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PROTEOMICS, ISSN 1615-9853, 11/2019, Volume 19, Issue 21-22, pp. e1900026 - n/a
While metastasis is the primary cause of colorectal cancer (CRC) mortality, the molecular mechanisms underpinning it remains elusive. Metastasis is propagated... 
uPAR | colorectal cancer | membrane protein extraction | hallmarks of cancer | Epidermal growth factor receptors | Caveolin | Colorectal carcinoma | Vitronectin | Genomes | Metastasis | Cell surface | Metastases | Genomic instability | Membrane proteins | U-Plasminogen activator | Proteins | Urokinase | Molecular modelling | Pathways | Cell death | Proteomics | Lysis | Mutation | Cancer
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 15029 - 15045
Urokinase-type plasminogen activator (uPA) regulates angiogenesis and vascular permeability through proteolytic degradation of extracellular matrix and... 
SIGNAL-TRANSDUCTION | CELL-MIGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KRINGLE DOMAIN | NUCLEOLIN | SURFACE | SINGLE-CHAIN PROUROKINASE | EXTRACELLULAR-MATRIX | STROMAL CELLS | BINDING | CORONARY-ARTERY-DISEASE | Neovascularization, Physiologic - drug effects | Homeodomain Proteins - metabolism | Humans | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Cell Nucleus - metabolism | Protein Binding - drug effects | HEK293 Cells | Vascular Endothelial Growth Factor A - pharmacology | Vascular Endothelial Growth Factor Receptor-1 - genetics | Endothelial Cells - metabolism | RNA, Messenger - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Mice, Knockout | Transcription Factors - metabolism | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Urokinase-Type Plasminogen Activator - metabolism | Endothelial Cells - cytology | K562 Cells | Cell Proliferation - drug effects | Cell Nucleus - drug effects | Endothelial Cells - drug effects | nuclear translocation | angiogenesis | endothelial cell | VEGF Receptors | PRH | urokinase plasminogen activator | vascular endothelial growth factor (VEGF) | vascular biology | HHEX transcription factor | Cell Biology
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 11/2016, Volume 65, Issue 11, pp. 1365 - 1375
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, p. e0117786
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2009, Volume 179, Issue 4, pp. 288 - 298
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 09/2008, Volume 6, Issue 9, pp. 1469 - 1477
Glioblastoma multiforme is an invasive primary brain tumor, which evades the current standard treatments. The invasion of glioblastoma cells into healthy brain... 
invasion | glioblastoma | SIGNALING PATHWAYS | INVASION | ONCOLOGY | PROTEIN-COUPLED RECEPTOR | EPIDERMAL-GROWTH-FACTOR | SPHINGOSINE KINASE-1 | GENE AMPLIFICATION | GASTRIC-CANCER CELLS | MULTIFORME | HUMAN-BRAIN-TUMORS | XENOGRAFT MODEL | CELL BIOLOGY | Humans | Brain Neoplasms - pathology | RNA, Messenger - metabolism | Receptors, Cell Surface - antagonists & inhibitors | Brain Neoplasms - metabolism | Receptors, Urokinase Plasminogen Activator | Plasminogen Activator Inhibitor 1 - metabolism | Lysophospholipids - pharmacology | Glioblastoma - metabolism | Plasminogen Activator Inhibitor 1 - genetics | Tumor Cells, Cultured | Neoplasm Invasiveness | RNA, Messenger - genetics | Receptors, Cell Surface - metabolism | Phosphotransferases (Alcohol Group Acceptor) - genetics | Urokinase-Type Plasminogen Activator - genetics | Brain Neoplasms - drug therapy | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Interleukin-1 - pharmacology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - pharmacology | Blotting, Northern | Sphingosine - analogs & derivatives | Plasminogen Activator Inhibitor 1 - chemistry | Signal Transduction - drug effects | Urokinase-Type Plasminogen Activator - metabolism | Cell Adhesion - physiology | Glioblastoma - pathology | Mitogen-Activated Protein Kinases - genetics | Glioblastoma - drug therapy | Mitogen-Activated Protein Kinases - metabolism | Receptors, Cell Surface - genetics
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 03/2012, Volume 259, Issue 2, pp. 248 - 256
Urokinase-type plasminogen activator receptor (uPAR) expression is elevated during inflammation, tissue remodeling and in many human cancers. This study... 
Endothelia | uPAR | MAPK | Invasiveness | ROS | Nicotine | UPAR | ANGIOGENESIS | LEUKEMIA-VIRUS TYPE-1 | INDUCTION | GASTRIC-CANCER CELLS | LUNG CARCINOGENESIS | ACETYLCHOLINE-RECEPTOR | INVASION | INHIBITION | PHARMACOLOGY & PHARMACY | UP-REGULATES UPAR | TOXICOLOGY | NF-KAPPA-B | Reactive Oxygen Species - metabolism | Endothelial Cells - metabolism | Humans | RNA, Messenger - genetics | NF-kappa B - metabolism | Imidazoles - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Transcription Factor AP-1 - metabolism | Anthracenes - pharmacology | Nicotine - pharmacology | Receptors, Urokinase Plasminogen Activator - metabolism | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | RNA, Messenger - chemistry | Flavonoids - pharmacology | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Receptors, Urokinase Plasminogen Activator - genetics | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinases - metabolism | Thrombolytic drugs | Protein kinases | Nervous system agents | Endothelium | Index Medicus | ANTIBODIES | TRANSCRIPTION FACTORS | MUTAGENESIS | ANTIOXIDANTS | NEOPLASMS | NICOTINE | 60 APPLIED LIFE SCIENCES | PLASMINOGEN | MOLECULES | MESSENGER-RNA | HYDROGEN PEROXIDE | PROMOTERS | INFLAMMATION | PHOSPHOTRANSFERASES | RECEPTORS | UROKINASE
Journal Article