X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (51294) 51294
Publication (10376) 10376
Book Review (7924) 7924
Newsletter (630) 630
Book Chapter (561) 561
Conference Proceeding (260) 260
Dissertation (40) 40
Book / eBook (31) 31
Web Resource (14) 14
Reference (9) 9
Magazine Article (8) 8
Streaming Video (8) 8
Newspaper Article (7) 7
Data Set (3) 3
Government Document (1) 1
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (48197) 48197
humans (31452) 31452
animals (25349) 25349
ubiquitin (18431) 18431
biochemistry & molecular biology (16793) 16793
cell biology (14309) 14309
proteins (11703) 11703
mice (11292) 11292
ubiquitin - metabolism (9855) 9855
ubiquitin-protein ligases - metabolism (9370) 9370
ubiquitination (7875) 7875
protein binding (6907) 6907
male (6824) 6824
signal transduction (6764) 6764
degradation (6338) 6338
research (6329) 6329
phosphorylation (6128) 6128
female (6069) 6069
cell line (6004) 6004
mutation (5858) 5858
proteasome endopeptidase complex - metabolism (5714) 5714
amino acid sequence (5706) 5706
ubiquitin-protein ligases - genetics (5663) 5663
molecular sequence data (5632) 5632
article (5546) 5546
proteolysis (5273) 5273
expression (5177) 5177
gene expression (5089) 5089
protein (5024) 5024
apoptosis (4955) 4955
physiological aspects (4924) 4924
cell line, tumor (4708) 4708
cancer (4696) 4696
analysis (4518) 4518
ligases (4303) 4303
multidisciplinary sciences (4182) 4182
ubiquitins - metabolism (3969) 3969
activation (3877) 3877
oncology (3824) 3824
genetic aspects (3714) 3714
cells (3634) 3634
neurosciences (3597) 3597
hela cells (3585) 3585
ubiquitin ligase (3560) 3560
rats (3481) 3481
proteasome (3423) 3423
cells, cultured (3306) 3306
enzymes (3279) 3279
protein structure, tertiary (3267) 3267
research article (3213) 3213
genetics & heredity (3167) 3167
ubiquitin-protein ligases (3133) 3133
ubiquitin-proteasome system (3120) 3120
saccharomyces-cerevisiae (3110) 3110
biology (3093) 3093
dna-binding proteins - metabolism (3093) 3093
cell cycle (2995) 2995
hek293 cells (2940) 2940
nuclear proteins - metabolism (2906) 2906
genes (2902) 2902
models, biological (2874) 2874
gene-expression (2861) 2861
gene (2835) 2835
autophagy (2778) 2778
biophysics (2758) 2758
complex (2718) 2718
gene expression regulation (2714) 2714
transcription factors - metabolism (2703) 2703
molecular biology (2652) 2652
pathway (2639) 2639
cell cycle proteins - metabolism (2603) 2603
transfection (2592) 2592
blotting, western (2503) 2503
oxidative stress (2468) 2468
in-vivo (2466) 2466
biochemistry (2416) 2416
identification (2376) 2376
protein processing, post-translational (2360) 2360
binding sites (2357) 2357
immunohistochemistry (2314) 2314
binding (2305) 2305
proteasome endopeptidase complex (2271) 2271
carrier proteins - metabolism (2259) 2259
middle aged (2249) 2249
kinases (2233) 2233
nf-kappa-b (2209) 2209
proteins - metabolism (2209) 2209
medicine (2183) 2183
down-regulation (2158) 2158
ubiquitin-protein ligase (2136) 2136
health aspects (2111) 2111
models, molecular (2092) 2092
yeast (2081) 2081
saccharomyces cerevisiae proteins - metabolism (2071) 2071
dna damage (2064) 2064
e3 ubiquitin ligase (2060) 2060
mice, inbred c57bl (2056) 2056
mice, knockout (2017) 2017
life sciences (1997) 1997
saccharomyces cerevisiae - metabolism (1991) 1991
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (51520) 51520
Japanese (241) 241
Chinese (174) 174
Russian (48) 48
French (37) 37
Polish (24) 24
German (14) 14
Czech (11) 11
Spanish (8) 8
Hungarian (4) 4
Portuguese (4) 4
Korean (3) 3
Finnish (2) 2
Hebrew (2) 2
Ukrainian (2) 2
Arabic (1) 1
Dutch (1) 1
Malay (1) 1
Romanian (1) 1
Welsh (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Neuroscience, ISSN 1097-6256, 11/2012, Volume 15, Issue 11, pp. 1488 - 1497
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.... 
NEURODEGENERATIVE DISEASE | GENE | AMYOTROPHIC-LATERAL-SCLEROSIS | FAMILY PROTEINS | FUS PATHOLOGY | MUTATIONS | FRONTOTEMPORAL LOBAR DEGENERATION | BINDING | NEUROSCIENCES | BRAIN | NASCENT TRANSCRIPTION | RNA, Small Interfering - genetics | Protein Binding - genetics | Oligonucleotide Array Sequence Analysis | Humans | tau Proteins - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Kv Channel-Interacting Proteins - metabolism | Brain - metabolism | Frontotemporal Dementia - metabolism | RNA Splicing - genetics | Frontotemporal Dementia - genetics | RNA-Binding Protein FUS - deficiency | Amyotrophic Lateral Sclerosis - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | RNA-Binding Protein FUS - genetics | Mice, Knockout | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Shal Potassium Channels - metabolism | Brain - pathology | Mice | Neurofilament Proteins - metabolism | RNA, Small Interfering - metabolism | Immunoprecipitation | Spinal Cord - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | tau Proteins - genetics | Cell Cycle Proteins - genetics | Female | RNA Precursors - metabolism | Excitatory Amino Acid Transporter 2 - genetics | Membrane Proteins - metabolism | Frontotemporal Dementia - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA Precursors - genetics | Protein Structure, Tertiary - genetics | RNA-Binding Protein FUS - metabolism | DNA-Binding Proteins - genetics | Excitatory Amino Acid Transporter 2 - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Neural Cell Adhesion Molecules - metabolism | Neural Stem Cells - metabolism | Cell Line, Transformed | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Messenger RNA | Health aspects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7343, pp. 361 - 365
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus... 
HIV-1 | CYCLOPHILIN-A | UNANCHORED POLYUBIQUITIN CHAINS | TRIM5-ALPHA PROTEIN | RECOGNITION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | INFECTION | RESTRICTION | Capsid - chemistry | Receptors, Pattern Recognition - immunology | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | Lipopolysaccharides - immunology | Transcription Factor AP-1 - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | HIV-1 - chemistry | HEK293 Cells | Carrier Proteins - immunology | Cell Line | Retroviridae - chemistry | Ubiquitin-Protein Ligases - metabolism | Retroviridae - immunology | MAP Kinase Kinase Kinases - metabolism | Transcription Factors - metabolism | Capsid - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | HIV-1 - immunology | Carrier Proteins - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Protein Binding | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Signal transduction | Efficiency | RNA polymerase | Pattern recognition | Kinases | Evacuations & rescues | Immune system | Index Medicus | HIV-1/immunology | Capsid/immunology | Life Sciences | MAP Kinase Kinase Kinases/metabolism | Carrier Proteins/immunology | Immunology | Transcription Factors/metabolism | Capsid/chemistry | HIV-1/chemistry | Ubiquitin/metabolism | Receptors, Pattern Recognition/immunology | Retroviridae/chemistry | Ubiquitin-Protein Ligases/immunology | Ubiquitin-Conjugating Enzymes/metabolism | HumansImmunity, Innate/immunology | Lipopolysaccharides/pharmacology | Signal Transduction/drug effects | Retroviridae/immunology | Transcription Factor AP-1/metabolism | Lipopolysaccharides/immunology | Ubiquitin-Protein Ligases/metabolism | Carrier Proteins/genetics | Signal Transduction/immunology | NF-kappa B/metabolism | Ubiquitin-Protein Ligases/genetics | Carrier Proteins/metabolism | Receptors, Pattern Recognition/metabolism
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 11/2016, Volume 99, Issue 5, pp. 1190 - 1198
Uveal melanoma (UM) is a rare intraocular tumor that, similar to cutaneous melanoma, originates from melanocytes. To gain insights into its genetics, we... 
OCULAR MELANOMA | CELLS | COLORECTAL-CANCER | PROTEINS DLK1 | METASTASES | GENETICS & HEREDITY | RISK | EXPRESSION | RADIATION | SF3B1 | SOMATIC MUTATIONS | Melanoma - diagnosis | Exons | Humans | Middle Aged | Male | Phosphoproteins - metabolism | Case-Control Studies | RNA Splicing Factors - metabolism | DNA Copy Number Variations | Melanoma - genetics | Melanocytes - pathology | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Ubiquitin Thiolesterase - metabolism | Adult | Female | Membrane Proteins - metabolism | Eukaryotic Initiation Factor-1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Uveal Neoplasms - genetics | Genome-Wide Association Study | Tumor Suppressor Proteins - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Tumor Suppressor p53-Binding Protein 1 - genetics | Membrane Proteins - genetics | Eukaryotic Initiation Factor-1 - genetics | Ubiquitin-Protein Ligases - metabolism | GTP-Binding Protein alpha Subunits - genetics | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Ubiquitin Thiolesterase - genetics | Skin Neoplasms | Uveal Neoplasms - diagnosis | Aged | Mutation | Ubiquitin-Protein Ligases - genetics | Genetic aspects | Nucleotide sequencing | Methods | Melanoma | DNA sequencing | Metastasis | Pathogenesis | Genomics | Deoxyribonucleic acid--DNA | Index Medicus | Report
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7413, pp. 665 - 669
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the... 
IN-VITRO | INHIBITION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | UBIQUITYLATION | SMALL-INTESTINE | COLON | BETA-CATENIN | LGR5 | CANCER | NEGATIVE REGULATOR | Oncogene Proteins - genetics | Receptors, Wnt - antagonists & inhibitors | Cell Proliferation | Receptors, G-Protein-Coupled - metabolism | Humans | Ubiquitin - metabolism | Paneth Cells - pathology | Stem Cells - cytology | Receptors, Wnt - metabolism | Stem Cells - metabolism | DNA-Binding Proteins - deficiency | Adenoma - metabolism | DNA-Binding Proteins - metabolism | Endocytosis | Ubiquitination | Lysosomes - metabolism | Stem Cells - enzymology | Tumor Suppressor Proteins - deficiency | Organoids - metabolism | Tumor Suppressor Proteins - genetics | HEK293 Cells | Colorectal Neoplasms - metabolism | Paneth Cells - metabolism | Tumor Suppressor Proteins - metabolism | Organoids - pathology | Oncogene Proteins - metabolism | Organoids - cytology | Ubiquitin-Protein Ligases - metabolism | Frizzled Receptors - metabolism | DNA-Binding Proteins - genetics | beta Catenin - metabolism | Animals | Wnt Signaling Pathway - drug effects | Adenoma - pathology | Ubiquitin-Protein Ligases - deficiency | Oncogene Proteins - deficiency | Mice | Receptors, G-Protein-Coupled - genetics | Colorectal Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Colorectal cancer | Physiological aspects | Development and progression | Research | Gene expression | Risk factors | Proteins | Epidermal growth factor | Mutation | Kinases | Rodents | Stem cells | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7340, pp. 637 - 641
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 05/2012, Volume 112, Issue 9, pp. 1529 - 1537
In this study, the coordinated activation of ubiquitin-proteasome pathway (UPP), autophagy-lysosomal pathway (ALP), and mitochondrial remodeling including... 
Muscle protein degradation | Mitochondrial remodelling | Mitophagy | LC3b | MuRF1 | MAMMALIAN TARGET | mitochondrial remodelling | SPORT SCIENCES | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | muscle protein degradation | EXERCISE-INDUCED MUSCLE | COORDINATE ACTIVATION | FOXO TRANSCRIPTION FACTORS | HUMAN SKELETAL-MUSCLE | MITOCHONDRIAL FISSION | mitophagy | RESISTANCE EXERCISE | GENE-EXPRESSION | C2C12 MYOTUBES | Protein Kinases - metabolism | AMP-Activated Protein Kinases - metabolism | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Middle Aged | Serine | Ubiquitin - metabolism | Male | Physical Endurance | Insulin - blood | Phosphoproteins - metabolism | Autophagy | Tripartite Motif Proteins | Quadriceps Muscle - enzymology | Time Factors | Forkhead Transcription Factors - metabolism | Mitochondrial Proteins - metabolism | Muscle Proteins - metabolism | Adult | Proto-Oncogene Proteins c-akt - metabolism | Quadriceps Muscle - pathology | Autophagy-Related Protein 12 | Mitochondrial Membrane Transport Proteins - metabolism | Mitochondria, Muscle - enzymology | Signal Transduction | Mitochondria, Muscle - pathology | Small Ubiquitin-Related Modifier Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | Energy Intake | GTP Phosphohydrolases - metabolism | Autophagy-Related Protein 5 | Energy Metabolism | Biopsy | Running | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Blood Glucose - metabolism | Forkhead Box Protein O3 | Proteins | Musculoskeletal system | Signal transduction | Physiology | Athletes | Index Medicus
Journal Article
BMC Biology, ISSN 1741-7007, 05/2012, Volume 10, Issue 1, pp. 44 - 44
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 307 - 325
The protein kinase PINK 1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65, and phosphoUb activates the E3 ligase Parkin allosterically. Here, we... 
PINK1 | phosphorylation | deubiquitinase | ubiquitin | Parkin | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | 63-LINKED POLYUBIQUITIN CHAINS | DAMAGED MITOCHONDRIA | CELL BIOLOGY | E3 LIGASE | ACTIVATE PARKIN | BINDING PROTEINS | CROSS-REACTIVITY | CONJUGATING ENZYME | REVEALS | Phosphorylation - physiology | Ubiquitin-Specific Proteases - genetics | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Mitochondrial Proteins - genetics | Phosphoproteins - metabolism | Polyubiquitin - genetics | Allosteric Regulation - physiology | Mitochondrial Proteins - metabolism | Protein Multimerization - physiology | Ubiquitin Thiolesterase - metabolism | TNF Receptor-Associated Factor 6 - genetics | Ubiquitination - physiology | Ubiquitin-Specific Proteases - metabolism | Polyubiquitin - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Serine - genetics | Ubiquitin-Conjugating Enzymes - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Ubiquitin Thiolesterase - genetics | Serine - metabolism | Hydrolysis | Transcription Factors - metabolism | Endopeptidases - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Thiolester Hydrolases - genetics | Thiolester Hydrolases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Enzymes | Phosphorylation | Kinases | Crystal structure | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7340, pp. 591 - 596
Members of the tumour necrosis factor (TNF) receptor superfamily have important functions in immunity and inflammation. Recently linear ubiquitin chains... 
RHEUMATOID-ARTHRITIS | KAPPA-B ACTIVATION | CHRONIC PROLIFERATIVE DERMATITIS | K11-LINKED POLYUBIQUITINATION | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | MICE | CHAINS | TNF | NEMO | MEDIATED REGULATION | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Inflammation - pathology | Skin - cytology | Skin - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Ubiquitin - metabolism | NF-kappa B - metabolism | Tumor Necrosis Factor-alpha - deficiency | Multiprotein Complexes - metabolism | Inflammation - metabolism | Nerve Tissue Proteins - chemistry | Ubiquitination | CD40 Ligand - metabolism | I-kappa B Kinase - metabolism | Interleukin-1beta - metabolism | Carrier Proteins - chemistry | Receptors, Tumor Necrosis Factor - deficiency | Skin - pathology | Receptors, Tumor Necrosis Factor - genetics | Skin - immunology | Receptors, Tumor Necrosis Factor - metabolism | Cell Line | Signal Transduction | Ubiquitin - chemistry | Ubiquitin-Protein Ligases - metabolism | Immunity - immunology | Ubiquitin-Protein Ligases - chemistry | Nerve Tissue Proteins - genetics | Ubiquitin-Protein Ligase Complexes - chemistry | Nerve Tissue Proteins - metabolism | Multiprotein Complexes - chemistry | Phenotype | Animals | Carrier Proteins - metabolism | Ubiquitin-Protein Ligase Complexes - metabolism | Inflammation - prevention & control | Mice | Transcription Factors | Prevention | Tumor necrosis factor | Genes | Physiological aspects | Inflammation | Genetic aspects | Cellular signal transduction | Research | Ubiquitin-proteasome system | Proteins | Mutation | Disease | Apoptosis | Recruitment | Index Medicus
Journal Article