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Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7343, pp. 361 - 365
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus... 
HIV-1 | CYCLOPHILIN-A | UNANCHORED POLYUBIQUITIN CHAINS | TRIM5-ALPHA PROTEIN | RECOGNITION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | INFECTION | RESTRICTION | Capsid - chemistry | Receptors, Pattern Recognition - immunology | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | Lipopolysaccharides - immunology | Transcription Factor AP-1 - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | HIV-1 - chemistry | HEK293 Cells | Carrier Proteins - immunology | Cell Line | Retroviridae - chemistry | Ubiquitin-Protein Ligases - metabolism | Retroviridae - immunology | MAP Kinase Kinase Kinases - metabolism | Transcription Factors - metabolism | Capsid - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | HIV-1 - immunology | Carrier Proteins - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Protein Binding | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Signal transduction | Efficiency | RNA polymerase | Pattern recognition | Kinases | Evacuations & rescues | Immune system | HIV-1/immunology | Capsid/immunology | Life Sciences | MAP Kinase Kinase Kinases/metabolism | Carrier Proteins/immunology | Immunology | Transcription Factors/metabolism | Capsid/chemistry | HIV-1/chemistry | Ubiquitin/metabolism | Receptors, Pattern Recognition/immunology | Retroviridae/chemistry | Ubiquitin-Protein Ligases/immunology | Ubiquitin-Conjugating Enzymes/metabolism | HumansImmunity, Innate/immunology | Lipopolysaccharides/pharmacology | Signal Transduction/drug effects | Retroviridae/immunology | Transcription Factor AP-1/metabolism | Lipopolysaccharides/immunology | Ubiquitin-Protein Ligases/metabolism | Carrier Proteins/genetics | Signal Transduction/immunology | NF-kappa B/metabolism | Ubiquitin-Protein Ligases/genetics | Carrier Proteins/metabolism | Receptors, Pattern Recognition/metabolism
Journal Article
Journal Article
Current Opinion in Immunology, ISSN 0952-7915, 2011, Volume 23, Issue 5, pp. 564 - 572
Highlights ► Overview of RIG-I mediated signaling to the IFN antiviral response: specificity, complexity and diversity. ► Overview of the recent findings... 
Allergy and Immunology | PROTEIN | VIRUS | RNA | INNATE IMMUNE-RESPONSES | NEGATIVE REGULATION | PEROXISOMAL FISSION | RIG-I | IMMUNOLOGY | NF-KAPPA-B | MAMMALIAN-CELLS | E3 UBIQUITIN LIGASE | RNA Helicases - metabolism | Humans | NF-kappa B - immunology | Endoplasmic Reticulum - metabolism | NF-kappa B - metabolism | Mitochondria - immunology | Interferon Type I - immunology | Interferon-Induced Helicase, IFIH1 | Signal Transduction - immunology | RNA Viruses - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | DEAD-box RNA Helicases - metabolism | RNA Virus Infections - immunology | Transcription Factors - immunology | Mitochondrial Membranes - immunology | Peroxisomes - immunology | Mitochondria - metabolism | RNA Virus Infections - virology | Immunity, Innate | Peroxisomes - metabolism | Mitochondrial Membranes - metabolism | Transcription Factors - metabolism | Apoptosis - immunology | Endoplasmic Reticulum - immunology | DEAD-box RNA Helicases - immunology | RNA, Viral - immunology | RNA Helicases - immunology | Adaptor Proteins, Signal Transducing - metabolism | Mitochondrial DNA | Interferon | Biological response modifiers | Ligases | Pathogens | RNA viruses | Immune response | Phagosomes | Inflammation | adaptor proteins | Infection | Signal transduction | Mitochondria | NF- Kappa B protein | Peroxisomes | Reviews | Endoplasmic reticulum | Apoptosis
Journal Article
PLoS Pathogens, ISSN 1553-7366, 10/2011, Volume 7, Issue 10, p. e1002322
Chikungunya virus (CHIKV) is a re-emerging alphavirus that has caused significant disease in the Indian Ocean region since 2005. During this outbreak, in... 
ACTIVATION | INTERFERON-STIMULATED GENE-15 | REUNION ISLAND | UBIQUITIN-LIKE PROTEIN | MICROBIOLOGY | IDENTIFICATION | ANTIVIRAL MOLECULE | RESPONSES | ENZYME | VIROLOGY | EPIDEMIC | PARASITOLOGY | AGE | Alphavirus Infections - diagnosis | Animals, Newborn | Chikungunya Fever | Ubiquitins - immunology | Cytokines - metabolism | Humans | Mice, Inbred C57BL | Ubiquitin-Activating Enzymes - immunology | Alphavirus Infections - immunology | Interferon Type I - immunology | Ubiquitin-Activating Enzymes - metabolism | Animals | Recombination, Genetic | Alphavirus Infections - metabolism | Interferon Type I - metabolism | Protein Binding | Chikungunya virus - physiology | Mice | Retrospective Studies | Ubiquitins - metabolism | Chikungunya virus - pathogenicity | Cytokines - immunology | Disease Models, Animal | Physiological aspects | Development and progression | Interferon | Chikungunya fever | Immune response | Research | Proteins | Infections | Viral infections | Immune system | Alphavirus Infections/metabolism | Ubiquitin-Activating Enzymes/immunology | Cytokines/immunology | Life Sciences | Alphavirus Infections/immunology | Immunology | Alphavirus Infections/diagnosis | Chikungunya virus/pathogenicity | Interferon Type I/immunology | Ubiquitins/metabolism | Cytokines/metabolism | Chikungunya virus/physiology | Interferon Type I/metabolism | Ubiquitins/immunology | Ubiquitin-Activating Enzymes/metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 50, pp. 36223 - 36229
The Rip2 kinase contains a caspase recruitment domain and has been implicated in the activation of the transcriptional factor NF-κB downstream of Toll-like... 
PEPTIDOGLYCAN | PROTEIN | INNATE IMMUNE-RESPONSES | HOST RECOGNITION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTOR | SYSTEMS | NF-KAPPA-B | TLR4 | MYD88 | Mycobacterium tuberculosis - immunology | Ubiquitin - metabolism | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Ubiquitination - drug effects | TNF Receptor-Associated Factor 6 - genetics | Toll-Like Receptors - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Macrophages - microbiology | MAP Kinase Kinase Kinases - genetics | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Protein Ligases - metabolism | Nod2 Signaling Adaptor Protein - immunology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ubiquitin - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Macrophages - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Toll-Like Receptors - genetics | I-kappa B Kinase - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Adjuvants, Immunologic - pharmacology | NF-kappa B - immunology | TNF Receptor-Associated Factor 6 - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Enzyme Activation - immunology | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | I-kappa B Kinase - metabolism | Myeloid Differentiation Factor 88 - immunology | Ubiquitin-Conjugating Enzymes - immunology | Tuberculosis - metabolism | Macrophages - immunology | Cells, Cultured | Ubiquitination - immunology | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Tuberculosis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | NF-kappa B - genetics | Tuberculosis - genetics | TNF Receptor-Associated Factor 6 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Ubiquitin - immunology
Journal Article
Immunity, ISSN 1074-7613, 07/2013, Volume 39, Issue 1, pp. 111 - 122
Immune cells sense microbial products through Toll-like receptors (TLR), which trigger host defense responses including type 1 interferons (IFNs) secretion. A... 
TUMOR-NECROSIS-FACTOR | ACTIVATION | I INTERFERONS | CHORIOMENINGITIS VIRUS | PROTEIN-TYROSINE PHOSPHATASES | HOST-DEFENSE | MURINE LUPUS | INFLAMMATORY ARTHRITIS | IMMUNOLOGY | NF-KAPPA-B | T-CELLS | Lymphocytic choriomeningitis virus - immunology | Colitis - genetics | Humans | Autoimmunity - genetics | Immunoblotting | Arthritis - genetics | Interferon Type I - immunology | Lymphocytic Choriomeningitis - immunology | Host-Pathogen Interactions - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Autoimmunity - immunology | Myeloid Cells - immunology | TNF Receptor-Associated Factor 3 - genetics | Colitis - chemically induced | HEK293 Cells | Arthritis - immunology | Interferon Type I - metabolism | Lymphocytic choriomeningitis virus - physiology | Toll-Like Receptors - metabolism | Colitis - immunology | Lymphocytic Choriomeningitis - genetics | Cell Line | Lymphocytic Choriomeningitis - virology | Mice, Inbred C57BL | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - metabolism | Toll-Like Receptors - immunology | Cells, Cultured | Immunity - immunology | Mice, Transgenic | TNF Receptor-Associated Factor 3 - metabolism | Ubiquitination - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Animals | Dextran Sulfate - immunology | TNF Receptor-Associated Factor 3 - immunology | Toll-Like Receptors - genetics | Interferon Type I - genetics | Myeloid Cells - metabolism | Mice | Immunity - genetics | Ubiquitin | Autoimmunity | Interferon | Biological response modifiers
Journal Article
Virus Research, ISSN 0168-1702, 2011, Volume 162, Issue 1, pp. 12 - 18
Influenza A and B viruses are a major cause of respiratory disease in humans. In addition, influenza A viruses continuously re-emerge from animal reservoirs... 
Influenza A | Review | Type 1 interferon | Influenza B | DOUBLE-STRANDED-RNA | B VIRUS | A-VIRUS | SENSOR RIG-I | PLASMACYTOID DENDRITIC CELLS | NS1 PROTEIN | ANTIVIRAL RESPONSES | VIROLOGY | STRUCTURAL BASIS | TOLL-LIKE RECEPTORS | INFECTED-CELLS | Antigens, CD - immunology | Ubiquitins - genetics | Virus Replication - genetics | Humans | Viral Proteins - immunology | eIF-2 Kinase - immunology | Interferon Type I - immunology | Antigens, CD - genetics | GTP-Binding Proteins - genetics | Viral Proteins - metabolism | Host-Pathogen Interactions - immunology | Orthomyxoviridae - immunology | Interferon Type I - biosynthesis | Myxovirus Resistance Proteins | Influenza, Human - virology | Cytokines - genetics | Cytokines - immunology | eIF-2 Kinase - genetics | DEAD Box Protein 58 | GPI-Linked Proteins - immunology | Ubiquitins - immunology | GTP-Binding Proteins - immunology | Toll-Like Receptors - immunology | Orthomyxoviridae - metabolism | Viral Proteins - genetics | Virus Replication - immunology | Immunity, Innate | Proteins - immunology | 2',5'-Oligoadenylate Synthetase - genetics | Proteins - genetics | DEAD-box RNA Helicases - genetics | Animals | Immune Evasion | 2',5'-Oligoadenylate Synthetase - immunology | Toll-Like Receptors - genetics | DEAD-box RNA Helicases - immunology | Antigens, Differentiation - genetics | Mice | Antigens, Differentiation - immunology | GPI-Linked Proteins - genetics | Influenza, Human - immunology | Influenza viruses | Interferon | Biological response modifiers | Health aspects | Influenza
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2013, Volume 288, Issue 23, pp. 16225 - 16234
Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate... 
IFN-BETA | CELLS | ACTIVATION | PROTEIN | NEGATIVE REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | DEGRADATION | SEPSIS | TRIGGERED INFLAMMATORY RESPONSES | INNATE IMMUNITY | Interferon-beta - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | Intracellular Signaling Peptides and Proteins - immunology | Male | Monocytes - immunology | Lipopolysaccharides - immunology | Gene Knockdown Techniques | Ubiquitin-Protein Ligases - immunology | Sepsis - pathology | Reactive Oxygen Species - immunology | Monocytes - pathology | Tumor Necrosis Factor-alpha - immunology | Interferon-beta - genetics | Female | Tumor Necrosis Factor alpha-Induced Protein 3 | Hydro-Lyases - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Macrophages - immunology | Immune Tolerance - drug effects | Cysteine Endopeptidases | Sepsis - immunology | DNA-Binding Proteins - immunology | Lipopolysaccharides - toxicity | Histones - immunology | Immunity, Innate - drug effects | Interleukin-6 - genetics | Macrophages - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | DNA-Binding Proteins - genetics | Nuclear Proteins - immunology | Proteins - immunology | Sepsis - genetics | Gene Expression Regulation - drug effects | Proteins - genetics | Animals | Histones - genetics | Interleukin-6 - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Hydro-Lyases - immunology | Toll-like Receptors (TLR) | Immunology | Reactive Oxygen Species (ROS) | Innate Immunity | Endotoxin Tolerance | ROS | Inflammation | Macrophages | A20 | Immune Responsive Gene 1
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2013, Volume 9, Issue 5, p. e1003384
Persistent infection of basal keratinocytes with high-risk human papillomavirus (hrHPV) may cause cancer. Keratinocytes are equipped with different pattern... 
ACTIVATION | VIRUS | MICROBIOLOGY | CERVICAL-CANCER | TYPE-16 | MESSENGER-RNAS | VIROLOGY | E7 ONCOPROTEIN | INFECTION | NF-KAPPA-B | PARASITOLOGY | TERMINAL HYDROLASE L1 | E2 PROTEIN | Keratinocytes - virology | Humans | Uterine Cervical Neoplasms - pathology | Human papillomavirus 16 - immunology | Papillomavirus Infections - pathology | Signal Transduction - immunology | Uterine Cervical Neoplasms - metabolism | Papillomavirus Infections - immunology | Transcription Factor RelA - immunology | Female | Phosphorylation - immunology | Keratinocytes - enzymology | Protein-Serine-Threonine Kinases - metabolism | Cytokines - immunology | Cytokines - metabolism | Papillomavirus Infections - enzymology | Cells, Cultured | Uterine Cervical Neoplasms - immunology | TNF Receptor-Associated Factor 3 - metabolism | Ubiquitination - immunology | Immunity, Innate | Gene Expression Regulation, Viral - immunology | Human papillomavirus 16 - metabolism | Keratinocytes - immunology | Keratinocytes - pathology | Animals | Transcription Factor RelA - metabolism | Up-Regulation - immunology | TNF Receptor-Associated Factor 3 - immunology | Uterine Cervical Neoplasms - virology | Protein-Serine-Threonine Kinases - immunology | Ubiquitin Thiolesterase - biosynthesis | Mice | Gene Expression Regulation, Enzymologic - immunology | Ubiquitin Thiolesterase - immunology | 3T3 Cells | Ubiquitin | Immune response | Keratinocytes | Physiological aspects | Host-parasite relationships | Research | Health aspects | Papillomavirus infections | Proteins | Medical research | Human papillomavirus | Cytokines | Kinases | Immune system
Journal Article
P L o S Biology (Print), ISSN 1544-9173, 01/2014, Volume 12, Issue 1, p. e1001762
textabstractMast cells are implicated in the pathogenesis of inflammatory and autoimmune diseases. However, this notion based on studies in mast cell-deficient... 
CYTOKINE PRODUCTION | DENDRITIC CELLS | AUTOIMMUNITY | ASTHMA MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | INDUCED ARTHRITIS | INTERLEUKIN-33 | MICE | HOUSE-DUST MITE | IL-33 | A20 | Interleukin-1 Receptor-Like 1 Protein | Serum Albumin, Bovine - administration & dosage | Receptors, Interleukin-1 - genetics | Dinitrophenols - administration & dosage | Encephalomyelitis, Autoimmune, Experimental - immunology | Male | Myelin-Oligodendrocyte Glycoprotein - administration & dosage | Intracellular Signaling Peptides and Proteins - deficiency | Interleukins - genetics | Anaphylaxis - chemically induced | Arthritis, Experimental - chemically induced | Pneumonia - immunology | Tumor Necrosis Factor alpha-Induced Protein 3 | Intracellular Signaling Peptides and Proteins - genetics | Cysteine Endopeptidases | Gene Expression | DNA-Binding Proteins - immunology | Receptors, Interleukin - immunology | Interleukin-33 | Toll-Like Receptors - immunology | Anaphylaxis - pathology | Mice, Transgenic | Receptors, Interleukin - genetics | Toll-Like Receptors - genetics | Mice | Pneumonia - metabolism | Ubiquitin-Protein Ligases - genetics | Encephalomyelitis, Autoimmune, Experimental - metabolism | NF-kappa B - immunology | Pneumonia - pathology | Intracellular Signaling Peptides and Proteins - immunology | DNA-Binding Proteins - deficiency | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | Ubiquitin-Protein Ligases - immunology | Immunoglobulin E - immunology | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Immunoglobulin E - genetics | Pneumonia - chemically induced | Interleukins - immunology | Mast Cells - metabolism | Anaphylaxis - immunology | Receptors, IgE - immunology | Lung - metabolism | Collagen Type II - administration & dosage | Mast Cells - immunology | Lung - pathology | Encephalomyelitis, Autoimmune, Experimental - pathology | Receptors, Interleukin-1 - immunology | Peptide Fragments - administration & dosage | Arthritis, Experimental - immunology | Receptors, IgE - genetics | DNA-Binding Proteins - genetics | Animals | NF-kappa B - genetics | Mast Cells - pathology | Ubiquitin-Protein Ligases - deficiency | Anaphylaxis - metabolism | Lung - immunology | Pyroglyphidae - immunology | Antigens | Cytokines | Disease | Arthritis | Grants | Pattern recognition | Gene expression | Kinases | Experiments | Allergies | Asthma | Studies | Histamine | Rodents
Journal Article
Journal Article