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Journal Article
Immunity, ISSN 1074-7613, 07/2013, Volume 39, Issue 1, pp. 111 - 122
Immune cells sense microbial products through Toll-like receptors (TLR), which trigger host defense responses including type 1 interferons (IFNs) secretion. A... 
TUMOR-NECROSIS-FACTOR | ACTIVATION | I INTERFERONS | CHORIOMENINGITIS VIRUS | PROTEIN-TYROSINE PHOSPHATASES | HOST-DEFENSE | MURINE LUPUS | INFLAMMATORY ARTHRITIS | IMMUNOLOGY | NF-KAPPA-B | T-CELLS | Lymphocytic choriomeningitis virus - immunology | Colitis - genetics | Humans | Autoimmunity - genetics | Immunoblotting | Arthritis - genetics | Interferon Type I - immunology | Lymphocytic Choriomeningitis - immunology | Host-Pathogen Interactions - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Autoimmunity - immunology | Myeloid Cells - immunology | TNF Receptor-Associated Factor 3 - genetics | Colitis - chemically induced | HEK293 Cells | Arthritis - immunology | Interferon Type I - metabolism | Lymphocytic choriomeningitis virus - physiology | Toll-Like Receptors - metabolism | Colitis - immunology | Lymphocytic Choriomeningitis - genetics | Cell Line | Lymphocytic Choriomeningitis - virology | Mice, Inbred C57BL | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - metabolism | Toll-Like Receptors - immunology | Cells, Cultured | Immunity - immunology | Mice, Transgenic | TNF Receptor-Associated Factor 3 - metabolism | Ubiquitination - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Animals | Dextran Sulfate - immunology | TNF Receptor-Associated Factor 3 - immunology | Toll-Like Receptors - genetics | Interferon Type I - genetics | Myeloid Cells - metabolism | Mice | Immunity - genetics | Ubiquitin | Autoimmunity | Interferon | Biological response modifiers
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 50, pp. 36223 - 36229
The Rip2 kinase contains a caspase recruitment domain and has been implicated in the activation of the transcriptional factor NF-κB downstream of Toll-like... 
PEPTIDOGLYCAN | PROTEIN | INNATE IMMUNE-RESPONSES | HOST RECOGNITION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTOR | SYSTEMS | NF-KAPPA-B | TLR4 | MYD88 | Mycobacterium tuberculosis - immunology | Ubiquitin - metabolism | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Ubiquitination - drug effects | TNF Receptor-Associated Factor 6 - genetics | Toll-Like Receptors - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Macrophages - microbiology | MAP Kinase Kinase Kinases - genetics | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Protein Ligases - metabolism | Nod2 Signaling Adaptor Protein - immunology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ubiquitin - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Macrophages - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Toll-Like Receptors - genetics | I-kappa B Kinase - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Adjuvants, Immunologic - pharmacology | NF-kappa B - immunology | TNF Receptor-Associated Factor 6 - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Enzyme Activation - immunology | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | I-kappa B Kinase - metabolism | Myeloid Differentiation Factor 88 - immunology | Ubiquitin-Conjugating Enzymes - immunology | Tuberculosis - metabolism | Macrophages - immunology | Cells, Cultured | Ubiquitination - immunology | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Tuberculosis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | NF-kappa B - genetics | Tuberculosis - genetics | TNF Receptor-Associated Factor 6 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Ubiquitin - immunology
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2017, Volume 18, Issue 8, pp. 832 - 842
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2015, Volume 195, Issue 9, pp. 4415 - 4425
Tripartite motif (TRIM) 38 is an E3 ubiquitin ligase that was reported to regulate signaling in innate immune and inflammatory responses in certain cell lines.... 
ACTIVATION | IRF3 | I INTERFERON INDUCTION | ADAPTER | CELLULAR ANTIVIRAL RESPONSE | K63-LINKED UBIQUITINATION | RIG-I | DEGRADATION | FAMILY PROTEINS | IMMUNOLOGY | NF-KAPPA-B | Interferon-beta - immunology | Gene Expression - drug effects | Dendritic Cells - immunology | Humans | Immunity, Innate - genetics | Immunoblotting | Male | Lipopolysaccharides - immunology | Signal Transduction - immunology | Bone Marrow Cells - immunology | Gene Expression - immunology | HEK293 Cells | Inflammation Mediators - metabolism | Tumor Necrosis Factor-alpha - immunology | Female | Poly I-C - immunology | Cytokines - genetics | Carrier Proteins - immunology | Dendritic Cells - metabolism | Macrophages - immunology | Macrophages - microbiology | Cytokines - immunology | Inflammation Mediators - immunology | Salmonella typhimurium - physiology | Poly I-C - pharmacology | Cytokines - metabolism | Salmonella typhimurium - immunology | Cells, Cultured | Toll-Like Receptor 3 - immunology | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Reverse Transcriptase Polymerase Chain Reaction | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Carrier Proteins - genetics | Immunity, Innate - immunology | Tumor Necrosis Factor-alpha - pharmacology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Interferon-beta - pharmacology | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Bone Marrow Cells - microbiology | Dendritic Cells - microbiology | Bone Marrow Cells - metabolism
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2013, Volume 9, Issue 5, p. e1003384
Persistent infection of basal keratinocytes with high-risk human papillomavirus (hrHPV) may cause cancer. Keratinocytes are equipped with different pattern... 
ACTIVATION | VIRUS | MICROBIOLOGY | CERVICAL-CANCER | TYPE-16 | MESSENGER-RNAS | VIROLOGY | E7 ONCOPROTEIN | INFECTION | NF-KAPPA-B | PARASITOLOGY | TERMINAL HYDROLASE L1 | E2 PROTEIN | Keratinocytes - virology | Humans | Uterine Cervical Neoplasms - pathology | Human papillomavirus 16 - immunology | Papillomavirus Infections - pathology | Signal Transduction - immunology | Uterine Cervical Neoplasms - metabolism | Papillomavirus Infections - immunology | Transcription Factor RelA - immunology | Female | Phosphorylation - immunology | Keratinocytes - enzymology | Protein-Serine-Threonine Kinases - metabolism | Cytokines - immunology | Cytokines - metabolism | Papillomavirus Infections - enzymology | Cells, Cultured | Uterine Cervical Neoplasms - immunology | TNF Receptor-Associated Factor 3 - metabolism | Ubiquitination - immunology | Immunity, Innate | Gene Expression Regulation, Viral - immunology | Human papillomavirus 16 - metabolism | Keratinocytes - immunology | Keratinocytes - pathology | Animals | Transcription Factor RelA - metabolism | Up-Regulation - immunology | TNF Receptor-Associated Factor 3 - immunology | Uterine Cervical Neoplasms - virology | Protein-Serine-Threonine Kinases - immunology | Ubiquitin Thiolesterase - biosynthesis | Mice | Gene Expression Regulation, Enzymologic - immunology | Ubiquitin Thiolesterase - immunology | 3T3 Cells | Ubiquitin | Immune response | Keratinocytes | Physiological aspects | Host-parasite relationships | Research | Health aspects | Papillomavirus infections | Proteins | Medical research | Human papillomavirus | Cytokines | Kinases | Immune system
Journal Article
Immunological Reviews, ISSN 0105-2896, 01/2009, Volume 227, Issue 1, pp. 75 - 86
The innate immune system is essential for the initial detection of invading viruses and subsequent activation of adaptive immunity. Three classes of receptors,... 
type I interferon | Toll‐like receptor | signaling | RIG‐I‐like receptor | Signaling | Type I interferon | Toll-like receptor | RIG-I-like receptor | INDEPENDENT ANTIVIRAL RESPONSE | DOUBLE-STRANDED-RNA | HEPATITIS-C-VIRUS | TANK-BINDING KINASE-1 | IMMUNOLOGY | TOLL-LIKE RECEPTOR-3 | PLASMACYTOID DENDRITIC CELLS | DOMAIN-CONTAINING ADAPTER | INDUCIBLE GENE-I | NF-KAPPA-B | INTERFERON-ALPHA INDUCTION | RNA Helicases - metabolism | Humans | RNA Viruses - physiology | Interferon Type I - immunology | Host-Pathogen Interactions - immunology | Interferon-Induced Helicase, IFIH1 | RNA Virus Infections - prevention & control | Signal Transduction - immunology | RNA, Viral - genetics | RNA Helicases - genetics | RNA, Viral - metabolism | DEAD-box RNA Helicases - metabolism | RNA Virus Infections - immunology | DEAD Box Protein 58 | Mitochondrial Membranes - immunology | Endoribonucleases - metabolism | Ubiquitination - immunology | Immunity, Innate | DEAD-box RNA Helicases - genetics | Animals | RNA Virus Infections - physiopathology | DEAD-box RNA Helicases - immunology | RNA, Viral - immunology | RNA Helicases - immunology | Immunity, Cellular | Mitochondrial Proteins - immunology | Endoribonucleases - immunology | Oligomers | Dendritic cells | RNA | Biological response modifiers | Health aspects | Type I Interferon
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 24, pp. 9933 - 9938
The molecular mechanisms regulating noncanonical protein transport across cellular membranes are poorly understood. Cross-presentation of exogenous antigens on... 
T lymphocytes | Antigens | Cross priming | Receptors | Dendritic cells | Ubiquitins | Antibodies | Ova | Physiological regulation | Endosomes | ACTIVATION | DENDRITIC CELLS | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | RETRO-TRANSLOCATION | PROTEASOME | DEGRADATION | ENDOPLASMIC-RETICULUM | EXOGENOUS ANTIGENS | PROTEIN DISLOCATION | Ovalbumin - immunology | Dendritic Cells - immunology | Endosomal Sorting Complexes Required for Transport - genetics | Green Fluorescent Proteins - genetics | Adenosine Triphosphatases - immunology | Endosomes - metabolism | Endosomal Sorting Complexes Required for Transport - immunology | Lectins, C-Type - metabolism | Protein Transport - immunology | RNA Interference | Bone Marrow Cells - immunology | Transcription Factors - immunology | Endocytosis - immunology | DNA-Binding Proteins - immunology | Adenosine Triphosphatases - metabolism | Receptors, Cell Surface - immunology | Blotting, Western | Mice, Knockout | Mannose-Binding Lectins - immunology | Cytosol - metabolism | Adenosine Triphosphatases - genetics | Mice | Receptors, Cell Surface - genetics | Mannose-Binding Lectins - metabolism | Endosomes - immunology | Cytosol - immunology | Lectins, C-Type - immunology | Lectins, C-Type - genetics | DNA-Binding Proteins - metabolism | Ovalbumin - metabolism | Flow Cytometry | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Polyubiquitin - metabolism | Green Fluorescent Proteins - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | Antigens - metabolism | Ubiquitination - immunology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - immunology | Transcription Factors - metabolism | Animals | Mannose-Binding Lectins - genetics | Antigens - immunology | Cross-Priming | Bone Marrow Cells - metabolism | Microscopy, Fluorescence | Physiological aspects | Cell receptors | Research | Translocation (Genetics) | Biological transport | Biological Sciences
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1219 - 1228
The mammalian immune system has the ability to discriminate between pathogenic microbes and nonpathogenic microbes to control inflammation. Here we... 
TRANSLOCATION | LEGIONELLA-PNEUMOPHILA | INTRACELLULAR GROWTH | REGULATES AKT UBIQUITINATION | MACROPHAGES | PROTEIN COMPLEXES | INFECTION | AUTOPHAGY | IMMUNOLOGY | TRANSLATION | IDENTIFICATION | TOR Serine-Threonine Kinases - metabolism | Legionnaires' Disease - metabolism | Eukaryotic Initiation Factor-4E - metabolism | Molecular Sequence Data | Immunoblotting | Legionella pneumophila - genetics | Mutation - immunology | Proto-Oncogene Proteins c-akt - genetics | Host-Pathogen Interactions - immunology | Legionnaires' Disease - immunology | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | Base Sequence | Eukaryotic Initiation Factor-4E - immunology | Gene Expression - immunology | Legionnaires' Disease - microbiology | Proto-Oncogene Proteins c-akt - metabolism | Cytokines - genetics | Eukaryotic Initiation Factor-4E - genetics | Macrophages - immunology | Macrophages - microbiology | Cytokines - immunology | Cell Line | Legionella pneumophila - immunology | RNA Interference - immunology | Cytokines - metabolism | Cells, Cultured | Ubiquitination - immunology | Reverse Transcriptase Polymerase Chain Reaction | TOR Serine-Threonine Kinases - immunology | Macrophages - metabolism | Animals | Proto-Oncogene Proteins c-akt - immunology | Mice | Host-bacteria relationships | Immune response | Physiological aspects | Research | Macrophages | Properties | Protein kinases | Testing
Journal Article