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NATURE, ISSN 0028-0836, 11/2015, Volume 527, Issue 7577, pp. 249 - 249
Epigenetic silencing including histone modifications and DNA methylation is an important tumorigenic mechanism(1). However, its role in cancer immunopathology... 
SURVIVAL | INHIBITION | MULTIDISCIPLINARY SCIENCES | UTX | DEATH | MODEL | BLOCKADE | CANCER | T-CELLS | EZH2
Journal Article
BLOOD, ISSN 0006-4971, 10/2015, Volume 126, Issue 15, pp. 1741 - 1752
Angioimmunoblastic T-cell lymphoma (AITL) is a common subtype of peripheral T-cell lymphoma (PTCL) with a poor prognosis. We performed targeted resequencing on... 
IDH2 MUTATIONS | FREQUENT | LANDSCAPE | TET2 | UTX | ACUTE MYELOID-LEUKEMIA | HEMATOLOGY | ONCOMETABOLITE 2-HYDROXYGLUTARATE | RHOA | FOLLICULAR HELPER-CELLS
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 3, pp. 628 - 640
Loss or inactivation of the histone H3K27 demethylase occurs in several malignancies, including multiple myeloma (MM). Using an isogenic cell system, we found... 
multiple myeloma | BCL6 | PRC2 | IRF4 | epigenetic regulator | UTX | EZH2 inhibitors | KDM6A | H3K27me3 | HISTONE H3 | ACUTE LYMPHOBLASTIC-LEUKEMIA | GROWTH | TUMOR-SUPPRESSOR | LYMPHOMA | METHYLTRANSFERASE EZH2 | EXPRESSION | CANCER | SOMATIC MUTATIONS | DEMETHYLASE UTX | CELL BIOLOGY | Multiple Myeloma
Journal Article
Journal of Neurosurgery, ISSN 0022-3085, 05/2017, Volume 126, Issue 5, pp. 1461 - 1471
OBJECTIVE The purpose of the present study was to investigate the epigenetic and prognostic roles of an H3K4 methyltransferase (mixed lineage leukemia 4... 
UTX - MLL4 complex | Prognosis | O-6-methyl guanine methyltransferase | Glioblastoma | Oncology | Epigenome | Survival | CANCER-CELLS | SURGERY | epigenome | survival | UTX-MLL4 complex | prognosis | oncology | CELL CARCINOMA | CLINICAL NEUROLOGY | TEMOZOLOMIDE | glioblastoma | HUMAN GENOME
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 04/2018, Volume 97, pp. 78 - 82
The X-linked histone demethylase UTX has a pivotal role in cellular and developmental processes including embryogenesis, hematopoiesis and cancer. UTX removes... 
Demethylase-independent | NLS | UTX | Demethylase | UTY | Histone | Localization | JMJD3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYCOMB | CANCER | H3K27ME3 DEMETHYLASE UTX | CELL BIOLOGY | EMBRYONIC STEM-CELLS | DIFFERENTIATION | PROTEINS | EXPRESSION
Journal Article
Genes and Development, ISSN 0890-9369, 03/2016, Volume 30, Issue 5, pp. 508 - 521
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2017, Volume 67, Issue 2, pp. 308 - 321.e6
Journal Article
Oncotarget, ISSN 1949-2553, 09/2017, Volume 8, Issue 37, pp. 62131 - 62142
Androgen receptor (AR) mediates initiation and progression of prostate cancer (PCa); AR-driven transcription is activated by binding of androgens to the... 
GSK-J4 | H3K27Me2/3 | Cabazitaxel | Castration resistant prostate cancer | JMJD3/UTX | ANDROGEN RECEPTOR | ACTIVATION | VARIANTS | castration resistant prostate cancer | HISTONE DEMETHYLASES | OPEN-LABEL | COMBINATION | PACLITAXEL | CELL BIOLOGY | TRIAL | EXPRESSION
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 43, pp. E9046 - E9055
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 06/2019, Volume 476, Issue 12, pp. 1741 - 1751
Podocytes are terminally differentiated and highly specialized glomerular cells, which have an essential role as a filtration barrier against proteinuria.... 
JMJD3 | NEPHRIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | UTX | EXPRESSION | CELL BIOLOGY | INSIGHTS
Journal Article
Molecular therapy : the journal of the American Society of Gene Therapy, ISSN 1525-0016, 08/2019
The regeneration of the blood vessel system post spinal cord injury (SCI) is essential for the repair of neurological function. As a significant means to... 
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2019, Volume 202, Issue 4, pp. 1088 - 1098
Although the methylation status of histone H3K27 plays a critical role in CD4(+) T cell differentiation and its function, the role of Utx histone H3K27... 
EFFECTOR | JMJD3 | IMMUNITY | CHROMATIN | TRANSCRIPTIONAL CONTROL | UTX | INFECTION | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | PLASTICITY
Journal Article