnover | Proteins | Atrophy | Ratios | Cell growth | Medical laboratories | Cell cycle | Ubiquitin-protein ligase | Food | G1 phase | Isoleucine | Animal nutrition | Myotubes | Myogenin | Nutrition | Ribosomal protein S6 | Gene expression | Metabolism | Interleukin 15 | Ribosomal protein S6 kinase | Musculoskeletal system | Protein synthesis | Valine | S phase | Differentiation | Viability | Transporter
Journal Article
Cellular and Molecular Biology, ISSN 0145-5680, 2018, Volume 64, Issue 4, pp. 39 - 45
The receptor interaction protein 140 (RIP140) cofactor is a key regulator of metabolic balance, but its function in glucose-and lipid-mediated damage in islet... 
Glucolipotoxicity | Expression analysis | Receptor interaction protein 140 | Oxidative damage | Islet β cell | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL-FUNCTION | DEATH | ENDOPLASMIC-RETICULUM STRESS | PALMITATE | OXIDATIVE-METABOLISM | NUCLEAR RECEPTOR | CELL BIOLOGY | Islet beta cell | SKELETAL-MUSCLE | PANCREATIC BETA-CELLS | TRANSCRIPTIONAL COREPRESSOR RIP140 | EXPRESSION | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | RNA, Small Interfering - genetics | Palmitic Acid - pharmacology | Oxidative Stress | Apoptosis - drug effects | Homeodomain Proteins - metabolism | Humans | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Insulin-Secreting Cells - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - genetics | Trans-Activators - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Insulin-Secreting Cells - cytology | Nuclear Proteins - genetics | Insulin Secretion | Cell Survival - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Nuclear Proteins - agonists | Signal Transduction | Uncoupling Protein 2 - metabolism | RNA, Messenger - genetics | Nuclear Proteins - metabolism | Glucose - pharmacology | Adaptor Proteins, Signal Transducing - agonists | Homeodomain Proteins - genetics | Nuclear Receptor Interacting Protein 1 | Gene Expression Regulation - drug effects | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Uncoupling Protein 2 - genetics | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Nuclear Proteins - antagonists & inhibitors | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Trans-Activators - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Cell Line, Transformed | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism
Journal Article
Journal Article
Science Signaling, ISSN 1945-0877, 01/2017, Volume 10, Issue 464, p. eaaf7478
Journal Article
Diabetes, ISSN 0012-1797, 02/2014, Volume 63, Issue 2, pp. 514 - 525
The number and activity of brown adipocytes are linked to the ability of mammals to resist body fat accumulation. In some conditions, certain white adipose... 
OBESITY | GENE | ENDOCRINOLOGY & METABOLISM | MUSCLE | RECEPTOR | PROLIFERATION | DIFFERENTIATION | EXPRESSION | FAT-CELL | EXERCISE | ADIPOSE-TISSUE | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Adipose Tissue, White - metabolism | Caenorhabditis elegans Proteins - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Recombinant Proteins | Extracellular Signal-Regulated MAP Kinases - genetics | Pichia - metabolism | Membrane Transport Proteins - genetics | Dietary Fats | Membrane Transport Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Butadienes - pharmacology | Fibronectins - pharmacology | Fibronectins - administration & dosage | Mice, Inbred C57BL | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | 3T3-L1 Cells | Rats, Sprague-Dawley | Animals | Adipocytes - metabolism | Pichia - genetics | Protein Binding | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Fibronectins - genetics | Mice | Pyridines - pharmacology | Mutation | Mitochondrial Uncoupling Proteins | Caenorhabditis elegans Proteins - genetics | Adipose Tissue, White - drug effects | Physiological research | Cellular signal transduction | Research | Identification and classification | Membrane proteins
Journal Article
Circulation research, ISSN 0009-7330, 02/2015, Volume 116, Issue 5, pp. E28 - E39
Rationale: Sustained activation of Gq transgenic (Gq) signaling during pressure overload causes cardiac hypertrophy that ultimately progresses to dilated... 
Heart failure | Mitochondrial uncoupling protein 3 | Oxidative stress | G-protein | Calcium-calmodulin-dependent protein kinase type 2 | heart failure | OXYGEN SPECIES PRODUCTION | PRESSURE-OVERLOAD | CARDIAC & CARDIOVASCULAR SYSTEMS | UNCOUPLING PROTEINS | HEART-FAILURE | Gq | calcium-calmodulin-dependent protein kinase type 2 | KINASE-II | CARDIAC-HYPERTROPHY | MYOCARDIAL HYPERTROPHY | PERIPHERAL VASCULAR DISEASE | MICE | mitochondrial uncoupling protein 3 | PPAR-ALPHA AGONIST | DYSFUNCTION | HEMATOLOGY | oxidative stress | Reactive Oxygen Species | Oxidative Stress | GTP-Binding Protein alpha Subunits, Gq-G11 - deficiency | Heart Failure - physiopathology | Ion Channels - genetics | Male | Gene Expression Profiling | Ion Channels - physiology | Mitochondrial Proteins - genetics | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - deficiency | Cardiomyopathy, Dilated - prevention & control | RNA, Messenger - biosynthesis | Transfection | RNA Interference | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology | Heart Failure - etiology | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Ion Channels - biosynthesis | PPAR alpha - biosynthesis | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Cells, Cultured | Cardiomegaly - physiopathology | Mitochondrial Proteins - physiology | Rats | Mice, Transgenic | PPAR alpha - genetics | GTP-Binding Protein alpha Subunits, Gq-G11 - physiology | Mitochondrial Proteins - biosynthesis | Cardiomegaly - enzymology | Sulfonamides - pharmacology | Pressure | Disease Progression | Mice, Knockout | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Point Mutation | Animals | Sequence Analysis, RNA | Cardiomyopathy, Dilated - etiology | Cardiomyopathy, Dilated - physiopathology | Mitochondria, Heart - physiology | Acetylcysteine - pharmacology | Myocytes, Cardiac - metabolism | Mice | Benzylamines - pharmacology | Uncoupling Protein 3 | Apoptosis | UCP | calcium | calmodulin-dependent protein kinase II | peroxisome proliferator-activated receptor alpha and gamma
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2016, Volume 6, Issue 1, p. 34747
Nesfatin-1, an 82 amino acid gastric peptide, is involved in regulation of food uptake and in multiple metabolic activities. Whether nesfatin-1 modulates the... 
THERMOGENESIS | TARGET | LIPID-METABOLISM | WHITE ADIPOSE-TISSUES | FOOD-INTAKE | MULTIDISCIPLINARY SCIENCES | MOUSE | DIFFERENTIATION | DIET-INDUCED OBESITY | MODULATION | TRANSDIFFERENTIATION | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Leucine - pharmacology | Lipolysis - drug effects | Adipocytes, Brown - metabolism | TOR Serine-Threonine Kinases - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Lipolysis - genetics | Mitochondrial Proton-Translocating ATPases - genetics | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | TOR Serine-Threonine Kinases - genetics | Gene Deletion | Tumor Suppressor Proteins - genetics | Nerve Tissue Proteins - pharmacology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Phosphorylation - drug effects | Calcium-Binding Proteins - metabolism | DNA-Binding Proteins - pharmacology | Tumor Suppressor Proteins - metabolism | Uncoupling Protein 1 - genetics | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Mice, Transgenic | Signal Transduction - genetics | Lipase - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Mitochondrial Proton-Translocating ATPases - metabolism | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Phenotype | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Tuberous Sclerosis Complex 1 Protein | Mice | Calcium-Binding Proteins - pharmacology | Primary Cell Culture | Adipocytes, Brown - cytology | Calcium-Binding Proteins - genetics | Lipase - genetics | TOR protein | Phosphorylation | Clonal deletion | Amino acids | mRNA | Lipid metabolism | Leucine | Adipocytes | TSC1 protein | Lipolysis | Food
Journal Article