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index medicus (191) 191
humans (189) 189
animals (107) 107
ubiquitin (89) 89
ubiquitin-specific proteases - metabolism (70) 70
biochemistry & molecular biology (68) 68
cell biology (62) 62
proteins (62) 62
ubiquitination (62) 62
ubiquitin-specific proteases - antagonists & inhibitors (61) 61
cell line, tumor (58) 58
mice (57) 57
cancer (47) 47
apoptosis (43) 43
ubiquitin - metabolism (43) 43
ubiquitin thiolesterase - metabolism (43) 43
signal transduction (42) 42
ubiquitin-specific proteases - genetics (42) 42
proteases (41) 41
ubiquitin-specific peptidase 7 (41) 41
article (40) 40
ubiquitin thiolesterase - antagonists & inhibitors (40) 40
ubiquitin-specific proteases (39) 39
enzymes (37) 37
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endopeptidases - metabolism (36) 36
ubiquitin-specific protease (36) 36
cell line (31) 31
nf-kappa-b (31) 31
p53 (31) 31
activation (30) 30
degradation (30) 30
expression (30) 30
hek293 cells (30) 30
male (29) 29
oncology (29) 29
ubiquitin thiolesterase - genetics (29) 29
deubiquitinating enzyme (27) 27
small-molecule inhibitor (27) 27
antineoplastic agents - pharmacology (26) 26
deubiquitinating enzymes (26) 26
mutation (26) 26
endopeptidases - genetics (25) 25
multidisciplinary sciences (25) 25
protein binding (25) 25
tumor suppressor protein p53 - metabolism (25) 25
analysis (24) 24
proteasome endopeptidase complex - metabolism (24) 24
deubiquitination (23) 23
apoptosis - drug effects (22) 22
enzyme inhibitors - pharmacology (22) 22
protein (22) 22
research (22) 22
ubiquitin-specific proteinase (21) 21
hausp (20) 20
usp7 (20) 20
cells (19) 19
gene expression (19) 19
medicine (19) 19
rna interference (19) 19
hela cells (18) 18
pathway (18) 18
protease inhibitors - pharmacology (18) 18
research article (18) 18
tumors (18) 18
ubiquitination - drug effects (18) 18
biophysics (17) 17
deubiquitinase (17) 17
drug discovery (17) 17
health aspects (17) 17
biochemistry (16) 16
cell proliferation (16) 16
cells, cultured (16) 16
genetic aspects (16) 16
neoplasms - drug therapy (16) 16
rna, small interfering - genetics (16) 16
science (16) 16
ubiquitin-protein ligases - metabolism (16) 16
viruses (16) 16
cell proliferation - drug effects (15) 15
dna damage (15) 15
gene knockdown techniques (15) 15
kinases (15) 15
neoplasms - metabolism (15) 15
proteasome (15) 15
ubiquitin-proteasome system (15) 15
biology (14) 14
cell cycle (14) 14
dna repair (14) 14
in-vivo (14) 14
inhibition (14) 14
molecular targeted therapy (14) 14
signal transduction - drug effects (14) 14
immunology (13) 13
life sciences (13) 13
ligases (13) 13
molecular biology (13) 13
phosphorylation (13) 13
physiological aspects (13) 13
binding sites (12) 12
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Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2014, Volume 10, Issue 4, pp. 298 - 304
Protein ubiquitination and deubiquitination are central to the control of a large number of cellular pathways and signaling networks in eukaryotes. Although... 
REPAIR | UBIQUITIN CONJUGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | POL-ETA | NUCLEAR ANTIGEN PCNA | TRANSLESION SYNTHESIS | CISPLATIN RESISTANCE | HOMOLOGOUS RECOMBINATION | FANCONI-ANEMIA | MAMMALIAN-CELLS | CANCER | RNA, Small Interfering - genetics | Antineoplastic Agents - chemical synthesis | Butyrates - pharmacology | Humans | Drug Resistance, Neoplasm | DNA, Neoplasm - biosynthesis | Ubiquitination - drug effects | DNA Damage - physiology | DNA Damage - genetics | Antineoplastic Agents - pharmacology | Colony-Forming Units Assay | Fanconi Anemia - genetics | Cell Survival - drug effects | Ubiquitin-Specific Proteases - antagonists & inhibitors | Electrophoresis, Polyacrylamide Gel | Fanconi Anemia Complementation Group D2 Protein - antagonists & inhibitors | Recombinant Proteins - chemistry | Cisplatin - pharmacology | Proliferating Cell Nuclear Antigen - drug effects | Pimozide - pharmacology | Sister Chromatid Exchange - drug effects | Algorithms | High-Throughput Screening Assays | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | DNA, Neoplasm - antagonists & inhibitors | Indicators and Reagents | Phenylurea Compounds - pharmacology | Proliferating Cell Nuclear Antigen - metabolism | Arabidopsis Proteins - antagonists & inhibitors | Recombination, Genetic - drug effects | Proteins | Signal transduction | DNA repair | DNA damage | Pharmaceutical sciences | Cancer
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2015, Volume 58, Issue 4, pp. 1581 - 1595
The diverse roles of deubiquitinating enzymes, or DUBs, in determining the fate of specific proteins continue to unfold. Concurrent with the revelation of DUBs... 
Ubiquitin-Specific Proteases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Humans | Enzyme Inhibitors - pharmacology | Models, Molecular | Crystallography, X-Ray | Molecular Structure | Structure-Activity Relationship | Ubiquitin-Specific Proteases - metabolism | Drug Discovery
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2013, Volume 12, Issue 12, pp. 2651 - 2662
Journal Article
Journal Article