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1. Full Text Novel 5'-Norcarbocyclic Pyrimidine Derivatives as Antibacterial Agents
by Khandazhinskaya, Anastasia L and Khandazhinskaya, Anastasia L and Alexandrova, Liudmila A and Alexandrova, Liudmila A and Matyugina, Elena S and Matyugina, Elena S and Solyev, Pavel N and Solyev, Pavel N and Efremenkova, Olga V and Efremenkova, Olga V and Buckheit, Karen W and Wilkinson, Maggie and Buckheit, Robert W and Chernousova, Larisa N and Smirnova, Tatiana G and Smirnova, Tatiana G and Andreevskaya, Sofya N and Andreevskaya, Sofya N and Leonova, Olga G and Leonova, Olga G and Popenko, Vladimir I and Popenko, Vladimir I and Kochetkov, Sergey N and Kochetkov, Sergey N and Seley-Radtke, Katherine L and Seley-Radtke, Katherine L
Molecules, ISSN 1420-3049, 11/2018, Volume 23, Issue 12, p. 3069
A series of novel 5-norcarbocyclic derivatives of 5-alkoxymethyl or 5-alkyltriazolyl-methyl uracil were synthesized and the activity of the compounds evaluated... 
Antibacterial activity | Uracil derivatives | 5′-norcarbocyclic nucleosides | Mycobacterium tuberculosis | norcarbocyclic nucleosides | antibacterial activity | MYCOBACTERIUM-TUBERCULOSIS | NONNUCLEOSIDE INHIBITORS | DESIGN | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG-RESISTANCE | SIDEROPHORE BIOSYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | 5-norcarbocyclic nucleosides | uracil derivatives | ANTIVIRAL PROPERTIES | NEPLANOCIN-A | CARBOCYCLIC NUCLEOSIDES | MODIFIED CYCLOPENTANE RING | Antitubercular Agents - chemistry | Humans | Antitubercular Agents - pharmacology | Mycobacterium tuberculosis - ultrastructure | Structure-Activity Relationship | Pyrimidines - pharmacology | Mycobacterium tuberculosis - drug effects | Pyrimidines - chemistry | Microbial Sensitivity Tests | Uracil - pharmacology | Anti-Bacterial Agents - chemistry | Anti-Bacterial Agents - pharmacology | Molecular Structure | Uracil - chemistry | Uracil - analogs & derivatives
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2. Full Text 1,6-Bis[(benzyloxy)methyl]uracil derivatives—Novel antivirals with activity against HIV-1 and influenza H1N1 virus
by Geisman, Alexander N and Valuev-Elliston, Vladimir T and Ozerov, Alexander A and Khandazhinskaya, Anastasia L and Chizhov, Alexander O and Kochetkov, Sergey N and Pannecouque, Christophe and Naesens, Lieve and Seley-Radtke, Katherine L and Novikov, Mikhail S
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2016, Volume 24, Issue 11, pp. 2476 - 2485
A series of 1,6-bis[(benzyloxy)methyl]uracil derivatives combining structural features of both diphenyl ether and pyridone types of NNRTIs were synthesized.... 
Non-nucleoside reverse transcriptase inhibitors | HIV | Influenza virus | Uracil | NNRTIs | NONNUCLEOSIDE INHIBITORS | WILD-TYPE | CHEMISTRY, MEDICINAL | COLORIMETRIC ASSAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CRYSTAL-STRUCTURES | DRUG-RESISTANCE | HUMAN-IMMUNODEFICIENCY-VIRUS | ANGSTROM RESOLUTION | MUTANT STRAINS | REVERSE-TRANSCRIPTASE INHIBITORS | CONFORMATIONAL-CHANGES | Antiviral Agents - pharmacology | Madin Darby Canine Kidney Cells - virology | HIV-1 - drug effects | Cells, Cultured | Models, Molecular | Structure-Activity Relationship | Influenza A Virus, H1N1 Subtype - drug effects | Madin Darby Canine Kidney Cells - drug effects | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Uracil - pharmacology | Animals | Antiviral Agents - chemistry | Dogs | Antiviral Agents - chemical synthesis | Uracil - chemical synthesis | Molecular Structure | Uracil - chemistry | Uracil - analogs & derivatives | Antiviral agents | Pyrimidines | HIV (Viruses) | Influenza | Influenza viruses | Chemotherapy | Nucleosides | DNA polymerases | Research institutes | Molecular biology | Cancer | Index Medicus
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3. Full Text The competition between chemistry and biology in assembling iron–sulfur derivatives. Molecular structures and electrochemistry. Part V. {[Fe4S4](SCysγ)4} proteins
by Zanello, Piero
Coordination Chemistry Reviews, ISSN 0010-8545, 03/2017, Volume 335, pp. 172 - 227
Cyclic voltammogram and digitally simulated voltammetric profiles of the } clusters harbored by “unmaturated” [FeFe]-hydrogenase from ATCC 7757. Continuing our... 
Electrochemistry | [formula omitted] proteins | Synthetic analogs | Molecular structures | S | proteins | Fe | X-RAY-STRUCTURE | PERIPLASMIC NITRATE REDUCTASE | DISSIMILATORY SULFITE REDUCTASE | PYROGALLOL-PHLOROGLUCINOL TRANSHYDROXYLASE | CHEMISTRY, INORGANIC & NUCLEAR | COMPLETE GENOME SEQUENCE | ELECTRON-TRANSFER FLAVOPROTEIN | CARBON-MONOXIDE DEHYDROGENASE | HYBRID-CLUSTER PROTEIN | URACIL-DNA GLYCOSYLASE | DESULFOVIBRIO-VULGARIS HILDENBOROUGH | {[Fe4S4](S-Cys(gamma))} proteins | Sulfur compounds | Electrochemical reactions | Enzymes | Green technology | Iron proteins | Sulfur
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4. Full Text Synthesis and antitumor activity of novel substituted uracil-1′(N)-acetic acid ester derivatives of 20(S)-camptothecins
by Li, Xing-Yu and Li, Di-Zao and Zhang, Qiang-Zhe and Zhang, Yan-Ling and Wang, Cun-Ying and Huang, Ji-Tao and Liu, Hong-Yan and Fu, Zhao-Di and Song, Hua-Xian and Lin, Jin-Ping and Ji, Teng-Fei and Pan, Xian-Dao
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 125, pp. 1235 - 1246
A series of novel substituted uracil-1′( )-acetic acid esters ( – ) of camptothecins (CPTs) were synthesized by the acylation method. These new compounds were... 
Camptothecin | Antitumor activity | The mechanism of antitumor activity | Synthesis | Substituted uracil-1′(N)-acetic acid | APOPTOSIS | CELLS | DESIGN | CHEMISTRY, MEDICINAL | VIVO | Substituted uracil-1'(N)-acetic acid | TOXICITY | DISCOVERY | CAMPTOTHECIN DERIVATIVES | AGENTS | TOPOISOMERASE-I INHIBITORS | HYDROXYCAMPTOTHECINE | Neoplasms - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Acetates - chemistry | Antineoplastic Agents - therapeutic use | Camptothecin - chemical synthesis | Uracil - pharmacology | Topoisomerase I Inhibitors - pharmacology | Uracil - chemical synthesis | Acetates - therapeutic use | Antineoplastic Agents - pharmacology | Topoisomerase I Inhibitors - chemistry | Camptothecin - analogs & derivatives | Cell Survival - drug effects | Camptothecin - therapeutic use | DNA Topoisomerases, Type I - metabolism | Uracil - therapeutic use | Acetates - chemical synthesis | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Topoisomerase I Inhibitors - chemical synthesis | Animals | Mice, Nude | Topoisomerase I Inhibitors - therapeutic use | Cell Line, Tumor | Acetates - pharmacology | Neoplasms - pathology | Camptothecin - pharmacology | Uracil - analogs & derivatives | Antimitotic agents | Medical colleges | Pyrimidines | Pharmacy | Liver | Esters | Acetic acid | Antineoplastic agents | Organic acids | Tumors
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5. Full Text Singlet Excited-State Behavior of Uracil and Thymine in Aqueous Solution:  A Combined Experimental and Computational Study of 11 Uracil Derivatives
by Gustavsson, Thomas and Bányász, Ákos and Lazzarotto, Elodie and Markovitsi, Dimitra and Scalmani, Giovanni and Frisch, Michael J and Barone, Vincenzo and Improta, Roberto
Journal of the American Chemical Society, ISSN 0002-7863, 01/2006, Volume 128, Issue 2, pp. 607 - 619
The excited-state properties of uracil, thymine, and nine other derivatives of uracil have been studied by steady-state and time-resolved spectroscopy. The... 
DNA BASES | RESOLVED PHOTOELECTRON-SPECTROSCOPY | AB-INITIO | ELECTRONIC RELAXATION DYNAMICS | GAS-PHASE | FLUORESCENCE UP-CONVERSION | 300 DEGREES K | ULTRAFAST INTERNAL-CONVERSION | DENSITY-FUNCTIONAL THEORY | CHEMISTRY, MULTIDISCIPLINARY | NUCLEIC-ACIDS | Thermodynamics | Thymine - chemistry | Solutions | Water - chemistry | Models, Molecular | Spectrometry, Fluorescence | Uracil - chemistry | Uracil - analogs & derivatives | or physical chemistry | Chemical Sciences | Theoretical and
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6. Full Text In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications
by Pałasz, Aleksandra and Cież, Dariusz
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2015, Volume 97, Issue 1, pp. 582 - 611
This review article is an effort to summarize recent developments in researches providing uracil derivatives with promising biological potential. This article... 
Antiviral | Antibacterial | 5-Fluorouracil | Anticancer | Fused uracils | Uracils | CHEMISTRY, MEDICINAL | DIELS-ALDER REACTIONS | NUCLEOSIDE ANALOGS | PHOSPHORYLASE INHIBITOR DESIGN | ONE-POT SYNTHESIS | GLYCOGEN-PHOSPHORYLASE | ANTITUMOR-ACTIVITY | BREAST-CANCER CELLS | HERPES-SIMPLEX-VIRUS | HEPATIC GLUCOSE-PRODUCTION | THYMIDINE PHOSPHORYLASE | Uracil - pharmacology | Animals | Humans | Uracil - chemical synthesis | Drug Discovery - methods | Uracil - chemistry | Chemistry Techniques, Synthetic - methods | Antiviral agents | Nitriles | Drug discovery | Health aspects | Gastrointestinal system | Fluorouracil
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7. Increase in the photoreactivity of uracil derivatives by doubling thionation
by Pollum, M and Jockusch, S and Crespo-Hernandez, CE
Physical Chemistry Chemical Physics, ISSN 1463-9076, 10/2015, Volume 17, Issue 41, pp. 27851 - 27861
The ability of 4-thiouracil to strongly absorb UVA radiation and to populate a reactive triplet state in high yield has enabled its use as a versatile... 
Oxygen | Foundations | Unity | Photochemical | Deoxyribonucleic acid | Derivatives | Adenines | Uracil
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8. Full Text Increase in the photoreactivity of uracil derivatives by doubling thionation
by Pollum, M and Jockusch, S and Crespo-Hernández, C.E
Physical Chemistry Chemical Physics, ISSN 1463-9076, 2015, Volume 17, Issue 41, pp. 27851 - 27861
The ability of 4-thiouracil to strongly absorb UVA radiation and to populate a reactive triplet state in high yield has enabled its use as a versatile... 
ULTRAVIOLET-ABSORPTION | PHOTO-CROSS-LINKING | QUANTUM YIELDS | NUCLEIC-ACID BASES | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | SINGLET OXYGEN | MICRORNA TARGETS | TRANSFER-RNA | TRIPLET EXCITED-STATE | UVA PHOTOACTIVATION | PROBE 4-THIOURIDINE | Thiouracil - chemistry | Molecular Structure | Ultraviolet Rays | Thiouracil - analogs & derivatives | Singlet Oxygen - analysis | Photochemical Processes
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9. Full Text Multicomponent solids of uracil derivatives-orotic and isoorotic acids
by Kumar, Vineet and Goswami, Pramod Kumar and Thaimattam, Ram and Ramanan, Arunachalam
CrystEngComm, ISSN 1466-8033, 2018, Volume 20, Issue 25, pp. 3490 - 3504
Cocrystallization of two multifunctional structural isomers viz. orotic and isoorotic acids was explored with a series of amine and pyridine-based coformers.... 
OROTATE COMPLEXES | CO-CRYSTAL | BASES | CRYSTAL-STRUCTURE | DNA | NUCLEOBASES | CRYSTALLOGRAPHY | P-AMINOSALICYLIC ACID | STRUCTURAL LANDSCAPE | SALTS | CHEMISTRY, MULTIDISCIPLINARY | PHARMACEUTICAL APPLICABILITY | Acids | Solubility | Cocrystallization | Isomers | Uracil | Hydrates | Carbonyls | Structural analysis
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10. Full Text The synthesis and antituberculosis activity of 5′-nor carbocyclic uracil derivatives
by Matyugina, Elena and Khandazhinskaya, Anastasia and Chernousova, Larisa and Andreevskaya, Sofia and Smirnova, Tatiana and Chizhov, Alexander and Karpenko, Inna and Kochetkov, Sergey and Alexandrova, Ludmila
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2012, Volume 20, Issue 22, pp. 6680 - 6686
A series of new carbocyclic uracil derivatives were synthesized and evaluated as potential antituberculosis agents. Racemic... 
Carbocyclic nucleosides | Uracil derivatives | Mycobacterium tuberculosis | Enantiomers | MYCOBACTERIUM-TUBERCULOSIS | DESIGN | CHEMISTRY, MEDICINAL | 5'-NORARISTEROMYCIN | ANALOGS | NUCLEOSIDES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PYRIMIDINES | CHEMISTRY, ORGANIC | AVIUM | IN-VITRO | INHIBITION | BOVIS | Antitubercular Agents - chemical synthesis | Cell Survival - drug effects | Antitubercular Agents - chemistry | Stereoisomerism | Cercopithecus aethiops | Mycobacterium tuberculosis - drug effects | Mycobacterium tuberculosis - isolation & purification | Microbial Sensitivity Tests | Uracil - toxicity | Animals | Uracil - chemical synthesis | Antitubercular Agents - toxicity | Vero Cells | Uracil - analogs & derivatives | Nucleosides | Antitubercular agents | Pyrimidines
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11. Full Text Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
by Novikov, Mikhail S and Babkov, Denis A and Paramonova, Maria P and Khandazhinskaya, Anastasia L and Ozerov, Alexander A and Chizhov, Alexander O and Andrei, Graciela and Snoeck, Robert and Balzarini, Jan and Seley-Radtke, Katherine L
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2013, Volume 21, Issue 14, pp. 4151 - 4157
HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In... 
Antiviral | Nonnucleoside | Uracil derivatives | Nucleobase | HCMV | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ZOSTER-VIRUS VZV | POTENT | BIOLOGICAL-ACTIVITY | GANCICLOVIR | ANTIVIRAL ACTIVITY | HUMAN CYTOMEGALOVIRUS HCMV | INFECTION | PHARMACOKINETIC PROPERTIES | INHIBITORS | RETINITIS | Uracil - pharmacology | Virus Replication - drug effects | Antiviral Agents - pharmacology | Antiviral Agents - chemistry | Humans | Cells, Cultured | Antiviral Agents - chemical synthesis | Uracil - chemical synthesis | Receptors, Virus - drug effects | Structure-Activity Relationship | Uracil - chemistry | Cytomegalovirus - drug effects | Pyrimidines | Index Medicus | Antiviral activity
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12. Full Text Electrochemically synthesized molecularly imprinted polymer of thiophene derivatives for flow-injection analysis determination of adenosine-5′-triphosphate (ATP)
by Huynh, Tan-Phat and Pietrzyk-Le, Agnieszka and Bikram K.C, Chandra and Noworyta, Krzysztof R and Sobczak, Janusz W and Sharma, Piyush Sindhu and D'Souza, Francis and Kutner, Wlodzimierz
Biosensors and Bioelectronics, ISSN 0956-5663, 03/2013, Volume 41, Issue 1, pp. 634 - 641
Two selective chemosensors for adenosine-5′-triphosphate (ATP) determination featuring molecularly imprinted polymer (MIP) film recognition units were... 
Adenosine-5′-triphosphate ATP | Piezoelectric microgravimetry | Capacitive impedometry | Molecularly imprinted polymer | Flow-injection analysis | Adenosine-5'-triphosphate ATP | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | RECOGNITION | FILM | ELECTRODES | ADENOSINE | APTAMER | NANOSCIENCE & NANOTECHNOLOGY | QUARTZ-CRYSTAL MICROBALANCE | SENSORS | AQUEOUS-SOLUTION | BIOPHYSICS | FLUORESCENCE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Adenosine-5 '-triphosphate ATP | TRIPHOSPHATE | Reproducibility of Results | Adenosine Triphosphate - analysis | Microfluidic Analytical Techniques - instrumentation | Equipment Design | Molecular Imprinting - methods | Conductometry - instrumentation | Flow Injection Analysis - instrumentation | Sensitivity and Specificity | Biosensing Techniques - instrumentation | Micro-Electrical-Mechanical Systems - instrumentation | Electroplating - methods | Thiophenes - chemistry | Equipment Failure Analysis | Methane | Phosphates | Adenosine | Pyrimidines | Universities and colleges | Thiophene | Polymers
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