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Journal Article
Nature Genetics, ISSN 1061-4036, 07/2012, Volume 44, Issue 7, pp. 751 - 759
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7659, pp. 549 - 553
Journal Article
Nature, ISSN 0028-0836, 05/2010, Volume 465, Issue 7295, pp. 243 - 247
Journal Article
Science, ISSN 0036-8075, 9/2012, Volume 337, Issue 6101, pp. 1541 - 1546
De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur... 
Spleen | Myeloid cells | Genes | DNA | REPORTS | Stem cells | Neutrophils | Bone marrow | Bone marrow cells | Genetic mutation | Tumors | ASXL1 | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | LEUKEMIA | UBIQUITIN HYDROLASE | PREDISPOSE | MYELODYSPLASTIC SYNDROMES | Myeloid Cells - cytology | Humans | Leukemia, Myelomonocytic, Chronic - genetics | Myeloid Cells - physiology | Host Cell Factor C1 - metabolism | Leukemia, Myelomonocytic, Chronic - metabolism | Chromatin Immunoprecipitation | Hematopoiesis | Gene Deletion | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Bone Marrow Transplantation | Myeloid Progenitor Cells - cytology | Ubiquitin Thiolesterase - metabolism | Leukemia, Myelomonocytic, Chronic - pathology | Genes, Tumor Suppressor | Repressor Proteins - metabolism | Promoter Regions, Genetic | Myelodysplastic Syndromes - metabolism | Tumor Suppressor Proteins - metabolism | Gene Expression Regulation | Embryonic Development | Ubiquitin Thiolesterase - genetics | N-Acetylglucosaminyltransferases - metabolism | Gene Knock-In Techniques | Mice, Knockout | Animals | Myeloid Progenitor Cells - physiology | Cell Transformation, Neoplastic | Mice | Myelodysplastic Syndromes - genetics | Myelodysplastic Syndromes - pathology | Ubiquitin Thiolesterase - chemistry | Gene silencing | Tumor suppressor genes | Genetic engineering | Research | Properties | Observations | Enzymes | Mutation | Gene expression | Molecular biology | Leukemia | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2011, Volume 17, Issue 12, pp. 1636 - 1640
Ubiquitin-tagged substrates are degraded by the 26S proteasome, which is a multisubunit complex comprising a proteolytic 20S core particle capped by 19S... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BORTEZOMIB | 26S PROTEASOME | CELL-DEATH | P53 | CELL BIOLOGY | UBIQUITINATION | ROLES | DEGRADATION | EXPRESSION | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Ubiquitin - metabolism | Breast Neoplasms | Protease Inhibitors - pharmacology | Multiple Myeloma - drug therapy | Ubiquitination | Proteasome Endopeptidase Complex - drug effects | Microarray Analysis | Ubiquitin Thiolesterase - metabolism | Female | Antineoplastic Agents - pharmacology | Ubiquitin Thiolesterase - antagonists & inhibitors | Disease Models, Animal | Bortezomib | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Carboxypeptidases - antagonists & inhibitors | Mice, SCID | Piperidones - pharmacology | Ubiquitin Thiolesterase - genetics | bcl-2-Associated X Protein - antagonists & inhibitors | Gene Expression Regulation, Enzymologic | Animals | Cell Line, Tumor | Carboxypeptidases - metabolism | Mice | Mice, Inbred BALB C | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Pyrazines - pharmacology | Apoptosis | Boronic Acids - pharmacology | Physiological aspects | Care and treatment | Research | Ubiquitin-proteasome system | Cancer | Proteins | Inhibitor drugs | Molecular biology | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/2010, Volume 463, Issue 7277, pp. 103 - 107
MCL1 is essential for the survival of stem and progenitor cells of multiple lineages, and is unique among pro-survival BCL2 family members in that it is... 
MULTIPLE-MYELOMA | BREAST-CANCER | APOPTOSIS | IN-VITRO | ACTIVATION | UBIQUITIN LIGASE | PATHWAY | MULTIDISCIPLINARY SCIENCES | PROTEINS | BCL-2 FAMILY | EXPRESSION | Neoplasms - metabolism | Prognosis | Taxoids - pharmacology | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Half-Life | Neoplasms - diagnosis | Gene Knockdown Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Ubiquitination | Ultraviolet Rays | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | Ubiquitin Thiolesterase - deficiency | Protein Binding - radiation effects | Ubiquitin Thiolesterase - metabolism | Female | Lysine - metabolism | Protein Stability | Polyubiquitin - metabolism | Cell Line | Cell Survival | Docetaxel | Etoposide - pharmacology | Mice, SCID | Sulfonamides - pharmacology | Ubiquitin Thiolesterase - genetics | Piperazines - pharmacology | Xenograft Model Antitumor Assays | Phosphorylation - radiation effects | Animals | Myeloid Cell Leukemia Sequence 1 Protein | Cell Line, Tumor | Mice | DNA Damage | Neoplasms - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | Care and treatment | Multiple myeloma | Physiological aspects | Genetic aspects | Research | Ubiquitin-proteasome system | Health aspects | Oncogenes | Cancer | Proteins | Lymphomas | Mass spectrometry | Apoptosis | Index Medicus
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 307 - 325
The protein kinase PINK 1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65, and phosphoUb activates the E3 ligase Parkin allosterically. Here, we... 
PINK1 | phosphorylation | deubiquitinase | ubiquitin | Parkin | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | 63-LINKED POLYUBIQUITIN CHAINS | DAMAGED MITOCHONDRIA | CELL BIOLOGY | E3 LIGASE | ACTIVATE PARKIN | BINDING PROTEINS | CROSS-REACTIVITY | CONJUGATING ENZYME | REVEALS | Phosphorylation - physiology | Ubiquitin-Specific Proteases - genetics | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Mitochondrial Proteins - genetics | Phosphoproteins - metabolism | Polyubiquitin - genetics | Allosteric Regulation - physiology | Mitochondrial Proteins - metabolism | Protein Multimerization - physiology | Ubiquitin Thiolesterase - metabolism | TNF Receptor-Associated Factor 6 - genetics | Ubiquitination - physiology | Ubiquitin-Specific Proteases - metabolism | Polyubiquitin - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Serine - genetics | Ubiquitin-Conjugating Enzymes - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Ubiquitin Thiolesterase - genetics | Serine - metabolism | Hydrolysis | Transcription Factors - metabolism | Endopeptidases - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Thiolester Hydrolases - genetics | Thio