X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (495) 495
humans (319) 319
umbelliferones - pharmacology (307) 307
umbelliferones - metabolism (300) 300
index medicus (289) 289
male (259) 259
rats (227) 227
pharmacology & pharmacy (188) 188
biochemistry & molecular biology (157) 157
kinetics (152) 152
mice (144) 144
umbelliferone (128) 128
coumarins (126) 126
female (125) 125
umbelliferones - chemistry (120) 120
coumarins - metabolism (103) 103
coumarin (90) 90
hymecromone - analogs & derivatives (89) 89
metabolism (78) 78
esculetin (77) 77
liver - metabolism (75) 75
analysis (70) 70
toxicology (69) 69
antioxidants - pharmacology (68) 68
dose-response relationship, drug (68) 68
cells, cultured (65) 65
in vitro techniques (65) 65
chemistry, medicinal (63) 63
hydrogen-ion concentration (60) 60
enzymes (59) 59
rats, wistar (59) 59
apoptosis (57) 57
coumarins - pharmacology (57) 57
umbelliferones (57) 57
cells (56) 56
expression (54) 54
hymecromone - metabolism (54) 54
plant sciences (53) 53
rats, sprague-dawley (53) 53
cytochrome p-450 enzyme system - metabolism (50) 50
hydrolysis (50) 50
inhibition (50) 50
umbelliferones - therapeutic use (48) 48
spectrometry, fluorescence (47) 47
oxidative stress (45) 45
apoptosis - drug effects (44) 44
coumarins - chemistry (44) 44
chromatography, high pressure liquid (43) 43
induction (43) 43
inflammation (43) 43
liver (43) 43
physiological aspects (43) 43
substrate specificity (43) 43
in-vitro (42) 42
liver - enzymology (42) 42
biosynthesis (41) 41
cell line (41) 41
adult (40) 40
molecular structure (40) 40
fluorescence (39) 39
antioxidants (38) 38
cell biology (38) 38
rats, inbred strains (38) 38
protein binding (36) 36
identification (35) 35
liver - drug effects (35) 35
structure-activity relationship (35) 35
7-hydroxycoumarin (34) 34
mixed function oxygenases - metabolism (34) 34
research (34) 34
time factors (34) 34
cancer (33) 33
cell line, tumor (33) 33
metabolites (33) 33
plants (33) 33
umbelliferones - pharmacokinetics (32) 32
chemistry, analytical (31) 31
disease models, animal (31) 31
rat (31) 31
umbelliferones - administration & dosage (31) 31
activation (30) 30
cell survival - drug effects (30) 30
indomethacin - pharmacology (30) 30
microsomes, liver - metabolism (30) 30
oncology (30) 30
proteins (30) 30
biotechnology & applied microbiology (29) 29
cattle (29) 29
coumarin derivatives (29) 29
daphnetin (29) 29
antioxidant (28) 28
enzyme inhibitors - pharmacology (28) 28
research article (28) 28
biotransformation (27) 27
cytochrome p-450 cyp2a6 (27) 27
models, molecular (27) 27
oxidative stress - drug effects (27) 27
umbelliferones - chemical synthesis (27) 27
coumarins - pharmacokinetics (26) 26
umbelliferones - analysis (26) 26
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (882) 882
Chinese (13) 13
Japanese (4) 4
Russian (4) 4
German (3) 3
Italian (1) 1
Polish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Toxicology and Applied Pharmacology, ISSN 0041-008X, 2007, Volume 221, Issue 1, pp. 1 - 12
Hydrolytic metabolism of pyrethroid insecticides in humans is one of the major catabolic pathways that clear these compounds from the body. Rodent models are... 
Pyrethroids | Xenobiotic metabolism | Carboxylesterases | CHOLESTERYL ESTER HYDROLASE | carboxylesterases | IDENTIFICATION | xenobiotic metabolism | PESTICIDES | pyrethroids | DELTAMETHRIN | IN-VITRO | PLASMA | METABOLISM | ENZYMES | PURIFICATION | MAMMALIAN CARBOXYLESTERASES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Liver - enzymology | Humans | Microsomes, Liver - metabolism | Chlorpyrifos - metabolism | Carboxylic Ester Hydrolases - blood | Valerates - chemistry | Umbelliferones - metabolism | Chlorpyrifos - chemistry | Microsomes, Liver - enzymology | Molecular Structure | Pyrethrins - metabolism | Pancreas - enzymology | Benzyl Alcohols - chemistry | Carboxylesterase - blood | Chlorpyrifos - analogs & derivatives | Electrophoresis, Polyacrylamide Gel | Rats | Umbelliferones - chemistry | Valerates - metabolism | Lipase - metabolism | Carboxylesterase - metabolism | Blotting, Western | Pyrethrins - chemistry | Hydrolysis | Nitrobenzoates - metabolism | Animals | Benzyl Alcohols - metabolism | Thiolester Hydrolases - metabolism | Kinetics | Carboxylic Ester Hydrolases - metabolism | Intestines - enzymology | Physiological aspects | Liver | Adenosine triphosphatase | SMALL INTESTINE | CLEARANCE | LIPASES | SUBSTRATES | HYDROLYSIS | RATS | 60 APPLIED LIFE SCIENCES | ALCOHOLS | IN VITRO | MICROSOMES | LIVER | ACETATES | STEARATES | MAN | INSECTICIDES
Journal Article
Phytomedicine, ISSN 0944-7113, 02/2014, Volume 21, Issue 3, pp. 240 - 246
Coumarins, also known as benzopyrones, are plant-derived products with several pharmacological properties, including antioxidant and anti-inflammatory... 
Inflammatory bowel disease | Antioxidant | Coumarin derivatives | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | 4-METHYLESCULETIN | INDUCTION | PLANT SCIENCES | TRINITROBENZENESULFONIC ACID MODEL | ESCULETIN | INFLAMMATORY-BOWEL-DISEASE | METABOLISM | GLUTATHIONE | INTEGRATIVE & COMPLEMENTARY MEDICINE | RAT COLITIS | SULFASALAZINE | PHARMACOLOGY & PHARMACY | Rats, Wistar | Glutathione - metabolism | Plant Extracts - pharmacology | Alkaline Phosphatase - metabolism | Colon - drug effects | Male | Esculin - therapeutic use | Biphenyl Compounds - metabolism | Inflammatory Bowel Diseases - metabolism | Esculin - pharmacology | Inflammation - metabolism | Lipid Peroxidation - drug effects | Anti-Inflammatory Agents - therapeutic use | Umbelliferones - therapeutic use | Phytotherapy | Inflammatory Bowel Diseases - prevention & control | Anti-Inflammatory Agents - pharmacology | Picrates - metabolism | Rats | Antioxidants - pharmacology | Inflammation - etiology | Colon - metabolism | Coumarins - therapeutic use | Coumarins - pharmacology | Umbelliferones - pharmacology | Antioxidants - therapeutic use | Colitis - etiology | Animals | Colitis - metabolism | Inflammation - prevention & control | Oxidative Stress - drug effects | Colitis - prevention & control | Plant Extracts - therapeutic use | Peroxidase - metabolism | Antioxidants | Coumarins | Care and treatment | Inflammation | Research | Health aspects
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, p. e0151135
Banana is an extensively cultivated plant worldwide, mainly for its fruit, while its ancillary product, the banana flower is consumed as a vegetable and is... 
GLYCOGEN | ANTIOXIDANT | MULTIDISCIPLINARY SCIENCES | Diabetes Mellitus, Experimental - drug therapy | Rats, Wistar | Plant Extracts - pharmacology | Glycated Hemoglobin A - metabolism | Body Weight - drug effects | Male | Flowers - chemistry | Hyperglycemia - drug therapy | Liver - drug effects | Female | Phytotherapy - methods | Diabetes Mellitus, Experimental - metabolism | Liver - metabolism | Rats | Pentacyclic Triterpenes - pharmacology | Streptozocin - pharmacology | Musa - chemistry | Aspartate Aminotransferases - metabolism | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Hyperglycemia - metabolism | Umbelliferones - pharmacology | Fructose-Bisphosphatase - metabolism | Insulin - metabolism | Animals | Glucose - metabolism | Glucosephosphate Dehydrogenase - metabolism | Alanine Transaminase - metabolism | Complications and side effects | Oxidative stress | Care and treatment | Physiological aspects | Influence | Research | Diabetes | Banana | Pathogenesis | Liver | Body weight | Lipid peroxidation | Glucose | Dehydrogenase | Antioxidants | Glucose 6 phosphate dehydrogenase | Hyperglycemia | Glucose dehydrogenase | Aspartate transaminase | Carbohydrates | Enzymes | Ethanol | Abnormalities | Metabolism | Insulin | Studies | Alloxan | Urea | Hypercholesterolemia | Weight reduction | Biomarkers | Glucose-6-phosphatase | Phosphates | Alkaline phosphatase | Biotechnology | Laboratories | Lipids | Glucose metabolism | Glucosephosphate dehydrogenase | Polydipsia | Urine | Creatinine | Alanine | Engineering schools | Pyruvate kinase | Secretion | Complications | Diabetes mellitus | Lactate dehydrogenase | Hexokinase | Fructose | L-Lactate dehydrogenase | Solvent extraction processes | Regeneration | Glycolysis | Alanine transaminase | In vivo methods and tests
Journal Article
Plant Physiology, ISSN 0032-0889, 1/2014, Volume 164, Issue 1, pp. 160 - 172
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2012, Volume 109, Issue 15, pp. E869 - E878
IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the... 
High-throughput screening | 8-formyl-umbelliferone | Aldehydes | Reversible covalent inhibitor | Unfolded protein response | reversible covalent inhibitor | ACTIVATION | UNFOLDED-PROTEIN RESPONSE | ER-STRESS | MULTIDISCIPLINARY SCIENCES | high-throughput screening | KINASE | IRE1-ALPHA | TRANSCRIPTION FACTOR XBP-1 | ENDOPLASMIC-RETICULUM STRESS | CELL-SURVIVAL | unfolded protein response | aldehydes | IRE1 | TRANSMEMBRANE PROTEIN | Humans | Coumarins - chemistry | Endoribonucleases - antagonists & inhibitors | RNA, Messenger - metabolism | Ribonucleases - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Ribonucleases - antagonists & inhibitors | Proteolysis - drug effects | Protein Binding - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Membrane Proteins - metabolism | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | RNA Splicing - drug effects | Endoribonucleases - metabolism | RNA, Messenger - genetics | Regulatory Factor X Transcription Factors | Coumarins - pharmacology | Transcription Factors - metabolism | Secretory Pathway - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress | Schiff Bases - chemistry | Mice | Schiff Bases - metabolism | Biological Sciences | PNAS Plus
Journal Article
Journal Article
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2011, Volume 670, Issue 1, pp. 286 - 294
Daphnetin extracted from . contains coumarin compounds, which possess properties of analgesic and anti-inflammatory effects. In this study, we investigated the... 
Daphnetin | Rheumatoid arthritis | Collagen-induced arthritis | Treg | IL-17 | TGF-β | Foxp3 | Th17 | RORγt | RHEUMATOID-ARTHRITIS | CELLS | ROR-GAMMA-T | ROR gamma t | PROINFLAMMATORY CYTOKINES | TGF-beta | INTERLEUKIN-17 | INFLAMMATION | AUTOIMMUNE ARTHRITIS | THERAPEUTIC TARGET | RECEPTOR ACTIVATOR | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | T-Lymphocytes, Regulatory - metabolism | Arthritis, Experimental - drug therapy | Rats, Wistar | NF-kappa B - metabolism | Th2 Cells - drug effects | Arthritis, Experimental - metabolism | Th1 Cells - metabolism | Inflammation - metabolism | Th17 Cells - drug effects | Th17 Cells - metabolism | Cattle | Forkhead Transcription Factors - metabolism | Inflammation - drug therapy | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Female | Umbelliferones - therapeutic use | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Th1 Cells - drug effects | Trihexosylceramides - metabolism | Cytokines - metabolism | Autoimmune Diseases - immunology | Rats | Arthritis, Experimental - immunology | Inflammation - immunology | Down-Regulation - drug effects | Umbelliferones - isolation & purification | Th2 Cells - metabolism | Disease Progression | Umbelliferones - pharmacology | Up-Regulation - drug effects | T-Lymphocytes, Regulatory - drug effects | Animals | Daphne - chemistry | Collagen Type II - adverse effects | Rheumatoid factor | Transforming growth factors | Analysis
Journal Article
New Phytologist, ISSN 0028-646X, 07/2016, Volume 211, Issue 1, pp. 332 - 344
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 05/2010, Volume 38, Issue 5, pp. 732 - 739
Journal Article
Inflammation Research, ISSN 1023-3830, 07/2017, Volume 66, Issue 7, pp. 579 - 589
Here, we used various approaches to investigate the suppressive role of daphnetin in LPS-induced inflammatory response, with the goal to understand the... 
JAK/STATs | iNOS | Daphnetin | COX-2 | ROS | JAK-STAT | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | PROTEIN-KINASE | MACROPHAGES | IMMUNOLOGY | CELL BIOLOGY | LIPOPOLYSACCHARIDE-INDUCED INOS | PATHWAY | NF-KAPPA-B | EXPRESSION | GENE-TRANSCRIPTION | Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Male | Endotoxemia - pathology | Lipopolysaccharides | STAT1 Transcription Factor - metabolism | Anti-Inflammatory Agents - therapeutic use | Acute Lung Injury - drug therapy | Acute Lung Injury - metabolism | Umbelliferones - therapeutic use | STAT3 Transcription Factor - metabolism | Lung - pathology | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Endotoxemia - drug therapy | Acute Lung Injury - pathology | Dinoprostone - metabolism | Umbelliferones - pharmacology | Animals | Lung - drug effects | Cyclooxygenase 2 - metabolism | RAW 264.7 Cells | Mice | Endotoxemia - metabolism | Nitric Oxide Synthase Type II - metabolism | COX-2 inhibitors | Inflammation | Interleukins | Analysis | Nitric oxide | Prostaglandins E | Interleukin | Prostaglandin E2 | Immunoblotting | Inflammatory response | Lethality | Activation | Nitrite | Assaying | Nuclei | Prostaglandin endoperoxide synthase | Interleukin 6 | Signal transduction | Rodents | Cascades | Interleukin 1 | Tumor necrosis factor-TNF | Mathematical models | Inhibition | Stat1 protein | Injuries | Endotoxemia | Enzyme-linked immunosorbent assay | Activation analysis | Retarding | Oxygen | Antiinflammatory agents | Stat3 protein | Survival | Nitric-oxide synthase | Injury prevention | Lungs | Tumor necrosis factor | In vivo methods and tests | Cyclooxygenase-2 | In vitro methods and tests
Journal Article