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uncultivated bacterial symbiont (36) 36
index medicus (29) 29
animals (20) 20
biochemistry & molecular biology (20) 20
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natural products (16) 16
bryozoan bugula-neritina (15) 15
chemistry, medicinal (13) 13
genomics (13) 13
polyketide synthase gene (13) 13
drug discovery (11) 11
polyketides (11) 11
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polyketide synthases - metabolism (10) 10
biological products - chemistry (9) 9
biotechnology & applied microbiology (9) 9
molecular sequence data (9) 9
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article (8) 8
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candidatus-endobugula-sertula (7) 7
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uncultivated bacterial symbionts (6) 6
amino acid sequence (5) 5
bacteria - metabolism (5) 5
candidatus endobugula sertula (5) 5
heterologous expression (5) 5
multigene family (5) 5
nonribosomal peptide synthetases (5) 5
peptide synthetase (5) 5
review (5) 5
sponge theonella-swinhoei (5) 5
sponges (5) 5
symbionts (5) 5
bioactive compounds (4) 4
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marine natural products (4) 4
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polyketide synthases - chemistry (4) 4
secondary metabolites (4) 4
substrate specificity (4) 4
theonella-swinhoei (4) 4
acyl carrier protein (3) 3
acyltransferases - genetics (3) 3
adenylation domains (3) 3
analysis (3) 3
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1. Full Text Polyketide synthases of bacterial symbionts in sponges – Evolution-based applications in natural products research
by Hochmuth, Thomas and Piel, Jörn
Phytochemistry, ISSN 0031-9422, 2009, Volume 70, Issue 15, pp. 1841 - 1849
Marine sponges are a rich source of bioactive polyketides and often harbor diverse bacterial communities. This review summarizes studies of our group to obtain... 
Symbiosis | Polyketides | Sponges | Uncultivated bacteria | Fatty acids | Polyketide synthases | METABOLITES | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | METHYL | IDENTIFICATION | MARINE SPONGES | PHOSPHOLIPID FATTY-ACIDS | PLANT SCIENCES | GENE-CLUSTER | PATHWAY | BIOSYNTHESIS | DIVERSITY | Biological Evolution | Animals | Biological Products | Bacteria - enzymology | Porifera - microbiology | Polyketide Synthases - genetics
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2. Full Text Patellamide A and C Biosynthesis by a Microcin-Like Pathway in Prochloron didemni, the Cyanobacterial Symbiont of Lissoclinum patella
by Eric W. Schmidt and James T. Nelson and David A. Rasko and Sebastian Sudek and Jonathan A. Eisen and Margo G. Haygood and Jacques Ravel and Robert Haselkorn
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2005, Volume 102, Issue 20, pp. 7315 - 7320
Prochloron spp. are obligate cyanobacterial symbionts of many didemnid family ascidians. It has been proposed that the cyclic peptides of the patellamide class... 
Proteins | Symbiosis | Polymerase chain reaction | Symbionts | Physical Sciences | Patella | Biosynthesis | Genomes | Libraries | Bacteriocins | Sequencing | Lantibiotic | Heterocycle | Genome sequencing | Tunicate | Ascidian | SEQUENCE-ANALYSIS | LEADER PEPTIDE | MULTIDISCIPLINARY SCIENCES | tunicate | B17 | DNA-GYRASE INHIBITOR | heterocycle | IDENTIFICATION | UNCULTIVATED BACTERIAL SYMBIONT | CYCLIC-PEPTIDES | ascidian | lantibiotic | genome sequencing | SYNTHETASE | LACTOCOCCUS-LACTIS | PLASMID GENES | Cyanobacteria - genetics | Amino Acid Sequence | Urochordata - microbiology | Escherichia coli | Prochloron - genetics | Molecular Sequence Data | Prochloron - metabolism | Chromatography, High Pressure Liquid | DNA Primers | Open Reading Frames - genetics | Peptides, Cyclic - biosynthesis | Sequence Analysis, DNA | Peptides, Cyclic - chemistry | Animals | Peptides, Cyclic - genetics | Palau | Bacteriocins - metabolism | Cyanobacteria | Research | Biological Sciences
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3. Full Text Parallel lives of symbionts and hosts: chemical mutualism in marine animals
by Morita, Maho and Schmidt, Eric W
Natural Product Reports, ISSN 0265-0568, 4/2018, Volume 35, Issue 4, pp. 357 - 378
Covering: up to 2018 Symbiotic microbes interact with animals, often by producing natural products (specialized metabolites; secondary metabolites) that exert... 
CHEMISTRY, MEDICINAL | CANDIDATUS-ENDOBUGULA-SERTULA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | POLYBROMINATED DIPHENYL ETHERS | UNCULTIVATED BACTERIAL SYMBIONT | BRYOZOAN BUGULA-NERITINA | HIGHLY CYTOTOXIC POLYPEPTIDES | TUNICATE ECTEINASCIDIA-TURBINATA | ASCIDIAN LISSOCLINUM-PATELLA | SPONGE THEONELLA-SWINHOEI | POLYKETIDE SYNTHASE GENE | DIVERSITY-GENERATING BIOSYNTHESIS | Predatory Behavior | Aquatic Organisms - microbiology | Cyanobacteria - chemistry | Cyanobacteria - metabolism | Symbiosis - physiology | Halogenated Diphenyl Ethers - chemistry | Crustacea | Halogenated Diphenyl Ethers - metabolism | Biological Products - chemistry | Animals | Ultraviolet Rays | Ships | Urochordata - metabolism | Biological Products - metabolism | Porifera - microbiology | Tetrodotoxin - metabolism | Bryozoa - metabolism | Bryozoa - chemistry
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4. Full Text The Biosynthetic Logic of Polyketide Diversity
by Hertweck, Christian
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2009, Volume 48, Issue 26, pp. 4688 - 4716
Molecular Lego: Polyketides represent a highly diverse group of natural products with structurally intriguing carbon skeletons (see picture) which are... 
natural products | enzymes | polyketides | antibiotics | biosynthesis | Enzymes | Polyketides | Biosynthesis | Antibiotics | Natural products | NATURAL-PRODUCT | ANGIOGENESIS INHIBITOR BORRELIDIN | NONRIBOSOMAL PEPTIDE ANTIBIOTICS | ACYL-CARRIER PROTEIN | UNCULTIVATED BACTERIAL SYMBIONT | CHEMISTRY, MULTIDISCIPLINARY | CHAIN-LENGTH CONTROL | STARTER-UNIT | I FATTY-ACID | HETEROLOGOUS EXPRESSION | SYNTHASE GENE-CLUSTER | Polyketide Synthases - metabolism | Cyclization | Macrocyclic Compounds - chemistry | Macrolides - chemistry | Polyphenols | Phenols - chemistry | Flavonoids - biosynthesis | Flavonoids - chemistry | Multienzyme Complexes - chemistry
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5. Parallel lives of symbionts and hosts: chemical mutualism in marine animals
by Maho Morita and Eric W Schmidt
Natural Product Reports, ISSN 0265-0568, 01/2018, Volume 35, Issue 4, pp. 357 - 378
Covering: up to 2018Symbiotic microbes interact with animals, often by producing natural products (specialized metabolites; secondary metabolites) that exert a... 
Symbionts | Marine chemistry | Secondary metabolites | Animals | Metabolites | Historical account | Natural products | Marine organisms | Chemical interactions | Mutualism | Marine animals
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6. Full Text Natural products: A continuing source of novel drug leads
by Cragg, Gordon M and Newman, David J
BBA - General Subjects, ISSN 0304-4165, 06/2013, Volume 1830, Issue 6, pp. 3670 - 3695
Nature has been a source of medicinal products for millennia, with many useful drugs developed from plant sources. Following discovery of the penicillins, drug... 
synthesis | Microbial diversity | genomics | natural product drugs | SOLID-PHASE SYNTHESIS | MARINE ACTINOMYCETE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPONGE KIRKPATRICKIA-VARIALOSA | UNCULTIVATED BACTERIAL SYMBIONTS | MICROTUBULE-STABILIZING AGENTS | DIVERSITY-ORIENTED SYNTHESIS | BIOSYNTHETIC GENE-CLUSTER | BIOPHYSICS | FUNGAL CELL-WALL | METASTATIC BREAST-CANCER | COMPOUND LIBRARY DEVELOPMENT | Animals | Bacteria - chemistry | Drug Discovery - history | History, 21st Century | Plants - genetics | History, 20th Century | Humans | Cloning, Molecular | Drug Discovery - methods | Plants - chemistry | Bacteria - genetics | Drugs | Combinatorial chemistry
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7. Full Text Targeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidates
by Trindade, Marla and van Zyl, Leonardo Joaquim and Navarro-Fernández, José and Elrazak, Ahmed Abd
Frontiers in Microbiology, ISSN 1664-302X, 2015, Volume 6, p. 890
Microbial natural products exhibit immense structural diversity and complexity and have captured the attention of researchers for several decades. They have... 
Symbionts | Metagenomics | Functional screening | Drug discovery | Marine natural products | Uncultured microbes | SECONDARY METABOLITES | NONRIBOSOMAL PEPTIDES | symbionts | ESCHERICHIA-COLI | MICROBIOLOGY | marine natural products | UNCULTIVATED BACTERIAL SYMBIONT | ENDOBUGULA SERTULA | MASS-SPECTROMETRY | functional screening | drug discovery | uncultured microbes | metagenomics | MICROBIAL DIVERSITY | ANTITUMOR COMPOUNDS | HETEROLOGOUS EXPRESSION | POLYKETIDE SYNTHASE GENE | Drug Discovery | Marine Natural Products
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