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1. Full Text Correlating kinetic and structural data on ubiquinone binding and reduction by respiratory complex I
by Fedor, Justin G and Jones, Andrew J. Y and Di Luca, Andrea and Kaila, Ville R. I and Hirst, Judy
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 48, pp. 12737 - 12742
Respiratory complex I (NADH: ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in mammalian cells, powers ATP synthesis by using the energy... 
Electron transport chain | NADH:ubiquinone oxidoreductase | Mitochondria | Bioenergetics | Coenzyme Q10 | SUBMITOCHONDRIAL PARTICLES | coenzyme Q10 | electron transport chain | ALTERNATIVE OXIDASE | mitochondria | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | CHAIN | NADH | bioenergetics | ESCHERICHIA-COLI NDH-1 | BEEF-HEART | COENZYME-Q | HEART-MITOCHONDRIA | LIPID-BILAYER | Proteolipids - metabolism | Substrate Specificity | Ubiquinone - metabolism | Electron Transport Complex I - metabolism | Oxidoreductases - chemistry | Terpenes - chemistry | Thermodynamics | Terpenes - metabolism | Cattle | Electron Transport Complex I - genetics | Swine | Protein Interaction Domains and Motifs | Binding Sites | Recombinant Proteins - metabolism | Thermus thermophilus - enzymology | Gene Expression | Mitochondria, Heart - chemistry | Thermus thermophilus - chemistry | Biocatalysis | Oxidoreductases - metabolism | Protein Structure, Secondary | Oxidoreductases - genetics | Ubiquinone - analogs & derivatives | Mitochondria, Heart - enzymology | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Static Electricity | Amino Acid Motifs | Electron Transport Complex I - chemistry | Animals | Hydrophobic and Hydrophilic Interactions | Protein Binding | Kinetics | Ubiquinone - chemistry | Proteolipids - chemistry | Physiological aspects | Ubiquinones | Genetic aspects | Oxidoreductases | Research | Protons | Energy use | Oxidoreductase | Electron transfer | Quinol oxidase | Hydrophobicity | Mammalian cells | Quinones | Ubiquinol | Ubiquinone | Energy | Energy conversion | Reaction kinetics | Ubiquinone oxidoreductase | Catalysis | Quinol | Adenosine triphosphate | Translocation | NADH-ubiquinone oxidoreductase | Travel time | Quinone | Cells | Correlation analysis | Nicotinamide adenine dinucleotide | Ubiquinone-10 | Energy of dissociation | Terpenes | Binding sites | Index Medicus | Biological Sciences
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2. Full Text ADCK4 mutations promote steroid-Resistant nephrotic syndrome through CoQ10 biosynthesis disruption
by Ashraf, Shazia and Gee, Heon Yung and Woerner, Stephanie and Xie, Letian X and Vega-Warner, Virginia and Lovric, Svjetlana and Fang, Humphrey and Song, Xuewen and Cattran, Daniel C and Avila-Casado, Carmen and Paterson, Andrew D and Nitschké, Patrick and Bole-Feysot, Christine and Cochat, Pierre and Esteve-Rudd, Julian and Haberberger, Birgit and Allen, Susan J and Zhou, Weibin and Airik, Rannar and Otto, Edgar A and Barua, Moumita and Al-Hamed, Mohamed H and Kari, Jameela A and Evans, Jonathan and Bierzynska, Agnieszka and Saleem, Moin A and Böckenhauer, Detlef and Kleta, Robert and Desoky, Sherif El and Hacihamdioglu, Duygu O and Gok, Faysal and Washburn, Joseph and Wiggins, Roger C and Choi, Murim and Lifton, Richard P and Levy, Shawn and Han, Zhe and Salviati, Leonardo and Prokisch, Holger and Williams, David S and Pollak, Martin and Clarke, Catherine F and Pei, York and Antignac, Corinne and Hildebrandt, Friedhelm
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5179 - 5189
Identification of single-gene causes of steroid-resistant nephrotic syndrome (SRNS) has furthered the understanding of the pathogenesis of this disease. Here,... 
Protein Kinases - genetics | Humans | Nephrotic Syndrome - metabolism | Molecular Sequence Data | Ubiquinone - metabolism | Nephrotic Syndrome - genetics | Nephrotic Syndrome - drug therapy | Adrenal Cortex Hormones - therapeutic use | Zebrafish - embryology | Gene Knockdown Techniques | Ubiquinone - biosynthesis | Young Adult | DNA Mutational Analysis | Conserved Sequence | Ubiquinone - therapeutic use | Protein Kinases - deficiency | Child | Drosophila Proteins - antagonists & inhibitors | Drug Resistance | Disease Models, Animal | Fibroblasts - metabolism | Amino Acid Sequence | Podocytes - metabolism | Ubiquinone - analogs & derivatives | Zebrafish Proteins - antagonists & inhibitors | Cells, Cultured | Adrenal Cortex Hormones - pharmacology | Nephrotic Syndrome - pathology | Rats | Ubiquinone - antagonists & inhibitors | Zebrafish - genetics | Sequence Homology, Amino Acid | Exome - genetics | Podocytes - ultrastructure | Sequence Alignment | Animals | Protein Kinases - physiology | Adolescent | Consanguinity | Drosophila Proteins - genetics | Mutation | Zebrafish Proteins - genetics | Mitochondria - physiology | Biosynthesis | Nephrotic syndrome | Genetic aspects | Research | Gene mutations | Index Medicus | Abridged Index Medicus
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3. Full Text Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants
by He, Cuiwen H and Xie, Letian X and Allan, Christopher M and Tran, UyenPhuong C and Clarke, Catherine F
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 04/2014, Volume 1841, Issue 4, pp. 630 - 644
Coenzyme Q biosynthesis in yeast requires a multi-subunit Coq polypeptide complex. Deletion of any one of the genes leads to respiratory deficiency and... 
Q-biosynthetic intermediate | Mitochondrial metabolism | Protein complex | Coenzyme Q supplementation | Ubiquinone | Saccharomyces cerevisiae | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIIRON CARBOXYLATE PROTEINS | Q DEFICIENCY | O-METHYLTRANSFERASE STEPS | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | Q BIOSYNTHESIS | BIOPHYSICS | DIPHOSPHATE SYNTHASE | PARA-AMINOBENZOIC ACID | UBIQUINONE BIOSYNTHESIS | MITOCHONDRIAL INTERMEMBRANE SPACE | GENETIC-EVIDENCE | Gene Expression Regulation, Fungal | Methyltransferases - chemistry | Saccharomyces cerevisiae - genetics | Methyltransferases - metabolism | Multiprotein Complexes | Methyltransferases - genetics | Ubiquinone - metabolism | Mitochondrial Proteins - genetics | Ubiquinone - genetics | Saccharomyces cerevisiae Proteins - genetics | Ubiquinone - biosynthesis | Mitochondrial Proteins - metabolism | Mitochondrial Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Respiration - genetics | Mutation | Dietary Supplements | Ubiquinone - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Enzymes | Analysis | Mitochondrial DNA
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4. Biomedical and clinical aspects of coenzyme Q, volume 3
: proceedings of the third International Symposium on Coenzyme Q, held in Austin, Texas, U.S.A., January 18-21, 1981
by Folkers, K. (Karl August) and Yamamura, Yūichi, 1918
1981, ISBN 044480319X, xv, 414
Ubiquinones | Ubiquinone | Congresses | Therapeutic use
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5. Full Text Secondary coenzyme Q10 deficiency and oxidative stress in cultured fibroblasts from patients with riboflavin responsive multiple Acyl-CoA dehydrogenation deficiency
by Cornelius, Nanna and Byron, Colleen and Hargreaves, Iain and Guerra, Paula Fernandez and Furdek, Andrea K and Land, John and Radford, Weston W and Frerman, Frank and Corydon, Thomas J and Gregersen, Niels and Olsen, Rikke K.J
Human Molecular Genetics, ISSN 0964-6906, 10/2013, Volume 22, Issue 19, pp. 3819 - 3827
Coenzyme Q10 (CoQ10) is essential for the energy production of the cells and as an electron transporter in the mitochondrial respiratory chain. CoQ10 links the... 
FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE | SUPPLEMENTATION | ELECTRON-TRANSFER | FIBROMYALGIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | MITOCHONDRIAL DYSFUNCTION | COQ DEFICIENCIES | Q DEFICIENCY | ETFDH MUTATIONS | CORONARY-ARTERY-DISEASE | CELL-DEATH | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Ubiquinone - deficiency | Mitochondrial Diseases - metabolism | Iron-Sulfur Proteins - genetics | Ubiquinone - metabolism | Multiple Acyl Coenzyme A Dehydrogenase Deficiency - complications | Riboflavin - pharmacology | Multiple Acyl Coenzyme A Dehydrogenase Deficiency - drug therapy | Ubiquinone - pharmacology | Genetic Variation | Riboflavin - metabolism | Oxidation-Reduction - drug effects | Rhodobacter sphaeroides - metabolism | Ubiquinone - therapeutic use | Rhodobacter sphaeroides - genetics | Multiple Acyl Coenzyme A Dehydrogenase Deficiency - metabolism | Acyl Coenzyme A - metabolism | Ataxia - metabolism | Fibroblasts - metabolism | Electron-Transferring Flavoproteins - genetics | Ubiquinone - analogs & derivatives | Bacterial Proteins - genetics | Cells, Cultured | Oxidoreductases Acting on CH-NH Group Donors - genetics | Mitochondria - metabolism | Oxidoreductases Acting on CH-NH Group Donors - metabolism | Electron-Transferring Flavoproteins - metabolism | Muscle Weakness - metabolism | Bacterial Proteins - metabolism | Iron-Sulfur Proteins - metabolism | Index Medicus | Amino acids
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6. Full Text Clinical syndromes associated with Coenzyme Q 10 deficiency
by Alcázar-Fabra, María and Trevisson, Eva and Brea-Calvo, Gloria
Essays in Biochemistry, ISSN 0071-1365, 07/2018, Volume 62, Issue 3, pp. 377 - 398
Primary Coenzyme Q deficiencies represent a group of rare conditions caused by mutations in one of the genes required in its biosynthetic pathway at the... 
Mitochondrial Diseases - genetics | Ataxia - physiopathology | Ataxia - therapy | Muscle Weakness - diagnosis | Humans | Ubiquinone - analogs & derivatives | Ubiquinone - deficiency | Genotype | Structure-Activity Relationship | Ubiquinone - genetics | Ataxia - diagnosis | Muscle Weakness - genetics | Syndrome | Ubiquinone - biosynthesis | Phenotype | Ubiquinone - physiology | Mitochondrial Diseases - therapy | Muscle Weakness - physiopathology | Muscle Weakness - therapy | Mutation | Ataxia - genetics | Mitochondrial Diseases - physiopathology | Mitochondrial Diseases - diagnosis | Ubiquinone - chemistry
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7. Full Text Bypassing human CoQ 10 deficiency
by Herebian, Diran and López, Luis C and Distelmaier, Felix
Molecular genetics and metabolism, ISSN 1096-7192, 03/2018, Volume 123, Issue 3, pp. 289 - 291
Primary disorders of the human coenzyme Q (CoQ ) biosynthesis pathway are a known cause of severe pediatric diseases. So far, oral administration of CoQ is the... 
Mitochondrial Diseases - pathology | Apoptosis - drug effects | Humans | Ubiquinone - deficiency | Cytochrome P-450 Enzyme System - metabolism | Ubiquinone - metabolism | Muscle Weakness - genetics | Pyrimidines - metabolism | Ubiquinone - biosynthesis | Hydroxybenzoates - pharmacology | Biosynthetic Pathways - genetics | Muscle Weakness - pathology | Ataxia - drug therapy | Ubiquinone - therapeutic use | Hydroxybenzoates - therapeutic use | Ataxia - genetics | Ataxia - pathology | Disease Models, Animal | Mitochondrial Diseases - genetics | Mitochondrial Diseases - drug therapy | Ubiquinone - analogs & derivatives | Solubility | Treatment Outcome | Mitochondria - metabolism | Ubiquinone - genetics | Vitamins - therapeutic use | Animals | Biosynthetic Pathways - drug effects | Muscle Weakness - drug therapy | Cytochrome P-450 Enzyme System - genetics | Mice
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8. Full Text Effect of Coenzyme Q10 on Myopathic Symptoms in Patients Treated With Statins
by Caso, Giuseppe, MD, MSc, PhD and Kelly, Patricia, DO and McNurlan, Margaret A., PhD and Lawson, William E., MD
American Journal of Cardiology, The, ISSN 0002-9149, 2007, Volume 99, Issue 10, pp. 1409 - 1412
Treatment of hypercholesterolemia with statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) is effective in the primary and secondary... 
Cardiovascular | LIPID-LOWERING DRUGS | CARDIAC & CARDIOVASCULAR SYSTEMS | COA REDUCTASE INHIBITORS | SERUM UBIQUINONE | PAIN | Q LEVEL | MUSCLE | HUMANS | DECREASES | ATORVASTATIN | BLOOD | Coenzymes - pharmacology | Coenzymes - drug effects | Humans | Middle Aged | Male | Pain - chemically induced | Hypercholesterolemia - drug therapy | Vitamins - pharmacology | Ubiquinone - pharmacology | Activities of Daily Living | Muscular Diseases - physiopathology | Pain - drug therapy | Muscular Diseases - drug therapy | Vitamin E - therapeutic use | Ubiquinone - therapeutic use | Cholesterol, LDL - blood | Female | Surveys and Questionnaires | Muscular Diseases - chemically induced | Severity of Illness Index | Creatine Kinase - blood | Double-Blind Method | Ubiquinone - analogs & derivatives | Cholesterol, LDL - drug effects | Treatment Outcome | Biomarkers - blood | Coenzymes - therapeutic use | Vitamins - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Pain - physiopathology | Ubiquinone - drug effects | Triglycerides - blood | Creatine Kinase - drug effects | Aged | Patient Compliance | Pain Measurement | Enzymes | Care and treatment | Hypercholesterolemia | Statins | Cardiovascular agents | Index Medicus | Abridged Index Medicus
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9. Full Text Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency
by Salviati, Leonardo and Trevisson, Eva and Rodriguez Hernandez, Maria Angeles and Casarin, Alberto and Pertegato, Vanessa and Doimo, Mara and Cassina, Matteo and Agosto, Caterina and Desbats, Maria Andrea and Sartori, Geppo and Sacconi, Sabrina and Memo, Luigi and Zuffardi, Orsetta and Artuch, Rafael and Quinzii, Catarina and DiMauro, Salvatore and Hirano, Michio and Santos-Ocaña, Carlos and Navas, Plácido
Journal of Medical Genetics, ISSN 0022-2593, 03/2012, Volume 49, Issue 3, pp. 187 - 191
BackgroundCOQ4 encodes a protein that organises the multienzyme complex for the synthesis of coenzyme Q10 (CoQ10). A 3.9 Mb deletion of chromosome 9q34.13 was... 
Electron Transport | Fibroblasts - enzymology | Saccharomyces cerevisiae - genetics | Humans | Ubiquinone - analogs & derivatives | Ubiquinone - deficiency | Child, Preschool | Male | Abnormalities, Multiple - drug therapy | Mitochondrial Proteins - genetics | Haploinsufficiency | Ubiquinone - pharmacology | Comparative Genomic Hybridization | Mitochondrial Proteins - metabolism | Electron Transport Chain Complex Proteins - metabolism | Abnormalities, Multiple - enzymology | Saccharomyces cerevisiae - enzymology | Ubiquinone - therapeutic use | Transcription, Genetic | Cell Proliferation - drug effects | HeLa Cells | Abnormalities, Multiple - genetics | Fibroblasts - metabolism | Yeast | Dehydrogenases | Genes | Fibroblasts | Ataxia | Skin | Mutation | Bioavailability | Chromosomes | Patients | Deoxyribonucleic acid--DNA | Index Medicus | Cell Proliferation | Abnormalities, Multiple | Mitochondrial Proteins | Life Sciences | Ubiquinone | Development Biology | Saccharomyces cerevisiae | Electron Transport Chain Complex Proteins
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10. Full Text ADCK3, an Ancestral Kinase, Is Mutated in a Form of Recessive Ataxia Associated with Coenzyme Q10 Deficiency
by Lagier-Tourenne, Clotilde and Tazir, Meriem and López, Luis Carlos and Quinzii, Catarina M and Assoum, Mirna and Drouot, Nathalie and Busso, Cleverson and Makri, Samira and Ali-Pacha, Lamia and Benhassine, Traki and Anheim, Mathieu and Lynch, David R and Thibault, Christelle and Plewniak, Frédéric and Bianchetti, Laurent and Tranchant, Christine and Poch, Olivier and DiMauro, Salvatore and Mandel, Jean-Louis and Barros, Mario H and Hirano, Michio and Koenig, Michel
American Journal of Human Genetics, ISSN 0002-9297, 03/2008, Volume 82, Issue 3, pp. 661 - 672
Muscle coenzyme Q (CoQ or ubiquinone) deficiency has been identified in more than 20 patients with presumed autosomal-recessive ataxia. However, mutations in... 
Amino Acid Sequence | Humans | Ubiquinone - analogs & derivatives | Ubiquinone - deficiency | Molecular Sequence Data | Male | Ubiquinone - genetics | Genes, Recessive | Sequence Analysis, DNA | Magnetic Resonance Imaging | Yeasts - genetics | Cerebellar Ataxia - genetics | Pedigree | Brain - pathology | Coenzymes - deficiency | Female | Mutation | Cerebellar Ataxia - enzymology | Phosphotransferases - genetics | Index Medicus | Brain | Yeasts | Coenzymes | Biochemistry, Molecular Biology | Life Sciences | Ubiquinone | Molecular biology | Phosphotransferases | Cerebellar Ataxia
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11. Full Text Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation
by Gomez, Fernando and Saiki, Ryoichi and Chin, Randall and Srinivasan, Chandra and Clarke, Catherine F
Gene, ISSN 0378-1119, 09/2012, Volume 506, Issue 1, pp. 106 - 116
Coenzyme Q (ubiquinone or Q) is an essential lipid component of the mitochondrial electron transport chain. In Q biosynthesis involves at least nine steps,... 
Mitochondria | Ubiquinone | Fertility | Operon | Dietary supplements | Methyltransferase | LIFE-SPAN | CLK-1 MUTANTS | MITOCHONDRIAL | SACCHAROMYCES-CEREVISIAE | DEFICIENCY | YEAST | GENE | COMPLEMENTATION | GENETICS & HEREDITY | PARA-AMINOBENZOIC ACID | UBIQUINONE BIOSYNTHESIS | DNA, Helminth - genetics | Sequence Deletion | Methyltransferases - metabolism | Ubiquinone - deficiency | Genes, Helminth | Methyltransferases - genetics | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Ubiquinone - metabolism | Male | Genetic Complementation Test | Fertility - physiology | Ubiquinone - biosynthesis | Fertility - genetics | Base Sequence | Escherichia coli - metabolism | Female | Recombinant Proteins - metabolism | Amino Acid Sequence | Ubiquinone - administration & dosage | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - genetics | Escherichia coli Proteins - metabolism | Recombinant Proteins - genetics | Ubiquinone - genetics | Sequence Homology, Amino Acid | Homozygote | Phenotype | Animals | Caenorhabditis elegans - drug effects | Escherichia coli - genetics | Models, Biological | Escherichia coli Proteins - genetics | Mutation | Caenorhabditis elegans Proteins - genetics | Purines | Caenorhabditis elegans | Enzymes | Analysis | Physiological aspects | Mitochondrial DNA | Chromosomes | Index Medicus | ubiquinone | dietary supplements | methyltransferase | mitochondria | operon | fertility
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12. Full Text Further phenotypic heterogeneity of CoQ10 deficiency associated with steroid resistant nephrotic syndrome and novel COQ2 and COQ6 variants
by Gigante, M and Diella, S and Santangelo, L and Trevisson, E and Acosta, M.J and Amatruda, M and Finzi, G and Caridi, G and Murer, L and Accetturo, M and Ranieri, E and Ghiggeri, G.M and Giordano, M and Grandaliano, G and Salviati, L and Gesualdo, L
Clinical Genetics, ISSN 0009-9163, 08/2017, Volume 92, Issue 2, pp. 224 - 226
GENETICS & HEREDITY | Nephrotic syndrome | Nucleotide sequencing | DNA sequencing | Index Medicus
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13. Full Text Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems
by Balakrishnan, Prabagar and Lee, Beom-Jin and Oh, Dong Hoon and Kim, Jong Oh and Lee, Young-Im and Kim, Dae-Duk and Jee, Jun-Pil and Lee, Yong-Bok and Woo, Jong Soo and Yong, Chul Soon and Choi, Han-Gon
International Journal of Pharmaceutics, ISSN 0378-5173, 06/2009, Volume 374, Issue 1-2, pp. 66 - 72
To enhance the solubility and bioavailability of poorly water-soluble Coenzyme Q (CoQ ), self-emulsifying drug delivery system (SEDDS) composed of oil,... 
Coenzyme Q | Bioavailability | Self-emulsifying drug delivery system | Solubility | Glycerides - chemistry | Ubiquinone - administration & dosage | Emulsions | Ubiquinone - pharmacokinetics | Administration, Oral | Area Under Curve | Ubiquinone - analogs & derivatives | Vitamins - chemistry | Organic Chemicals - chemistry | Rats | Biological Availability | Male | Polyethylene Glycols - chemistry | Phase Transition | Rats, Sprague-Dawley | Drug Delivery Systems | Particle Size | Vitamins - pharmacokinetics | Animals | Surface-Active Agents - chemistry | Oils - chemistry | Ubiquinone - chemistry | Vitamins - administration & dosage | Index Medicus
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14. Full Text Enhancement of solubility and dissolution of Coenzyme Q10 using solid dispersion formulation
by Nepal, Pushp R and Han, Hyo-Kyung and Choi, Hoo-Kyun
International Journal of Pharmaceutics, ISSN 0378-5173, 01/2010, Volume 383, Issue 1-2, pp. 147 - 153
This study aimed to develop a stable solid dispersion of Coenzyme Q (CoQ ) with high aqueous solubility and dissolution rate. Among various carriers screened,... 
Melting method | Coenzyme Q | Solid dispersion | 200 | Poloxamer 407 | Aerosil | Poloxamer - chemistry | Drug Carriers - metabolism | Microscopy, Electron, Scanning | Chemistry, Pharmaceutical - methods | Ubiquinone - analogs & derivatives | Enzyme Stability | Solubility | Ubiquinone - metabolism | Ubiquinone - chemical synthesis | Drug Carriers - chemical synthesis | Drug Carriers - chemistry | Poloxamer - metabolism | Ubiquinone - ultrastructure | Ubiquinone - chemistry | Index Medicus
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15. Full Text Coenzyme Q 10 deficiencies: pathways in yeast and humans
by Awad, Agape M and Bradley, Michelle C and Fernández-Del-Río, Lucía and Nag, Anish and Tsui, Hui S and Clarke, Catherine F
Essays in biochemistry, ISSN 0071-1365, 07/2018, Volume 62, Issue 3, pp. 361 - 376
Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial respiratory electron transport and serves as an important antioxidant.... 
Saccharomyces cerevisiae - genetics | Humans | Ubiquinone - deficiency | Mitochondrial Diseases - metabolism | Ubiquinone - metabolism | Mitochondrial Proteins - genetics | Muscle Weakness - genetics | Ubiquinone - biosynthesis | Saccharomyces cerevisiae - metabolism | Parabens - metabolism | Mitochondrial Proteins - metabolism | Ataxia - drug therapy | Ubiquinone - therapeutic use | Genes, Fungal | Ataxia - genetics | Ataxia - metabolism | Mitochondrial Diseases - genetics | Mitochondrial Diseases - drug therapy | Ubiquinone - analogs & derivatives | Ubiquinone - genetics | Saccharomyces cerevisiae Proteins - genetics | Models, Biological | Muscle Weakness - drug therapy | Muscle Weakness - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Mutation | Genome, Human
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