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Nature cell biology, ISSN 1476-4679, 2014, Volume 16, Issue 5, pp. 415 - 424
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12089 - 12099
E1 enzymes for ubiquitin (Ub) and Ub-like modifiers (Ubls) harbor two catalytic activities that are required for Ub/Ubl activation... 
SYSTEM | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTRATE-ASSISTED INHIBITION | PROTEIN-ACTIVATION | ACTIVATING ENZYME | INSIGHTS | Disulfides - metabolism | Schizosaccharomyces pombe Proteins - chemistry | Ubiquitin-Activating Enzymes - chemistry | Ubiquitin - metabolism | Crystallography, X-Ray | Ubiquitin-Conjugating Enzymes - chemistry | SUMO-1 Protein - chemistry | Protein Processing, Post-Translational - drug effects | SUMO-1 Protein - genetics | Disulfides - chemistry | Databases, Protein | Enzyme Inhibitors - chemistry | Schizosaccharomyces pombe Proteins - metabolism | Disulfides - pharmacology | Cysteine - metabolism | Protein Interaction Domains and Motifs | Schizosaccharomyces pombe Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Ubiquitin-Activating Enzymes - genetics | Catalytic Domain | Schizosaccharomyces pombe Proteins - genetics | Enzyme Inhibitors - metabolism | Enzyme Inhibitors - pharmacology | Protein Refolding | Ubiquitin - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Ubiquitin-Conjugating Enzymes - genetics | Ubiquitin - genetics | Ubiquitin-Activating Enzymes - metabolism | Ubiquitin-Conjugating Enzymes - metabolism | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Ligands | Protein Conformation | SUMO-1 Protein - metabolism | Structural Homology, Protein | Enzyme Activation | Mutation | Protein Multimerization - drug effects | Amino Acid Substitution | X-ray crystallography | Protein Structure and Folding | domain alternation | thioester | adenylation | structure-function | conformational change | enzyme mechanism | enzyme structure | ubiquitin
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2007, Volume 282, Issue 50, pp. 36223 - 36229
.... We also demonstrate a requirement for the E2-conjugating enzyme Ubc13, the E3 ubiquitin ligase Traf6, and the ubiquitin-activated kinase Tak1 in Nod2-mediated NF-κB activation... 
PEPTIDOGLYCAN | PROTEIN | INNATE IMMUNE-RESPONSES | HOST RECOGNITION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTOR | SYSTEMS | NF-KAPPA-B | TLR4 | MYD88 | Mycobacterium tuberculosis - immunology | Ubiquitin - metabolism | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Ubiquitination - drug effects | TNF Receptor-Associated Factor 6 - genetics | Toll-Like Receptors - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Macrophages - microbiology | MAP Kinase Kinase Kinases - genetics | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Protein Ligases - metabolism | Nod2 Signaling Adaptor Protein - immunology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ubiquitin - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Macrophages - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Toll-Like Receptors - genetics | I-kappa B Kinase - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Adjuvants, Immunologic - pharmacology | NF-kappa B - immunology | TNF Receptor-Associated Factor 6 - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Enzyme Activation - immunology | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | I-kappa B Kinase - metabolism | Myeloid Differentiation Factor 88 - immunology | Ubiquitin-Conjugating Enzymes - immunology | Tuberculosis - metabolism | Macrophages - immunology | Cells, Cultured | Ubiquitination - immunology | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Tuberculosis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | NF-kappa B - genetics | Tuberculosis - genetics | TNF Receptor-Associated Factor 6 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Ubiquitin - immunology
Journal Article
Plant molecular biology, ISSN 1573-5028, 2009, Volume 72, Issue 4-5, pp. 357 - 367
.... In the present study, the ubiquitin-conjugating enzyme gene GmUBC2, a homologue of yeast RAD6, was cloned from soybean and functionally characterized... 
Life Sciences | Plant Pathology | Biochemistry, general | Ubiquitination | Salt and drought tolerance | Stress-responsive genes | Soybean | Plant Sciences | GmUBC2 | Ubiquitin-congugating enzyme | PROTEIN | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | NA+/H+ ANTIPORTER | PLANT SCIENCES | SIGNAL-TRANSDUCTION | THALIANA | DEGRADATION | ACCUMULATION | PROLINE | LIGASE | Potassium - metabolism | Arabidopsis - growth & development | Genes, Plant | Proline - metabolism | Stress, Physiological | Molecular Sequence Data | DNA Primers - genetics | Green Fluorescent Proteins - genetics | Chloride Channels - genetics | Phylogeny | Sodium - metabolism | Recombinant Fusion Proteins - metabolism | Soybeans - genetics | Sodium-Hydrogen Exchangers - metabolism | Arabidopsis Proteins - metabolism | Cation Transport Proteins - metabolism | Droughts | Base Sequence | Plants, Genetically Modified | Soybeans - enzymology | Cation Transport Proteins - genetics | Sodium-Hydrogen Exchangers - genetics | DNA, Plant - genetics | Superoxide Dismutase - metabolism | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Arabidopsis Proteins - genetics | Gene Expression | Ubiquitin-Conjugating Enzymes - genetics | Arabidopsis - metabolism | Salinity | Arabidopsis - genetics | Chloride Channels - metabolism | Sequence Homology, Amino Acid | Genetic Engineering | Ubiquitin-Conjugating Enzymes - metabolism | Recombinant Fusion Proteins - genetics | Arabidopsis thaliana | Ubiquitin | Enzymes | Anopheles | Genetically modified organisms | Physiological aspects | Genetic research | Superoxide | Gene expression | Plant biology | Soybeans | Stress response | Abiotic stress
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2010, Volume 42, Issue 10, pp. 864 - 868
Journal Article
PloS one, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0178925
... intranucleolar bodies (INoBs). Here, we demonstrate that these INoBs also contain SUMO-1 and UBC9, the E2 SUMO-conjugating enzyme... 
Proto-Oncogene Proteins c-mdm2 - genetics | Humans | Protein Multimerization | Cyclin E - genetics | Cyclin-Dependent Kinase Inhibitor p21 - deficiency | Tumor Suppressor Protein p53 - genetics | Organelle Biogenesis | Organelles - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cysteine Endopeptidases - metabolism | Proliferating Cell Nuclear Antigen - genetics | SUMO-1 Protein - genetics | Cell Nucleolus - metabolism | Promyelocytic Leukemia Protein - metabolism | Proto-Oncogene Proteins c-mdm2 - metabolism | Promyelocytic Leukemia Protein - genetics | Cyclin-Dependent Kinase 2 - metabolism | Cell Nucleolus - genetics | Signal Transduction | HCT116 Cells | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase 2 - genetics | Ubiquitin-Conjugating Enzymes - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Protein Transport | Karyopherins - metabolism | Cysteine Endopeptidases - genetics | Karyopherins - genetics | Protein Binding | SUMO-1 Protein - metabolism | Cyclin E - metabolism | DNA Damage | Proliferating Cell Nuclear Antigen - metabolism | Organelles - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Ubiquitin-Conjugating Enzymes - deficiency | GTP-binding protein | Regulators | Complex formation | p53 Protein | DNA damage | Biosynthesis | Cancer therapies | Nuclei | Accumulation | Proteins | Nucleoli | Cell cycle | Proliferating cell nuclear antigen | Cyclin E | Protein transport | Localization | Damage accumulation | Deoxyribonucleic acid--DNA | Translocation | Enzymes | MDM2 protein | Hydrolase | Cyclin-dependent kinase 2 | Cyclin-dependent kinase inhibitor p21 | Depletion | Microscopy | Disruption | Intracellular | Cytoplasm | Impact damage | Apoptosis | Biosíntesi | Biologia molecular | RNA | Citoplasma | Ribosomes | Mutació (Biologia) | Molecular biology | Mutation (Biology) | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 63, Issue 5, pp. 753 - 767
ER-associated degradation (ERAD) is essential for protein quality control in the ER, not only when the ER is stressed, but also at steady state. We report a... 
COMPLEX | UNFOLDED PROTEIN RESPONSE | MISFOLDED GLYCOPROTEINS | DISLOCATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALNEXIN | SEL1L | EDEM | I HEAVY-CHAINS | ER-ASSOCIATED DEGRADATION | UBE2J1 | CELL BIOLOGY | Enzymes | Glycoproteins | Quality control | Quality management
Journal Article