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Neurobiology of Disease, ISSN 0969-9961, 02/2020, Volume 134, p. 104624
Fatty-acid amide hydrolase (FAAH) is an intracellular serine hydrolase that catalyzes the cleavage of endogenous fatty-acid amides, including the... 
URB597 | Nitroglycerin | Migraine
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 07/2017, Volume 108, pp. S55 - S55
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 04/2017, Volume 8, p. 200
Journal Article
Journal Article
Neuropharmacology, ISSN 0028-3908, 2008, Volume 55, Issue 1, pp. 85 - 93
Journal Article
European Neuropsychopharmacology, ISSN 0924-977X, 05/2018, Volume 28, Issue 5, pp. 630 - 642
Activating the endocannabinoid system has become a major focus in the search for novel therapeutics for anxiety and deficits in fear extinction, two defining... 
WIN55,212-2 | N-arachidonylethanolamine (AEA) | Cannabinoids | Extinction | Post traumatic stress disorder (PTSD) | fatty acid hydrolase (FAAH) inhibitor URB597 | POSTTRAUMATIC-STRESS-DISORDER | INHIBITOR URB597 | PSYCHIATRY | BASOLATERAL AMYGDALA | ENDOCANNABINOID SYSTEM | NEUROSCIENCES | PREFRONTAL CORTEX | CLINICAL NEUROLOGY | ANTIDEPRESSANT-LIKE ACTIVITY | RESTRAINT STRESS | MEMORY CONSOLIDATION | FEAR EXTINCTION | CANNABINOID RECEPTOR ACTIVATION | PHARMACOLOGY & PHARMACY | Endocannabinoids - metabolism | Electric Stimulation | Receptor, Cannabinoid, CB2 - physiology | Extinction, Psychological - drug effects | Male | Carbamates - administration & dosage | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Glycerides - blood | Piperidines - pharmacology | Arachidonic Acids - blood | Stress Disorders, Post-Traumatic - drug therapy | Reflex, Startle - drug effects | Cannabinoid Receptor Antagonists - pharmacology | CA1 Region, Hippocampal - metabolism | Benzamides - pharmacology | Reflex, Startle - physiology | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | Benzoxazines - administration & dosage | Morpholines - administration & dosage | Morpholines - pharmacology | Rats | Amidohydrolases - antagonists & inhibitors | Basolateral Nuclear Complex - metabolism | Naphthalenes - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Animals | Naphthalenes - administration & dosage | Benzoxazines - pharmacology | Endocannabinoids - blood | Fatty acids | Post-traumatic stress disorder
Journal Article
Journal Article
Redox Biology, ISSN 2213-2317, 05/2018, Volume 15, Issue C, pp. 41 - 50
Primary and secondary hypertension is associated with kidney redox imbalance resulting in enhanced reactive oxygen species (ROS) and enzymes dependent... 
Hypertension | URB597 | Redox balance | Endocannabinoid system | Kidney | OXIDATIVE STRESS | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ANANDAMIDE | OXIDASE ACTIVITY | MASS-SPECTROMETRY | CELL-DEATH | CANNABINOID RECEPTORS | GLUTATHIONE | CARDIOVASCULAR FUNCTION
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2011, Volume 2, Issue 2, pp. 91 - 96
Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling lipids, including the... 
endocannabinoid | FAAH | irreversible inhibitor | clinical candidate | ALPHA-KETOHETEROCYCLE INHIBITORS | TARGET | URB597 | CHEMISTRY, MEDICINAL | MECHANISM | ANANDAMIDE | INACTIVATION | ENZYME | ACID AMIDE HYDROLASE | ESTERS | CHEMISTRY
Journal Article
Psychopharmacology, ISSN 0033-3158, 4/2014, Volume 231, Issue 7, pp. 1417 - 1425
Drug addicts constantly relapse to drug seeking after recall of memories linked to the drug experience. It is believed that a successful application of... 
URB597 | Reconsolidation | Neurosciences | Biomedicine | Conditioned place preference | Endocannabinoid | CB1 receptors | Morphine | Pharmacology/Toxicology | Psychiatry | ANANDAMIDE HYDROLYSIS | PSYCHIATRY | RECEPTOR ANTAGONIST RIMONABANT | NEUROSCIENCES | OPIOID SYSTEM | ESTER URB597 | ACID AMIDE HYDROLASE | CANNABINOID CB1 RECEPTORS | CONTEXTUAL FEAR MEMORY | DRUG-ADDICTION | PHARMACOLOGY & PHARMACY | SPATIAL MEMORY | Memory - drug effects | Recurrence | Rats, Wistar | Receptor, Cannabinoid, CB2 - agonists | Male | Benzoxazines | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Secondary Prevention - methods | Endocannabinoids - physiology | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Cues | Morphine - pharmacology | Conditioning (Psychology) - drug effects | Conditioning (Psychology) - physiology | Rats | Amidohydrolases - antagonists & inhibitors | Morpholines | Naphthalenes | Animals | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Memory - physiology | Complications and side effects | Drug addicts | Physiological aspects | Dosage and administration | Genetic aspects | Research | Endocannabinoids | Drug addiction | Narcotics | Psychopharmacology | Rodents | Animal memory | Addicts
Journal Article
Neuroscience Letters, ISSN 0304-3940, 10/2019, Volume 711, p. 134408
Heavy episodic drinking or binge drinking during adolescence may elicit serious neurotoxic consequences in cerebral areas (e.g., the prefrontal cortex, i.e.,... 
URB597 | Adolescence | Neuroinflammation | Endocannabinoid system | Alcohol binging | NEUROTROPHIC FACTOR | MEMORY IMPAIRMENT | FAAH INHIBITION | NEUROSCIENCES | PREFRONTAL CORTEX | CHRONIC EXPOSURE | CANNABINOID SYSTEM | OBJECT RECOGNITION | SPATIAL MEMORY | WORKING-MEMORY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2005, Volume 102, Issue 51, pp. 18620 - 18625
Journal Article