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Cancer Research, ISSN 0008-5472, 12/2009, Volume 69, Issue 23, pp. 8844 - 8852
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates cell growth, differentiation, and apoptosis of various types of cells.... 
SURVIVAL | THERAPY | BECLIN-1 | ONCOLOGY | INDUCED APOPTOSIS | MESANGIAL CELLS | PAI-1 GENE-EXPRESSION | INDUCTION | TUMORIGENESIS | CANCER | LC3 | Microtubule-Associated Proteins - genetics | Humans | Ubiquitin-Activating Enzymes - biosynthesis | Cell Growth Processes - physiology | JNK Mitogen-Activated Protein Kinases - metabolism | Autophagy - physiology | Proto-Oncogene Proteins - biosynthesis | Transforming Growth Factor beta - biosynthesis | Breast Neoplasms - metabolism | Transfection | Bcl-2-Like Protein 11 | Carcinoma, Hepatocellular - genetics | Apoptosis Regulatory Proteins - genetics | Liver Neoplasms - pathology | Apoptosis Regulatory Proteins - biosynthesis | Beclin-1 | Ubiquitin-Activating Enzymes - genetics | Liver Neoplasms - genetics | Membrane Proteins - genetics | Transforming Growth Factor beta - physiology | Proto-Oncogene Proteins - genetics | Microtubule-Associated Proteins - antagonists & inhibitors | Microtubule-Associated Proteins - biosynthesis | Autophagy-Related Protein 7 | Membrane Proteins - biosynthesis | Breast Neoplasms - genetics | Transforming Growth Factor beta - genetics | Autophagy-Related Protein 5 | Membrane Proteins - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Breast Neoplasms - pathology | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | Apoptosis Regulatory Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Smad Proteins - metabolism | Carcinoma, Hepatocellular - metabolism
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 08/2012, Volume 131, Issue 3, pp. 548 - 557
Multikinase inhibitor sorafenib inhibits proliferation and angiogenesis of tumors by suppressing the Raf/MEK/ERK signaling pathway and VEGF receptor tyrosine... 
mTOR | HCC | apoptosis | liver | tumor | CANCER-CELLS | ACTIVATION | PROTEIN | MECHANISM | INDUCED APOPTOSIS | HEPATOMA-CELLS | INDUCTION | CELL-DEATH | FAMILY | THERAPY | ONCOLOGY | Niacinamide - analogs & derivatives | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Multiprotein Complexes | Ubiquitin-Activating Enzymes - biosynthesis | Drug Resistance, Neoplasm | Phenylurea Compounds | Autophagy - drug effects | Mechanistic Target of Rapamycin Complex 1 | Chloroquine - pharmacology | Benzenesulfonates - pharmacology | Carcinoma, Hepatocellular - drug therapy | Lysosomes - metabolism | RNA Interference | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Ubiquitin-Activating Enzymes - genetics | Liver Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Autophagy-Related Protein 7 | Animals | Proteins - metabolism | Mice, Nude | Sorafenib | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | RNA, Small Interfering | TOR Serine-Threonine Kinases | Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - metabolism | Liver cancer | Chemotherapy | Kinases | Autophagy | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2011, Volume 286, Issue 15, pp. 12924 - 12932
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 42, pp. 35576 - 35588
Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the broadly used Chinese medicinal herb Stephaniae tetrandrae, exhibits potent antitumor effects... 
CYTOCHROME-C | APOPTOSIS | COLON-CANCER CELLS | ACTIVATION | THERAPY | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | GROWTH | DEATH | PERMEABILIZATION | Transcription, Genetic - drug effects | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - genetics | Humans | Ubiquitin-Activating Enzymes - biosynthesis | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Neoplasm Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Autophagy - drug effects | Benzylisoquinolines - chemistry | Dose-Response Relationship, Drug | Carcinoma, Hepatocellular - drug therapy | MAP Kinase Signaling System - genetics | Mitochondria - genetics | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Autophagy - genetics | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Stephania tetrandra - chemistry | Antineoplastic Agents, Phytogenic - pharmacokinetics | Benzylisoquinolines - pharmacology | Gene Expression Regulation, Neoplastic - genetics | Ubiquitin-Activating Enzymes - genetics | Liver Neoplasms - genetics | Liver Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - chemistry | Mitochondria - metabolism | Mitochondria - pathology | Microtubule-Associated Proteins - biosynthesis | Hep G2 Cells | Xenograft Model Antitumor Assays | Autophagy-Related Protein 7 | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Mice | Mice, Inbred BALB C | Transcription, Genetic - genetics | Carcinoma, Hepatocellular - metabolism | Gene Regulation | Cancer Therapy | Autophagy-related Gene 7 (ATG7) | Tetrandrine | Reactive Oxygen Species (ROS) | Signal Transduction | Autophagy | Anticancer Drug | ERK | Hepatocellular Carcinoma
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 06/2012, Volume 113, Issue 6, pp. 2027 - 2039
Umbilical cord mesenchymal stem cells (MSCs) have been shown to inhibit breast cancer cell growth but it is not known whether this effect is specific to only... 
CELL INHIBITION | APOPTOSIS | HUMAN WHARTON'S JELLY STEM CELL CONDITIONED MEDIUM AND LYSATE | AUTOPHAGY | CANCER CELLS | MATRIX | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | MODEL | CELL BIOLOGY | BREAST-CANCER | TISSUES | CARCINOMA | Osteosarcoma - drug therapy | Adenocarcinoma - pathology | Gene Expression - drug effects | Apoptosis - drug effects | Humans | Ubiquitin-Activating Enzymes - biosynthesis | Umbilical Cord - cytology | Ovarian Neoplasms - pathology | bcl-2-Associated X Protein - biosynthesis | Ovarian Neoplasms - genetics | bcl-Associated Death Protein - biosynthesis | Umbilical Cord - metabolism | Neoplasms - genetics | Mesenchymal Stem Cells - cytology | Female | Adenocarcinoma - genetics | Mesenchymal Stem Cells - metabolism | Ovarian Neoplasms - drug therapy | Beclin-1 | Apoptosis Regulatory Proteins - immunology | Inhibitor of Apoptosis Proteins - biosynthesis | Membrane Proteins - immunology | Survivin | Cell Extracts - pharmacology | Microtubule-Associated Proteins - biosynthesis | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Microtubule-Associated Proteins - immunology | Cell Movement - drug effects | Culture Media, Conditioned | Autophagy-Related Protein 7 | Breast Neoplasms - genetics | Autophagy-Related Protein 5 | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Osteosarcoma - genetics | Cell Cycle - drug effects | Neoplasms - pathology | Osteosarcoma - pathology | Wharton Jelly - cytology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 09/2011, Volume 338, Issue 3, pp. 829 - 840
Journal Article
Journal Article
Molecular Biotechnology, ISSN 1073-6085, 7/2012, Volume 51, Issue 3, pp. 254 - 261
Research in the ubiquitin field requires large amounts of ubiquitin-activating enzyme (E1) for in vitro ubiquitination assays. Typically, the mammalian enzyme... 
Human Genetics | Protein Science | Biochemistry, general | Ubiquitin-activating enzyme | Biotechnology | Chemistry | Purification | Escherichia coli | In vitro ubiquitination assays | Biological Techniques | UBA1 | Cell Biology | SYSTEM | COMPLEX | MEMBERS | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | FAMILY | CLONING | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SEQUENCE | DEGRADATION | PROTEINS | PEROXISOMAL IMPORT RECEPTOR | Recombinant Fusion Proteins - biosynthesis | Histidine - analogs & derivatives | Recombinant Fusion Proteins - isolation & purification | Ubiquitin-Activating Enzymes - genetics | Temperature | Escherichia coli - enzymology | Ubiquitin-Activating Enzymes - biosynthesis | Histidine - genetics | Ubiquitin-Activating Enzymes - isolation & purification | Enzyme Assays | Chromatography, High Pressure Liquid | Escherichia coli - chemistry | Liver - chemistry | Animals | Escherichia coli - genetics | Peroxisome-Targeting Signal 1 Receptor | Receptors, Cytoplasmic and Nuclear - chemistry | Recombinant Fusion Proteins - genetics | Liver - cytology | Mice | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Histidine - chemistry | Receptors, Cytoplasmic and Nuclear - metabolism | Ubiquitin | Enzymes | Proteins | E coli | Rodents | Gene expression | Biological assays | Cell culture | Temperature effects | ubiquitination | Insect cells
Journal Article