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index medicus (84) 84
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prenyltransferase (31) 31
alkyl and aryl transferases - metabolism (30) 30
undecaprenyl diphosphate synthase (30) 30
alkyl and aryl transferases - chemistry (28) 28
undecaprenyl pyrophosphate synthase (27) 27
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escherichia coli - enzymology (14) 14
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polyisoprenyl phosphates - chemistry (14) 14
alkyl and aryl transferases - antagonists & inhibitors (13) 13
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peptidoglycan (12) 12
site-directed mutagenesis (12) 12
undecaprenyl pyrophosphate synthetase (12) 12
chain-length determination (11) 11
enzyme inhibitors - pharmacology (11) 11
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transferases - genetics (11) 11
anti-bacterial agents - pharmacology (10) 10
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glycosylation (10) 10
molecular structure (10) 10
phosphates (10) 10
sequence homology, amino acid (10) 10
transferases - chemistry (10) 10
undecaprenyl phosphate (10) 10
binding sites (9) 9
cell biology (9) 9
chemistry, medicinal (9) 9
cloning, molecular (9) 9
crystallography, x-ray (9) 9
dimethylallyltranstransferase - metabolism (9) 9
dolichol (9) 9
isopentenyl diphosphate (9) 9
recombinant proteins - metabolism (9) 9
alkyl and aryl transferases - isolation & purification (8) 8
bacillus-stearothermophilus (8) 8
bacterial proteins - metabolism (8) 8
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anti-bacterial agents - chemistry (7) 7
arabidopsis-thaliana (7) 7
bacterial proteins - genetics (7) 7
base sequence (7) 7
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dimethylallyltranstransferase - genetics (7) 7
diphosphate synthase (7) 7
farnesyl-diphosphate synthase (7) 7
microbial sensitivity tests (7) 7
micrococcus luteus - enzymology (7) 7
micrococcus-luteus (7) 7
mycobacterium tuberculosis - enzymology (7) 7
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Journal Article
Journal Article
Acta Crystallographica Section F, ISSN 2053-230X, 04/2019, Volume 75, Issue 4, pp. 212 - 216
Journal Article
FEBS Journal, ISSN 1742-464X, 10/2012, Volume 279, Issue 20, pp. 3813 - 3827
In eukaryotes, dolichols ( C 70‐120 ) play indispensable roles as glycosyl carrier lipids in the biosynthesis of glycoproteins on endoplasmic reticulum. In... 
dolichol | isoprenoid biosynthesis | cis | prenyltransferase | rabidopsis thaliana | polyprenol | Arabidopsis thaliana | cis-prenyltransferase | MYCOBACTERIUM-TUBERCULOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | UNDECAPRENYL PYROPHOSPHATE SYNTHETASE | RUBBER BIOSYNTHESIS | FUNCTIONAL-ANALYSIS | KEY ENZYME | MOLECULAR-CLONING | ENDOPLASMIC-RETICULUM | EXPRESSION | CIS-PRENYLTRANSFERASES | DOLICHYL-PHOSPHATE | Alkyl and Aryl Transferases - classification | Gene Expression Regulation, Enzymologic - drug effects | Arabidopsis - enzymology | Sesquiterpenes - metabolism | Saccharomyces cerevisiae - genetics | Alkyl and Aryl Transferases - metabolism | Substrate Specificity | Green Fluorescent Proteins - genetics | Phylogeny | Cations, Divalent - pharmacology | Genetic Complementation Test | Transferases - genetics | Arabidopsis Proteins - metabolism | Alkyl and Aryl Transferases - genetics | Transferases - classification | Transferases - metabolism | Endoplasmic Reticulum - enzymology | Recombinant Proteins - metabolism | Green Fluorescent Proteins - metabolism | Arabidopsis Proteins - genetics | Cold Temperature | Biocatalysis | Arabidopsis - cytology | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Polyisoprenyl Phosphates - metabolism | Blotting, Western | Arabidopsis - genetics | Abscisic Acid - pharmacology | Microscopy, Confocal | Gene Expression Regulation, Plant - drug effects | Saccharomyces cerevisiae - enzymology | Kinetics | Mutation | Plant Growth Regulators - pharmacology | Saccharomyces cerevisiae - growth & development | Physiological aspects | Lipids | Glycoproteins | Chemical properties | Cells | Genotype & phenotype | Enzymes | Eukaryotes | Cellular biology | Plant biology | Biosynthesis | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2008, Volume 377, Issue 1, pp. 17 - 22
Journal Article
Angewandte Chemie, ISSN 0044-8249, 04/2016, Volume 128, Issue 15, p. 4799
  We report the first X-ray structure of the unique "head-to-middle" monoterpene synthase, lavandulyl diphosphate synthase (LPPS). LPPS catalyzes the... 
Residential areas | Phosphates | Houses | Condensates | Bacteria | Undecaprenyl diphosphate synthase | Catalysis | Housing | Isopentenyl diphosphate | Structure-function relationships
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 24, pp. 10022 - 10027
Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS), resulting in decreased... 
Enzymes | Yeasts | Electronic structure | Molecular structure | Terpenoids | Diphosphonates | Ligands | Biosynthesis | Diphosphates | Binding sites | Undecaprenyl diphosphate synthase | Geranylgeranyl diphosphate synthase | X-ray structure | Cell wall | FARNESYL DIPHOSPHATE SYNTHASE | POTENTIAL ROUTE | INHIBITION | MECHANISM | ISOPRENOID BIOSYNTHESIS | STRUCTURAL BASIS | NITROGEN-CONTAINING BISPHOSPHONATES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GERANYLGERANYL PYROPHOSPHATE SYNTHASE | DRUGS | Diphosphates - metabolism | Polyisoprenyl Phosphates - chemistry | Sesquiterpenes - metabolism | Models, Chemical | Stereoisomerism | Alkyl and Aryl Transferases - antagonists & inhibitors | Substrate Specificity | Crystallography, X-Ray | Isoenzymes - chemistry | Isoenzymes - metabolism | Transferases - metabolism | Farnesyltranstransferase - antagonists & inhibitors | Molecular Structure | Transferases - antagonists & inhibitors | Diterpenes - metabolism | Binding Sites | Dimerization | Diterpenes - chemistry | Alkyl and Aryl Transferases - chemistry | Sesquiterpenes - chemistry | Protein Structure, Secondary | Models, Molecular | Transferases - chemistry | Diphosphonates - metabolism | Polyisoprenyl Phosphates - metabolism | Farnesyltranstransferase - chemistry | Diphosphates - chemistry | Diphosphonates - chemistry | Hydrophobic and Hydrophilic Interactions | Saccharomyces cerevisiae - enzymology | Isoenzymes - antagonists & inhibitors | Usage | Research | X-ray spectroscopy | Plant cell walls | Guanosine triphosphatase | Biochemistry | Inhibitor drugs | Drug therapy | Index Medicus | Biological Sciences | undecaprenyl diphosphate synthase | x-ray structure | geranylgeranyl diphosphate synthase | cell wall
Journal Article
FRONTIERS IN MICROBIOLOGY, ISSN 1664-302X, 01/2019, Volume 9, pp. 3322 - 3322
We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from Escherichia... 
inhibitors | STATES | MECHANISM | LIGANDS | UppS | antibacterial agents | undecaprenyl pyrophosphate synthase | DIPHOSPHATE SYNTHASE | pharmacophore model | MICROBIOLOGY | cell-wall | Usage | Analysis | Molecular dynamics | Bacterial cell walls | Biosynthesis | Research | Undecylenic acid
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 42, pp. 17351 - 17361
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 2/2015, Volume 58, Issue 3, pp. 1215 - 1227
We report the results of an investigation of the activity of a series of amidine and bisamidine compounds against Staphylococcus aureus and Escherichia coli .... 
DNA minor groove binder | Undecaprenyl diphosphate synthase | Drug discovery | Protein structure
Journal Article