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Molecular Cell, ISSN 1097-2765, 2011, Volume 42, Issue 1, pp. 23 - 35
Journal Article
Journal Article
British Journal of Haematology, ISSN 0007-1048, 05/2015, Volume 169, Issue 4, pp. 534 - 543
Journal Article
EMBO reports, ISSN 1469-221X, 02/2009, Volume 10, Issue 2, pp. 173 - 179
Ubiquilins (UBQLNs) are adaptor proteins thought to deliver ubiquitinated substrates to proteasomes. Here, we show a role for UBQLN in autophagy: enforced... 
ubiquitin‐like | PLIC | autophagy | ubiquilin | autophagosomes | APOPTOSIS | ubiquitin-like | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | MITOPHAGY | DEATH | MATURATION | HUNTINGTIN | INCLUSION-BODY FORMATION | CELL BIOLOGY | PROTEASOME | DEGRADATION | PROMOTES | Ubiquitin-Activating Enzymes - physiology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Ubiquitins - genetics | Humans | Adaptor Proteins, Vesicular Transport - genetics | Recombinant Fusion Proteins - physiology | Autophagy - physiology | Autophagy - drug effects | Microscopy, Immunoelectron | Cell Cycle Proteins - antagonists & inhibitors | Recombinant Fusion Proteins - antagonists & inhibitors | RNA Interference | Cell Cycle Proteins - genetics | Carrier Proteins - physiology | Protein Structure, Tertiary | Ubiquitin-Activating Enzymes - genetics | Adaptor Proteins, Vesicular Transport - physiology | Adaptor Proteins, Vesicular Transport - antagonists & inhibitors | Phagosomes - metabolism | Carrier Proteins - antagonists & inhibitors | RNA, Small Interfering - physiology | Microtubule-Associated Proteins - antagonists & inhibitors | Ubiquitins - physiology | HeLa Cells - drug effects | Microtubule-Associated Proteins - physiology | Protein Interaction Mapping | Carrier Proteins - genetics | Autophagy-Related Protein 7 | Animals | Autophagy-Related Protein 5 | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Culture Media - pharmacology | Mice | HeLa Cells - cytology | Cell Cycle Proteins - physiology | Ubiquitins - antagonists & inhibitors | Proteins | Genetics | Nutrients | Molecular biology | Substrates | Scientific Report
Journal Article
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2013, Volume 23, Issue 4, pp. 508 - 523
Lysosome is a key subceilular organelle in the execution of the autophagic process and at present little is known whether lysosomal function is controlled in... 
溶酶体 | 自噬 | 调节作用 | 体功能 | 激活 | 雷帕霉素 | mTOR | 哺乳动物 | autophagy | autophagosome | lysosome | mTORC1 | CLEARANCE | COMPLEX | MECHANISM | MATURATION | MAMMALIAN-CELLS | CELL BIOLOGY | ENDOSOMES | BIOGENESIS | AMINO-ACIDS | DEGRADATION | INHIBITORS | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Lysosomes - genetics | Membrane Fusion - genetics | Multiprotein Complexes - genetics | Mechanistic Target of Rapamycin Complex 2 | Autophagy - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - agonists | Mechanistic Target of Rapamycin Complex 1 | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Indoles - pharmacology | Membrane Fusion - drug effects | Fibroblasts - metabolism | Phagosomes - drug effects | Lysosomes - drug effects | Ubiquitin-Activating Enzymes - genetics | Purines - pharmacology | Microtubule-Associated Proteins - antagonists & inhibitors | Ubiquitin-Activating Enzymes - metabolism | Sirolimus - pharmacology | Gene Expression Regulation - drug effects | Autophagy-Related Protein 7 | Animals | Autophagy-Related Protein 5 | Signal Transduction - drug effects | Fibroblasts - drug effects | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Fibroblasts - cytology | Mice | HeLa Cells | Naphthyridines - pharmacology | Phagosomes - genetics | Original
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2018, Volume 24, Issue 2, pp. 186 - 193
The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | MLN4924 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | KINASE | CELL BIOLOGY | DEGRADATION | SUBSTRATE-ASSISTED INHIBITION | E1 INHIBITOR | NEDD8-ACTIVATING ENZYME | PROTEASOME SYSTEM | MYELOMA | DNA Damage - drug effects | Imides - pharmacology | Small Molecule Libraries - pharmacology | Ubiquitin-Activating Enzymes - genetics | DNA Repair - drug effects | Ubiquitin-Activating Enzymes - chemistry | Ubiquitin - antagonists & inhibitors | Humans | Ubiquitin - chemistry | Proteasome Endopeptidase Complex - chemistry | Ubiquitin - genetics | Sulfonamides - pharmacology | Neoplasms - drug therapy | Proteasome Endopeptidase Complex - genetics | Xenograft Model Antitumor Assays | Animals | Proteasome Endopeptidase Complex - drug effects | Neoplasms - genetics | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Cell Line, Tumor | Nucleosides - pharmacology | Protein Binding | Mice | Neoplasms - pathology | Ubiquitin | Antimitotic agents | Physiological aspects | Genetic aspects | Research | Ubiquitin-proteasome system | Antineoplastic agents | Health aspects | Drugs | Enzymes | Immunomodulation | DNA damage | Homeostasis | Cancer therapies | DNA repair | Modulators | Proteasome inhibitors | Anticancer properties | Molecules | Signaling | Inhibitors | Interrogation | Cell cycle | Xenografts | Proteasomes | Antitumor activity | Conjugation | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Science, ISSN 0036-8075, 1/2012, Volume 335, Issue 6066, pp. 348 - 353
Journal Article