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Journal Article
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 04/2012, Volume 110, Issue 9, pp. 1211 - 1216
RATIONALE:Previous studies indicate uncoupling protein-2 (UCP2) as an antioxidant defense against endothelial dysfunction in hypertension. UCP2 also regulates... 
Endothelial dysfunction | Vasodilatation | Oxidative stress | Uncoupling protein | Diabetes | OXYGEN SPECIES PRODUCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | RESISTANCE ARTERIES | DIABETIC-RATS | endothelial dysfunction | uncoupling protein | vasodilatation | SKELETAL-MUSCLE | NITRIC-OXIDE | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HYDROGEN-PEROXIDE | MITOCHONDRIAL SUPEROXIDE | HEMATOLOGY | diabetes | UP-REGULATION | oxidative stress | Free Radical Scavengers - pharmacology | Myography | Mesenteric Arteries - physiopathology | Reactive Oxygen Species - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Oxidative Stress | Humans | Ion Channels - genetics | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Mesenteric Arteries - drug effects | Mitochondrial Proteins - genetics | Dose-Response Relationship, Drug | Transfection | Time Factors | Mitochondrial Proteins - metabolism | Diet, High-Fat | Obesity - etiology | Aorta, Thoracic - drug effects | Mitochondrial Proteins - deficiency | Organ Culture Techniques | Disease Models, Animal | Vasodilator Agents - pharmacology | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Obesity - physiopathology | Aorta, Thoracic - physiopathology | Mesenteric Arteries - metabolism | Regional Blood Flow | Mice, Knockout | Obesity - metabolism | Animals | Ion Channels - metabolism | Endothelium, Vascular - metabolism | Glucose - metabolism | Mice | Nitric Oxide Synthase - metabolism | Uncoupling Protein 2 | Vasodilation - drug effects | Nitric Oxide - metabolism | Ion Channels - deficiency
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 03/2010, Volume 106, Issue 4, pp. 730 - 738
RATIONALE:Uncoupling protein (UCP)2 is a mitochondrial inner membrane protein that is expressed in mammalian myocardium under normal conditions and upregulated... 
Uncoupling protein-2 | Mitochondria | Calcium | Excitation- contraction coupling | Calcium sparks | CARDIAC & CARDIOVASCULAR SYSTEMS | calcium | uncoupling protein-2 | mitochondria | CYTOSOLIC CA2+ SIGNALS | SARCOPLASMIC-RETICULUM | RELEASE | CARDIOMYOCYTES | MITOCHONDRIAL CA2 | RABBIT CARDIAC MYOCYTES | CALCIUM TRANSIENTS | HEART | RYANODINE RECEPTORS | PERIPHERAL VASCULAR DISEASE | calcium sparks | RAT VENTRICULAR MYOCYTES | HEMATOLOGY | excitation-contraction coupling | Electric Stimulation | Mitochondria, Heart - metabolism | Uncoupling Agents - pharmacology | Rats, Wistar | Calcium - metabolism | Humans | Homeostasis | Ion Channels - genetics | Myocardial Contraction - drug effects | Mitochondrial Proteins - genetics | Mitochondria, Heart - drug effects | Transfection | Mitochondrial Proteins - metabolism | Adenosine Triphosphate - metabolism | Membrane Potential, Mitochondrial | Adenoviridae - genetics | Animals, Newborn | Excitation Contraction Coupling - drug effects | Mitochondrial Proteins - antagonists & inhibitors | Cells, Cultured | Oxygen Consumption | Rats | Ion Channels - antagonists & inhibitors | Microscopy, Confocal | Animals | Myocytes, Cardiac - drug effects | Energy Metabolism | Ion Channels - metabolism | Iridoids - pharmacology | 2,4-Dinitrophenol - pharmacology | Iridoid Glycosides | Myocytes, Cardiac - metabolism | Uncoupling Protein 2 | Kinetics | Genetic Vectors
Journal Article
Diabetologia, ISSN 0012-186X, 1/2007, Volume 50, Issue 1, pp. 84 - 93
Journal Article
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 03/2011, Volume 50, Issue 5, pp. 609 - 616
Glucose-stimulated insulin secretion (GSIS) by pancreatic β cells is regulated by mitochondrial uncoupling protein-2 (UCP2), but opposing phenotypes, GSIS... 
Type 2 diabetes | Reactive oxygen species | Free radicals | Uncoupling protein 2 | Pancreatic β cells | Mitochondrial respiration | Glucose-stimulated insulin secretion | Coupling efficiency of oxidative phosphorylation | Metabolic syndrome | CAPACITY | Pancreatic beta cells | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OBESITY | DIET | PROTON LEAK | UCP2 | ENDOCRINOLOGY & METABOLISM | NEURONS | PANCREATIC BETA-CELLS | DYSFUNCTION | EXPRESSION | Reactive Oxygen Species - metabolism | Ion Channels - genetics | Mitochondrial Proteins - physiology | Rats | Ion Channels - physiology | Mitochondria - metabolism | Mitochondrial Proteins - genetics | Antioxidants - pharmacology | Diabetes Mellitus, Type 2 - metabolism | Metalloporphyrins - pharmacology | Gene Knockdown Techniques | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Cell Line, Tumor | Glucose - metabolism | Mice | Uncoupling Protein 2 | Energy Metabolism - physiology | Insulin Secretion | DHE, hydroethidine | FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone | MnTBAP, manganese tetrakis-(4-benzoic acid) porphyrin | ψ, mitochondrial membrane potential | Original Contribution | DAPI, 4′,6-diamidino-2-phenylindole | UCP2, uncoupling protein-2 | KRH, Hepes-buffered Krebs–Ringer medium | TTNPB, 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1-propenyl]benzoic acid | MnTMPyP, manganese tetrakis-(N-methyl-4-pyridyl) porphyrin | GSIS, glucose-stimulated insulin secretion | MitoSOX, mitochondria-targeted hydroethidine | ROS, reactive oxygen species | FCS, fetal calf serum
Journal Article
Cellular Immunology, ISSN 0008-8749, 09/2015, Volume 297, Issue 1, pp. 40 - 45
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 10/2014, Volume 21, Issue 11, pp. 1571 - 1581
Journal Article