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The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 307 - 325
The protein kinase PINK1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65, and phosphoUb activates the E3 ligase Parkin allosterically. Here, we... 
PINK1 | phosphorylation | deubiquitinase | ubiquitin | Parkin | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | 63-LINKED POLYUBIQUITIN CHAINS | DAMAGED MITOCHONDRIA | CELL BIOLOGY | E3 LIGASE | ACTIVATE PARKIN | BINDING PROTEINS | CROSS-REACTIVITY | CONJUGATING ENZYME | REVEALS | Phosphorylation - physiology | Ubiquitin-Specific Proteases - genetics | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Mitochondrial Proteins - genetics | Phosphoproteins - metabolism | Polyubiquitin - genetics | Allosteric Regulation - physiology | Mitochondrial Proteins - metabolism | Protein Multimerization - physiology | Ubiquitin Thiolesterase - metabolism | TNF Receptor-Associated Factor 6 - genetics | Ubiquitination - physiology | Ubiquitin-Specific Proteases - metabolism | Polyubiquitin - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Serine - genetics | Ubiquitin-Conjugating Enzymes - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Ubiquitin Thiolesterase - genetics | Serine - metabolism | Hydrolysis | Transcription Factors - metabolism | Endopeptidases - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Thiolester Hydrolases - genetics | Thiolester Hydrolases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Enzymes | Phosphorylation | Kinases | Crystal structure
Journal Article
Journal Article
Journal Article
Science Signaling, ISSN 1945-0877, 01/2014, Volume 7, Issue 307, pp. ra3 - ra3
Ubiquitylation is an important mechanism for regulating innate immune responses to viral infections. Attachment of lysine 63 (Lys(63))-linked ubiquitin chains... 
INTERFERON INDUCTION | RESPONSES | PHOSPHORYLATION | NEGATIVE REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYUBIQUITIN CHAINS | RNA VIRUSES | NF-KAPPA-B | ADAPTER PROTEIN | INNATE IMMUNITY | LIGASE | CELL BIOLOGY | Protein Binding - genetics | Ubiquitin-Specific Proteases - genetics | Interferon-beta - immunology | Antiviral Agents - immunology | Humans | Green Fluorescent Proteins - genetics | Antiviral Agents - metabolism | Tripartite Motif Proteins | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | Ubiquitination | RNA Interference | Proteolysis | HEK293 Cells | Lysine - metabolism | DEAD-box RNA Helicases - metabolism | Newcastle disease virus - immunology | Transcription Factors - immunology | Ubiquitin-Specific Proteases - metabolism | DEAD Box Protein 58 | Green Fluorescent Proteins - metabolism | Interferon-alpha - metabolism | Vesicular stomatitis Indiana virus - genetics | Sendai virus - immunology | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Virus Replication - immunology | Signal Transduction - genetics | Transcription Factors - genetics | Protein Binding - immunology | Blotting, Western | Interferon-alpha - immunology | Transcription Factors - metabolism | DEAD-box RNA Helicases - genetics | Immunity, Innate - immunology | Microscopy, Confocal | Interferon-beta - metabolism | Newcastle disease virus - genetics | Ubiquitin-Specific Proteases - immunology | DEAD-box RNA Helicases - immunology | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Vesicular stomatitis Indiana virus - immunology
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article