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Journal of Clinical Investigation, ISSN 0021-9738, 05/2016, Volume 126, Issue 5, pp. 1704 - 1716
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 12/2017, Volume 23, Issue 12, pp. 1454 - 1454
Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a... 
MEDICINE, RESEARCH & EXPERIMENTAL | MALIGNANT HYPERTHERMIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | BROWN ADIPOSE-TISSUE | ENDOPLASMIC-RETICULUM STRESS | RYANODINE RECEPTOR GENE | RELEASE CHANNEL | MASS-SPECTROMETRY | ADAPTIVE NONSHIVERING THERMOGENESIS | CELL BIOLOGY | ENERGY-EXPENDITURE | UNCOUPLING PROTEIN-1 | FK506-BINDING PROTEIN FKBP12.6 | Animals, Newborn | Thermogenesis - genetics | Uncoupling Protein 1 - genetics | Calcium - metabolism | Humans | Mice, Inbred C57BL | Cells, Cultured | Signal Transduction - genetics | Mice, Knockout | Sarcoplasmic Reticulum Calcium-Transporting ATPases - physiology | Animals | Swine | HEK293 Cells | Glucose - metabolism | Mice | Calcium Signaling - genetics | Adipose Tissue, Beige - metabolism | Homeostasis - genetics | Uncoupling Protein 1 - physiology | Physiological aspects | Homeostasis | Brown adipose tissue | Genetic aspects | Research | Calcium ions | Cycles | Calcium | Body weight | Ryanodine receptors | Pyruvic acid | Body weight loss | Glucose | Adipocytes | Ca2+-transporting ATPase | Calcium signalling | Receptors | Uncoupling protein 1 | Rodents | Calcium homeostasis | Metabolism | Glucose tolerance | Energy balance | Thermogenesis | Glycolysis | Adrenergic receptors | Endoplasmic reticulum | ATP | Receptors (physiology) | Adenosine triphosphatase | Calcium (reticular) | Calcium cycling | SERCA2 | Non-canonical thermogenesis | Obesity | Beige fat | UCP1 | Diabetes
Journal Article
Obesity, ISSN 1930-7381, 01/2017, Volume 25, Issue 1, pp. 111 - 121
Objective To analyze whether a combination of quercetin (Q) and resveratrol (RSV) would induce a white adipose tissue (WAT) browning effect. Methods Thirty‐six... 
ENERGY | HOMEOSTASIS | ACTIVATION | NUTRITION & DIETETICS | C57BL/6J MICE | ADIPOCYTES | HIGH-FAT DIET | INSULIN-RESISTANCE | GLUCOSE | ENDOCRINOLOGY & METABOLISM | ADULT HUMANS | EXPRESSION | Body Weight | Bone Morphogenetic Protein 4 - genetics | Adipocytes - drug effects | Fatty Acid-Binding Proteins - metabolism | Stilbenes - pharmacology | RNA, Messenger - metabolism | Bone Morphogenetic Protein 4 - metabolism | Cyclooxygenase 2 - genetics | Adipose Tissue, White - physiology | Apoptosis Regulatory Proteins - genetics | Uncoupling Protein 1 - genetics | Uncoupling Protein 1 - metabolism | RNA, Messenger - genetics | Adipose Tissue, Brown - physiology | Rats | Amino Acid Transport Systems, Neutral - metabolism | Lipase - metabolism | Fatty Acid-Binding Proteins - genetics | Symporters - metabolism | Amino Acid Transport Systems, Neutral - genetics | Apoptosis Regulatory Proteins - metabolism | Animals | Diet | Quercetin - pharmacology | Adipocytes - metabolism | Symporters - genetics | Cyclooxygenase 2 - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, White - drug effects | Lipase - genetics | Obesity | Homeostasis | Mitochondrial DNA | Adipocytes | Gene expression | Fatty acids | Proteins | Studies | Thermogenesis | Rodents | Morphology | Polyphenols | Protein expression | Oxidation | Deoxyribonucleic acid--DNA
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2017, Volume 487, Issue 4, pp. 795 - 800
Brown adipose tissue (BAT) is critical for mammal's survival in the cold environment. Uncoupling protein 1 (UCP1) is responsible for the non-shivering... 
UCP1 | Brown adipose tissue | Swine | Uncoupling respiration | THERMOGENESIS | ADIPOCYTES | BIOPHYSICS | BEIGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BROWN ADIPOSE-TISSUE | Male | Uncoupling Protein 1 - genetics | Animals | Animal genetics | Viral antibodies | RNA | Antibodies | Animal genetic engineering | Livestock | Meat | Anopheles | Messenger RNA | Genes
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2016, Volume 6, Issue 1, p. 34747
Nesfatin-1, an 82 amino acid gastric peptide, is involved in regulation of food uptake and in multiple metabolic activities. Whether nesfatin-1 modulates the... 
THERMOGENESIS | TARGET | LIPID-METABOLISM | WHITE ADIPOSE-TISSUES | FOOD-INTAKE | MULTIDISCIPLINARY SCIENCES | MOUSE | DIFFERENTIATION | DIET-INDUCED OBESITY | MODULATION | TRANSDIFFERENTIATION | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Leucine - pharmacology | Lipolysis - drug effects | Adipocytes, Brown - metabolism | TOR Serine-Threonine Kinases - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Lipolysis - genetics | Mitochondrial Proton-Translocating ATPases - genetics | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | TOR Serine-Threonine Kinases - genetics | Gene Deletion | Tumor Suppressor Proteins - genetics | Nerve Tissue Proteins - pharmacology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Phosphorylation - drug effects | Calcium-Binding Proteins - metabolism | DNA-Binding Proteins - pharmacology | Tumor Suppressor Proteins - metabolism | Uncoupling Protein 1 - genetics | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Mice, Transgenic | Signal Transduction - genetics | Lipase - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Mitochondrial Proton-Translocating ATPases - metabolism | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Phenotype | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Tuberous Sclerosis Complex 1 Protein | Mice | Calcium-Binding Proteins - pharmacology | Primary Cell Culture | Adipocytes, Brown - cytology | Calcium-Binding Proteins - genetics | Lipase - genetics | TOR protein | Phosphorylation | Clonal deletion | Amino acids | mRNA | Lipid metabolism | Leucine | Adipocytes | TSC1 protein | Lipolysis | Food
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2018, Volume 496, Issue 2, pp. 287 - 293
Recent studies have highlighted recruiting and activating brite adipocytes in WAT (so-called “browning”) would be an attractive anti-obesity strategy. Zinc... 
Obesity | Browning | Mitochondrial biogenesis | Zinc alpha2 glycoprotein | WHITE | ACTIVATION | LIPID-METABOLISM | BETA-ADRENERGIC-RECEPTORS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | BIOPHYSICS | FAT-LIKE PHENOTYPE | 3T3-L1 | ADIPOSE-TISSUE | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Carnitine O-Palmitoyltransferase - genetics | Adipocytes, Brown - metabolism | Glycoproteins - metabolism | Nuclear Respiratory Factor 1 - genetics | DNA-Binding Proteins - metabolism | Carbon-Carbon Ligases - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Isoquinolines - pharmacology | Carnitine O-Palmitoyltransferase - metabolism | Nuclear Respiratory Factor 1 - metabolism | Apoptosis Regulatory Proteins - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Lipid Metabolism - genetics | NF-E2-Related Factor 2 - genetics | Carbon-Carbon Ligases - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Glycoproteins - genetics | Uncoupling Protein 1 - genetics | Signal Transduction | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Gene Expression Regulation | Imidazoles - pharmacology | Lipase - metabolism | Transcription Factors - genetics | 3T3-L1 Cells | DNA-Binding Proteins - genetics | Sulfonamides - pharmacology | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | NF-E2-Related Factor 2 - metabolism | Mice | Pyridines - pharmacology | Adipocytes, Brown - cytology | Lipase - genetics | Lipids | Biosynthesis | Lipase | Body weight | Stem cells
Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 01/2017, Volume 31, Issue 1, pp. 333 - 345
Increasing energy expenditure through activation of brown adipose tissue (BAT) is a critical approach to treating obesity and diabetes. In this study, rutin, a... 
Energy expenditure | Obesity | Brown adipose tissue | Mitochondria | Rutin | RESVERATROL | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT HUMANS | rutin | energy expenditure | DIET-INDUCED OBESITY | INSULIN SENSITIVITY | SIRT1 | CELL BIOLOGY | GLUCOSE-HOMEOSTASIS | WHITE FAT | brown adipose tissue | METABOLISM | BIOLOGY | MICE | ADIPOSE-TISSUE THERMOGENESIS | obesity | Sirtuin 1 - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Cold Temperature | Glucose Tolerance Test | Uncoupling Protein 1 - genetics | Body Temperature Regulation - physiology | High Mobility Group Proteins - metabolism | Obesity - drug therapy | Uncoupling Protein 1 - metabolism | Humans | Rutin - pharmacology | Adipose Tissue, Brown - physiology | Diet, High-Fat - adverse effects | DNA-Binding Proteins - genetics | Sirtuin 1 - genetics | DNA-Binding Proteins - metabolism | Animals | HEK293 Cells | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Body Temperature Regulation - drug effects | Mice, Obese | Mice | Energy Metabolism - drug effects | High Mobility Group Proteins - genetics | Energy metabolism | Animal models | Adipose tissue | Diabetes mellitus | Homeostasis | Metabolism | SIRT1 protein | Side effects | Rodents | Adipose tissue (brown) | Metabolic disorders
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2017, Volume 23, Issue 5, pp. 623 - 630
Journal Article
Journal of Molecular Evolution, ISSN 0022-2844, 12/2018, Volume 86, Issue 9, pp. 618 - 634
Low oxygen and fluctuant ambient temperature pose serious challenges to mammalian survival. Physiological adaptations in mammals to hypoxia and low... 
Adaptive evolution | Hypoxia | Differential expression | HIF pathway | NST | Low temperature | INDUCIBLE FACTOR | ECHOLOCATING BATS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLE-RAT | HEAT-EXCHANGE | BOTTLE-NOSED DOLPHINS | EVOLUTIONARY BIOLOGY | AMINO-ACID-SEQUENCE | POSITIVE SELECTION | MITOCHONDRIAL UNCOUPLING PROTEIN | GENETICS & HEREDITY | HETEROCEPHALUS-GLABER | ADIPOSE-TISSUE | Mammals - genetics | Mammals - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Thermogenesis - genetics | Uncoupling Protein 1 - genetics | Cold-Shock Response - physiology | Uncoupling Protein 1 - metabolism | Acclimatization | Phylogeny | Cold-Shock Response - genetics | Lagomorpha - genetics | Cold Temperature - adverse effects | Hypoxia - metabolism | Selection, Genetic - genetics | Biological Evolution | Hypoxia - genetics | Animals | Adaptation, Physiological - genetics | Ecosystem | Rodentia - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Evolution, Molecular | Anopheles | Genes | Zoology | Genetic research | Amino acids | Evolution | Genetic aspects | Cetacea | Identification and classification | Adaptations | High altitude | Biological evolution | Burrows | Positive selection | Variations | Evolutionary genetics | Shivering | Marine mammals | Proteins | Connective tissues | Marine environment | Taxa | Non-shivering | Cold tolerance | Ambient temperature | Uncoupling protein 1 | Rodents | Diving | Genetics | Species | Invasions | Plateaus | Exploration | Mammals | Gene expression | Natural selection | Molecular modelling | Thermogenesis | Peroxisome proliferator-activated receptors | Blubber | Temperature tolerance | Aquatic ecosystems
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2016, Volume 99, pp. 179 - 188
Reactive oxygen species (ROS) are a byproduct of normal metabolism and play important roles in cell signaling and homeostasis. Mitochondria, the main... 
Obesity | Isocitrate dehydrogenase 2 | Reactive oxygen species | ACTIVATION | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYSTEMIC OXIDATIVE STRESS | P53 | DIABETES-MELLITUS | GLUTATHIONE | ENDOCRINOLOGY & METABOLISM | FAT DEVELOPMENT | EXPRESSION | BROWN | ADIPOCYTE | Thermogenesis - genetics | Isocitrate Dehydrogenase - deficiency | Reactive Oxygen Species - metabolism | Oxidative Stress | Diabetes Mellitus, Type 2 - genetics | Adipocytes - cytology | Intra-Abdominal Fat - cytology | Diabetes Mellitus, Type 2 - metabolism | Obesity - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Energy Metabolism - genetics | Sterol Regulatory Element Binding Protein 1 - metabolism | Uncoupling Protein 1 - genetics | Oxidation-Reduction | Signal Transduction | Uncoupling Protein 1 - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 2 - prevention & control | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Isocitrate Dehydrogenase - genetics | Mitochondria - metabolism | Intra-Abdominal Fat - metabolism | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Insulin - metabolism | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Adipocytes - metabolism | Obesity - prevention & control | Insulin Resistance - genetics | Mice | Diabetes Mellitus, Type 2 - pathology | Type 2 diabetes | Physiological aspects | Medical colleges
Journal Article