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Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 1 - 9
Reactive oxygen species (ROS) are continuously produced as a by-product of mitochondrial metabolism and eliminated via antioxidant systems. Regulation of... 
senescence | mitochondria | ROS | AMPK | PGC-1α | ULK1 | LKB1 | oxidative stress | nutrient signaling energy stress | CANCER-CELLS | SURVIVAL | COMPLEX-III | ENERGY STRESS | ACTIVATED PROTEIN-KINASE | GROWTH | NEURODEGENERATION | HYDROGEN-PEROXIDE | DIRECT PHOSPHORYLATION | CELL BIOLOGY | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Uncoupling Protein 3 - genetics | Humans | Autophagy-Related Protein-1 Homolog - metabolism | AMP-Activated Protein Kinases - deficiency | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - deficiency | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Superoxide Dismutase-1 - metabolism | HEK293 Cells | Protein Stability | Superoxide Dismutase - metabolism | Fibroblasts - metabolism | Cellular Senescence - genetics | Glutathione Peroxidase - metabolism | Uncoupling Protein 3 - metabolism | Signal Transduction | Uncoupling Protein 2 - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Gene Expression Regulation | Mice, Transgenic | Mitochondria - metabolism | Glutathione Peroxidase - genetics | Uncoupling Protein 2 - genetics | Metabolic Networks and Pathways - genetics | Animals | Superoxide Dismutase-1 - genetics | Fibroblasts - cytology | Mice | Primary Cell Culture | Autophagy-Related Protein-1 Homolog - genetics | AMP-Activated Protein Kinases - genetics | Homeostasis - genetics
Journal Article
Science Signaling, ISSN 1945-0877, 01/2017, Volume 10, Issue 464, p. eaaf7478
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 12/2016, Volume 101, pp. 305 - 316
Several evidence indicate that metabolic alterations play a pivotal role in cancer development. Here, we report that the mitochondrial uncoupling protein 2... 
Uncoupling proteins | Metabolism | UCP2 | Proteomics | Cancer | Warburg effect | OXIDATIVE STRESS | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | STATHMIN | ADENOCARCINOMA CELLS | REACTIVE OXYGEN | ROS | ENDOCRINOLOGY & METABOLISM | PHYSIOLOGICAL-ROLE | UP-REGULATION | L-Lactate Dehydrogenase - metabolism | RNA, Small Interfering - genetics | Uncoupling Protein 2 - antagonists & inhibitors | Reactive Oxygen Species - metabolism | Humans | Gene Expression Regulation, Neoplastic | Glucose Transporter Type 1 - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Glycolysis - drug effects | Glycolysis - genetics | Oxidative Phosphorylation - drug effects | Insulin-Secreting Cells - metabolism | Deoxyglucose - pharmacology | Membrane Proteins - metabolism | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - genetics | Signal Transduction | Uncoupling Protein 2 - metabolism | Membrane Proteins - genetics | RNA, Messenger - genetics | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Thyroid Hormones - genetics | Uncoupling Protein 2 - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | L-Lactate Dehydrogenase - genetics | Glucose Transporter Type 1 - genetics | Insulin-Secreting Cells - drug effects | Iridoids - pharmacology | Thyroid Hormones - metabolism | Acetylcysteine - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Insulin-Secreting Cells - pathology | RNA, Small Interfering - metabolism | Oxidases | Cysteine | Development and progression | Glucose | Dextrose | Cystine | Proteins | Cytochrome c | Antioxidants | Prevention | Glucose metabolism | Analysis | Pancreatic cancer | Cancer cells | Mass spectrometry | Physiological aspects | Lactic acid
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1163 - 18
Human proteins MTO1 and GTPBP3 are thought to jointly catalyze the modification of the wobble uridine in mitochondrial tRNAs. Defects in each protein cause... 
RESPIRATORY-CHAIN DEFICIENCY | HYPOXIA-INDUCIBLE FACTOR | ACTIVATED PROTEIN-KINASE | HYPERTROPHIC CARDIOMYOPATHY | LIPID-METABOLISM | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | LACTIC-ACIDOSIS | UNCOUPLING PROTEIN-2 | QUALITY-CONTROL | NEGATIVE REGULATOR | AMP-Activated Protein Kinases - metabolism | Acidosis, Lactic - genetics | GTP-Binding Proteins - deficiency | Humans | PPAR gamma - metabolism | GTP-Binding Proteins - genetics | Glycolysis - genetics | Mitochondria - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | RNA, Transfer - genetics | Fibroblasts - metabolism | PPAR gamma - genetics | Cardiomyopathy, Hypertrophic - genetics | Signal Transduction | Uncoupling Protein 2 - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | RNA, Transfer - metabolism | Cardiomyopathy, Hypertrophic - metabolism | Gene Expression Regulation | Oxidative Phosphorylation | Lipid Metabolism | Mitochondria - metabolism | Mitochondria - pathology | Fibroblasts - pathology | Acidosis, Lactic - pathology | Uncoupling Protein 2 - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Acidosis, Lactic - metabolism | Mutation | Primary Cell Culture | AMP-Activated Protein Kinases - genetics | Cardiomyopathy, Hypertrophic - pathology | Mitochondrial uncoupling protein 2 | Hypoxia-inducible factor 1 | Phosphorylation | tRNA Ala | tRNA | Cardiomyopathy | Metabolism | Fatty acids | Defects | Mitochondria | Oxidative phosphorylation | Transcription activation | Fibroblasts | Uridine | Glycolysis | Hypoxia | Oxidation | Acidosis | Lactic acidosis
Journal Article
FASEB Journal, ISSN 0892-6638, 2017, Volume 31, Issue 11, pp. 5087 - 5101
In visceral leishmaniasis, we found that the antileishmanial drug Amp B produces a higher level of IL-1 beta over the infected control. Moreover, administering... 
NF-κB | IL-1β | ROS | Caspase-1 | MYCOBACTERIUM-TUBERCULOSIS | ENZYME A20 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MURINE MACROPHAGES | IL-1 beta | NLRP3 INFLAMMASOME | CELL BIOLOGY | NF-kappa B | PATTERN-RECOGNITION | HOST IMMUNE-RESPONSE | GENE | EXPERIMENTAL VISCERAL LEISHMANIASIS | BIOLOGY | UNCOUPLING PROTEIN-2 | caspase-1 | EXPRESSION | Reactive Oxygen Species - economics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Macrophages - pathology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | NF-kappa B - metabolism | Interleukin-1beta - genetics | Leishmaniasis, Visceral - metabolism | Leishmaniasis, Visceral - pathology | Inflammasomes - genetics | Macrophage Activation | Leishmania donovani - metabolism | Macrophages - parasitology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Uncoupling Protein 2 - genetics | Tumor Necrosis Factor alpha-Induced Protein 3 - genetics | Macrophages - metabolism | Animals | NF-kappa B - genetics | Leishmaniasis, Visceral - genetics | Uncoupling Protein 2 - biosynthesis | Interleukin-1beta - biosynthesis | Mice | Tumor Necrosis Factor alpha-Induced Protein 3 - biosynthesis | Mitochondrial uncoupling protein 2 | Reactive oxygen species | Liver | Activation | Macrophages | Proteins | Mitochondria | Cell activation | Parasitic diseases | Visceral leishmaniasis | Rodents | A20 protein | Spleen | Vector-borne diseases | NF-κB protein | Maturation | AMP | Caspase | Leishmaniasis | Ribonucleic acid--RNA | Signaling | Regulatory proteins
Journal Article
Cellular and Molecular Biology, ISSN 0145-5680, 2018, Volume 64, Issue 4, pp. 39 - 45
The receptor interaction protein 140 (RIP140) cofactor is a key regulator of metabolic balance, but its function in glucose-and lipid-mediated damage in islet... 
Glucolipotoxicity | Expression analysis | Receptor interaction protein 140 | Oxidative damage | Islet β cell | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL-FUNCTION | DEATH | ENDOPLASMIC-RETICULUM STRESS | PALMITATE | OXIDATIVE-METABOLISM | NUCLEAR RECEPTOR | CELL BIOLOGY | Islet beta cell | SKELETAL-MUSCLE | PANCREATIC BETA-CELLS | TRANSCRIPTIONAL COREPRESSOR RIP140 | EXPRESSION | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | RNA, Small Interfering - genetics | Palmitic Acid - pharmacology | Oxidative Stress | Apoptosis - drug effects | Homeodomain Proteins - metabolism | Humans | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Insulin-Secreting Cells - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - genetics | Trans-Activators - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Insulin-Secreting Cells - cytology | Nuclear Proteins - genetics | Insulin Secretion | Cell Survival - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Nuclear Proteins - agonists | Signal Transduction | Uncoupling Protein 2 - metabolism | RNA, Messenger - genetics | Nuclear Proteins - metabolism | Glucose - pharmacology | Adaptor Proteins, Signal Transducing - agonists | Homeodomain Proteins - genetics | Nuclear Receptor Interacting Protein 1 | Gene Expression Regulation - drug effects | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Uncoupling Protein 2 - genetics | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Nuclear Proteins - antagonists & inhibitors | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Trans-Activators - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Cell Line, Transformed | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 06/2016, Volume 95, pp. 16 - 26
Oxidative stress plays an important role in the development of beta-cell dysfunction and insulin resistance, two major pathophysiological abnormalities of type... 
Oxidative stress | Glutathione-related enzymes | GLP-1 | Beta cell | APOPTOSIS | ACTIVATION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVE OXYGEN | EXENDIN-4 | GLUTATHIONE | ENDOCRINOLOGY & METABOLISM | FAT | EXPRESSION | Reactive Oxygen Species - metabolism | Antioxidants - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Type 2 - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Glucagon-Like Peptide 1 - genetics | Glutathione Reductase - genetics | Glutathione - biosynthesis | Insulin-Secreting Cells - metabolism | Isoquinolines - pharmacology | NF-E2-Related Factor 2 - genetics | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Insulin Secretion | Glucagon-Like Peptide 1 - metabolism | Uncoupling Protein 2 - metabolism | Glucagon-Like Peptide 1 - pharmacology | Glutathione Reductase - biosynthesis | Oxidative Stress - genetics | Rats | Antioxidants - pharmacology | Sulfonamides - pharmacology | tert-Butylhydroperoxide - metabolism | Uncoupling Protein 2 - genetics | Insulin - metabolism | Animals | NF-E2-Related Factor 2 - metabolism | Insulin Resistance - genetics | Glucose - metabolism | Diabetes Mellitus, Type 2 - pathology | Insulin-Secreting Cells - pathology | Type 2 diabetes | Antioxidants | Enzymes | Pancreatic beta cells | Glucagon | Cell death | Insulin resistance | Protein kinases
Journal Article
Genetic testing and molecular biomarkers, ISSN 1945-0265, 09/2017, Volume 21, Issue 9, pp. 531 - 538
Background: Obesity, one of the most common disorders observed in clinical practice, has been associated with energy metabolism-related protein genes such as... 
polymorphism | dyslipidemia | children | obesity | uncoupling protein | UCP3 GENE | BETA-3-ADRENERGIC RECEPTOR | DENSITY-LIPOPROTEIN CHOLESTEROL | ENERGY-EXPENDITURE | PIMA-INDIANS | METABOLISM | INSULIN-RESISTANCE | GENETICS & HEREDITY | BODY-MASS INDEX | EXPRESSION | Gene Frequency - genetics | Exons | Uncoupling Protein 3 - genetics | Humans | Asian Continental Ancestry Group - genetics | Ion Channels - genetics | Male | Mitochondrial Proteins - genetics | Obesity - genetics | Mitochondrial Uncoupling Proteins - metabolism | Mitochondrial Uncoupling Proteins - genetics | Female | Child | Genetic Predisposition to Disease | Uncoupling Protein 1 - genetics | Uncoupling Protein 3 - metabolism | Uncoupling Protein 2 - metabolism | Uncoupling Protein 1 - metabolism | Genetic Association Studies - methods | Genotype | Pediatric Obesity - genetics | Pediatric Obesity - metabolism | Uncoupling Protein 2 - genetics | Turkey | Energy Metabolism | Adolescent | Alleles | Polymorphism, Single Nucleotide - genetics | Adolescence | Mitochondrial uncoupling protein 2 | Energy metabolism | Genes | Dyslipidemia | Insertion | Gene polymorphism | Protein turnover | Proteins | Synergistic effects | Genotype & phenotype | Clonal deletion | Deletion | Children | Adolescents | Lipoproteins (high density) | Genotypes | Hypertension | Obesity | Metabolism | Insulin | Laboratory tests | Hypertriglyceridemia | Polymorphism
Journal Article
Genetic testing and molecular biomarkers, ISSN 1945-0265, 11/2018, Volume 22, Issue 11, pp. 637 - 643
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2017, Volume 18, Issue 6, pp. 665 - 674
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 5, pp. 8083 - 8094
Hypoxic microenvironment is critically involved in the response of non-small cell lung cancer (NSCLC) to chemotherapy, the mechanisms of which remain largely... 
Hypoxia | Chemotherapeutic resistance | PPAR-γ | Non-small cell lung cancer (NSCLC) | Uncoupling protein 2 (UCP2) | hypoxia | TRANSPORTER | uncoupling protein 2 (UCP2) | DRUG-RESISTANCE | non-small cell lung cancer (NSCLC) | PPAR-gamma | CELL BIOLOGY | MITOCHONDRIAL ROS | INHIBITION | GENE | chemotherapeutic resistance | UCP2 | BIOLOGY | GROWTH | STRESS | EXPRESSION | Lung Neoplasms - drug therapy | Reactive Oxygen Species - metabolism | Taxoids - pharmacology | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Tumor Microenvironment | Lung Neoplasms - pathology | Neoplasm Proteins - metabolism | PPAR gamma - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Dose-Response Relationship, Drug | Tumor Hypoxia | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | PPAR gamma - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Uncoupling Protein 2 - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Down-Regulation | Carcinoma, Non-Small-Cell Lung - metabolism | Cisplatin - pharmacology | Cellular Reprogramming - drug effects | Uncoupling Protein 2 - genetics | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Glucose - metabolism | Carcinoma, Non-Small-Cell Lung - drug therapy | Energy Metabolism - drug effects
Journal Article
Journal Article