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Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 25, pp. 22665 - 22677
Data from clinical studies, cell culture, and animal models implicate the urokinase plasminogen activator (uPA)/uPA receptor (uPAR)/plasminogen system in the... 
MYOCARDIAL-INFARCTION | DENDRITIC CELLS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIGH-DENSITY LIPOPROTEIN | IN-VIVO | ENDOTHELIAL-CELLS | RECEPTOR | KNOCKOUT MICE | E-DEFICIENT MICE | VESSEL WALL | Up-Regulation | Calgranulin B - metabolism | Calgranulin A - metabolism | Atherosclerosis - genetics | Humans | Aorta - metabolism | Calgranulin A - genetics | RNA, Messenger - metabolism | Vasodilation | Coronary Artery Disease - physiopathology | Time Factors | Coronary Artery Disease - pathology | Female | Lipid Metabolism - genetics | Transcription, Genetic | Calgranulin B - genetics | Aorta - physiopathology | Transgenes | Aorta - enzymology | Atherosclerosis - pathology | Atherosclerosis - physiopathology | Coronary Artery Disease - metabolism | RNA, Messenger - genetics | Apolipoprotein A-I - metabolism | Urokinase-Type Plasminogen Activator - genetics | Atherosclerosis - metabolism | Protein Interaction Mapping | Aorta - pathology | Receptors, Urokinase Plasminogen Activator - metabolism | Macrophages - metabolism | Animals | Receptors, Scavenger - genetics | Urokinase-Type Plasminogen Activator - metabolism | Coronary Artery Disease - genetics | Mice | Receptors, Urokinase Plasminogen Activator - genetics | Molecular Bases of Disease | Urokinase | Atherosclerosis | Lipoprotein | Plasminogen | Microarray | Plasminogen Activation | Macrophage
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2014, Volume 289, Issue 51, pp. 35193 - 35204
Mucin 1 (MUC1) is overexpressed in various human malignant tumors and its expression is correlated with a poor prognosis. MUC1 engages in signal transduction... 
PROTEOLYTIC CLEAVAGE | Transcription Regulation | INTERCELLULAR-ADHESION MOLECULE-1 | ONCOPROTEIN FUNCTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | uPA | BREAST CARCINOMAS | DOWN-REGULATION | Cell Surface Associated (MUC1) | NF-B Transcription Factor | E-CADHERIN | BETA-CATENIN | REGULATORY LOOP | Cell Invasion | TARGET GENES | CARCINOMA-ASSOCIATED ANTIGEN | Mucin 1 | Cancer | Immunohistochemistry | Neoplasms - metabolism | Oligonucleotide Array Sequence Analysis | Transcription Factor RelA - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Immunoblotting | Gene Expression Profiling | Promoter Regions, Genetic - genetics | Transcription Factor RelA - genetics | Cell Movement - genetics | Neoplasms - genetics | RNA Interference | Protein Binding - drug effects | Mucin-1 - metabolism | Neoplasm Invasiveness | Dipeptides - pharmacology | HCT116 Cells | Matrix Metalloproteinase 2 | Binding Sites - genetics | Urokinase-Type Plasminogen Activator - genetics | Cell Movement - drug effects | Transcription Factor RelA - metabolism | Urokinase-Type Plasminogen Activator - metabolism | Cell Line, Tumor | Phenylenediamines - pharmacology | Neoplasms - pathology | Matrix Metalloproteinase 9 | Mucin-1 - genetics | Mucin 1, Cell Surface Associated (MUC1) | NF-κB Transcription Factor | Glycobiology and Extracellular Matrices
Journal Article
Epilepsia, ISSN 0013-9580, 09/2017, Volume 58, Issue 9, pp. 1615 - 1625
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 06/2009, Volume 107, Issue 3, pp. 516 - 527
3,3′‐Diindolylmethane (DIM) has been studied for its putative anti‐cancer properties, especially against prostate cancer; however, its exact mechanism of... 
PC3 | prostate cancer | 3,3′‐diindolylmethane | VEGF | uPA | migration | MMP‐9 | Migration | 3,3′-diindolylmethane | MMP-9 | Prostate cancer | MIGRATION | APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | CYCLE ARREST | PLASMINOGEN-ACTIVATOR RECEPTOR | CELL BIOLOGY | PROSTATE CANCER | 3,3 '-DIINDOLYLMETHANE | CDNA MICROARRAY ANALYSIS | IN-VIVO | GENE-EXPRESSION | UROKINASE RECEPTOR | NF-KAPPA-B | TUMOR-GROWTH | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Urokinase-Type Plasminogen Activator - antagonists & inhibitors | Humans | Gene Silencing | Male | Vascular Endothelial Growth Factor A - metabolism | Urokinase-Type Plasminogen Activator - genetics | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | Receptors, Urokinase Plasminogen Activator - metabolism | Cell Movement - drug effects | Matrix Metalloproteinase 9 - metabolism | Transfection | Urokinase-Type Plasminogen Activator - metabolism | Indoles - pharmacology | Cell Proliferation - drug effects | Receptors, Urokinase Plasminogen Activator - genetics | Anticarcinogenic Agents - pharmacology | Apoptosis | Angiogenesis | Overexpression | Secretion | Data processing | Tumorigenicity | siRNA | Vascular endothelial growth factor | Cell migration | Gelatinase B | Metastases | 3, 3'-Diindolylmethane
Journal Article
Amino Acids, ISSN 0939-4451, 12/2014, Volume 46, Issue 12, pp. 2809 - 2822
Metformin has been shown to exert anti-cancer activities in several cancer cells and animal models. However, the molecular mechanisms of its anti-metastatic... 
Biochemistry, general | Migration | Neurobiology | uPA | Hepatocellular carcinoma cells | Invasion | Life Sciences | Analytical Chemistry | Life Sciences, general | Sorafenib | Biochemical Engineering | Proteomics | Metformin | MMP-9 | TUMOR INVASION | ACTIVATION | METASTASIS | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATRIX METALLOPROTEINASE-2 | DIABETIC-PATIENTS | LIVER-CANCER | BREAST-CANCER CELLS | IN-VITRO | GROWTH | Niacinamide - analogs & derivatives | Humans | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Matrix Metalloproteinase 9 - metabolism | Carcinoma, Hepatocellular - drug therapy | MAP Kinase Kinase 4 - metabolism | Matrix Metalloproteinase 9 - genetics | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Gene Expression Regulation, Neoplastic - drug effects | Liver Neoplasms - genetics | Neoplasm Invasiveness | Metformin - pharmacology | Liver Neoplasms - drug therapy | Urokinase-Type Plasminogen Activator - genetics | Cell Movement - drug effects | NF-kappa B - genetics | Signal Transduction - drug effects | Urokinase-Type Plasminogen Activator - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Carcinoma, Hepatocellular - metabolism | Human | Retarding | Inhibitors | Pathways | Blocking | Amino acids
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