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American journal of human genetics, ISSN 0002-9297, 2016, Volume 99, Issue 5, pp. 1190 - 1198
.... To gain insights into its genetics, we performed whole-genome sequencing at very deep coverage of tumor-control pairs in 33 samples... 
OCULAR MELANOMA | CELLS | COLORECTAL-CANCER | PROTEINS DLK1 | METASTASES | GENETICS & HEREDITY | RISK | EXPRESSION | RADIATION | SF3B1 | SOMATIC MUTATIONS | Melanoma - diagnosis | Exons | Humans | Middle Aged | Male | Phosphoproteins - metabolism | Case-Control Studies | RNA Splicing Factors - metabolism | DNA Copy Number Variations | Melanoma - genetics | Melanocytes - pathology | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Ubiquitin Thiolesterase - metabolism | Adult | Female | Membrane Proteins - metabolism | Eukaryotic Initiation Factor-1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Uveal Neoplasms - genetics | Genome-Wide Association Study | Tumor Suppressor Proteins - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Tumor Suppressor p53-Binding Protein 1 - genetics | Membrane Proteins - genetics | Eukaryotic Initiation Factor-1 - genetics | Ubiquitin-Protein Ligases - metabolism | GTP-Binding Protein alpha Subunits - genetics | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Ubiquitin Thiolesterase - genetics | Skin Neoplasms | Uveal Neoplasms - diagnosis | Aged | Mutation | Ubiquitin-Protein Ligases - genetics | Genetic aspects | Nucleotide sequencing | Methods | Melanoma | DNA sequencing | Report
Journal Article
Journal Article
Nature genetics, ISSN 1546-1718, 2012, Volume 44, Issue 7, pp. 751 - 759
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 11/2010, Volume 30, Issue 21, pp. 5071 - 5085
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
COACTIVATOR | CELL FACTOR-I | BETA-INTERFERON PROMOTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR YY1 | CROSS-LINKING | BRCA1-ASSOCIATED PROTEIN-1 | ASSOCIATION | POLYCOMB | O-GLCNAC TRANSFERASE | HISTONE METHYLTRANSFERASE | CELL BIOLOGY | Cell Proliferation | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Multiprotein Complexes | Transcriptional Activation | Molecular Sequence Data | YY1 Transcription Factor - chemistry | YY1 Transcription Factor - metabolism | Host Cell Factor C1 - metabolism | Ubiquitination | RNA Interference | Cattle | Base Sequence | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Ubiquitin Thiolesterase - metabolism | YY1 Transcription Factor - antagonists & inhibitors | Host Cell Factor C1 - chemistry | Nuclear Proteins - genetics | Host Cell Factor C1 - antagonists & inhibitors | Ubiquitin Thiolesterase - antagonists & inhibitors | Cell Line | Promoter Regions, Genetic | Tumor Suppressor Proteins - metabolism | Signal Transduction | Binding Sites - genetics | DNA - metabolism | Electron Transport Complex IV - genetics | YY1 Transcription Factor - genetics | Ubiquitin Thiolesterase - genetics | Sequence Homology, Nucleic Acid | Host Cell Factor C1 - genetics | DNA - genetics | Animals | Models, Biological | Mice | HeLa Cells | In Vitro Techniques | Ubiquitin Thiolesterase - chemistry
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 465, Issue 7295, pp. 243 - 247
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2012, Volume 337, Issue 6101, pp. 1541 - 1546
De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur... 
Spleen | Myeloid cells | Genes | DNA | REPORTS | Stem cells | Neutrophils | Bone marrow | Bone marrow cells | Genetic mutation | Tumors | ASXL1 | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | LEUKEMIA | UBIQUITIN HYDROLASE | PREDISPOSE | MYELODYSPLASTIC SYNDROMES | Myeloid Cells - cytology | Humans | Leukemia, Myelomonocytic, Chronic - genetics | Myeloid Cells - physiology | Host Cell Factor C1 - metabolism | Leukemia, Myelomonocytic, Chronic - metabolism | Chromatin Immunoprecipitation | Hematopoiesis | Gene Deletion | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Bone Marrow Transplantation | Myeloid Progenitor Cells - cytology | Ubiquitin Thiolesterase - metabolism | Leukemia, Myelomonocytic, Chronic - pathology | Genes, Tumor Suppressor | Repressor Proteins - metabolism | Promoter Regions, Genetic | Myelodysplastic Syndromes - metabolism | Tumor Suppressor Proteins - metabolism | Gene Expression Regulation | Embryonic Development | Ubiquitin Thiolesterase - genetics | N-Acetylglucosaminyltransferases - metabolism | Gene Knock-In Techniques | Mice, Knockout | Animals | Myeloid Progenitor Cells - physiology | Cell Transformation, Neoplastic | Mice | Myelodysplastic Syndromes - genetics | Myelodysplastic Syndromes - pathology | Ubiquitin Thiolesterase - chemistry | Gene silencing | Tumor suppressor genes | Genetic engineering | Research | Properties | Observations | Enzymes | Mutation | Gene expression | Molecular biology | Leukemia
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 1, pp. 105 - 119
Cyclic GMP-AMP synthase (cGAS) is an essential DNA virus sensor that triggers type I interferon (IFN) signaling by producing cGAMP to initiate antiviral... 
cGAS | USP14 | TRIM14 | autophagy | p62 | type I interferon (IFN) signaling | ANTIVIRAL RESPONSE | DNA SENSOR | CYCLIC GMP-AMP | ACTIVATION | SENSOR CGAS | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOSOLIC DNA | SELF-DNA | PATTERN-RECOGNITION RECEPTORS | I INTERFERON | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Herpes Simplex - genetics | Autophagy - drug effects | Lung - virology | Herpesvirus 1, Human - growth & development | Interferon Type I - pharmacology | Ubiquitin Thiolesterase - deficiency | HEK293 Cells | Trans-Activators - genetics | Herpesvirus 1, Human - immunology | Ubiquitin Thiolesterase - antagonists & inhibitors | Trans-Activators - immunology | Herpes Simplex - mortality | Signal Transduction | Immunity, Innate | Ubiquitin Thiolesterase - genetics | Herpes Simplex - immunology | Mice, Knockout | Host-Pathogen Interactions | Sequestosome-1 Protein - immunology | Sequestosome-1 Protein - genetics | Feedback, Physiological | Herpes Simplex - virology | Animals | Lung - drug effects | Survival Analysis | Nucleotidyltransferases - genetics | Mice | Protein Processing, Post-Translational | Nucleotidyltransferases - immunology | Lung - immunology | RNA, Small Interfering - metabolism | Ubiquitin | Epigenetic inheritance | Immune response | Biological control | Disease susceptibility | Pests | Biological response modifiers | Cyclic guanylic acid | Lysine | Genetically modified organisms | Genetic engineering | Interferon | Sensors | Health aspects
Journal Article
Journal of Medical Genetics, ISSN 0022-2593, 12/2011, Volume 48, Issue 12, pp. 856 - 859
ObjectiveTo investigate the potential contribution of germline sequence alterations in the BAP1 gene in uveal melanoma (UM) patients with possible... 
BREAST-CANCER | GENE | HIGH-RISK | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | BRCA1 | UBIQUITIN HYDROLASE | BRCA1-ASSOCIATED PROTEIN-1 | Adenocarcinoma - pathology | Genetic Testing | Adenocarcinoma of Lung | Humans | Lung Neoplasms - metabolism | Middle Aged | Gene Expression Regulation, Neoplastic | Genetic Diseases, Inborn - genetics | Lung Neoplasms - pathology | Male | Meningioma - genetics | Genetic Diseases, Inborn - pathology | Loss of Heterozygosity | Adenocarcinoma - metabolism | DNA Mutational Analysis | Melanoma - genetics | Tumor Suppressor Proteins - genetics | Germ-Line Mutation | Ubiquitin Thiolesterase - metabolism | Adult | Female | Adenocarcinoma - genetics | Genetic Diseases, Inborn - metabolism | Uveal Neoplasms - metabolism | Microsatellite Repeats | Lung Neoplasms - genetics | Melanoma - metabolism | Uveal Neoplasms - genetics | Genetic Predisposition to Disease - genetics | Tumor Suppressor Proteins - metabolism | Meningeal Neoplasms - genetics | Meningioma - metabolism | Uveal Neoplasms - pathology | Gene Silencing | Chromosomes, Human, Pair 3 - metabolism | Melanoma - pathology | Ubiquitin Thiolesterase - genetics | Meningioma - pathology | Pedigree | Meningeal Neoplasms - metabolism | Meningeal Neoplasms - pathology | Chromosomes, Human, Pair 3 - genetics | Genetic aspects | Research | BRCA mutations | Cancer
Journal Article
Oncogene, ISSN 1476-5594, 2015, Volume 35, Issue 15, pp. 1996 - 2002
Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with... 
CELLS | SUPPRESSOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | CROCIDOLITE ASBESTOS | CELL BIOLOGY | REGULATOR | ONCOLOGY | GENETICS & HEREDITY | DEUBIQUITINASE BAP1 | TUMOR-ASSOCIATED MACROPHAGES | MUTATIONS | UBIQUITIN HYDROLASE | POLARIZATION | Leukocytes - pathology | Peritoneal Neoplasms - etiology | Cytokines - analysis | Male | Dose-Response Relationship, Drug | Peritonitis - genetics | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Ubiquitin Thiolesterase - deficiency | Germ-Line Mutation | Female | Peritonitis - etiology | Ascitic Fluid - chemistry | Genetic Predisposition to Disease | Macrophages, Peritoneal - physiology | Mice, Inbred C57BL | Asbestos, Crocidolite - administration & dosage | Mesothelioma - genetics | Ubiquitin Thiolesterase - physiology | Random Allocation | Ubiquitin Thiolesterase - genetics | Asbestos, Crocidolite - toxicity | Chemokines - analysis | Tumor Suppressor Proteins - physiology | Animals | Peritoneal Neoplasms - genetics | Macrophages, Peritoneal - classification | Mineral Fibers - toxicity | Heterozygote | Mice | Mesothelioma - etiology | Asbestos | Immune response | Gene mutations | Mesothelioma | Development and progression | Genetic aspects | Health aspects | Oncology | Mutation | Cytokines | Chemokines | Index Medicus | dose | macrophages | germline | asbestos | inflammation | BAP1 cancer syndrome | polarization | mesothelioma | BAP1
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2016, Volume 212, Issue 7, pp. 845 - 860
Journal Article