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ubiquitin (154) 154
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Nature Chemical Biology, ISSN 1552-4450, 02/2018, Volume 14, Issue 2, pp. 118 - 125
Given the importance of ubiquitin-specific protease 7 (USP7) in oncogenic pathways, identification of USP7 inhibitors has attracted considerable interest.... 
INACTIVATION | DUBS | STABILIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HAUSP | ACTIVATES P53 | PROTEASES | Ubiquitin | Cell culture | MDM2 protein | Ubiquitin-specific proteinase | Antagonists | Tumor cell lines | Optimization | Allosteric properties | Inhibitors | Cell lines | Binding sites | Crystal structure | Cancer
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/2017, Volume 36, Issue 11, pp. 1623 - 1639
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7677, pp. 481 - 486
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases remove... 
DEUBIQUITINATING ENZYME | CELLS | ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | CATALYTIC DOMAIN | UBIQUITIN SYSTEM | CANCER-THERAPY | GMP-SYNTHETASE | P53 | PROTEASES | Transcription, Genetic - drug effects | Pyrazoles - chemical synthesis | Pyrimidines - chemical synthesis | Ubiquitin-Specific Peptidase 7 - chemistry | Humans | Substrate Specificity | Crystallography, X-Ray | Proto-Oncogene Proteins c-mdm2 - chemistry | Ubiquitination - drug effects | Piperidines - pharmacology | Apoenzymes - metabolism | Female | Proto-Oncogene Proteins c-mdm2 - metabolism | Apoenzymes - antagonists & inhibitors | Pyrazoles - pharmacology | Tumor Suppressor Protein p53 - metabolism | Models, Molecular | Neoplasms - enzymology | Ubiquitin-Specific Peptidase 7 - antagonists & inhibitors | Pyrimidines - pharmacology | Ubiquitin-Specific Peptidase 7 - metabolism | Piperidines - chemical synthesis | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Apoenzymes - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Proteins | Structure | Proteases | Ligases | Cells | Crystals | Ubiquitin | Enzymes | MDM2 protein | Deregulation | Ubiquitin-specific proteinase | Transcription | p53 Protein | Kinases | Substrates | Degradation | Ubiquitination | Fingers & toes | DNA methylation | Control stability | Catalysis | Inhibition | Ubiquitin-protein ligase | Cancer | Crystal structure | Tumors
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2018, Volume 115, Issue 21, p. 5546
Checkpoint kinase 1 (CHK1), a Ser/Thr protein kinase, is modified by the K63-linked ubiquitin chain in response to genotoxic stress, which promotes its nuclear... 
Ubiquitin | Enzymes | Chromatin | Phosphorylation | Ubiquitin-specific proteinase | DNA damage | Genomics | CHK1 protein | Genotoxicity | Chains | Activation | Kinases | Substrates | Mutants | Proteins | Ubiquitination | Protein kinase | Localization | Deoxyribonucleic acid--DNA
Journal Article