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PLoS Biology, ISSN 1544-9173, 06/2017, Volume 15, Issue 6, p. e2000784
MACC1 (Metastasis Associated in Colon Cancer 1) is a key driver and prognostic biomarker for cancer progression and metastasis in a large variety of solid... 
SURVIVAL | OVEREXPRESSION | LOVASTATIN | DIAGNOSIS | APOPTOSIS | GENE MACC1 | MESSENGER-RNA | MARKER | COLORECTAL-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | EXPRESSION | Uncoupling Agents - adverse effects | Benzopyrans - therapeutic use | Transcription Factors - chemistry | Uncoupling Agents - pharmacology | Humans | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Liver Neoplasms, Experimental - prevention & control | Promoter Regions, Genetic - drug effects | Benzopyrans - chemistry | Colorectal Neoplasms - drug therapy | Neoplasm Proteins - genetics | Binding Sites | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Random Allocation | Uncoupling Agents - chemistry | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Small Molecule Libraries | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Cell Line, Tumor | Molecular Docking Simulation | Benzopyrans - adverse effects | Liver Neoplasms, Experimental - secondary | Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry | Neoplasm Proteins - metabolism | Uncoupling Agents - therapeutic use | Antineoplastic Agents - adverse effects | Acetophenones - pharmacology | Female | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Benzopyrans - pharmacology | Colorectal Neoplasms - metabolism | Recombinant Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Acetophenones - adverse effects | Animals | Acetophenones - chemistry | Acetophenones - therapeutic use | Tumor Burden - drug effects | Genes, Reporter - drug effects | Cell Proliferation - drug effects | Colorectal Neoplasms - pathology | Transcription factors | Liver | Colorectal carcinoma | Colorectal cancer | High-throughput screening | Lovastatin | Metastasis | Kinases | Metastases | Consortia | Colon cancer | Rodents | Xenografts | Physiology | Libraries | Colon | Inhibition | Bioinformatics | Statins | c-Jun protein | Metabolism | Sp1 protein | Medicine | Inhibitors | Biomarkers | Software | Clinical medicine | Cancer
Journal Article
BBA - Bioenergetics, ISSN 0005-2728, 08/2017, Volume 1858, Issue 8, pp. 700 - 711
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2016, Volume 100, pp. 153 - 163
There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative stress in the pathogenesis of many of the major neurodegenerative... 
Neuroprotection | PPARγ agonists | Mitochondrial function | Neurodegenerative disorders | OXIDATIVE STRESS | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPINAL-CORD | TRANSCRIPTIONAL COACTIVATOR | AGONIST ROSIGLITAZONE | NEUROPATHIC PAIN | PPAR gamma agonists | ENDOCRINOLOGY & METABOLISM | ACTIVATED-RECEPTOR-GAMMA | GENE-EXPRESSION | NEUROBLASTOMA SH-SY5Y CELLS | TRANSGENIC MOUSE MODEL | Neuroprotective Agents - therapeutic use | Humans | Alzheimer Disease - drug therapy | Mitochondria - metabolism | Parkinson Disease - drug therapy | Mitochondria - drug effects | Neurodegenerative Diseases - metabolism | Neurodegenerative Diseases - drug therapy | Huntington Disease - metabolism | Amyotrophic Lateral Sclerosis - drug therapy | PPAR gamma - pharmacology | PPAR gamma - therapeutic use | Animals | Neurodegenerative Diseases - physiopathology | Neuroprotective Agents - pharmacology | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Parkinson Disease - metabolism | Huntington Disease - drug therapy | Mitochondria - physiology | Disease Models, Animal | GSK-3β, glycogen synthase kinase-3β | BDNF, brain derived neurotrophic factor | SRC, steroid receptor coactivator | Aβ, protein amyloid-β | UCP-2, uncoupling protein 2 | Bcl-2, B-cell lymphoma2 | Review | Nrf2, nuclear factor erythroid-derived 2-like 2 | ALS, amyotrophic lateral sclerosis | HD, huntington's disease | NRF1, nuclear respiratory factor 1 | AF-1, transcriptional activation domain | LPS, lipopolysacchacaride | PPARγ, peroxisome proliferation-activated receptor gamma | UCP-1, uncoupling protein 1 | mtDNA, mitochondrial DNA | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PD, parkinson's disease | TDP-43, TAR DNA-binding protein 43 | Cdk5, cyclin-dependent kinase 5 | COX-2, cyclooxygenase-2 | PGC1α, peroxisome proliferator-activated receptor gamma coactivator 1α | SOD1, superoxide dismutase 1 | HO-1, haem oxygenase-1 | BAT, brown adipose tissue | AD, alzheimer's disease | Bax, Bcl-2-associated X protein | TZDs, thiazolidinediones | ΔΨm, mitochondrial membrane potential | 15D-PGJ2, 15-deoxy-Δ12,14-Prostaglandin J2 | MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | CBP, CREB-binding protein | CNS, central nervous system | WAT, white adipose tissue | 6-OHDA, 6-hydroxydopamine | NF-κB, nuclear factor-κB | iNOS, inducible nitric oxide synthase | TFAM, mitochondrial transcription factor A | MPP+, 1-methyl-4-phenylpyridinium ion | NRF2, nuclear respiratory factor 2
Journal Article
Nutrients, ISSN 2072-6643, 06/2019, Volume 11, Issue 6, p. 1294
Background: 1,4-naphthoquinones, especially juglone, are known for their anticancer activity. However, plumbagin, lawsone, and menadione have been less... 
plumbagin | C6 glioma cell culture | lawsone | menadione | reactive oxygen species | mitochondrial respiration | MEDIATED APOPTOSIS | MULTIFORME | CULTURE | COLON-CANCER | NUTRITION & DIETETICS | RAT GLIOMA | ANTIOXIDANT | PROSTATE-CANCER CELLS | GROWTH | STRESS | Oxidants - pharmacology | Phosphorylation | Reactive Oxygen Species - metabolism | Uncoupling Agents - pharmacology | Plant Extracts - pharmacology | Vitamin K 3 - therapeutic use | Antineoplastic Agents - therapeutic use | Uncoupling Agents - therapeutic use | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Phytotherapy | Oxidation-Reduction | Cell Survival | Naphthoquinones - therapeutic use | Rats | Naphthoquinones - pharmacology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Oxidants - therapeutic use | Vitamin K 3 - pharmacology | Antioxidants - therapeutic use | Animals | Cell Line, Tumor | Oxidative Stress - drug effects | Glioblastoma - drug therapy | Plant Extracts - therapeutic use | Apoptosis | Health sciences | Cell culture | Neurosciences | Glioblastoma | Colorectal cancer | Cytotoxicity | Microflora | Vaccines | Anticancer properties | Antioxidants | Mitochondria | Folk medicine | Plumbagin | Metabolites | Intestine | Immunotherapy | Cell cycle | Intestinal microflora | Cell survival | Menadione | Oxygen consumption | Gastrointestinal tract | Bioavailability | Disease prevention | Organic chemistry | Medical prognosis | Alternative medicine | Gastrointestinal system | Antitumor activity | Glioblastoma cells | In vivo methods and tests | Respiration | Prostate cancer | Viability
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 11, pp. 1263 - 1269
Type 2 diabetes (T2D) has reached an epidemic level globally. Most current treatments ameliorate the hyperglycemic symptom of the disease but are not effective... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | INDUCED INSULIN-RESISTANCE | REVERSAL | CELL BIOLOGY | SKELETAL-MUSCLE | HYPERGLYCEMIA | OBESE GENE | LIVER | FAT | EXPRESSION | NIH 3T3 Cells | Diabetes Mellitus, Experimental - drug therapy | Liver - pathology | Uncoupling Agents - pharmacology | Fatty Liver - pathology | Humans | Fatty Liver - complications | Hyperglycemia - complications | Male | Hyperglycemia - drug therapy | Mitochondria - ultrastructure | Uncoupling Agents - therapeutic use | Diabetes Mellitus, Experimental - blood | Liver - drug effects | Niclosamide - administration & dosage | Fasting - blood | Niclosamide - chemistry | Niclosamide - pharmacology | Diet, High-Fat | Cell Respiration - drug effects | Hyperglycemia - pathology | Diabetes Mellitus, Experimental - complications | Disease Models, Animal | Mammals - metabolism | Liver - ultrastructure | Administration, Oral | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Mitochondria - metabolism | Mitochondria - drug effects | Uncoupling Agents - administration & dosage | Uncoupling Agents - chemistry | Fatty Liver - drug therapy | Hep G2 Cells | Animals | Hyperglycemia - blood | Diabetes Mellitus, Experimental - pathology | Mice | Glucose Clamp Technique | Blood Glucose - metabolism | Energy Metabolism - drug effects | Niclosamide - therapeutic use | Type 2 diabetes | Mitochondria | Research | Analysis | Hyperglycemia | Transgenic animals | Rodents | Lipids | Diabetes | Metabolism
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2068 - 11
Acetaminophen (APAP) is the active component of many medications used to treat pain and fever worldwide. Its overuse provokes liver injury and it is the second... 
ELECTRON-TRANSPORT CHAIN | RESPIRATORY-CHAIN | PROTEIN | SUPERCOMPLEXES | COMPLEX-I | RESPIRASOME | HEPATECTOMY | MULTIDISCIPLINARY SCIENCES | ARCHITECTURE | ENERGY-METABOLISM | REPRESSOR | Liver - pathology | Molecular Chaperones - metabolism | Uncoupling Agents - pharmacology | Mitochondria, Liver - metabolism | Humans | Middle Aged | Male | Mitochondrial Proteins - genetics | Electron Transport Complex I - metabolism | Uncoupling Agents - therapeutic use | Young Adult | Rotenone - therapeutic use | Mitochondrial Proteins - metabolism | Rotenone - pharmacology | Drug Overdose - etiology | Adult | Female | Drug Overdose - complications | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Disease Models, Animal | HSP40 Heat-Shock Proteins - metabolism | Acetaminophen - toxicity | Mice, Inbred C57BL | Mitochondrial Proteins - antagonists & inhibitors | Molecular Chaperones - genetics | HSP40 Heat-Shock Proteins - antagonists & inhibitors | Gene Knockout Techniques | Molecular Chaperones - antagonists & inhibitors | Animals | Hepatocytes | Adolescent | Chemical and Drug Induced Liver Injury - drug therapy | Liver - cytology | Mice | Primary Cell Culture | RNA, Small Interfering - metabolism | Mitochondria | Injury prevention | Liver diseases | Pain | Analgesics | Toxicity | Acetaminophen | Liver | Acetylcysteine | Biocompatibility | Overdose | Fever
Journal Article