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Journal of Cellular Biochemistry, ISSN 0730-2312, 01/2020, Volume 121, Issue 1, pp. 804 - 815
Anticancer drugs exert their effects on cancer cells by deregulating many pathways linked to cell cycle, apoptosis, etc. but cancer cells gradually become... 
XIAP | drug sensitivity | cancer | N‐end rule | UBR1 | RAD21
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 2014, Volume 24, Issue 10, pp. 603 - 611
Journal Article
EUROPEAN JOURNAL OF PEDIATRICS, ISSN 0340-6199, 02/2011, Volume 170, Issue 2, pp. 179 - 183
Johanson-Blizzard syndrome is a very rare autosomal recessive disorder caused by mutations in the Ubiquitin-Protein Ligase E3 Component N-Recognin 1 (UBR1)... 
APLASIA | JOHANSON-BLIZZARD-SYNDROME | Johanson-Blizzard syndrome | GROWTH | PEDIATRICS | Pancreatic insufficiency | UBR1 | BONE | DEFICIENCY | UBR1 gene
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 06/2018, Volume 217, Issue 6, pp. 2019 - 2032
Misfolded cytosolic proteins are degraded by the ubiquitin proteasome system through quality control (QC) pathways defined by E3 ubiquitin ligases and... 
HEAT-STRESS | UBIQUITIN-PROTEASOME SYSTEM | CONTROL MECHANISM | STRUCTURAL BASIS | RETICULUM-ASSOCIATED DEGRADATION | LIGASE UBR1 | EXCHANGE FACTOR FES1 | ENDOPLASMIC-RETICULUM | END RULE PATHWAY | MISFOLDED PROTEINS | CELL BIOLOGY
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 05/2018, Volume 14, Issue 5, pp. 466 - 466
The N-end rule pathway senses the N-terminal destabilizing residues of degradation substrates for the ubiquitin-proteasome system, whose integrity shields... 
SYSTEM | N-TERMINAL ACETYLATION | COMPLEX | PROTEIN | CLPS | UBIQUITIN LIGASE | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | UBR1 | PRINCIPLES | SUBSTRATE RECOGNITION | Ubiquitin | Residues | Proteasomes | Proline | Cardiovascular diseases | Heart diseases | Substrates | Recognition | Ubiquitin-protein ligase | Crystal structure | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 22, pp. E4370 - E4379
We found that the heat shock protein 90 (Hsp90) chaperone system of the yeast Saccharomyces cerevisiae is greatly impaired in naa10 Delta cells, which lack the... 
Ufd4 | Protein degradation | Chk1 | Ubr1 | Naa10 | MOLECULAR CHAPERONES | DEGRADATION SIGNAL | MULTIDISCIPLINARY SCIENCES | UBIQUITIN LIGASES | STRUCTURAL BASIS | PROTEIN-QUALITY CONTROL | GLUCONEOGENIC ENZYMES | SPLIT-UBIQUITIN | ARGINYLATION | CELLULAR-PROTEINS | protein degradation | Biological Sciences | PNAS Plus
Journal Article
by Tran, A
JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 05/2019, Volume 132, Issue 9, p. jcs231662
The Arg/N-end rule pathway and Ubr1, a ubiquitin E3 ligase conserved from yeast to humans, is involved in the degradation of misfolded proteins in the cytosol.... 
EXPOSED HYDROPHOBICITY | PRECURSOR | Ubr1 | MECHANISM | TERMINAL ACETYLATION | QUALITY-CONTROL DEGRADATION | NEURODEGENERATION | Protein quality control | CELL BIOLOGY | N-degron | Ubiquitin-mediated degradation | Protein misfolding | Proteolysis | N-end rule pathway | CytoQC | AGGREGATION | METHIONINE
Journal Article