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Biochemistry (Easton), ISSN 0006-2960, 03/2017, Volume 56, Issue 12, pp. 1768 - 1784
Journal Article
Molecular cancer therapeutics, ISSN 1538-8514, 2017, Volume 16, Issue 5, pp. 956 - 965
Sarcomas differ from carcinomas in their mesenchymal origin. Therapeutic advancements have come slowly, so alternative drugs and models are urgently needed.... 
CANINE HEMANGIOSARCOMA | SYNOVIAL SARCOMA | RECOMBINANT IMMUNOTOXIN | SOFT-TISSUE SARCOMAS | ONCOLOGY | UROKINASE PLASMINOGEN-ACTIVATOR | EPIDERMAL-GROWTH-FACTOR | SPLENIC HEMANGIOSARCOMA | PHASE-I | PSEUDOMONAS EXOTOXIN | LIGAND-DIRECTED TOXIN | Virulence Factors - genetics | Humans | ErbB Receptors - genetics | Hemangiosarcoma - genetics | Molecular Targeted Therapy | ADP Ribose Transferases - administration & dosage | Exotoxins - administration & dosage | Epidermal Growth Factor - chemistry | Bacterial Toxins - genetics | Urokinase-Type Plasminogen Activator - chemistry | ADP Ribose Transferases - chemistry | Disease Models, Animal | Doxorubicin - administration & dosage | Hemangiosarcoma - pathology | ErbB Receptors - antagonists & inhibitors | Exotoxins - chemistry | Epidermal Growth Factor - genetics | Hemangiosarcoma - drug therapy | Virulence Factors - chemistry | Urokinase-Type Plasminogen Activator - genetics | Bacterial Toxins - chemistry | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | ADP Ribose Transferases - genetics | Animals | Dogs | Exotoxins - genetics | Cell Line, Tumor | Bacterial Toxins - administration & dosage | Mice | Receptors, Urokinase Plasminogen Activator - genetics | Neoplasm Staging | Virulence Factors - administration & dosage | Spleen | Drugs | Animal models | Carcinoma | Sarcoma | Epidermal growth factor receptors | Mesenchyme | Toxicity | Minimal residual disease | Doxorubicin | Biological activity | U-Plasminogen activator | Urokinase | Epidermal growth factor | Life span | Data collection | Biocompatibility | In vivo methods and tests | Drug dosages | targeted toxin | canine | sarcoma | epidermal growth factor receptor | adaptive clinical trial | urokinase plasminogen activator receptor
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 14, pp. 10982 - 10992
The high affinity interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) is decisive for cell... 
CELLULAR-BINDING SITE | LIGAND-BINDING | PLASMINOGEN-ACTIVATOR | COMBINATORIAL CHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FUNCTIONAL EPITOPE | IN-VIVO | VITRONECTIN | ANTHRAX TOXIN | TUMOR-CELLS | DEFICIENT MICE | Activating Transcription Factor 1 - genetics | Surface Plasmon Resonance | Amino Acid Sequence | Receptors, Urokinase Plasminogen Activator - chemistry | Mutagenesis, Site-Directed | Species Specificity | Humans | Crystallization | Activating Transcription Factor 1 - metabolism | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Urokinase-Type Plasminogen Activator - genetics | Activating Transcription Factor 1 - chemistry | Neoplasms - drug therapy | Receptors, Urokinase Plasminogen Activator - metabolism | Sequence Homology, Amino Acid | Animals | Urokinase-Type Plasminogen Activator - metabolism | Drug Design | Protein Conformation | Urokinase-Type Plasminogen Activator - chemistry | Mice | Receptors, Urokinase Plasminogen Activator - genetics | DESIGN | MUTAGENESIS | PROTEIN STRUCTURE | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | CRYSTAL STRUCTURE | national synchrotron light source | IN VIVO | HEALING | PLASMINOGEN | PLASMONS | FIBRINOLYSIS | THERAPY | RESONANCE | AFFINITY | ENZYMES | KINETICS | WOUNDS | RADIOLOGY AND NUCLEAR MEDICINE | TARGETS | FIBRINOLYSIN | RESIDUES | FUNCTIONALS | UROKINASE | Site-directed Mutagenesis | Molecular Co-evolution | Protein Structure and Folding | Molecular Bases of Disease | Receptor Structure-Function | Extracellular Matrix | Protein Structure | Fibrinolysis | Proteolytic Enzymes | Protein-Protein Interactions
Journal Article
ACS chemical biology, ISSN 1554-8937, 2015, Volume 10, Issue 6, pp. 1521 - 1534
The urokinase receptor (uPAR) is a GPI-anchored cell surface receptor that is at the center of an intricate network of protein-protein interactions. Its... 
Focal Adhesion Kinase 1 - genetics | Integrin alphaVbeta3 - chemistry | Small Molecule Libraries - pharmacology | Urokinase-Type Plasminogen Activator - antagonists & inhibitors | Humans | Integrins - genetics | Vitronectin - genetics | Integrins - metabolism | Vitronectin - antagonists & inhibitors | Integrin alphaVbeta3 - metabolism | Thermodynamics | Integrin alphaVbeta3 - genetics | HEK293 Cells | Urokinase-Type Plasminogen Activator - chemistry | Binding Sites | Focal Adhesion Kinase 1 - metabolism | Serine Proteinase Inhibitors - pharmacology | Integrin alphaVbeta3 - antagonists & inhibitors | Binding, Competitive | Cell Survival - drug effects | Receptors, Urokinase Plasminogen Activator - chemistry | Serine Proteinase Inhibitors - chemical synthesis | Signal Transduction | Gene Expression Regulation | Small Molecule Libraries - chemical synthesis | Urokinase-Type Plasminogen Activator - genetics | Cell Adhesion - drug effects | Vitronectin - metabolism | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | Peptides - pharmacology | Receptors, Urokinase Plasminogen Activator - metabolism | Cell Movement - drug effects | Pyrroles - pharmacology | Pyrroles - chemical synthesis | Urokinase-Type Plasminogen Activator - metabolism | Vitronectin - chemistry | Cell Line, Tumor | Protein Binding | Receptors, Urokinase Plasminogen Activator - genetics | Kinetics | rac1 GTP-Binding Protein - metabolism | Receptor Cross-Talk - drug effects | rac1 GTP-Binding Protein - genetics
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 1, p. e85349
The urokinase plasminogen activator receptor (uPAR) plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We... 
SYSTEM | MIGRATION | UROKINASE-PLASMINOGEN-ACTIVATOR | MULTIDISCIPLINARY SCIENCES | CELL INVASION | BONE-MARROW | RECEPTOR | EXTRACELLULAR-MATRIX | GROWTH-FACTOR | EXPRESSION | ASSOCIATION | Epitope Mapping | Receptors, Urokinase Plasminogen Activator - immunology | Humans | Cercopithecus aethiops | Molecular Sequence Data | Epitopes - immunology | Protein Binding - drug effects | Urokinase-Type Plasminogen Activator - chemistry | Urokinase-Type Plasminogen Activator - immunology | CD11b Antigen - chemistry | Antibodies, Monoclonal - chemistry | Amino Acid Sequence | Receptors, Urokinase Plasminogen Activator - chemistry | Mutagenesis, Site-Directed | Vitronectin - immunology | CD11b Antigen - immunology | Antibodies, Monoclonal - pharmacology | Models, Molecular | Recombinant Proteins - chemistry | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | Sequence Homology, Amino Acid | Animals | Recombinant Proteins - immunology | Dogs | Vitronectin - chemistry | Cell Line, Tumor | Epitopes - chemistry | Mice | Drosophila melanogaster | Care and treatment | Analysis | Monoclonal antibodies | Health aspects | Cancer | Antigenic determinants | Integrins | Animal models | Leukocyte migration | Laboratories | Homology | Vitronectin | Mapping | Biology | Metastasis | Ovarian cancer | Anticancer properties | Proteins | Urokinase | Angiogenesis | Signal transduction | Antitumor agents | Xenografts | Epitope mapping | Complement fixation | Binding | CD11b antigen | Alanine | Complementarity | Scanning mutagenesis | C-Terminus | Thrombosis | U-Plasminogen activator | White blood cells | Mutagenesis | Ligands | Scientific imaging | Solid tumors | Prostate | Mass spectrometry | Leukocyte rolling | Tumors
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 8, p. e0133592
Pulmonary metastasis is the major untreatable complication of osteosarcoma (OS) resulting in 10-20% long-term survival. The factors and pathways regulating... 
CARCINOMA-CELLS | SYSTEM | TARGET | CANCER INVASION | THERAPY | UROKINASE-PLASMINOGEN-ACTIVATOR | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | RECEPTOR | INHIBITOR | TUMOR-GROWTH | Neoplasm Transplantation | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | Liver Neoplasms - pathology | Bone Neoplasms - genetics | Liver Neoplasms - secondary | Osteosarcoma - metabolism | Autocrine Communication | Liver Neoplasms - genetics | Paracrine Communication | Urokinase-Type Plasminogen Activator - genetics | Disease Progression | Receptors, Urokinase Plasminogen Activator - metabolism | Animals | Urokinase-Type Plasminogen Activator - metabolism | Liver Neoplasms - metabolism | Cell Line, Tumor | Mice | Receptors, Urokinase Plasminogen Activator - genetics | Osteosarcoma - genetics | Osteosarcoma - pathology | Cell Movement | Paracrine signalling | Activation | Metastasis | Exosomes | Cancer therapies | Metastases | Proteins | Genotype & phenotype | Urokinase | Biomedical materials | Pathways | Osteosarcoma | Bone marrow | Biocompatibility | Inhibition | Autocrine signalling | Phenotypes | Therapeutic applications | Pharmacology | Gene expression | Molecular chains | U-Plasminogen activator | Bone cancer | Chemotherapy | Inhibitors | Cell migration | Tumors
Journal Article
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2015, Volume 194, Issue 11, pp. 5161 - 5173
Journal Article
British Journal of Cancer, ISSN 0007-0920, 02/2010, Volume 102, Issue 4, pp. 731 - 737
Journal Article
Nature reviews. Molecular cell biology, ISSN 1471-0080, 2010, Volume 11, Issue 1, pp. 23 - 36
Journal Article